Geodemographics, GIS and Neighbourhood Targeting

Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.

The growing potential of GIS for supporting policing and crime reduction is now being recognised by a broader community. GIS can be employed at different levels to support operational policing, tactical crime mapping, detection, and wider-ranging strategic analyses. With the use of GIS for crime mapping increasing, this book provides a definitive reference. GIS and Crime Mapping provides essential information and reference material to support readers in developing and implementing crime mapping. Relevant case studies help demonstrate the key principles, concepts and applications of crime mapping. This book combines the topics of theoretical principles, GIS, analytical techniques, data processing solutions, information sharing, problem-solving approaches, map design, and organisational structures for using crime mapping for policing and crime reduction. Delivered in an accessible style, topics are covered in a manner that underpins crime mapping use in the three broad areas of operations, tactics and strategy. Provides a complete start-to-finish coverage of crime mapping, including theory, scientific methodologies, analysis techniques and design principles. Includes a comprehensive presentation of crime mapping applications for operational, tactical and strategic purposes. Includes global case studies and examples to demonstrate good practice. Co-authored by Spencer Chainey, a leading researcher and consultant on GIS and crime mapping, and Jerry Ratcliffe, a renowned professor and former police officer. This book is essential reading for crime analysts and other professionals working in intelligence roles in law enforcement or crime reduction, at the local, regional and national government levels. It is also an excellent reference for undergraduate and Masters students taking courses in GIS, Geomatics, Crime Mapping, Crime Science, Criminal Justice and Criminology.

The academic and policy interest in the development of cities, the renewal of residential and older industrial neighbourhoods in cities, and issues to do with race, polarisation and inequality in cities has remained at the forefront of policy and academic debate across Europe and North America. This book provides an important new contribution to these debates and highlights specific issues and developments which are crucial to an understanding of debates about residence, renewal and community empowerment. engages with the urban regeneration, development and housing aspects of real estate places debates on polarisation, inequality and race in a city-based structure provides up-to-date account of policy developments

In an age of unprecedented proliferation of data from disparate sources the urgency is to create efficient methodologies that can optimise data combinations and at the same time solve increasingly complex application problems. Integration of GIS and Remote Sensing explores the tremendous potential that lies along the interface between GIS and remote sensing for activating interoperable databases and instigating information interchange. It concentrates on the rigorous and meticulous aspects of analytical data matching and thematic compatibility – the true roots of all branches of GIS/remote sensing applications. However closer harmonization is tempered by numerous technical and institutional issues, including scale incompatibility, measurement disparities, and the inescapable notion that data from GIS and remote sensing essentially represent diametrically opposing conceptual views of reality. The first part of the book defines and characterises GIS and remote sensing and presents the reader with an awareness of the many scale, taxonomical and analytical problems when attempting integration. The second part of the book moves on to demonstrate the benefits and costs of integration across a number of human and environmental applications. This book is an invaluable reference for students and professionals dealing not only with GIS and remote sensing, but also computer science, civil engineering, environmental science and urban planning within the academic, governmental and commercial/business sectors.

Remote sensing and geographical information science (GIS) have advanced considerably in recent years. However, the potential of remote sensing and GIS within the environmental sciences is limited by uncertainty, especially in connection with the data sets and methods used. In many studies, the issue of uncertainty has been incompletely addressed. The situation has arisen in part from a lack of appreciation of uncertainty and the problems it can cause as well as of the techniques that may be used to accommodate it. This book provides general overviews on uncertainty in remote sensing and GIS that illustrate the range of uncertainties that may occur, in addition to describing the means of measuring uncertainty and the impacts of uncertainty on analyses and interpretations made. Uncertainty in Remote Sensing and GIS provides readers with comprehensive coverage of this largely undocumented subject: * Relevant to a broad variety of disciplines including geography, environmental science, electrical engineering and statistics * Covers range of material from base overviews to specific applications * Focuses on issues connected with uncertainty at various points along typical data analysis chains used in remote sensing and GIS Written by an international team of researchers drawn from a variety of disciplines, Uncertainty in Remote Sensing and GIS provides focussed discussions on topics of considerable importance to a broad research and user community. The book is invaluable reading for researchers, advanced students and practitioners who want to understand the nature of uncertainty in remote sensing and GIS, its limitations and methods of accommodating it.

GIS and Geocomputation for Water Resource Science and Engineering not only provides a comprehensive introduction to the fundamentals of geographic information systems but also demonstrates how GIS and mathematical models can be integrated to develop spatial decision support systems to support water resources planning, management and engineering. The book uses a hands-on active learning approach to introduce fundamental concepts and numerous case-studies are provided to reinforce learning and demonstrate practical aspects. The benefits and challenges of using GIS in environmental and water resources fields are clearly tackled in this book, demonstrating how these technologies can be used to harness increasingly available digital data to develop spatially-oriented sustainable solutions. In addition to providing a strong grounding on fundamentals, the book also demonstrates how GIS can be combined with traditional physics-based and statistical models as well as information-theoretic tools like neural networks and fuzzy set theory.

This book is concerned with the government of “illegal” immigration since the passage of the U.S. Immigration Act of 1965, exploring how certain mentalities and intellectual machineries have rendered illegal immigrants as targets of government. Examines how various authorities have created knowledge about and constructed “illegal” immigration as an ethical problem. Analyzes the tactics that have been deployed to govern immigration, particularly at the US-Mexico border. Using an ethnographic approach, draws on primary source materials – including government publications, archival documents, newspapers, and popular magazines. Studies measures (e.g. Operation Gatekeeper and Operation Hold-the-Line) for reforming the conduct of “illegal” immigrants in order to forestall illicit border crossings. Frames the study of immigration within Foucauldian theories of governmentality. Highlights the role of numbers and statistics in constructing the “illegal” immigrant.

A major challenge in constraint programming is to develop efficient generic approaches to solve instances of the constraint satisfaction problem (CSP). With this aim in mind, this book provides an accessible synthesis of the author's research and work in this area, divided into four main topics: representation, inference, search, and learning. The results obtained and reproduced in this book have a wide applicability, regardless of the nature of the problem or the constraints involved, making it an extremely user-friendly resource for those involved in this field.

Explains how GIS enhances the development of chemical fate and transport models Over the past decade, researchers have discovered that geographic information systems (GIS) are not only excellent tools for managing and displaying maps, but also useful in the analysis of chemical fate and transport in the environment. Among its many benefits, GIS facilitates the identification of critical factors that drive chemical fate and transport. Moreover, GIS makes it easier to communicate and explain key model assumptions. Based on the author's firsthand experience in environmental assessment, GIS Based Chemical Fate Modeling explores both GIS and chemical fate and transport modeling fundamentals, creating an interface between the two domains. It then explains how GIS analytical functions enable scientists to develop simple, yet comprehensive spatially explicit chemical fate and transport models that support real-world applications. In addition, the book features: Practical examples of GIS based model calculations that serve as templates for the development of new applications Exercises enabling readers to create their own GIS based models Accompanying website featuring downloadable datasets used in the book's examples and exercises References to the literature, websites, data repositories, and online reports to facilitate further research Coverage of important topics such as spatial decision support systems and multi-criteria analysis as well as ecological and human health risk assessment in a spatial context GIS Based Chemical Fate Modeling makes a unique contribution to the environmental sciences by explaining how GIS analytical functions enhance the development and interpretation of chemical fate and transport models. Environmental scientists should turn to this book to gain a deeper understanding of the role of GIS in describing what happens to chemicals when they are released into the environment.

Mapping: A Critical Introduction to Cartography and GIS is an introduction to the critical issues surrounding mapping and Geographic Information Systems (GIS) across a wide range of disciplines for the non-specialist reader. Examines the key influences Geographic Information Systems (GIS) and cartography have on the study of geography and other related disciplines Represents the first in-depth summary of the “new cartography” that has appeared since the early 1990s Provides an explanation of what this new critical cartography is, why it is important, and how it is relevant to a broad, interdisciplinary set of readers Presents theoretical discussion supplemented with real-world case studies Brings together both a technical understanding of GIS and mapping as well as sensitivity to the importance of theory