Genotoxic Impurities. Strategies for Identification and Control

Process Identification and PID Control enables students and researchers to understand the basic concepts of feedback control, process identification, autotuning as well as design and implement feedback controllers, especially, PID controllers. The first The first two parts introduce the basics of process control and dynamics, analysis tools (Bode plot, Nyquist plot) to characterize the dynamics of the process, PID controllers and tuning, advanced control strategies which have been widely used in industry. Also, simple simulation techniques required for practical controller designs and research on process identification and autotuning are also included. Part 3 provides useful process identification methods in real industry. It includes several important identification algorithms to obtain frequency models or continuous-time/discrete-time transfer function models from the measured process input and output data sets. Part 4 introduces various relay feedback methods to activate the process effectively for process identification and controller autotuning. Combines the basics with recent research, helping novice to understand advanced topics Brings several industrially important topics together: Dynamics Process identification Controller tuning methods Written by a team of recognized experts in the area Includes all source codes and real-time simulated processes for self-practice Contains problems at the end of every chapter PowerPoint files with lecture notes available for instructor use

An in-depth review of hybrid control techniques for smart prosthetic hand technology by two of the world’s pioneering experts in the field Long considered the stuff of science fiction, a prosthetic hand capable of fully replicating all of that appendage’s various functions is closer to becoming reality than ever before. This book provides a comprehensive report on exciting recent developments in hybrid control techniques—one of the most crucial hurdles to be overcome in creating smart prosthetic hands. Coauthored by two of the world’s foremost pioneering experts in the field, Fusion of Hard and Soft Control Strategies for Robotic Hand treats robotic hands for multiple applications. Itbegins withan overview of advances in main control techniques that have been made over the past decade before addressing the military context for affordable robotic hand technology with tactile and/or proprioceptive feedback for hand amputees. Kinematics, homogeneous transformations, inverse and differential kinematics, trajectory planning, and dynamic models of two-link thumb and three-link index finger are discussed in detail. The remainder of the book is devoted to the most promising soft computing techniques, particle swarm optimization techniques, and strategies combining hard and soft controls. In addition, the book: Includes a report on exciting new developments in prosthetic/robotic hand technology, with an emphasis on the fusion of hard and soft control strategies Covers both prosthetic and non-prosthetic hand designs for everything from routine human operations, robotic surgery, and repair and maintenance, to hazardous materials handling, space applications, explosives disposal, and more Provides a comprehensive overview of five-fingered robotic hand technology kinematics, dynamics, and control Features detailed coverage of important recent developments in neuroprosthetics Fusion of Hard and Soft Control Strategies for Robotic Hand is a must-read for researchers in control engineering, robotic engineering, biomedical sciences and engineering, and rehabilitation engineering.

Algebraic Identification and Estimation Methods in Feedback Control Systems presents a model-based algebraic approach to online parameter and state estimation in uncertain dynamic feedback control systems. This approach evades the mathematical intricacies of the traditional stochastic approach, proposing a direct model-based scheme with several easy-to-implement computational advantages. The approach can be used with continuous and discrete, linear and nonlinear, mono-variable and multi-variable systems. The estimators based on this approach are not of asymptotic nature, and do not require any statistical knowledge of the corrupting noises to achieve good performance in a noisy environment. These estimators are fast, robust to structured perturbations, and easy to combine with classical or sophisticated control laws. This book uses module theory, differential algebra, and operational calculus in an easy-to-understand manner and also details how to apply these in the context of feedback control systems. A wide variety of examples, including mechanical systems, power converters, electric motors, and chaotic systems, are also included to illustrate the algebraic methodology. Key features: Presents a radically new approach to online parameter and state estimation. Enables the reader to master the use and understand the consequences of the highly theoretical differential algebraic viewpoint in control systems theory. Includes examples in a variety of physical applications with experimental results. Covers the latest developments and applications. Algebraic Identification and Estimation Methods in Feedback Control Systems is a comprehensive reference for researchers and practitioners working in the area of automatic control, and is also a useful source of information for graduate and undergraduate students.

Algebraic Identification and Estimation Methods in Feedback Control Systems presents a model-based algebraic approach to online parameter and state estimation in uncertain dynamic feedback control systems. This approach evades the mathematical intricacies of the traditional stochastic approach, proposing a direct model-based scheme with several easy-to-implement computational advantages. The approach can be used with continuous and discrete, linear and nonlinear, mono-variable and multi-variable systems. The estimators based on this approach are not of asymptotic nature, and do not require any statistical knowledge of the corrupting noises to achieve good performance in a noisy environment. These estimators are fast, robust to structured perturbations, and easy to combine with classical or sophisticated control laws. This book uses module theory, differential algebra, and operational calculus in an easy-to-understand manner and also details how to apply these in the context of feedback control systems. A wide variety of examples, including mechanical systems, power converters, electric motors, and chaotic systems, are also included to illustrate the algebraic methodology. Key features: Presents a radically new approach to online parameter and state estimation. Enables the reader to master the use and understand the consequences of the highly theoretical differential algebraic viewpoint in control systems theory. Includes examples in a variety of physical applications with experimental results. Covers the latest developments and applications. Algebraic Identification and Estimation Methods in Feedback Control Systems is a comprehensive reference for researchers and practitioners working in the area of automatic control, and is also a useful source of information for graduate and undergraduate students.

UHF Radio Frequency Identification (RFID) is an electronic tagging technology that allows an object, place or person to be automatically identified at a distance without a direct line-of-sight using a radio wave exchange. Applications include inventory tracking, prescription medication tracking and authentication, secure automobile keys, and access control for secure facilities. This book begins with an overview of UHF RFID challenges describing the applications, markets, trades and basic technologies. It follows this by highlighting the main features distinguishing UHF (860MHz-960MHz) and HF (125 kHz and 13.56 MHz) identifications, in terms of reading range, environmental sensitivity, throughput and safety. The architecture of the integrated circuits and the organization of the memory are then described. One chapter is devoted to the air interface protocol aspects, including coding, modulation, multi readers operation and anti-collision algorithms to manage the tag responses. Focus will be put upon the EPC Gen2 protocol adopted in the ISO 18000 Part 6. The core of the book will cover the design and manufacturing issues of RFID tags. The influence of the propagation medium (warehouse, libraries, etc.), the tag close environment (bottles, linens, containers, carton boxes,etc.) and the coupling between tags will also be carefully addressed. The final chapter is dedicated to an industrial use case in the supply chain management, either in the retail inventory or blood traceability.

Learn to implement effective control measures for mutagenic impurities in pharmaceutical development  In  Mutagenic Impurities: Strategies for Identification and Control , distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective.  The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment.  The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination.  Readers will also benefit from the inclusion of:  A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals,  Mutagenic Impurities: Strategies for Identification and Control  will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

A voltage converter changes the voltage of an electrical power source and is usually combined with other components to create a power supply. This title is devoted to the control of static converters, which deals with pulse-width modulation (PWM) techniques, and also discusses methods for current control. Various application cases are treated. The book is ideal for professionals in power engineering, power electronics, and electric drives industries, as well as practicing engineers, university professors, postdoctoral fellows, and graduate students.

Are you ready to master the advanced concepts of partnership taxation? Provide your clients with valuable advice and tax planning strategies and gain a working knowledge of the Internal Revenue Code's sophisticated partnership tax rules and regulations. This book takes a deep dive into the complexities of partnership tax law. It includes step-by-step examples to help guide you through the complicated world of advanced partnership and LLC tax law. Some of the many concepts covered in this course include special allocations, liquidating and non-liquidation distributions, property basis calculations under various scenarios, and sales of a partnership interest.

This book discusses scenarios for risk management and developing global investment strategies. What are the chances that various future events will occur over time and how should these events and probable occurrence influence investment decisions? Assessing all possible outcomes is fundamental to risk management, financial engineering and investment and hedge fund strategies. A careful consideration of future scenarios will lead to better investment decisions and avoid financial disasters. The book presents tools and case studies around the world for analyzing a wide variety of investment strategies, building scenarios to optimize returns.