Complex Analysis

Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases , a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.

The only integrative approach to chaos and random fractal theory Chaos and random fractal theory are two of the most important theories developed for data analysis. Until now, there has been no single book that encompasses all of the basic concepts necessary for researchers to fully understand the ever-expanding literature and apply novel methods to effectively solve their signal processing problems. Multiscale Analysis of Complex Time Series fills this pressing need by presenting chaos and random fractal theory in a unified manner. Adopting a data-driven approach, the book covers: DNA sequence analysis EEG analysis Heart rate variability analysis Neural information processing Network traffic modeling Economic time series analysis And more Additionally, the book illustrates almost every concept presented through applications and a dedicated Web site is available with source codes written in various languages, including Java, Fortran, C, and MATLAB, together with some simulated and experimental data. The only modern treatment of signal processing with chaos and random fractals unified, this is an essential book for researchers and graduate students in electrical engineering, computer science, bioengineering, and many other fields.

A complete guide to carrying out complex survey analysis using R As survey analysis continues to serve as a core component of sociological research, researchers are increasingly relying upon data gathered from complex surveys to carry out traditional analyses. Complex Surveys is a practical guide to the analysis of this kind of data using R, the freely available and downloadable statistical programming language. As creator of the specific survey package for R, the author provides the ultimate presentation of how to successfully use the software for analyzing data from complex surveys while also utilizing the most current data from health and social sciences studies to demonstrate the application of survey research methods in these fields. The book begins with coverage of basic tools and topics within survey analysis such as simple and stratified sampling, cluster sampling, linear regression, and categorical data regression. Subsequent chapters delve into more technical aspects of complex survey analysis, including post-stratification, two-phase sampling, missing data, and causal inference. Throughout the book, an emphasis is placed on graphics, regression modeling, and two-phase designs. In addition, the author supplies a unique discussion of epidemiological two-phase designs as well as probability-weighting for causal inference. All of the book's examples and figures are generated using R, and a related Web site provides the R code that allows readers to reproduce the presented content. Each chapter concludes with exercises that vary in level of complexity, and detailed appendices outline additional mathematical and computational descriptions to assist readers with comparing results from various software systems. Complex Surveys is an excellent book for courses on sampling and complex surveys at the upper-undergraduate and graduate levels. It is also a practical reference guide for applied statisticians and practitioners in the social and health sciences who use statistics in their everyday work.

Well received in its first edition, Survival Analysis: A Practical Approach is completely revised to provide an accessible and practical guide to survival analysis techniques in diverse environments. Illustrated with many authentic examples, the book introduces basic statistical concepts and methods to construct survival curves, later developing them to encompass more specialised and complex models. During the years since the first edition there have been several new topics that have come to the fore and many new applications. Parallel developments in computer software programmes, used to implement these methodologies, are relied upon throughout the text to bring it up to date.

A comprehensive overview of the internationalisation of correspondence analysis Correspondence Analysis: Theory, Practice and New Strategies examines the key issues of correspondence analysis, and discusses the new advances that have been made over the last 20 years. The main focus of this book is to provide a comprehensive discussion of some of the key technical and practical aspects of correspondence analysis, and to demonstrate how they may be put to use. Particular attention is given to the history and mathematical links of the developments made. These links include not just those major contributions made by researchers in Europe (which is where much of the attention surrounding correspondence analysis has focused) but also the important contributions made by researchers in other parts of the world. Key features include: A comprehensive international perspective on the key developments of correspondence analysis. Discussion of correspondence analysis for nominal and ordinal categorical data. Discussion of correspondence analysis of contingency tables with varying association structures (symmetric and non-symmetric relationship between two or more categorical variables). Extensive treatment of many of the members of the correspondence analysis family for two-way, three-way and multiple contingency tables. Correspondence Analysis offers a comprehensive and detailed overview of this topic which will be of value to academics, postgraduate students and researchers wanting a better understanding of correspondence analysis. Readers interested in the historical development, internationalisation and diverse applicability of correspondence analysis will also find much to enjoy in this book.

Risk Analysis, Second Edition Terje Aven, University of Stavanger, Norway A practical guide to the varied challenges presented in the ever-growing field of risk analysis. Risk Analysis presents an accessible and concise guide to performing risk analysis, in a wide variety of field, with minimal prior knowledge required. Forming an ideal companion volume to Aven's previous Wiley text Foundations of Risk Analysis, it provides clear recommendations and guidance in the planning, execution anduse of risk analysis. This new edition presents recent developments related to risk conceptualization, focusing on related issues on risk assessment and their application. New examples are also featured to clarify the reader's understanding in the application of risk analysis and the risk analysis process. Key features: Fully updated to include recent developments related to risk conceptualization and related issues on risk assessments and their applications. Emphasizes the decision making context of risk analysis rather than just computing probabilities Demonstrates how to carry out predictive risk analysis using a variety of case studies and examples. Written by an experienced expert in the field, in a style suitable for both industrial and academic audiences. This book is ideal for advanced undergraduates, graduates, analysts and researchers from statistics, engineering, finance, medicine and physical sciences. Managers facing decision making problems involving risk and uncertainty will also benefit from this book.

Everyday we face decisions that carry an element of risk and uncertainty. The ability to analyze, predict, and prepare for the level of risk entailed by these decisions is, therefore, one of the most constant and vital skills needed for analysts, scientists and managers. Risk analysis can be defined as a systematic use of information to identify hazards, threats and opportunities, as well as their causes and consequences, and then express risk. In order to successfully develop such a systematic use of information, those analyzing the risk need to understand the fundamental concepts of risk analysis and be proficient in a variety of methods and techniques. Risk Analysis adopts a practical, predictive approach and guides the reader through a number of applications. Risk Analysis: Provides an accessible and concise guide to performing risk analysis in a wide variety of fields, with minimal prior knowledge required. Adopts a broad perspective on risk, with focus on predictions and highlighting uncertainties beyond expected values and probabilities, allowing a more flexible approach than traditional statistical analysis. Acknowledges that expected values and probabilities could produce poor predictions – surprises may occur. Emphasizes the planning and use of risk analyses, rather than just the risk analysis methods and techniques, including the statistical analysis tools. Features many real-life case studies from a variety of applications and practical industry problems, including areas such as security, business and economy, transport, oil & gas and ICT (Information and Communication Technology). Forms an ideal companion volume to Aven’s previous Wiley text Foundations of Risk Analysis. Professor Aven’s previous book Foundations of Risk Analysis presented and discussed several risk analysis approaches and recommended a predictive approach. This new text expands upon this predictive approach, exploring further the risk analysis principles, concepts, methods and models in an applied format. This book provides a useful and practical guide to decision-making, aimed at professionals within the risk analysis and risk management field.

A self-contained introduction to the fundamentals of mathematical analysis Mathematical Analysis: A Concise Introduction presents the foundations of analysis and illustrates its role in mathematics. By focusing on the essentials, reinforcing learning through exercises, and featuring a unique «learn by doing» approach, the book develops the reader's proof writing skills and establishes fundamental comprehension of analysis that is essential for further exploration of pure and applied mathematics. This book is directly applicable to areas such as differential equations, probability theory, numerical analysis, differential geometry, and functional analysis. Mathematical Analysis is composed of three parts: ?Part One presents the analysis of functions of one variable, including sequences, continuity, differentiation, Riemann integration, series, and the Lebesgue integral. A detailed explanation of proof writing is provided with specific attention devoted to standard proof techniques. To facilitate an efficient transition to more abstract settings, the results for single variable functions are proved using methods that translate to metric spaces. ?Part Two explores the more abstract counterparts of the concepts outlined earlier in the text. The reader is introduced to the fundamental spaces of analysis, including Lp spaces, and the book successfully details how appropriate definitions of integration, continuity, and differentiation lead to a powerful and widely applicable foundation for further study of applied mathematics. The interrelation between measure theory, topology, and differentiation is then examined in the proof of the Multidimensional Substitution Formula. Further areas of coverage in this section include manifolds, Stokes' Theorem, Hilbert spaces, the convergence of Fourier series, and Riesz' Representation Theorem. ?Part Three provides an overview of the motivations for analysis as well as its applications in various subjects. A special focus on ordinary and partial differential equations presents some theoretical and practical challenges that exist in these areas. Topical coverage includes Navier-Stokes equations and the finite element method. Mathematical Analysis: A Concise Introduction includes an extensive index and over 900 exercises ranging in level of difficulty, from conceptual questions and adaptations of proofs to proofs with and without hints. These opportunities for reinforcement, along with the overall concise and well-organized treatment of analysis, make this book essential for readers in upper-undergraduate or beginning graduate mathematics courses who would like to build a solid foundation in analysis for further work in all analysis-based branches of mathematics.