Applied Missing Data Analysis in the Health Sciences

An accessible and practical approach to the design and analysis of experiments in the health sciences Design and Analysis of Experiments in the Health Sciences provides a balanced presentation of design and analysis issues relating to data in the health sciences and emphasizes new research areas, the crucial topic of clinical trials, and state-of-the- art applications. Advancing the idea that design drives analysis and analysis reveals the design, the book clearly explains how to apply design and analysis principles in animal, human, and laboratory experiments while illustrating topics with applications and examples from randomized clinical trials and the modern topic of microarrays. The authors outline the following five types of designs that form the basis of most experimental structures: Completely randomized designs Randomized block designs Factorial designs Multilevel experiments Repeated measures designs A related website features a wealth of data sets that are used throughout the book, allowing readers to work hands-on with the material. In addition, an extensive bibliography outlines additional resources for further study of the presented topics. Requiring only a basic background in statistics, Design and Analysis of Experiments in the Health Sciences is an excellent book for introductory courses on experimental design and analysis at the graduate level. The book also serves as a valuable resource for researchers in medicine, dentistry, nursing, epidemiology, statistical genetics, and public health.

Guides readers through the quantitative data analysis process including contextualizing data within a research situation, connecting data to the appropriate statistical tests, and drawing valid conclusions Introduction to Quantitative Data Analysis in the Behavioral and Social Sciences presents a clear and accessible introduction to the basics of quantitative data analysis and focuses on how to use statistical tests as a key tool for analyzing research data. The book presents the entire data analysis process as a cyclical, multiphase process and addresses the processes of exploratory analysis, decision-making for performing parametric or nonparametric analysis, and practical significance determination. In addition, the author details how data analysis is used to reveal the underlying patterns and relationships between the variables and connects those trends to the data’s contextual situation. Filling the gap in quantitative data analysis literature, this book teaches the methods and thought processes behind data analysis, rather than how to perform the study itself or how to perform individual statistical tests. With a clear and conversational style, readers are provided with a better understanding of the overall structure and methodology behind performing a data analysis as well as the needed techniques to make informed, meaningful decisions during data analysis. The book features numerous data analysis examples in order to emphasize the decision and thought processes that are best followed, and self-contained sections throughout separate the statistical data analysis from the detailed discussion of the concepts allowing readers to reference a specific section of the book for immediate solutions to problems and/or applications. Introduction to Quantitative Data Analysis in the Behavioral and Social Sciences also features coverage of the following: • The overall methodology and research mind-set for how to approach quantitative data analysis and how to use statistics tests as part of research data analysis • A comprehensive understanding of the data, its connection to a research situation, and the most appropriate statistical tests for the data • Numerous data analysis problems and worked-out examples to illustrate the decision and thought processes that reveal underlying patterns and trends • Detailed examples of the main concepts to aid readers in gaining the needed skills to perform a full analysis of research problems • A conversational tone to effectively introduce readers to the basics of how to perform data analysis as well as make meaningful decisions during data analysis Introduction to Quantitative Data Analysis in the Behavioral and Social Sciences is an ideal textbook for upper-undergraduate and graduate-level research method courses in the behavioral and social sciences, statistics, and engineering. This book is also an appropriate reference for practitioners who require a review of quantitative research methods. Michael J. Albers, Ph.D., is Professor in the Department of English at East Carolina University. His research interests include information design with a focus on answering real-world questions, the presentation of complex information, and human–information interaction. Dr. Albers received his Ph.D. in Technical Communication and Rhetoric from Texas Tech University.

Features a practical approach to the analysis of biomedical data via mathematical methods and provides a MATLAB® toolbox for the collection, visualization, and evaluation of experimental and real-life data Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB® presents a practical approach to the task that biological scientists face when analyzing data. The primary focus is on the application of mathematical models and scientific computing methods to provide insight into the behavior of biological systems. The author draws upon his experience in academia, industry, and government–sponsored research as well as his expertise in MATLAB to produce a suite of computer programs with applications in epidemiology, machine learning, and biostatistics. These models are derived from real–world data and concerns. Among the topics included are the spread of infectious disease (HIV/AIDS) through a population, statistical pattern recognition methods to determine the presence of disease in a diagnostic sample, and the fundamentals of hypothesis testing. In addition, the author uses his professional experiences to present unique case studies whose analyses provide detailed insights into biological systems and the problems inherent in their examination. The book contains a well-developed and tested set of MATLAB functions that act as a general toolbox for practitioners of quantitative biology and biostatistics. This combination of MATLAB functions and practical tips amplifies the book’s technical merit and value to industry professionals. Through numerous examples and sample code blocks, the book provides readers with illustrations of MATLAB programming. Moreover, the associated toolbox permits readers to engage in the process of data analysis without needing to delve deeply into the mathematical theory. This gives an accessible view of the material for readers with varied backgrounds. As a result, the book provides a streamlined framework for the development of mathematical models, algorithms, and the corresponding computer code. In addition, the book features: Real–world computational procedures that can be readily applied to similar problems without the need for keen mathematical acumen Clear delineation of topics to accelerate access to data analysis Access to a book companion website containing the MATLAB toolbox created for this book, as well as a Solutions Manual with solutions to selected exercises Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB® is an excellent textbook for students in mathematics, biostatistics, the life and social sciences, and quantitative, computational, and mathematical biology. This book is also an ideal reference for industrial scientists, biostatisticians, product development scientists, and practitioners who use mathematical models of biological systems in biomedical research, medical device development, and pharmaceutical submissions.

Missing Data in Clinical Studies provides a comprehensive account of the problems arising when data from clinical and related studies are incomplete, and presents the reader with approaches to effectively address them. The text provides a critique of conventional and simple methods before moving on to discuss more advanced approaches. The authors focus on practical and modeling concepts, providing an extensive set of case studies to illustrate the problems described. Provides a practical guide to the analysis of clinical trials and related studies with missing data. Examines the problems caused by missing data, enabling a complete understanding of how to overcome them. Presents conventional, simple methods to tackle these problems, before addressing more advanced approaches, including sensitivity analysis, and the MAR missingness mechanism. Illustrated throughout with real-life case studies and worked examples from clinical trials. Details the use and implementation of the necessary statistical software, primarily SAS. Missing Data in Clinical Studies has been developed through a series of courses and lectures. Its practical approach will appeal to applied statisticians and biomedical researchers, in particular those in the biopharmaceutical industry, medical and public health organisations. Graduate students of biostatistics will also find much of benefit.

BIG DATA, ARTIFICIAL INTELLIGENCE AND DATA ANALYSIS SET Coordinated by Jacques Janssen Data analysis is a scientific field that continues to grow enormously, most notably over the last few decades, following rapid growth within the tech industry, as well as the wide applicability of computational techniques alongside new advances in analytic tools. Modeling enables data analysts to identify relationships, make predictions, and to understand, interpret and visualize the extracted information more strategically. This book includes the most recent advances on this topic, meeting increasing demand from wide circles of the scientific community. Applied Modeling Techniques and Data Analysis 2 is a collective work by a number of leading scientists, analysts, engineers, mathematicians and statisticians, working on the front end of data analysis and modeling applications. The chapters cover a cross section of current concerns and research interests in the above scientific areas. The collected material is divided into appropriate sections to provide the reader with both theoretical and applied information on data analysis methods, models and techniques, along with appropriate applications.

A modern, comprehensive treatment of latent class and latent transition analysis for categorical data On a daily basis, researchers in the social, behavioral, and health sciences collect information and fit statistical models to the gathered empirical data with the goal of making significant advances in these fields. In many cases, it can be useful to identify latent, or unobserved, subgroups in a population, where individuals' subgroup membership is inferred from their responses on a set of observed variables. Latent Class and Latent Transition Analysis provides a comprehensive and unified introduction to this topic through one-of-a-kind, step-by-step presentations and coverage of theoretical, technical, and practical issues in categorical latent variable modeling for both cross-sectional and longitudinal data. The book begins with an introduction to latent class and latent transition analysis for categorical data. Subsequent chapters delve into more in-depth material, featuring: A complete treatment of longitudinal latent class models Focused coverage of the conceptual underpinnings of interpretation and evaluationof a latent class solution Use of parameter restrictions and detection of identification problems Advanced topics such as multi-group analysis and the modeling and interpretation of interactions between covariates The authors present the topic in a style that is accessible yet rigorous. Each method is presented with both a theoretical background and the practical information that is useful for any data analyst. Empirical examples showcase the real-world applications of the discussed concepts and models, and each chapter concludes with a «Points to Remember» section that contains a brief summary of key ideas. All of the analyses in the book are performed using Proc LCA and Proc LTA, the authors' own software packages that can be run within the SAS® environment. A related Web site houses information on these freely available programs and the book's data sets, encouraging readers to reproduce the analyses and also try their own variations. Latent Class and Latent Transition Analysis is an excellent book for courses on categorical data analysis and latent variable models at the upper-undergraduate and graduate levels. It is also a valuable resource for researchers and practitioners in the social, behavioral, and health sciences who conduct latent class and latent transition analysis in their everyday work.

A comprehensive introduction to behavioral and social science research methods in the health sciences Understanding and Conducting Research in the Health Sciences is designed to develop and facilitate the ability to conduct research and understand the practical value of designing, conducting, interpreting, and reporting behavioral and social science research findings in the health science and medical fields. The book provides complete coverage of the process behind these research methods, including information-gathering, decision formation, and results presentation. Examining the application of behavioral and social science research methodologies within the health sciences, the book focuses on implementing and developing relevant research questions, collecting and managing data, and communicating various research perspectives. An essential book for readers looking to possess an understanding of all aspects of conducting research in the health science field, Understanding and Conducting Research in the Health Sciences features: Various research designs that are appropriate for use in the health sciences, including single-participant, multi-group, longitudinal, correlational, and experimental designs Step-by-step coverage of single-factor and multifactor studies as well as single-subject and nonexperimental methods Accessible chapter explanations, real-world examples, and numerous illustrations throughout Guidance regarding how to write about research within the formatting styles of the American Medical Association and the American Psychological Association The book is an excellent educational resource for healthcare and health service practitioners and researchers who are interested in conducting and understanding behavioral and social science research done within the health sciences arena. The book is also a useful resource for students taking courses in the fields of medicine, public health, epidemiology, biostatistics, and the health sciences.

This selection of in-depth, critical and comprehensive chapters on topical issues in applied health psychology features the work of key researchers and practitioners in the Australasian health system and deals with both theoretical and methodological aspects of the subject. The first health psychology text aimed specifically at regional postgraduate trainees Covers an array of topics and issues and focuses on applied aspects of clinical health and health promotion Includes both specialized topics and new frontiers of research Contextualizes health psychology teaching and learning for Australasian students

The field's bestselling reference, updated with the latest tools, data, and techniques Cost-Effectiveness Analysis in Health is a practical introduction to the tools, methods, and procedures used worldwide to perform cost-effective research. Covering every aspect of a complete cost-effectiveness analysis, this book shows you how to find which data you need, where to find it, how to analyze it, and how to prepare a high-quality report for publication. Designed for the classroom or the individual learner, the material is presented in simple and accessible language for those who lack a biostatistics or epidemiology background, and each chapter includes real-world examples and «tips and tricks» that highlight key information. Exercises throughout allow you to test your understanding with practical application, and the companion website features downloadable data sets for students, as well as lecture slides and a test bank for instructors. This new third edition contains new discussion on meta-analysis and advanced modeling techniques, a long worked example using visual modeling software TreeAge Pro, and updated recommendations from the U.S. Public Health Service's Panel on Cost-Effectiveness in Health and Medicine. Cost-effectiveness analysis is used to evaluate medical interventions worldwide, in both developed and developing countries. This book provides process-specific instruction in a concise, structured format to give you a robust working knowledge of common methods and techniques. Develop a thoroughly fleshed-out research project Work accurately with costs, probabilities, and models Calculate life expectancy and quality-adjusted life years Prepare your study and your data for publication Comprehensive analysis skills are essential for students seeking careers in public health, medicine, biomedical research, health economics, health policy, and more. Cost-Effectiveness Analysis in Health walks you through the process from a real-world perspective to help you build a skillset that's immediately applicable in the field.