Air Dispersion Modeling. Foundations and Applications

This latest addition to the successful Network Biology series presents current methods for determining the entropy of networks, making it the first to cover the recently established Quantitative Graph Theory. An excellent international team of editors and contributors provides an up-to-date outlook for the field, covering a broad range of graph entropy-related concepts and methods. The topics range from analyzing mathematical properties of methods right up to applying them in real-life areas. Filling a gap in the contemporary literature this is an invaluable reference for a number of disciplines, including mathematicians, computer scientists, computational biologists, and structural chemists.

A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professionals to the actual tools and practices needed to design and test safe drugs. A guide to the basics of modeling and simulation programs, Biopharmaceutics Modeling and Simulations offers pharmaceutical scientists the keys to understanding how they work and are applied in creating drugs with desired medicinal properties. Beginning with a focus on the oral absorption of drugs, the book discusses: The central dogma of oral drug absorption (the interplay of dissolution, solubility, and permeability of a drug), which forms the basis of the biopharmaceutical classification system (BCS) The concept of drug concentration How to simulate key drug absorption processes The physiological and drug property data used for biopharmaceutical modeling Reliable practices for reporting results With over 200 figures and illustrations and a peerless examination of all the key aspects of drug research—including running and interpreting models, validation, and compound and formulation selection—this reference seamlessly brings together the proven practical approaches essential to developing the safe and effective medicines of tomorrow.

Explains how GIS enhances the development of chemical fate and transport models Over the past decade, researchers have discovered that geographic information systems (GIS) are not only excellent tools for managing and displaying maps, but also useful in the analysis of chemical fate and transport in the environment. Among its many benefits, GIS facilitates the identification of critical factors that drive chemical fate and transport. Moreover, GIS makes it easier to communicate and explain key model assumptions. Based on the author's firsthand experience in environmental assessment, GIS Based Chemical Fate Modeling explores both GIS and chemical fate and transport modeling fundamentals, creating an interface between the two domains. It then explains how GIS analytical functions enable scientists to develop simple, yet comprehensive spatially explicit chemical fate and transport models that support real-world applications. In addition, the book features: Practical examples of GIS based model calculations that serve as templates for the development of new applications Exercises enabling readers to create their own GIS based models Accompanying website featuring downloadable datasets used in the book's examples and exercises References to the literature, websites, data repositories, and online reports to facilitate further research Coverage of important topics such as spatial decision support systems and multi-criteria analysis as well as ecological and human health risk assessment in a spatial context GIS Based Chemical Fate Modeling makes a unique contribution to the environmental sciences by explaining how GIS analytical functions enhance the development and interpretation of chemical fate and transport models. Environmental scientists should turn to this book to gain a deeper understanding of the role of GIS in describing what happens to chemicals when they are released into the environment.

Features mathematical modeling techniques and real-world processes with applications in diverse fields Mathematical Modeling with Multidisciplinary Applications details the interdisciplinary nature of mathematical modeling and numerical algorithms. The book combines a variety of applications from diverse fields to illustrate how the methods can be used to model physical processes, design new products, find solutions to challenging problems, and increase competitiveness in international markets. Written by leading scholars and international experts in the field, the book presents new and emerging topics in areas including finance and economics, theoretical and applied mathematics, engineering and machine learning, physics, chemistry, ecology, and social science. In addition, the book thoroughly summarizes widely used mathematical and numerical methods in mathematical modeling and features: Diverse topics such as partial differential equations (PDEs), fractional calculus, inverse problems by ordinary differential equations (ODEs), semigroups, decision theory, risk analysis, Bayesian estimation, nonlinear PDEs in financial engineering, perturbation analysis, and dynamic system modeling Case studies and real-world applications that are widely used for current mathematical modeling courses, such as the green house effect and Stokes flow estimation Comprehensive coverage of a wide range of contemporary topics, such as game theory, statistical models, and analytical solutions to numerical methods Examples, exercises with select solutions, and detailed references to the latest literature to solidify comprehensive learning New techniques and applications with balanced coverage of PDEs, discrete models, statistics, fractional calculus, and more Mathematical Modeling with Multidisciplinary Applications is an excellent book for courses on mathematical modeling and applied mathematics at the upper-undergraduate and graduate levels. The book also serves as a valuable reference for research scientists, mathematicians, and engineers who would like to develop further insights into essential mathematical tools.

A comprehensive overview of the research developments in the burgeoning field of metal-air batteries An innovation in battery science and technology is necessary to build better power sources for our modern lifestyle needs. One of the main fields being explored for the possible breakthrough is the development of metal-air batteries. Metal-Air Batteries: Fundamentals and Applications offers a systematic summary of the fundamentals of the technology and explores the most recent advances in the applications of metal-air batteries. Comprehensive in scope, the text explains the basics in electrochemical batteries and introduces various species of metal-air batteries. The author-a noted expert in the field-explores the development of metal-air batteries in the order of Li-air battery, sodium-air battery, zinc-air battery and Mg-O2 battery, with the focus on the Li-air battery. The text also addresses topics such as metallic anode, discharge products, parasitic reactions, electrocatalysts, mediator, and X-ray diffraction study in Li-air battery. Metal-Air Batteries provides a summary of future perspectives in the field of the metal-air batteries. This important resource: -Covers various species of metal-air batteries and their components as well as system designation -Contains groundbreaking content that reviews recent advances in the field of metal-air batteries -Focuses on the battery systems which have the greatest potential for renewable energy storage Written for electrochemists, physical chemists, materials scientists, professionals in the electrotechnical industry, engineers in power technology, Metal-Air Batteries offers a review of the fundamentals and the most recent developments in the area of metal-air batteries.

Discover how the latest computational tools are building our understanding of particle interactions and leading to new applications With this book as their guide, readers will gain a new appreciation of the critical role that particle interactions play in advancing research and developing new applications in the biological sciences, chemical engineering, toxicology, medicine, and manufacturing technology The book explores particles ranging in size from cations to whole cells to tissues and processed materials. A focus on recreating complex, real-world dynamical systems helps readers gain a deeper understanding of cell and tissue mechanics, theoretical aspects of multiscale modeling, and the latest applications in biology and nanotechnology. Following an introductory chapter, Multiscale Modeling of Particle Interactions is divided into two parts: Part I, Applications in Nanotechnology, covers: Multiscale modeling of nanoscale aggregation phenomena: applications in semiconductor materials processing Multiscale modeling of rare events in self-assembled systems Continuum description of atomic sheets Coulombic dragging and mechanical propelling of molecules in nanofluidic systems Molecular dynamics modeling of nanodroplets and nanoparticles Modeling the interactions between compliant microcapsules and patterned surfaces Part II, Applications in Biology, covers: Coarse-grained and multiscale simulations of lipid bilayers Stochastic approach to biochemical kinetics In silico modeling of angiogenesis at multiple scales Large-scale simulation of blood flow in microvessels Molecular to multicellular deformation during adhesion of immune cells under flow Each article was contributed by one or more leading experts and pioneers in the field. All readers, from chemists and biologists to engineers and students, will gain new insights into how the latest tools in computational science can improve our understanding of particle interactions and support the development of novel applications across the broad spectrum of disciplines in biology and nanotechnology.

“…a much-needed handbook with contributions from well-chosen practitioners. A primary accomplishment is to provide guidance for those involved in modeling and simulation in support of Systems of Systems development, more particularly guidance that draws on well-conceived academic research to define concepts and terms, that identifies primary challenges for developers, and that suggests fruitful approaches grounded in theory and successful examples.” Paul Davis, The RAND Corporation Modeling and Simulation Support for System of Systems Engineering Applications provides a comprehensive overview of the underlying theory, methods, and solutions in modeling and simulation support for system of systems engineering. Highlighting plentiful multidisciplinary applications of modeling and simulation, the book uniquely addresses the criteria and challenges found within the field. Beginning with a foundation of concepts, terms, and categories, a theoretical and generalized approach to system of systems engineering is introduced, and real-world applications via case studies and examples are presented. A unified approach is maintained in an effort to understand the complexity of a single system as well as the context among other proximate systems. In addition, the book features: Cutting edge coverage of modeling and simulation within the field of system of systems, including transportation, system health management, space mission analysis, systems engineering methodology, and energy State-of-the-art advances within multiple domains to instantiate theoretic insights, applicable methods, and lessons learned from real-world applications of modeling and simulation The challenges of system of systems engineering using a systematic and holistic approach Key concepts, terms, and activities to provide a comprehensive, unified, and concise representation of the field A collection of chapters written by over 40 recognized international experts from academia, government, and industry A research agenda derived from the contribution of experts that guides scholars and researchers towards open questions Modeling and Simulation Support for System of Systems Engineering Applications is an ideal reference and resource for academics and practitioners in operations research, engineering, statistics, mathematics, modeling and simulation, and computer science. The book is also an excellent course book for graduate and PhD-level courses in modeling and simulation, engineering, and computer science.

Presents Fundamentals of Modeling, Analysis, and Control of Electric Power Converters for Power System Applications Electronic (static) power conversion has gained widespread acceptance in power systems applications; electronic power converters are increasingly employed for power conversion and conditioning, compensation, and active filtering. This book presents the fundamentals for analysis and control of a specific class of high-power electronic converters—the three-phase voltage-sourced converter (VSC). Voltage-Sourced Converters in Power Systems provides a necessary and unprecedented link between the principles of operation and the applications of voltage-sourced converters. The book: Describes various functions that the VSC can perform in electric power systems Covers a wide range of applications of the VSC in electric power systems—including wind power conversion systems Adopts a systematic approach to the modeling and control design problems Illustrates the control design procedures and expected performance based on a comprehensive set of examples and digital computer time-domain simulation studies This comprehensive text presents effective techniques for mathematical modeling and control design, and helps readers understand the procedures and analysis steps. Detailed simulation case studies are included to highlight the salient points and verify the designs. Voltage-Sourced Converters in Power Systems is an ideal reference for senior undergraduate and graduate students in power engineering programs, practicing engineers who deal with grid integration and operation of distributed energy resource units, design engineers, and researchers in the area of electric power generation, transmission, distribution, and utilization.

This book combines the research activities of the authors, both of whom are researchers at Ecole Nationale de l’Aviation Civile (French National School of Civil Aviation), and presents their findings from the last 15 years. Their work uses air transport as its focal point, within the realm of mathematical optimization, looking at real life problems and theoretical models in tandem, and the challenges that accompany studying both approaches. The authors’ research is linked with the attempt to reduce air space congestion in Western Europe, USA and, increasingly, Asia. They do this through studying stochastic optimization (particularly artificial evolution), the sectorization of airspace, route distribution and takeoff slots, and by modeling airspace congestion. Finally, the authors discuss their short, medium and long term research goals. They hope that their work, although related to air transport, will be applied to other fields, such is the transferable nature of mathematical optimization. At the same time, they intend to use other areas of research, such as approximation and statistics to complement their continued inquiry in their own field. Contents 1. Introduction. Part 1. Optimization and Artificial Evolution 2. Optimization: State of the Art. 3. Genetic Algorithms and Improvements. 4. A new concept for Genetic Algorithms based on Order Statistics. Part 2. Applications to Air Traffic Control 5. Air Traffic Control. 6. Contributions to Airspace Sectorization. 7. Contribution to Traffic Assignment. 8. Airspace Congestion Metrics. 9. Conclusion and Future Perspectives. About the Authors Daniel Delahaye works for Ecole Nationale de l’Aviation Civile (French National School of Civil Aviation) in France. St?phane Puechmorel works for Ecole Nationale de l’Aviation Civile (French National School of Civil Aviation) in France.

A reference guide for applications of SEM using Mplus Structural Equation Modeling: Applications Using Mplus is intended as both a teaching resource and a reference guide. Written in non-mathematical terms, this book focuses on the conceptual and practical aspects of Structural Equation Modeling (SEM). Basic concepts and examples of various SEM models are demonstrated along with recently developed advanced methods, such as mixture modeling and model-based power analysis and sample size estimate for SEM. The statistical modeling program, Mplus, is also featured and provides researchers with a flexible tool to analyze their data with an easy-to-use interface and graphical displays of data and analysis results. Key features: Presents a useful reference guide for applications of SEM whilst systematically demonstrating various advanced SEM models, such as multi-group and mixture models using Mplus. Discusses and demonstrates various SEM models using both cross-sectional and longitudinal data with both continuous and categorical outcomes. Provides step-by-step instructions of model specification and estimation, as well as detail interpretation of Mplus results. Explores different methods for sample size estimate and statistical power analysis for SEM. By following the examples provided in this book, readers will be able to build their own SEM models using Mplus. Teachers, graduate students, and researchers in social sciences and health studies will also benefit from this book.