Developmental Approaches to Human Evolution

Many common human diseases have a multifactorial origin: they are influenced by a person's genetic predisposition as well as by factors in the environment. This volume deals with the application of recombinant DNA techniques to the identification of diseases that have more than one inherited component. Focus is on the polygenic factors responsible for coronary atherosclerosis. Several other disorders having a polygenic origin are also discussed, including hypertension, diabetes mellitus, psychiatric diseases, and autoimmune (HLA-related) disorders. Problems raised by the study of different families or different populations are covered, as well as the possibility of applying molecular techniques to disease prevention–for example, through gene therapy. Also, some of the ethical issues that relate to human gene mapping are briefly explored.

The brief length and focused coverage of Human Evolution: An Illustrated Introduction have made this best-selling textbook the ideal complement to any biology or anthropology course in which human evolution is taught. The text places human evolution in the context of humans as animals, while also showing the physical context of human evolution, including climate change and the impact of extinctions. Chapter introductions, numerous drawings and photographs, and an essential glossary all add to the accessibility of this text.The fifth edition has been thoroughly updated to include coverage of the latest discoveries and perspectives, including: · New early hominid fossils from Africa and Georgia, and their implications · New archaeological evidence from Africa on the origin of modern humans · Updated coverage of prehistoric art, including new sites · New perspectives on molecular evidence and their implications for human population history. An Instructor manual CD-ROM for this title is available. Please contact our Higher Education team at HigherEducation@wiley.com for more information.

Principles of Human Evolution presents an in-depth introduction to paleoanthropology and the study of human evolution. Focusing on the fundamentals of evolutionary theory and how these apply to ecological, molecular genetic, paleontological and archeological approaches to important questions in the field, this timely textbook will help students gain a perspective on human evolution in the context of modern biological thinking. The second edition of this successful text features the addition of Robert Foley, a leading researcher in Human Evolutionary Studies, to the writing team. Strong emphasis on evolutionary theory, ecology and behavior and scores of new examples reflect the latest evolutionary theories and recent archaeological finds. More than a simple update, the new edition is organized by issue rather than chronology, integrating behavior, adaptation and anatomy. A new design and new figure references make this edition more accessible for students and instructors. New author, Robert Foley – leading figure in Human Evolutionary Studies – joins the writing team. Dedicated website – www.blackwellpublishing.com/lewin – provides study resources and artwork downloadable for Powerpoint presentations. Beyond the Facts boxes – explore key scientific debates in greater depth. Margin Comments – indicate the key points in each section. Key Questions – review and test students’ knowledge of central chapter concepts and help focus the way a student approaches reading the text. New emphasis on ecological and behavioral evolution – in keeping with modern research. Fully up to date with recent fossil finds and interpretations; integration of genetic and paleoanthropological approaches.

As a practitioner in the field for over thirty years, I have been exposed to endless 'planning' sessions that are prescriptive to the point of being oppressive. Thistext 'gives permission' to the practitioner to allow for emergence, uncertainty, and ambiguity in the planning process. Comparative Approaches to Program Planning provides a guide for the manager, administrator, executive director, strategic planner, and CEO to embrace multiple planning strategies and the understanding of each. This is extremely worthwhile in a dynamic environment and an ever- changing landscape and worldview. —Paul D. McWhinney, ACSW, Director of Social Services City of Richmond, Richmond, Virginia «This is the book I've been waiting for. It provides not only a linear approach to program design, but gives language to the tacit knowledge many planners have of the circular nature of their work. Both linear and circular thinking are important to planning processes and now we have a resource for teaching.» —Jon E. Singletary, PhD, MSW, MDiv, Baylor University, School of Social Work The first text on program planning to guide readers in selecting program planning approaches appropriate to setting, culture, and context Valuable for students and practitioners in the social work, public administration, nonprofit management, and community psychology fields, Comparative Approaches to Program Planning provides practical and creative ways to effectively conduct program planning within human service organizations. Written by leaders in the social work education community, this innovative book explores program planning as a multi-layered and complex process. It examines both a traditional linear problem-solving model as well as an alternative emergent approach to program planning, helping professionals to successfully develop and enact effective and culturally competent planning in organizations and communities.

The development of materials for clean and efficient energy generation and storage is one of the most rapidly developing, multi-disciplinary areas of contemporary science, driven primarily by concerns over global warming, diminishing fossil-fuel reserves, the need for energy security, and increasing consumer demand for portable electronics. Computational methods are now an integral and indispensable part of the materials characterisation and development process. Computational Approaches to Energy Materials presents a detailed survey of current computational techniques for the development and optimization of energy materials, outlining their strengths, limitations, and future applications. The review of techniques includes current methodologies based on electronic structure, interatomic potential and hybrid methods. The methodological components are integrated into a comprehensive survey of applications, addressing the major themes in energy research. Topics covered include: • Introduction to computational methods and approaches • Modelling materials for energy generation applications: solar energy and nuclear energy • Modelling materials for storage applications: batteries and hydrogen • Modelling materials for energy conversion applications: fuel cells, heterogeneous catalysis and solid-state lighting • Nanostructures for energy applications This full colour text is an accessible introduction for newcomers to the field, and a valuable reference source for experienced researchers working on computational techniques and their application to energy materials.

The field of forensic archaeology has developed over recent years from being a branch of conventional archaeology into a well-established discipline in its own right. Forensic Approaches to Buried Remains takes an innovative approach to the subject by placing the role of the forensic archaeologist within the wider forensic environment; it identifies new areas of interdisciplinary research and practice, and evaluates practical difficulties. The authors see this book as a reflection of the subject’s development, and as a knowledge base for the next generation of forensic archaeologists. Areas covered include: Search logistics, integration and specialist search scenarios Levels of confidence in site search and elimination Urban and rural landscape reconstruction in both short and long term cases The integration of cadaver dogs and earth-moving machinery The recovery of multiple evidence types Sampling strategies, spatial relevance and dating Multiple burial scenarios As part of the Essential Forensic Science book series this book will provide students and practitioners alike with an invaluable resource outlining both the major developments in the discipline, as well as original approaches to the search for, and recovery of buried remains.

Computational Approaches to Studying the Co-evolution of Networks and Behaviour in Social Dilemmas shows students, researchers, and professionals how to use computation methods, rather than mathematical analysis, to answer research questions for an easier, more productive method of testing their models. Illustrations of general methodology are provided and explore how computer simulation is used to bridge the gap between formal theoretical models and empirical applications.

Written by one of the most consulted authorities on the subject, Atlas of Developmental Field Anomalies of the Human Skeleton is the pre-eminent resource for developmental defects of the skeleton. This guide focuses on localized bone structures utilizing the morphogenetic approach that addresses the origins of variability within specific developmental fields during embryonic development. Drawings and photographs make up most of the text, forming a picture atlas with descriptive text for each group of illustrations. Each section and subdivision is accompanied by brief discussions and drawings of morphogenetic development.

Geo-mathematical modelling: models from complexity science Sir Alan Wilson, Centre for Advanced Spatial Analysis, University College London Mathematical and computer models for a complexity science tool kit Geographical systems are characterised by locations, activities at locations, interactions between them and the infrastructures that carry these activities and flows. They can be described at a great variety of scales, from individuals and organisations to countries. Our understanding, often partial, of these entities, and in many cases this understanding is represented in theories and associated mathematical models. In this book, the main examples are models that represent elements of the global system covering such topics as trade, migration, security and development aid together with examples at finer scales. This provides an effective toolkit that can not only be applied to global systems, but more widely in the modelling of complex systems. All complex systems involve nonlinearities involving path dependence and the possibility of phase changes and this makes the mathematical aspects particularly interesting. It is through these mechanisms that new structures can be seen to ‘emerge’, and hence the current notion of ‘emergent behaviour’. The range of models demonstrated include account-based models and biproportional fitting, structural dynamics, space-time statistical analysis, real-time response models, Lotka-Volterra models representing ‘war’, agent-based models, epidemiology and reaction-diffusion approaches, game theory, network models and finally, integrated models. Geo-mathematical modelling: Presents mathematical models with spatial dimensions. Provides representations of path dependence and phase changes. Illustrates complexity science using models of trade, migration, security and development aid. Demonstrates how generic models from the complexity science tool kit can each be applied in a variety of situations This book is for practitioners and researchers in applied mathematics, geography, economics, and interdisciplinary fields such as regional science and complexity science. It can also be used as the basis of a modelling course for postgraduate students.

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of «personalized drugs» are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more