Handbook of Meningococcal Disease

The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.

The reference is a broad-ranging review of Alzheimer's disease and other dementias from both basic and clinical neuroscience perspectives; it provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances. Brings the reader up-to-date with cutting-edge developments in this exciting and fast-paced field Summarizes the most recent developments in the fields of Alzheimer's disease and dementia Brings together articles from a prominent and international group of contributors Encompasses a unique range of topics, combining basic molecular perspectives and cognitive neurosciences

This two-volume handbook is unique in spanning the entire field of evolution, from the origins of life up to the formation of social structures and science and technology. The author team of world-renowned experts considers the subject from a variety of disciplines, with continuous cross-referencing so as to retain a logical internal structure. The uniformly structured contributions discuss not merely the general knowledge behind the evolution of life, but also the corresponding development of language, society, economies, morality and politics. The result is an overview of the history and methods used in the study of evolution, including controversial theories and discussions. A must for researchers in the natural sciences, sociology and philosophy, as well as for those interested in an interdisciplinary view of the status of evolution today.

Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies. The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives. Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: «I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology.»

ATP-dependent active ion transport enables cells to regulate their pH value and to control their ion composition. The reverse process, transforming an ion imbalance into chemical energy, drives mitochondrial and chloroplast ATP synthesis. The mediators of these fundamental processes are ion-motive ATPases, highly conserved enzymes that play key roles in cell physiology from bacteria to man. As the first comprehensive overview of this important class of enzymes, this handbook summarizes recent knowledge about the molecular mechanism of ATPases, relating this information to the physiology and pathopyhsiology of ion transport, mitochondrial function, vesicle transport and lysosomal acidification. All important P-type, F-type and V-type ATPases are treated systematically, complemented by a special section on the cell biology and physiology of acidic compartments, and backed by an extensive bibliography and index. This premier reference source for physiologists, molecular biologists, biophysicists and clinical researchers contains contributions by the world's foremost ATPase research groups.

Handbook of Industrial Mixing will explain the difference and uses of a variety of mixers including gear mixers, top entry mixers, side entry mixers, bottom entry mixers, on-line mixers, and submerged mixers The Handbook discusses the trade-offs among various mixers, concentrating on which might be considered for a particular process. Handbook of Industrial Mixing explains industrial mixers in a clear concise manner, and also: * Contains a CD-ROM with video clips showing different type of mixers in action and a overview of their uses. * Gives practical insights by the top professional in the field. * Details applications in key industries. * Provides the professional with information he did receive in school

No other management tool provides the operational direction that a well-planned budget can. Now in a new edition, this book provides updated coverage on issues such as budgeting for exempt organizations and nonprofits in light of the IRS' newly issued Form 990; what manufacturing CFOs' budgeting needs are; current technology solutions; and updated information on value-based budgets. Controllers, budget directors, and CFOs will benefit from this practical «how-to» book's coverage, from the initial planning process to forecasting to specific industry budgets.

Written by a team of leading international researchers under the guidance of Frank Durso, the second edition of the Handbook of Applied Cognition brings together the latest research into this challenging and important field, and is presented across thirty stimulating and accessible chapters. Stewarded by experiences editors from around the globe, the handbook has been fully updated with eleven new chapters covering materials that focus on the topics critical to understanding human mental functions in complex environments. It is an essential single-source reference for researchers, cognitive engineers and applied cognitive psychologists, as well as advanced students in the flourishing field of applied cognition.

(Co)polymers prepared via free radical mechanism, together with polyolefins, comprise the largest portion of the commodity plastics industry and are also used for preparation of many specialty materials. Handbook of Radical Polymerization provides a concise source of information on mechanisms, synthetic techniques, and characterization methods and addresses future trends for polymers made by free radical intermediates. A one-stop, at-your-fingertips source of information for students, researchers, technologists, and industrial managers, the Handbook functions as a single reference of the conventional and controlled/living radical polymerization methods. Two expert editors collect and present historical background of the technique, basic information regarding various free radical polymerization systems, and state-of-the-art experimental techniques and industrial applications. Chapters written by internationally acclaimed experts in their respective fields include: Theory of Radical Reactions The Kinetics of Free Radical Polymerization Industrial Applications and Processes Nitroxide Mediated Living Radical Polymerization Atom Transfer Radical Polymerization Control of Free Radical Polymerization by Chain Transfer Methods Macromolecular Engineering by Controlled Radical Polymerization Guaranteed to have a long shelf life, the Handbook of Radical Polymerization promises to be an indispensable resource for chemists, chemical engineers, material scientists, and graduate students in the field, as well as a valuable addition to industrial, academic, and government libraries.

With the demands of quality management and process control in an industrial environment machine vision is becoming an important issue. This handbook of machine vision is written by experts from leading companies in this field. It goes through all aspects of image acquisition and image processing. From the viewpoint of the industrial application the authors also elucidate in topics like illumination or camera calibration. Attention is paid to all hardware aspects, starting from lenses and camera systems to camera-computer interfaces. Besides the detailed hardware descriptions the necessary software is discussed with equal profoundness. This includes sections on digital image basics as well as image analysis and image processing. Finally the user is introduced to general aspects of industrial applications of machine vision, such as case studies and strategies for the conception of complete machine vision systems. With this handbook the reader will be enabled not only to understand up to date systems for machine vision but will also be qualified for the planning and evaluation of such technology.