Bioavailability, Bioaccessibility and Mobility of Environmental Contaminants

Given the presence of a wide variety of contaminants in the environment, it is important to understand what drives a contaminant from one medium to another, as well as the manner and extent to which a contaminant associates with the different media or phases within a local environmental system. Partition and Adsorption of Organic Contaminants in Environmental Systems forms a comprehensive resource on the behavioral characteristics of contaminants so that appropriate strategies can be adopted to either prevent or minimize their adverse impacts on human welfare and natural resources. Cary Chiou’s far-reaching text depicts the processes by which nonionic organic contaminants are sorbed to natural biotic and abiotic substances. This book focuses on physical principles and system parameters that affect the contaminant uptake by soil from water, air, and other media; by fish from water; and by plants from soil and water. As contaminant uptake by natural organic substances is often predominantly a partition interaction, the partition characteristics in several solvent-water model mixtures are treated in detail to elucidate the relevant physicochemical parameters. The account of contaminant sorption to soils, fish, and plants is strengthened by companion chapters on: Fundamentals of solution theory Interphase partition equations Fundamentals of adsorption theory Vapor adsorption on mineral and carbonaceous solids No other single source in the field delivers as compelling a combination of background understanding and «state-of-the-science» comprehension of current issues. Ideally suited for a graduate-level environmental course, Partition and Adsorption of Organic Contaminants in Environmental Systems also serves as a technical guide to current and future research in the field.

Analytical Methods for Environmental Contaminants of Emerging Concern Provides the analytical methodology required to detect different families of organic compounds of emerging concern (CECs) from environmental samples Most contaminants of emerging concern (CECs) —such as pharmaceuticals, personal care products, pesticides, sunscreens, perfluorinated compounds, and microplastics—have been present in the environment for years, yet some have only recently been identified, and many of these organic compounds remain unregulated. Analytical methods have been developed to determine the toxicity and risk of different families of CECs. Analytical Methods for Environmental Contaminants of Emerging Concern presents the methods currently available to determine families of organic CECs in environmental samples. Each section of the book is devoted to a particular family of CECs, covering different analytical methods supported by examples of both cutting-edge research and commonly used methods. An international panel of experts describes every step of the analytical procedures, including sample preparation, chromatographic separation coupled to mass spectrometry or other instrumental techniques. Specific requirements are linked to the properties of the contaminants and the sample matrix for each procedure presented. Throughout the book, in-depth case studies of analytical procedures for CEC extraction, separation, and determination are presented to help readers transfer the analytical methods to their laboratories. Provides detailed descriptions of various approaches for determining each group of CECs in environmental samples Covers different types of aqueous, solid, and atmospheric samples Includes up-to-date information on CEC properties, relevant legislation, reported or potential metabolites/transformation products, and environmental occurrence Addresses CECs such as novel psychoactive substances, artificial sweeteners, musk fragrances, disinfection byproducts, and microplastics Offers practical tips and advice on special care procedures to assist readers in CEC determination Analytical Methods for Environmental Contaminants of Emerging Concern is an essential reference and guide for advanced students and researchers in analytical chemistry and science, environmental science, forensic science, and specialized subjects related to analytical chemistry.

An integrated approach to understanding the principles of sampling, chemical analysis, and instrumentation This unique reference focuses on the overall framework and why various methodologies are used in environmental sampling and analysis. An understanding of the underlying theories and principles empowers environmental professionals to select and adapt the proper sampling and analytical protocols for specific contaminants as well as for specific project applications. Covering both field sampling and laboratory analysis, Fundamentals of Environmental Sampling and Analysis includes: A review of the basic analytical and organic chemistry, statistics, hydrogeology, and environmental regulations relevant to sampling and analysis An overview of the fundamentals of environmental sampling design, sampling techniques, and quality assurance/quality control (QA/QC) essential to acquire quality environmental data A detailed discussion of: the theories of absorption spectroscopy for qualitative and quantitative environmental analysis; metal analysis using various atomic absorption and emission spectrometric methods; and the instrumental principles of common chromatographic and electrochemical methods An introduction to advanced analytical techniques, including various hyphenated mass spectrometries and nuclear magnetic resonance spectroscopy With real-life case studies that illustrate the principles plus problems and questions at the end of each chapter to solidify understanding, this is a practical, hands-on reference for practitioners and a great textbook for upper-level undergraduates and graduate students in environmental science and engineering.

Access state-of-the-art research about trace element contamination and its impact on human health in Trace Elements as Contaminants and Nutrients: Consequences in Ecosystems and Human Health. In this ground-breaking guide, find exhaustive evidence of trace element contamination in the environment with topics like the functions and essentiality of trace metals, bioavailability and uptake biochemistry, membrane biochemistry and transport mechanisms, and enzymology. Find case studies that will reinforce the fundamentals of mineral nutrition in plants and animals and current information about fortified foods and nutrient deficiencies.

This superb and highly-acclaimed dictionary includes over 4000 in-depth entries on scientific and technical terminology associated with environmental protection and resource management. In addition, it contains numerous illustrations, a wide range of international case studies and extensive cross-references to guide the reader. The new edition will be a major update with 30% new material, additional illustrations and a greatly expanded list of relevant web resources.

Oil and gas still power the bulk of our world, from automobiles and the power plants that supply electricity to our homes and businesses, to jet fuel, plastics, and many other products that enrich our lives. With the relatively recent development of hydraulic fracturing («fracking»), multilateral, directional, and underbalanced drilling, and enhanced oil recovery, oil and gas production is more important and efficient than ever before. Along with these advancements, as with any new engineering process or technology, come challenges, many of them environmental. More than just a text that outlines the environmental challenges of oil and gas production that have always been there, such as gas migration and corrosion, this groundbreaking new volume takes on the most up-to-date processes and technologies involved in this field. Filled with dozens of case studies and examples, the authors, two of the most well-known and respected petroleum engineers in the world, have outlined all of the major environmental aspects of oil and gas production and how to navigate them, achieving a more efficient, effective, and profitable operation. This groundbreaking volume is a must-have for any petroleum engineer working in the field, and for students and faculty in petroleum engineering departments worldwide.

The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real-life data. Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process. No other publication offers the same level of treatment on this crucial topic in modern drug development.

Environmental Experience and Plasticity of the Developing Brain goes beyond the genetic basis of neurodevelopment. Chapters illuminate the external factors that can dramatically impact the brain early in life and, consequently, the eventual accomplishment of developmental milestones and the construction of adult behavior and personality. Authored and edited by leaders in this rapidly growing field, Environmental Experience and Plasticity of the Developing Brain not only surveys preexisting literature on the effects of environment versus genetics, but also discusses more recent studies on the impacts of neurodevelopment in terms of maternal stimulation, environmental enrichment and sensory deprivation. The book also includes key examples of environmental impacts on preexisting genetic syndromes leading to developmental disabilities. Focus is also given to the consequences of early adverse experience in primates, as well as neurobiological and behavioral consequences in institutionalized human children and the reversibility of such consequences. Environmental Experience and Plasticity of the Developing Brain encompasses a broad area of research in the field of developmental neurobiology and offers a unique combination of different examples of environmental factors affecting brain development and behavior.