Каталог
Меню
Войти
0Сравнение
0Избранное
Каталог
Войти
0Сравнить
0Избранное

Evaluation of Enzyme Inhibitors in Drug Discovery

...Нажми для увеличения фото
 Сравнить
 В избранное
16 984 ₽Скидка: 13%

14 750 ₽

Товар в наличии
 Доставка в г. от 3 дней
 Оплата заказа
 Похожие товары
 Видео обзоры
 Как заказать и купить "Evaluation of Enzyme Inhibitors in Drug Discovery"?
 Нашли дешевле? Снизим цену!
  Узнать о снижении стоимости
Отправим письмо при снижении стоимости.

Рекомендательный сервис

  • Общий рейтинг 4.79
  • Рейтинг покупателей 4.96
  • Рейтинг экспертов 4.77
  • Качество материалов 4.91
  • Надежность 4.77
  • Простота в использовании 4.17
  • Ремонтопригодность 4.57
  • Эффективность выполнения своих функций 4.59
  • Коэффициент удивления "Вау!" 4.79
  • Безопасность для пользователя4.67
  • Внешний вид 4.77
  • Удобство в уходе и чистке 4.15
  • Экологическая безопасность 4.70
  • Гарантия на товар 4.11
  • Соответствие стандартам качества 4.77
  • Инновационные технологии 4.10
  • Хит продаж 4.79
  • Скорость морального устаревания 4.95
  • Энергоэффективность 4.57
  • Универсальность использования 4.99
  • Наличие дополнительных функций 4.10
  • Соотношение цена-качество 4.71
  • Практичность и удобство хранения 4.97
  • Стабильность работы в различных условиях 4.06
  • Возможность персонализации 4.09
  • Ликвидность 4.57
  • Индекс рекомендаций 4.11
2626 покупателей и эксперты портала 1ya.ru рекомендуют к покупке товар «Evaluation of Enzyme Inhibitors in Drug Discovery» или его аналог из списка ниже.
Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.
Информация о характеристиках, комплекте поставки, стране изготовления, внешнем виде и цвете товара носит справочный характер и взятая из открытых источников или размещена продавцом. Цена указана на дату: 09.05.2025 г. На текущий момент стоимость может отличаться. Предложение не является публичной офертой.
Эксперт: Аркадий И., E-commerce аналитик
Дата рецензии: 21 июня 2025 г.
Рекомендация к покупке положительная

Доставка покупки

    • В электронном виде;
    • Читать онлайн;
    • Скачать на компьютер или мобильные устройства.

Оплата заказа

    • Банковской картой;
    • электронными деньгами Яндекс-Деньги; WebMoney, Qiwi Кошелек, PayPal;
    • Наличными через терминалы;
    • Банковским переводом.
  • Наименование: ООО «ЛитРес»
  • ИНН: 7719571260

Рекомендуем аналогичные товары

- 13%
...
Evaluation of Drug Candidates for Preclinical Development
Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the «right» drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development. Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume: Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics Address developability issues that challenge pharma companies, moving beyond isolated experimental results Reveal connections between the key scientific areas that are critical for successful drug discovery and development Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.
Цена 12572 руб.
СравнитьКупить
  • Форматы
    PDF
12 572 ₽
- 21%
...
Polypharmacology in Drug Discovery
An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the «one drug, one target» philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.
Цена 13293 руб.
СравнитьКупить
  • Форматы
    PDF
13 293 ₽
- 21%
...
Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
Цена 21730 руб.
СравнитьКупить
  • Форматы
    PDF
21 730 ₽
...
Genome Editing in Drug Discovery
GENOME EDITING IN DRUG DISCOVERY A practical guide for researchers and professionals applying genome editing techniques to drug discovery In Genome Editing in Drug Discovery, a team of distinguished biologists delivers a comprehensive exploration of genome editing in the drug discovery process, with coverage of the technology’s history, current issues and techniques, and future perspectives and research directions. The book discusses techniques for disease modeling, target identification with CRISPR, safety studies, therapeutic editing, and intellectual property issues. The safety and efficacy of drugs and new target discovery, as well as next-generation therapeutics are also presented. Offering practical suggestions for practitioners and academicians involved in drug discovery, Genome Editing in Drug Discovery is a fulsome treatment of a technology that has become part of nearly every early step in the drug discovery pipeline. Selected contributions also include: A thorough introduction to the applications of CRISPRi and CRISPRa in drug discovery Comprehensive explorations of genome-editing applications in stem cell engineering and regenerative medicine Practical discussions of the safety aspects of genome editing with respect to immunogenicity and the specificity of CRISPR-Cas9 gene editing In-depth examinations of critical socio-economic and bioethical challenges in the CRISPR-Cas9 patent landscape Perfect for academic researchers and professionals in the biotech and pharmaceutical industries, Genome Editing in Drug Discovery will also earn a place in the libraries of medicinal chemists, biochemists, and molecular biologists.
Цена 18432 руб.
СравнитьКупить
18 432 ₽
- 13%
...
Heterocyclic Chemistry in Drug Discovery
Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
Цена 15690 руб.
СравнитьКупить
  • Форматы
    PDF
15 690 ₽
- 21%
...
Privileged Structures in Drug Discovery
A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.
Цена 18921 руб.
СравнитьКупить
  • Форматы
    PDF
18 921 ₽
- 13%
...
Data Mining in Drug Discovery
Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine. Clearly divided into four sections, the first part discusses the different data sources available, both commercial and non-commercial, while the next section looks at the role and value of data mining in drug discovery. The third part compares the most common applications and strategies for polypharmacology, where data mining can substantially enhance the research effort. The final section of the book is devoted to systems biology approaches for compound testing. Throughout the book, industrial and academic drug discovery strategies are addressed, with contributors coming from both areas, enabling an informed decision on when and which data mining tools to use for one's own drug discovery project.
Цена 15623 руб.
СравнитьКупить
  • Форматы
    PDF
15 623 ₽
- 21%
...
Protein Crystallography in Drug Discovery
The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.
Цена 20377 руб.
СравнитьКупить
  • Форматы
    PDF
20 377 ₽
- 13%
...
Drug Discovery
Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.
Цена 13069 руб.
СравнитьКупить
  • Форматы
    PDF
13 069 ₽
- 21%
...
Lead Generation Approaches in Drug Discovery
An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or «virtual» screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Цена 11838 руб.
СравнитьКупить
  • Издательство

    Academia

  • Форматы
    PDF
11 838 ₽

Дополнительно из категории

...
Жизнь в потоке: Коучинг
Быть в состоянии потока — значит полностью погрузиться в любимое дело, максимально сосредоточившись и не отвлекаясь ни на что. Именно так можно достичь максимальных результатов в любой деятельности. .В своей новой книге автор уникальной системы личностного развития Мэрилин Аткинсон научит вас входить в состояние потока, фиксировать его, снимать любые барьеры на пути личностного роста и самосовершенствования. Научитесь испытывать искреннюю благодарность, любовь, удовлетворение, стремление к творчеству — и вы наполните смыслом каждый день своей жизни! .Задача этой книги состоит в том, чтобы помочь не только профессионалам в области коучинга, но и всем тем, кто заинтересован во внутренних переменах, достичь внутренней согласованности и самореализации. .
Цена 459 руб.
СравнитьКупить
  • Серия

    Моя жизнь

  • Издательство

    Дело

459 ₽
...
Обрети Силу для получения Больших Денег! Секреты сверхбогатых людей планеты
У вас уже есть все, чтобы быть богатым! Определенность, Решительность, Упорство, Постоянство, Смелость, Надежда, Вера, Инициатива и Повторение - вот ваш капитал! Не бизнес-планы, не образование, не идеи, не эрудиция. Главное - ваша психическая сила. Да, образование и идеи - важны. Но "ментальный" капитал - в тысячу раз важнее. Эта книга научит вас, как пользоваться этим капиталом. Как развить в себе ментальную силу, которая сделает вас богатым. Читайте и обретите власть над деньгами! .Эта книга - мировая классика успеха, она помогла тысячам людей обрести состояние. Впервые на русском языке. .
Цена 321 руб.
СравнитьКупить
  • Серия

    Высшее образование Русский бизнес Книги, которые все ждали Бизнес-класс Бизнес Бизнес-образование Бизнес Бизнес-книга Идеи, которые работают Высший класс Бизнес для детей Аркаим(АСТ)

  • Язык

    Русский

  • Издательство

    АСТ Капитал Класс Дело

  • Тип носителя

    Чешихина В.

  • Направление

    6+

321 ₽
...
Эмоциональный интеллект. Российская практика
Эмоциональный интеллект – это способность распознать чувства, развить положительные и погасить разрушительные эмоции. Эта книга впервые рассказывает о понятии эмоционального интеллекта с точки зрения российской действительности, опыта и традиций.
Цена 1333 руб.
СравнитьКупить
  • Серия

    Книги, которые все ждали

  • Издательство

    Дело

  • Тип носителя

    Чешихина В.

1 333 ₽
...
Обрети Силу для получения Больших Денег! Секреты сверхбогатых людей планеты
У вас уже есть все, чтобы быть богатым! Определенность, Решительность, Упорство, Постоянство, Смелость, Надежда, Вера, Инициатива и Повторение - вот ваш капитал! Не бизнес-планы, не образование, не идеи, не эрудиция. Главное - ваша психическая сила. Да, образование и идеи - важны. Но "ментальный" капитал - в тысячу раз важнее. Эта книга научит вас, как пользоваться этим капиталом. Как развить в себе ментальную силу, которая сделает вас богатым. Читайте и обретите власть над деньгами! .Эта книга - мировая классика успеха, она помогла тысячам людей обрести состояние. Впервые на русском языке. .
Цена 441 руб.
СравнитьКупить
  • Серия

    Высшее образование Русский бизнес Книги, которые все ждали Бизнес-класс Бизнес Бизнес-образование Бизнес Бизнес-книга Идеи, которые работают Высший класс Бизнес для детей Аркаим(АСТ)

  • Язык

    Русский

  • Издательство

    АСТ Капитал Класс Дело

  • Тип носителя

    Чешихина В.

  • Направление

    6+

441 ₽
...
Популярность. Как найти счастье и добиться успеха в мире, одержимом статусом
Популярность в детские годы предопределяет успех и счастье во взрослой жизни в гораздо большей степени, чем уровень интеллекта, происхождение и другие факторы, считает известный психолог Митч Принстейн. В своей книге, в основу которой легли новейшие исследования в области психологии и нейробиологии, он рассказывает о том огромном влиянии, которое оказывает на жизнь человека степень популярности. Как ни парадоксально, не всегда самые популярные в традиционном смысле этого слова люди оказываются самыми счастливыми. По мнению Принстейна, каждый способен управлять своими естественными социальными импульсами и использовать их себе во благо. Только так наши отношения с другими людьми могут стать более разумными, искренними и конструктивными. . .
Цена 551 руб.
СравнитьКупить
  • Серия

    Психология, педагогика, технология обучения Сам себе психолог Право Книги, которые все ждали Психология Моя жизнь Аркаим(АСТ)

  • Издательство

    АСТ ИГ Весь Дело

  • Тип носителя

    Чешихина В.

551 ₽
Москва
Санкт-Петербург
Ангарск
Армавир
Архангельск
Астрахань
Балаково
Балашиха
Барнаул
Белгород
Бийск
Благовещенск
Братск
Брянск
Великий Новгород
Владивосток
Владикавказ
Владимир
Волгоград
Волжский
Вологда
Воронеж
Грозный
Дзержинск
Екатеринбург
Иваново
Ижевск
Иркутск
Йошкар-Ола
Казань
Калининград
Калуга
Кемерово
Киров
Комсомольск-на-Амуре
Королёв
Кострома
Краснодар
Красноярск
Курган
Курск
Липецк
Магнитогорск
Махачкала
Мурманск
Набережные Челны
Нальчик
Нижневартовск
Нижнекамск
Нижний Новгород
Нижний Тагил
Новокузнецк
Новороссийск
Новосибирск
Омск
Орёл
Оренбург
Орск
Пенза
Пермь
Петрозаводск
Петропавловск-Камчатский
Подольск
Прокопьевск
Псков
Ростов-на-Дону
Рыбинск
Рязань
Самара
Саранск
Саратов
Северодвинск
Смоленск
Сочи
Ставрополь
Старый Оскол
Стерлитамак
Сургут
Сыктывкар
Таганрог
Тамбов
Тверь
Тольятти
Томск
Тула
Тюмень
Улан-Удэ
Ульяновск
Уфа
Хабаровск
Химки
Чебоксары
Челябинск
Череповец
Чита
Шахты
Энгельс
Южно-Сахалинск
Якутск
Ярославль
другой город