Basics of Biomedical Ultrasound for Engineers

Ultrasound Elastography for Biomedical Applications and Medicine Ivan Z. Nenadic, Matthew W. Urban, James F. Greenleaf, Mayo Clinic Ultrasound Research Laboratory, Mayo Clinic College of Medicine, USA Jean-Luc Gennisson, Miguel Bernal, Mickael Tanter, Institut Langevin – Ondes et Images, ESPCI ParisTech CNRS, France Covers all major developments and techniques of Ultrasound Elastography and biomedical applications The field of ultrasound elastography has developed various techniques with the potential to diagnose and track the progression of diseases such as breast and thyroid cancer, liver and kidney fibrosis, congestive heart failure, and atherosclerosis. Having emerged in the last decade, ultrasound elastography is a medical imaging modality that can noninvasively measure and map the elastic and viscous properties of soft tissues. Ultrasound Elastography for Biomedical Applications and Medicine covers the basic physics of ultrasound wave propagation and the interaction of ultrasound with various media. The book introduces tissue elastography, covers the history of the field, details the various methods that have been developed by research groups across the world, and describes its novel applications, particularly in shear wave elastography. Key features: Covers all major developments and techniques of ultrasound elastography and biomedical applications. Contributions from the pioneers of the field secure the most complete coverage of ultrasound elastography available. The book is essential reading for researchers and engineers working in ultrasound and elastography, as well as biomedical engineering students and those working in the field of biomechanics.

Ultrasound Elastography for Biomedical Applications and Medicine Ivan Z. Nenadic, Matthew W. Urban, James F. Greenleaf, Mayo Clinic Ultrasound Research Laboratory, Mayo Clinic College of Medicine, USA Jean-Luc Gennisson, Miguel Bernal, Mickael Tanter, Institut Langevin – Ondes et Images, ESPCI ParisTech CNRS, France Covers all major developments and techniques of Ultrasound Elastography and biomedical applications The field of ultrasound elastography has developed various techniques with the potential to diagnose and track the progression of diseases such as breast and thyroid cancer, liver and kidney fibrosis, congestive heart failure, and atherosclerosis. Having emerged in the last decade, ultrasound elastography is a medical imaging modality that can noninvasively measure and map the elastic and viscous properties of soft tissues. Ultrasound Elastography for Biomedical Applications and Medicine covers the basic physics of ultrasound wave propagation and the interaction of ultrasound with various media. The book introduces tissue elastography, covers the history of the field, details the various methods that have been developed by research groups across the world, and describes its novel applications, particularly in shear wave elastography. Key features: Covers all major developments and techniques of ultrasound elastography and biomedical applications. Contributions from the pioneers of the field secure the most complete coverage of ultrasound elastography available. The book is essential reading for researchers and engineers working in ultrasound and elastography, as well as biomedical engineering students and those working in the field of biomechanics.

Features a practical approach to the analysis of biomedical data via mathematical methods and provides a MATLAB® toolbox for the collection, visualization, and evaluation of experimental and real-life data Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB® presents a practical approach to the task that biological scientists face when analyzing data. The primary focus is on the application of mathematical models and scientific computing methods to provide insight into the behavior of biological systems. The author draws upon his experience in academia, industry, and government–sponsored research as well as his expertise in MATLAB to produce a suite of computer programs with applications in epidemiology, machine learning, and biostatistics. These models are derived from real–world data and concerns. Among the topics included are the spread of infectious disease (HIV/AIDS) through a population, statistical pattern recognition methods to determine the presence of disease in a diagnostic sample, and the fundamentals of hypothesis testing. In addition, the author uses his professional experiences to present unique case studies whose analyses provide detailed insights into biological systems and the problems inherent in their examination. The book contains a well-developed and tested set of MATLAB functions that act as a general toolbox for practitioners of quantitative biology and biostatistics. This combination of MATLAB functions and practical tips amplifies the book’s technical merit and value to industry professionals. Through numerous examples and sample code blocks, the book provides readers with illustrations of MATLAB programming. Moreover, the associated toolbox permits readers to engage in the process of data analysis without needing to delve deeply into the mathematical theory. This gives an accessible view of the material for readers with varied backgrounds. As a result, the book provides a streamlined framework for the development of mathematical models, algorithms, and the corresponding computer code. In addition, the book features: Real–world computational procedures that can be readily applied to similar problems without the need for keen mathematical acumen Clear delineation of topics to accelerate access to data analysis Access to a book companion website containing the MATLAB toolbox created for this book, as well as a Solutions Manual with solutions to selected exercises Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB® is an excellent textbook for students in mathematics, biostatistics, the life and social sciences, and quantitative, computational, and mathematical biology. This book is also an ideal reference for industrial scientists, biostatisticians, product development scientists, and practitioners who use mathematical models of biological systems in biomedical research, medical device development, and pharmaceutical submissions.

This book offers a thorough revision and update to the first landmark book that presented a standardized approach to focused point-of-care ultrasound exams of the abdomen, thorax, musculoskeletal and eye in veterinary practice. Now incorporating new applications for focused ultrasound exams and additional species, this Second Edition continues to be a state-of-the-art reference for using abbreviated ultrasound exams in clinical practice. A companion website features supplementary video clips of these point-of-care techniques depicting actual ultrasound exams for comparison and comprehension.  New chapters in Point-of-Care Ultrasound Techniques for the Small Animal Practitioner, Second Edition cover ultrasound-guided nerve blocks, musculoskeletal, brain imaging, and applications of focused ultrasound techniques in cats, exotics and marine mammals—making it an essential purchase for veterinarians wanting to incorporate point-of-care ultrasound techniques into their veterinary practices.  Presents a standardized approach to point-of-care ultrasound as an extension of the physical exam, including trauma, non-trauma, and monitoring applications Includes coverage of new techniques for focused ultrasound exams, including lung, anesthesia and ultrasound guided nerve blocks, transcranial brain imaging, musculoskeletal, volume status evaluation, and rapid assessment for treatable forms of shock Adds cats, exotic and wildlife mammals, and marine mammals to the existing canine coverage Emphasizes the integration of point-of-care ultrasound techniques for optimizing patient care and accurate patient assessment Offers access to a companion website with supplementary video clips showing many clinically relevant didactic examples The second edition of Point-of-Care Ultrasound Techniques for the Small Animal Practitioner is an excellent resource for veterinary practitioners, ranging from the general practitioner to nearly all clinical specialists, including internal medicine, oncology, cardiology, emergency and critical care, anesthesiology, ophthalmology, exotics, and zoo medicine specialists, and veterinary students.

MATERIALS FOR BIOMEDICAL ENGINEERING A comprehensive yet accessible introductory textbook designed for one-semester courses in biomaterials Biomaterials are used throughout the biomedical industry in a range of applications, from cardiovascular devices and medical and dental implants to regenerative medicine, tissue engineering, drug delivery, and cancer treatment. Materials for Biomedical Engineering: Fundamentals and Applications provides an up-to-date introduction to biomaterials, their interaction with cells and tissues, and their use in both conventional and emerging areas of biomedicine. Requiring no previous background in the subject, this student-friendly textbook covers the basic concepts and principles of materials science, the classes of materials used as biomaterials, the degradation of biomaterials in the biological environment, biocompatibility phenomena, and the major applications of biomaterials in medicine and dentistry. Throughout the text, easy-to-digest chapters address key topics such as the atomic structure, bonding, and properties of biomaterials, natural and synthetic polymers, immune responses to biomaterials, implant-associated infections, biomaterials in hard and soft tissue repair, tissue engineering and drug delivery, and more. Offers accessible chapters with clear explanatory text, tables and figures, and high-quality illustrations Describes how the fundamentals of biomaterials are applied in a variety of biomedical applications Features a thorough overview of the history, properties, and applications of biomaterials Includes numerous homework, review, and examination problems, full references, and further reading suggestions Materials for Biomedical Engineering: Fundamentals and Applications is an excellent textbook for advanced undergraduate and graduate students in biomedical materials science courses, and a valuable resource for medical and dental students as well as students with science and engineering backgrounds with interest in biomaterials.

Brings together, analyzes, and contextualizes the latest findings and practical applications Polyphosphazenes, an emerging class of polymers, include macromolecules, which have been proven to be biocompatible, biodegradable, and bioactive. Their unprecedented structural diversity and unique properties make them suitable as vaccine adjuvants, microencapsulating agents, biodegradable materials, scaffolds for tissue engineering, biocompatible coatings, and carriers for gene delivery. Polyphosphazenes for Biomedical Applications offers a thorough review of polyphosphazene research findings in the life sciences, chemistry, and chemical engineering. It emphasizes biomedical applications as well as recent advances in polyphosphazene development such as high-throughput discovery and the latest controlled methods of synthesis. The book brings together, analyzes, and contextualizes a wealth of knowledge that previously could only be found scattered throughout the scientific literature. Following two introductory chapters, the book reviews: Vaccine delivery and immunomodulation Biomaterials Drug delivery systems Biodetection Well-defined polyphosphazenes: synthetic aspects and novel molecular architectures All the chapters have been written by leading researchers in the field. Editor Alexander Andrianov, who has led the effort to commercialize polyphosphazenes for biomedical applications, has carefully reviewed and edited all chapters to ensure readability, accuracy, and thoroughness. Polyphosphazenes for Biomedical Applications is not only intended for researchers working in polyphosphazene chemistry, but also for all researchers seeking solutions to problems arising in the areas of biomaterials, drug delivery systems, and controlled release formulations.

Filling a gap in the market, this textbook provides a concise, yet thorough introduction to polymer science for advanced engineering students and practitioners, focusing on the chemical, physical and materials science aspects that are most relevant for engineering applications. After covering polymer synthesis and properties, the major section of the book is devoted to polymeric materials, such as thermoplastics and polymer composites, polymer processing such as injection molding and extrusion, and methods for large-scale polymer characterization. The text concludes with an overview of engineering plastics. The emphasis throughout is on application-relevant topics, and the author focuses on real-life, industry-relevant polymeric materials.

A must-have compendium on biomedical telemetry for all biomedical professional engineers, researchers, and graduate students in the field Handbook of Biomedical Telemetry describes the main components of a typical biomedical telemetry system, as well as its technical challenges. Written by a diverse group of experts in the field, it is filled with overviews, highly-detailed scientific analyses, and example applications of biomedical telemetry. The book also addresses technologies for biomedical sensing and design of biomedical telemetry devices with special emphasis on powering/integration issues and materials for biomedical telemetry applications. Handbook of Biomedical Telemetry: Describes the main components of a typical biomedical telemetry system, along with the technical challenges Discusses issues of spectrum regulations, standards, and interoperability—while major technical challenges related to advanced materials, miniaturization, and biocompatibility issues are also included Covers body area electromagnetics, inductive coupling, antennas for biomedical telemetry, intra-body communications, non-RF communication links for biomedical telemetry (optical biotelemetry), as well as safety issues, human phantoms, and exposure assessment to high-frequency biotelemetry fields Presents biosensor network topologies and standards; context-aware sensing and multi-sensor fusion; security and privacy issues in biomedical telemetry; and the connection between biomedical telemetry and telemedicine Introduces clinical applications of Body Sensor Networks (BSNs) in addition to selected examples of wearable, implantable, ingestible devices, stimulator and integrated mobile healthcare system paradigms for monitoring and therapeutic intervention Covering biomedical telemetry devices, biosensor network topologies and standards, clinical applications, wearable and implantable devices, and the effects on the mobile healthcare system, this compendium is a must-have for professional engineers, researchers, and graduate students.

An overview of nanotechnology and its potential The field of nanotechnology is undergoing rapid developments on many fronts. This reference provides a comprehensive review of various nanotechnologies with a view to their biomedical applications. With chapters contributed by distinguished scientists from diverse disciplines, Biomedical Applications of Nanotechnology : Reviews recent advances in the designing of various nanotechnologies based on nucleic acids, polymers, biomaterials, and metals Discusses biomedical nanotechnology in areas such as drug and gene delivery Covers advanced aspects of imaging and diagnostics Includes a chapter on the issue of nanotoxicology Complete with figures and tables, this is a practical, hands-on reference book for researchers in pharmaceutical and biotech industries, biomedical engineers, pharmaceutical scientists, pharmacologists, and materials scientists as well as for the policymakers who need to understand the potential of nanotechnology. It is also an excellent resource book for graduate-level students in pharmaceutical sciences, biomedical engineering, and other fields in which nanotechnology is playing an increasingly important role.

Featuring contributions from internationally recognized experts in point-of-care sonography, Emergency Point-of-Care Ultrasound, Second Edition combines a wealth of images with clear, succinct text to help beginners, as well as experienced sonographers, develop and refine their sonography skills. The book contains chapters devoted to scanning the chest, abdomen, head and neck, and extremities, as well as paediatric evaluations, ultrasound-guided vascular access, and more. An entire section is devoted to the syndromic approach for an array of symptoms and patient populations, including chest and abdominal pain, respiratory distress, HIV and TB coinfected patients, and pregnant patients. Also included is expert guidance on administering ultrasound in a variety of challenging environments, such as communities and regions with underdeveloped healthcare systems, hostile environments, and cyberspace. Each chapter begins with an introduction to the focused scan under discussion and a detailed description of methods for obtaining useful images. This is followed by examples of normal and abnormal scans, along with discussions of potential pitfalls of the technique, valuable insights from experienced users, and summaries of the most up-to-date evidence. Emergency Point-of-Care Ultrasound, Second Edition is a valuable working resource for emergency medicine residents and trainees, practitioners who are just bringing ultrasound scanning into their practices, and clinicians with many years of sonographic experience.