Aptamers for Analytical Applications. Affinity Acquisition and Method Design

Discover how analytical chemistry supports the latest clinical research This book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab. Analytical Techniques for Clinical Chemistry opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as: Uncertainty in clinical chemistry measurements Metal toxicology in clinical, forensic, and chemical pathology Role of analytical chemistry in the safety of drug therapy Atomic spectrometric techniques for the analysis of clinical samples Biosensors for drug analysis Use of X-ray techniques in medical research Each chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth. Presenting the latest achievements and challenges in the field, Analytical Techniques for Clinical Chemistry sets the foundation for future advances in laboratory research techniques.

TRANSFER MATRIX METHOD FOR MULTIBODY SYSTEMS: THEORY AND APPLICATIONS Xiaoting Rui, Guoping Wang and Jianshu Zhang – Nanjing University of Science and Technology, China Featuring a new method of multibody system dynamics, this book introduces the transfer matrix method systematically for the first time. First developed by the lead author and his research team, this method has found numerous engineering and technological applications. Readers are first introduced to fundamental concepts like the body dynamics equation, augmented operator and augmented eigenvector before going in depth into precision analysis and computations of eigenvalue problems as well as dynamic responses. The book also covers a combination of mixed methods and practical applications in multiple rocket launch systems, self-propelled artillery as well as launch dynamics of on-ship weaponry. • Comprehensively introduces a new method of analyzing multibody dynamics for engineers • Provides a logical development of the transfer matrix method as applied to the dynamics of multibody systems that consist of interconnected bodies • Features varied applications in weaponry, aeronautics, astronautics, vehicles and robotics Written by an internationally renowned author and research team with many years' experience in multibody systems Transfer Matrix Method of Multibody System and Its Applications is an advanced level text for researchers and engineers in mechanical system dynamics. It is a comprehensive reference for advanced students and researchers in the related fields of aerospace, vehicle, robotics and weaponry engineering.

Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and proteins Peptidomimetics Design and synthesis of cyclic peptides Carbohydrates in peptide and protein design De novo design of peptides and proteins Medical development applications An extended case study – the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

Based on the fundamentals of electromagnetics, this clear and concise text explains basic and applied principles of transformer and inductor design for power electronic applications. It details both the theory and practice of inductors and transformers employed to filter currents, store electromagnetic energy, provide physical isolation between circuits, and perform stepping up and down of DC and AC voltages. The authors present a broad range of applications from modern power conversion systems. They provide rigorous design guidelines based on a robust methodology for inductor and transformer design. They offer real design examples, informed by proven and working field examples. Key features include: emphasis on high frequency design, including optimisation of the winding layout and treatment of non-sinusoidal waveforms a chapter on planar magnetic with analytical models and descriptions of the processing technologies analysis of the role of variable inductors, and their applications for power factor correction and solar power unique coverage on the measurements of inductance and transformer capacitance, as well as tests for core losses at high frequency worked examples in MATLAB, end-of-chapter problems, and an accompanying website containing solutions, a full set of instructors’ presentations, and copies of all the figures. Covering the basics of the magnetic components of power electronic converters, this book is a comprehensive reference for students and professional engineers dealing with specialised inductor and transformer design. It is especially useful for senior undergraduate and graduate students in electrical engineering and electrical energy systems, and engineers working with power supplies and energy conversion systems who want to update their knowledge on a field that has progressed considerably in recent years.

Validation describes the procedures used to analyze pharmaceutical products so that the data generated will comply with the requirements of regulatory bodies of the US, Canada, Europe and Japan. Calibration of Instruments describes the process of fixing, checking or correcting the graduations of instruments so that they comply with those regulatory bodies. This book provides a thorough explanation of both the fundamental and practical aspects of biopharmaceutical and bioanalytical methods validation. It teaches the proper procedures for using the tools and analysis methods in a regulated lab setting. Readers will learn the appropriate procedures for calibration of laboratory instrumentation and validation of analytical methods of analysis. These procedures must be executed properly in all regulated laboratories, including pharmaceutical and biopharmaceutical laboratories, clinical testing laboratories (hospitals, medical offices) and in food and cosmetic testing laboratories.

Varactors are passive semiconductor devices used in electronic circuits, as a voltage-controlled way of storing energy in order to boost the amount of electric charge produced. In the past, the use of low-cost fabrication processes such as complementary metal oxide semiconductor (CMOS) and silicon germanium (SiGe) were kept for integrated circuits working in frequency ranges below the GHz. Now, the increased working frequency of radio frequency integrated circuits (RF ICs) for communication devices, and the trend of system-on-chip technology, has pushed the requirements of varactors to the limit. As the frequency of RF applications continues to rise, it is essential that passive devices such as varactors are of optimum quality, making this a critical design issue. Initially describing the physical phenomena that occur in passive devices within standard IC fabrication processes, Design and Characterization of Integrated Varactors for RF Applications goes on to: present information on the design of wide band electrical varactor models (up to 5 GHz) which enable the accurate prediction of device performance; propose a specific methodology for the measurement of integrated varactors, covering on-wafer measurement structures, the calibration process, and detailed descriptions of the required equipment; explain de-embedding techniques and also analyse confidence level and uncertainty linked to the test set-up; examine the design of a voltage controlled oscillator (VCO) circuit as a practical example of the employment of methods discussed in the book. Providing the reader with the necessary technical knowledge for dealing with challenging VCO designs, this book is an essential guide for practising RF and microwave engineers working on the design of electronic devices for integrated circuits. It is also a useful reference for postgraduate students and researchers interested in electronic design for RF applications.

Introduces the theory and applications of the extended finite element method (XFEM) in the linear and nonlinear problems of continua, structures and geomechanics Explores the concept of partition of unity, various enrichment functions, and fundamentals of XFEM formulation. Covers numerous applications of XFEM including fracture mechanics, large deformation, plasticity, multiphase flow, hydraulic fracturing and contact problems Accompanied by a website hosting source code and examples

The first book to be published on the Theta method, outlining under what conditions the method outperforms other forecasting methods This book is the first to detail the Theta method of forecasting – one of the most difficult-to-beat forecasting benchmarks, which topped the biggest forecasting competition in the world in 2000: the M3 competition. Written by two of the leading experts in the forecasting field, it illuminates the exact replication of the method and under what conditions the method outperforms other forecasting methods. Recent developments such as multivariate models are also included, as are a series of practical applications in finance, economics, and healthcare. The book also offers practical tools in MS Excel and guidance, as well as provisional access, for the use of R source code and respective packages. Forecasting with the Theta Method: Theory and Applications includes three main parts. The first part, titled Theory, Methods, Models & Applications details the new theory about the method. The second part, Applications & Performance in Forecasting Competitions, describes empirical results and simulations on the method. The last part roadmaps future research and also include contributions from another leading scholar of the method – Dr. Fotios Petropoulos. First ever book to be published on the Theta Method Explores new theory and exact conditions under which methods would outperform most forecasting benchmarks Clearly written with practical applications Employs R – open source code with all included implementations Forecasting with the Theta Method: Theory and Applications is a valuable tool for both academics and practitioners involved in forecasting and respective software development.

Covering everything from the basic theoretical and practical knowledge to new exciting developments in the field with a focus on analytical and life science applications, this monograph shows how to apply surface-enhanced Raman scattering (SERS) for solving real world problems. From the contents: * Theory and practice of SERS * Analytical applications * SERS combined with other analytical techniques * Biophysical applications * Life science applications including various microscopies Aimed at analytical, surface and medicinal chemists, spectroscopists, biophysicists and materials scientists. Includes a Foreword by the renowned Raman spectroscopist Professor Wolfgang Kiefer, the former Editor-in-Chief of the Journal of Raman Spectroscopy.

Demonstrates the application of DSM to solve a broad range of operator equations The dynamical systems method (DSM) is a powerful computational method for solving operator equations. With this book as their guide, readers will master the application of DSM to solve a variety of linear and nonlinear problems as well as ill-posed and well-posed problems. The authors offer a clear, step-by-step, systematic development of DSM that enables readers to grasp the method's underlying logic and its numerous applications. Dynamical Systems Method and Applications begins with a general introduction and then sets forth the scope of DSM in Part One. Part Two introduces the discrepancy principle, and Part Three offers examples of numerical applications of DSM to solve a broad range of problems in science and engineering. Additional featured topics include: General nonlinear operator equations Operators satisfying a spectral assumption Newton-type methods without inversion of the derivative Numerical problems arising in applications Stable numerical differentiation Stable solution to ill-conditioned linear algebraic systems Throughout the chapters, the authors employ the use of figures and tables to help readers grasp and apply new concepts. Numerical examples offer original theoretical results based on the solution of practical problems involving ill-conditioned linear algebraic systems, and stable differentiation of noisy data. Written by internationally recognized authorities on the topic, Dynamical Systems Method and Applications is an excellent book for courses on numerical analysis, dynamical systems, operator theory, and applied mathematics at the graduate level. The book also serves as a valuable resource for professionals in the fields of mathematics, physics, and engineering.