Color Atlas of Clinical Hematology. Molecular and Cellular Basis of Disease

The field of lymphokine research has grown in parallel to the exciting developments around the two sets of cells which defend the body. While lymphokines are the «property» of immunologists, the molecular regulators of hemopoiesis (CSFs) belong to the hematologists. This book offers the rare opportunity to examine these separate fields of expertise together.

Sets the stage for the development of better diagnostic techniques and therapeutics Featuring contributions from an international team of leading clinicians and biomedical researchers, Molecular Basis of Oxidative Stress reviews the molecular and chemical bases of oxidative stress, describing how oxidative stress can lead to the development of cancer and cardiovascular and neurodegenerative diseases. Moreover, it explains the potential role of free radicals in both the diagnosis and the development of therapeutics to treat disease. Molecular Basis of Oxidative Stress is logically organized, beginning with a comprehensive discussion of the fundamental chemistry of reactive species. Next, the book: Presents new mechanistic insights into how oxidative damage of biomolecules occurs Examines how these oxidative events effect cellular metabolism Investigates the role of oxidative stress in the pathogenesis of cancer, neurodegenerative disease, cardiovascular disease, and cystic fibrosis Explores opportunities to improve the diagnosis of disease and the design of new therapeutic agents Readers will find much novel information, including new radical chemistries and the latest discoveries of how free radicals react with biomolecules. The contributors also present recent findings that help us better understand the initiation of oxidative stress and the mechanisms leading to the pathogenesis of various diseases. Throughout the book, the use of molecular structures helps readers better understand redox chemistry. In addition, plenty of detailed figures illustrate the mechanisms of oxidative stress and disease pathogenesis. Examining everything from the basic chemistry of oxidative stress to the pathogenesis of disease, Molecular Basis of Oxidative Stress will help readers continue to explore the nature of oxidative stress and then use that knowledge to develop new approaches to prevent, detect, and treat a broad range of disease conditions.

Unique text providing a core knowledge base for those with little exposure to molecular biological methods Molecular Haematology provides essential reading for those with minimal exposure to, or understanding of, molecular biological techniques. There is an extensive glossary and each chapter is written with the non-specialist in mind. Molecular Haematology is ideal for: Trainees and residents in hematology Hematologists in practice Why Buy This Book? Unique text providing a core knowledge base for those with little exposure to molecular biological methods Focuses on the clinical relevance of molecular biology in haematology Complete revision of text and ten new chapters to cover all groundbreaking developments in the field Each chapter summarizes the impact made by molecular research on understanding the pathogenesis of a variety of blood disorders International team of contributors recruited from top specialist units around the world

Recent application of the techniques of molecular biology and patch-clamp physiology has led to rapid advances in understanding the molecular events in chemosensory transduction. In this book, the latest results are presented and discussed by leading scientists. The extensive coverage encompasses many important topics, including mucous domains; microchemical heterogeneity in the mucociliary complex of the olfactory epithelium; membrane currents and mechanisms of olfactory transduction, and genetic and pathological taste variation.

ATLAS OF CLINICAL DERMATOPATHOLOGY INFECTIOUS AND PARASITIC DERMATOSES Differential diagnosis is at its most accurate and efficient when clinical presentation and histopathological features are considered in correlation with one another. With that being so, the expert team behind this innovative atlas has integrated both perspectives to provide all those working in dermatologic healthcare with a complete guide to infectious and parasitic dermatoses in their many forms. More than 600 high-quality images demonstrate the common presentation of a wide range of bacterial, viral, and fungal infections, as well those of parasitic conditions of various kinds. Accompanying these are direct and easily understood descriptions of key features and diagnostic clues, making this new text an essential quick-reference tool for trainees and practicing clinicians alike. The Atlas of Clinical Dermatopathology: Infectious and Parasitic Dermatoses includes: A straightforward, pattern-based approach to dermatologic diagnosis Full-color illustrations and clear descriptions for easy reference Combined clinical and histopathological perspectives Handy diagnostic tips throughout Featuring all this and more, this invaluable atlas offers a uniquely balanced, clear, and comprehensive guide to what can be a difficult process, and will be of tremendous assistance to students, dermatologists, dermatopathologists, and pathologists everywhere.

Contributors to this symposium focus on the interface between genes and cells, covering genetic analysis, cloning studies, and the investigation of cell lineages and cellular interactions. They note how the body axes are already determined in the eggs of invertebrates and amphibia, then consider the mechanisms as the egg cleaves, in annelids, arthropods, amphibia, and mice that underlie assignation of cells to specific lineages, which give rise to different tissues in the adult. Closing chapters characterize the molecules that mediate each cell's particular fate, its position in the final body plan as the result of cell sorting or, in some cases, cell migration.

Histologic Basis of Ocular Disease in Animals is a comprehensive reference covering pathology of the eye in a spectrum of animal species, including domestic animals, fish, birds, and laboratory animals. Offers a comprehensive resource on diseases and conditions of the eye and orbit in a wide range of species Covers domestic animals, fish, birds, and laboratory animals Presents more than 1200 high-quality images carefully selected to illustrate the ocular conditions covered Emphasizes unique pathological responses where necessary

The diversity of species in which drugs are used for clinical purposes and the emphasis on various classes of drugs make veterinary pharmacology a complex subject. Anatomical and physiological features influence the pharmacokinetic behaviour of a drug in a particular animal and the dosage required. This book is concerned with the basis of species differences, the selection of pharmacokinetic parameters and the interpretation of values obtained. There are chapters on bioavailability and its application to veterinary dosage forms, changes in drug disposition and interspecies scaling, clinical selectivity and stereoisomerism, drug permeation, antimicrobial disposition and specifics related to neonatal animals. The author has gathered all this information together in one place so allowing the reader to make better selection of drug preparations for animal dosages to effectively treat animal diseases. The book will prove valuable to clinical researchers in the areas of pharmacology, anaesthesia, microbial infections and, internal medicine as well as postgraduate students of these disciplines. The Author J Desmond Baggot (MVM, PhD, DSc, FRCVS, DipECVPT) is currently Visiting Professor of Veterinary Pharmacology at the School of Veterinary Medicine, St George's University, Grenada, West Indies. He was a contributing author and co-author of Antimicrobial Therapy in Veterinary Medicine, 3rd Edition (2000) and Development and Formulation of Veterinary Dosage Forms, 2nd Edition (1998) and the author of Principles of Drug Disposition in Domestic Animals (1977). Elucidations of the processes that underline species variation in the disposition of drugs and interpretation of the influence of disease states on drug disposition have been the focus of his research endeavours. He was a member of the Editorial Board of the Journal of Veterinary Pharmacology and Therapeutics from 1978 to 1996. He is a former Professor of Clinical Pharmacology at the School of Veterinary Medicine, University of California, Davis and Preclinical Veterinary Studies at the University of Zimbabwe, Harare.

The effects of time and temperature on the postharvest quality of fruits and vegetables are visually depicted in the Color Atlas of Postharvest Quality of Fruits and Vegetables. Through hundreds of vibrant color photographs, this unique resource illustrates how the appearance (e.g., color, shape, defects and injuries) of fruits and vegetables changes throughout their postharvest life and how storage temperature greatly contributes to critical quality changes. The book’s extensive coverage describes 37 different fruits and vegetables from different groups that were stored at five specific temperatures and photographed daily after specified elapsed periods of time. Individual fruits and vegetables from the following groups are covered: subtropical and tropical fruits pome and stone fruits soft fruits and berries cucurbitaceae solanaceous and other fruit vegetables legumes and brassicas stem, leaf and other vegetable and alliums Information is provided about each individual fruit/vegetable such as characteristics, quality criteria and composition; recommendations for storage, transport and retail; and effects of temperature on the visual and compositional quality of each individual fruit or vegetable, associated with photos of the appearance at particular times and temperatures. This visual documentation shows how important is to handle fruits and vegetables at the right temperature and what happens if the recommendations are not followed. Also shown is the importance of the initial harvest quality of the fruit/vegetable and the expected shelf life as a function of quality at harvest, storage temperature and storage time. The Color Atlas of Postharvest Quality of Fruits and Vegetables will appeal to a diverse group of food industry professionals in the areas of processing, distribution, retail, quality control, packaging, temperature control (refrigerated facilities or equipment) and marketing as a reference tool and to establish marketing priority criteria. Academic and scientific professionals in the area of postharvest physiology and technology, food science and nutrition can also use the book as a reference either for their study or in class to help students to visualize changes in the appearance of fruit/vegetables as a function of time/temperature.