Differential Equation Analysis in Biomedical Science and Engineering

Features a solid foundation of mathematical and computational tools to formulate and solve real-world ODE problems across various fields With a step-by-step approach to solving ordinary differential equations (ODEs), Differential Equation Analysis in Biomedical Science and Engineering: Ordinary Differential Equation Applications with R successfully applies computational techniques for solving real-world ODE problems that are found in a variety of fields, including chemistry, physics, biology, and physiology. The book provides readers with the necessary knowledge to reproduce and extend the computed numerical solutions and is a valuable resource for dealing with a broad class of linear and nonlinear ordinary differential equations. The author’s primary focus is on models expressed as systems of ODEs, which generally result by neglecting spatial effects so that the ODE dependent variables are uniform in space. Therefore, time is the independent variable in most applications of ODE systems. As such, the book emphasizes details of the numerical algorithms and how the solutions were computed. Featuring computer-based mathematical models for solving real-world problems in the biological and biomedical sciences and engineering, the book also includes: R routines to facilitate the immediate use of computation for solving differential equation problems without having to first learn the basic concepts of numerical analysis and programming for ODEs Models as systems of ODEs with explanations of the associated chemistry, physics, biology, and physiology as well as the algebraic equations used to calculate intermediate variables Numerical solutions of the presented model equations with a discussion of the important features of the solutions Aspects of general ODE computation through various biomolecular science and engineering applications Differential Equation Analysis in Biomedical Science and Engineering: Ordinary Differential Equation Applications with R is an excellent reference for researchers, scientists, clinicians, medical researchers, engineers, statisticians, epidemiologists, and pharmacokineticists who are interested in both clinical applications and interpretation of experimental data with mathematical models in order to efficiently solve the associated differential equations. The book is also useful as a textbook for graduate-level courses in mathematics, biomedical science and engineering, biology, biophysics, biochemistry, medicine, and engineering.

Features a solid foundation of mathematical and computational tools to formulate and solve real-world ODE problems across various fields With a step-by-step approach to solving ordinary differential equations (ODEs), Differential Equation Analysis in Biomedical Science and Engineering: Ordinary Differential Equation Applications with R successfully applies computational techniques for solving real-world ODE problems that are found in a variety of fields, including chemistry, physics, biology, and physiology. The book provides readers with the necessary knowledge to reproduce and extend the computed numerical solutions and is a valuable resource for dealing with a broad class of linear and nonlinear ordinary differential equations. The author’s primary focus is on models expressed as systems of ODEs, which generally result by neglecting spatial effects so that the ODE dependent variables are uniform in space. Therefore, time is the independent variable in most applications of ODE systems. As such, the book emphasizes details of the numerical algorithms and how the solutions were computed. Featuring computer-based mathematical models for solving real-world problems in the biological and biomedical sciences and engineering, the book also includes: R routines to facilitate the immediate use of computation for solving differential equation problems without having to first learn the basic concepts of numerical analysis and programming for ODEs Models as systems of ODEs with explanations of the associated chemistry, physics, biology, and physiology as well as the algebraic equations used to calculate intermediate variables Numerical solutions of the presented model equations with a discussion of the important features of the solutions Aspects of general ODE computation through various biomolecular science and engineering applications Differential Equation Analysis in Biomedical Science and Engineering: Ordinary Differential Equation Applications with R is an excellent reference for researchers, scientists, clinicians, medical researchers, engineers, statisticians, epidemiologists, and pharmacokineticists who are interested in both clinical applications and interpretation of experimental data with mathematical models in order to efficiently solve the associated differential equations. The book is also useful as a textbook for graduate-level courses in mathematics, biomedical science and engineering, biology, biophysics, biochemistry, medicine, and engineering.

Presents the methodology and applications of ODE and PDE models within biomedical science and engineering With an emphasis on the method of lines (MOL) for partial differential equation (PDE) numerical integration, Method of Lines PDE Analysis in Biomedical Science and Engineering demonstrates the use of numerical methods for the computer solution of PDEs as applied to biomedical science and engineering (BMSE). Written by a well-known researcher in the field, the book provides an introduction to basic numerical methods for initial/boundary value PDEs before moving on to specific BMSE applications of PDEs. Featuring a straightforward approach, the book’s chapters follow a consistent and comprehensive format. First, each chapter begins by presenting the model as an ordinary differential equation (ODE)/PDE system, including the initial and boundary conditions. Next, the programming of the model equations is introduced through a series of R routines that primarily implement MOL for PDEs. Subsequently, the resulting numerical and graphical solution is discussed and interpreted with respect to the model equations. Finally, each chapter concludes with a review of the numerical algorithm performance, general observations and results, and possible extensions of the model. Method of Lines PDE Analysis in Biomedical Science and Engineering also includes: Examples of MOL analysis of PDEs, including BMSE applications in wave front resolution in chromatography, VEGF angiogenesis, thermographic tumor location, blood-tissue transport, two fluid and membrane mass transfer, artificial liver support system, cross diffusion epidemiology, oncolytic virotherapy, tumor cell density in glioblastomas, and variable grids Discussions on the use of R software, which facilitates immediate solutions to differential equation problems without having to first learn the basic concepts of numerical analysis for PDEs and the programming of PDE algorithms A companion website that provides source code for the R routines Method of Lines PDE Analysis in Biomedical Science and Engineering is an introductory reference for researchers, scientists, clinicians, medical researchers, mathematicians, statisticians, chemical engineers, epidemiologists, and pharmacokineticists as well as anyone interested in clinical applications and the interpretation of experimental data with differential equation models. The book is also an ideal textbook for graduate-level courses in applied mathematics, BMSE, biology, biophysics, biochemistry, medicine, and engineering.

For engineering and scientific endeavors to progress there must be generally accepted ethical guidelines in place to which engineers and scientists must adhere. This book explores the various scientific and engineering disciplines, examining the potential for unethical behavior by professionals. Documented examples are presented to show where unethical behavior could have been halted before it became an issue. The authors also look to the future to see what is in store for professionals in the scientific and engineering disciplines and how the potential for unethical behavior can be negated.

A Practical, Interdisciplinary Guide to Advanced Mathematical Methods for Scientists and Engineers Mathematical Methods in Science and Engineering, Second Edition, provides students and scientists with a detailed mathematical reference for advanced analysis and computational methodologies. Making complex tools accessible, this invaluable resource is designed for both the classroom and the practitioners; the modular format allows flexibility of coverage, while the text itself is formatted to provide essential information without detailed study. Highly practical discussion focuses on the “how-to” aspect of each topic presented, yet provides enough theory to reinforce central processes and mechanisms. Recent growing interest in interdisciplinary studies has brought scientists together from physics, chemistry, biology, economy, and finance to expand advanced mathematical methods beyond theoretical physics. This book is written with this multi-disciplinary group in mind, emphasizing practical solutions for diverse applications and the development of a new interdisciplinary science. Revised and expanded for increased utility, this new Second Edition: Includes over 60 new sections and subsections more useful to a multidisciplinary audience Contains new examples, new figures, new problems, and more fluid arguments Presents a detailed discussion on the most frequently encountered special functions in science and engineering Provides a systematic treatment of special functions in terms of the Sturm-Liouville theory Approaches second-order differential equations of physics and engineering from the factorization perspective Includes extensive discussion of coordinate transformations and tensors, complex analysis, fractional calculus, integral transforms, Green's functions, path integrals, and more Extensively reworked to provide increased utility to a broader audience, this book provides a self-contained three-semester course for curriculum, self-study, or reference. As more scientific disciplines begin to lean more heavily on advanced mathematical analysis, this resource will prove to be an invaluable addition to any bookshelf.

A powerful, unified approach to mathematical and computational modeling in science and engineering Mathematical and computational modeling makes it possible to predict the behavior of a broad range of systems across a broad range of disciplines. This text guides students and professionals through the axiomatic approach, a powerful method that will enable them to easily master the principle types of mathematical and computational models used in engineering and science. Readers will discover that this axiomatic approach not only enables them to systematically construct effective models, it also enables them to apply these models to any macroscopic physical system. Mathematical Modeling in Science and Engineering focuses on models in which the processes to be modeled are expressed as systems of partial differential equations. It begins with an introductory discussion of the axiomatic formulation of basic models, setting the foundation for further topics such as: Mechanics of classical and non-classical continuous systems Solute transport by a free fluid Flow of a fluid in a porous medium Multiphase systems Enhanced oil recovery Fluid mechanics Throughout the text, diagrams are provided to help readers visualize and better understand complex mathematical concepts. A set of exercises at the end of each chapter enables readers to put their new modeling skills into practice. There is also a bibliography in each chapter to facilitate further investigation of individual topics. Mathematical Modeling in Science and Engineering is ideal for both students and professionals across the many disciplines of science and engineering that depend on mathematical and computational modeling to predict and understand complex systems.

Discover recent powerful advances in the theory, methods, and applications of decision and risk analysis Focusing on modern advances and innovations in the field of decision analysis (DA), Breakthroughs in Decision Science and Risk Analysis presents theories and methods for making, improving, and learning from significant practical decisions. The book explains these new methods and important applications in an accessible and stimulating style for readers from multiple backgrounds, including psychology, economics, statistics, engineering, risk analysis, operations research, and management science. Highlighting topics not conventionally found in DA textbooks, the book illustrates genuine advances in practical decision science, including developments and trends that depart from, or break with, the standard axiomatic DA paradigm in fundamental and useful ways. The book features methods for coping with realistic decision-making challenges such as online adaptive learning algorithms, innovations in robust decision-making, and the use of a variety of models to explain available data and recommend actions. In addition, the book illustrates how these techniques can be applied to dramatically improve risk management decisions. Breakthroughs in Decision Science and Risk Analysis also includes: An emphasis on new approaches rather than only classical and traditional ideas Discussions of how decision and risk analysis can be applied to improve high-stakes policy and management decisions Coverage of the potential value and realism of decision science within applications in financial, health, safety, environmental, business, engineering, and security risk management Innovative methods for deciding what actions to take when decision problems are not completely known or described or when useful probabilities cannot be specified Recent breakthroughs in the psychology and brain science of risky decisions, mathematical foundations and techniques, and integration with learning and pattern recognition methods from computational intelligence Breakthroughs in Decision Science and Risk Analysis is an ideal reference for researchers, consultants, and practitioners in the fields of decision science, operations research, business, management science, engineering, statistics, and mathematics. The book is also an appropriate guide for managers, analysts, and decision and policy makers in the areas of finance, health and safety, environment, business, engineering, and security risk management.

Volume 7 in the well-established series «Advances in Electrochemical Science and Engineering» covers – among others – important topics on electrodeposition. As in all previous volumes, the editors have succeeded in selecting highly topical areas of electrochemical research and in presenting authors who are leaders in their fields. The result is a compelling set of reviews which serves equally well as an excellent and up-to-date source of information for experienced researchers active in the field as well as an introduction for newcomers. From reviews of the previous volumes: 'This is an essential book for researchers in electrochemistry; it covers areas of both fundamental and practical importance, with reviews of high quality. The material is very well presented and the choice of topics reflects a balanced editorial policy that is welcomed.' The Analyst 'All the contributions in this volume are well up to the standard of this excellent series and will be of great value to electrochemists… The editors again deserve to be congratulated on this fine collection of reviews.' Journal of Electroanalytical Chemistry and Interfacial Chemistry '…competently and clearly written.' Berichte der Bunsen- Gesellschaft fur Physikalische Chemie

This is the second volume of the new series which continues the highly successful 'Advances in Electrochemistry and Electrochemical Engineering'. The series covers advanced topics in the area of fundamental and applied electrochemistry and engineering. Authors are selected with great care and usually represent the best talent available world-wide. The positive response by scientists worldwide to the new series is reflected in the following excerpts from reviews of the first volume: 'The editors must be congratulated on the first volume of this reborn series, which will be read with pleasure and profit by many.' Journal of Electroanalytical Chemistry 'This new book – and indeed the new series – can be recommended to all electrochemists in research and teaching as well as to all engineers and chemists in industry who are interested in recent developments in the field of electrochemistry.' Chemie – Ingenieur – Technik '… competently and clearly written.' Berichte der Bunsen-Gesellschaft fur Physikalische Chemie

As its title suggests, this innovative book has been written for life scientists needing to analyse their data sets, and programmers, wanting a better understanding of the types of experimental images life scientists investigate on a regular basis. Each chapter presents one self-contained biomedical experiment to be analysed. Part I of the book presents its two basic ingredients: essential concepts of image analysis and Matlab. In Part II, algorithms and techniques are shown as series of «recipes» or solved examples that show how specific techniques are applied to a biomedical experiments like Western Blots, Histology, Scratch Wound Assays and Fluoresence. Each recipe begins with simple techniques that gradually advance in complexity. Part III presents some advanced techniques for the generation of publication quality figures. The book does not assume any computational or mathematical expertise. A practical, clearly-written introduction to biomedical image analysis that provides the tools for life scientists and engineers to use when solving problems in their own laboratories. Presents the basic concepts of MATLAB software and uses it throughout to show how it can execute flexible and powerful image analysis programs tailored to the specific needs of the problem. Within the context of four biomedical cases, it shows algorithms and techniques as series of «recipes», or solved examples that show how a particular technique is applied in a specific experiment. Companion website containing example datasets, MATLAB files and figures from the book.