Hemostasis and Thrombosis. Practical Guidelines in Clinical Management

Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. Provides essential practical management for all those working in the field of hemostasis and thrombosis Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading Highlights controversial issues and provides advice for everyday questions encountered in the clinic

Provides a comprehensive yet concise and practical guide to the full range of clotting and bleeding disorders encountered in clinical practice. Presented in three sections, this book informs and advises clinicians in all stages of diagnosis, management and prevention of thrombotic and hemostatic disorders. Why Buy This Book? Essential practical management for all those working in the field of haemostasis and thrombosis A comprehensive yet concise and practical guide to the full range of clotting and bleeding disorders encountered in clinical practice. Advice to guide clinicians through the diagnosis, treatment and prevention of thrombotic and haemostatic disorders Each chapter to follow a standard template supplemented with a mini-contents list, key points, further reading and a summary box Highlights controversial issues and provides advice for everyday questions

Quality in Laboratory Hemostasis and Thrombosis Second Edition Edited by Steve Kitchen, Clinical Scientist, Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital and Scientific Director, UK National External Quality Assessment Scheme (FQAS) for Blood Coagulation, Scientific Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK John D Olson, Professor and Vice Chair for Clinical Affairs, Department of Pathology, University of Texas Health Sciences Centre, San Antonio, Texas, USA F. Eric Preston, Emeritus Professsor of Haematology, University of Sheffield and Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulations, Sheffield, UK The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Rapid changes in the number and complexity of tests in this discipline have presented challenges for laboratories, as they develop quality programs for the oversight of this testing. Quality in Laboratory Hemostasis and Thrombosis has been completely revised and updated to reflect the changing process of managing quality. The second edition provides information on all aspects of testing, from pre-analytic to analytic and result reporting, in addition to external quality assurance. Chapters throughout the book include the development of global guidelines for methods, as well as the preparation of international standard plasmas and reagents. Designed to capture the elements of quality at all levels of the practice of laboratory hemostasis and thrombosis, this book will guide the reader through the development of a quality program to support all activities in the hemostasis laboratory, both simple and complex. Titles of related interest Lee: Textbook of Hemophilia, 2e (2010) ISBN 9781405169141 Federici: Von Willebrand Disease: Basic and Clinical Aspects, 1e (2011) ISBN 9781405195126 Ma: Hemophilia and Hemostasis: A Case Based Approach to Management, 2e (2012) ISBN 9780470659762

Reproductive hemostasis: A global approach to a global challenge A hemostatic change in women through their reproductive lifetime is emerging as an issue of global importance. No wonder, as obstetric hemorrhage remains a major cause of maternal mortality in both developed and developing countries. Thrombophilias and pulmonary embolisms are a threat to maternal and fetal well-being. Hemostasis and Thrombosis in Obstetrics & Gynecology provides a framework for assessing and managing hemostatic disorders in women. Written by an international team, it provides globally applicable guidelines for obstetric hematology. The practical approach to clinical management includes: Hematologic changes in pregnancy Red cell disorders Platelet disorders Inherited and acquired thrombophilia Inherited bleeding disorders Postpartum hemorrhage Blood and bleeding disorders in women can be managed by obstetrician-gynecologists or hematologists, separately or together. Hemostasis and Thrombosis in Obstetrics & Gynecology provides specialists from both disciplines with the information necessary to manage their patients effectively.

Over the last decades, major progress has been made in quality assurance of hemostatic laboratory assays. This book will be an indispensable part of every hemostasis laboratory, where, given its hands-on nature, it will rarely sit to get dusty on the shelves. —Frits R. Rosendaal, Leiden University Medical Center The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Its role in the monitoring traditional anticoagulant therapy as well as therapy using new anticoagulants presents new challenges to the laboratory. Quality in Laboratory Hemostasis and Thrombosis not only addresses these important issues, but also covers international guidelines for testing, the development of international standard materials, management of hemostasis testing from the laboratory to the point of care as well as molecular genetic testing. Designed as a guide for all those working in hemostasis laboratories, this book details a quality program that, when put into place, will help to improve standards in testing. All of the authors are internationally recognised for their work in hemostasis and thrombosis. Using their experience, they provide information on standards, equipment and methods that will guide the development of a quality program to support all activities in the hemostasis laboratory.

The book begins by placing clinical guidelines within the context of the broader movement towards evidence based practice; it explores the concept of evidence, and defines clinical guidelines and care protocols. These are then examined in the clinical situation. The book goes on to discuss the relationship between them and the exercise of individual autonomy and expertise, and with individualised care and patient involvement and choice. The influence of cost on decision making is reviewed, and a chapter discusses the political aspects of care guidelines and protocols. Finally the book describes the implementation of guidelines and protocols and the barriers to implementation, and makes suggestions for the future.

Practical Weight Management in Dogs and Cats is a comprehensive, clinical reference for the veterinary health team, providing the necessary tools to successfully manage pet obesity. Bringing together specialists in nutrition, internal medicine, critical care, and surgery and rehabilitation, the book provides an overview of prevention techniques, clinical management, and practical tips for implementing successful programs and educating owners. Covering topics ranging from taking a nutritional history and body condition scoring to calculating food dosage and client communication tips, this book is a resource for both veterinarians and veterinary technicians to address the growing problem of pet obesity. The book begins by explaining the clinical importance of obesity, then moves on to diagnosing and preventing obesity. The heart of the book is devoted to managing body weight, with chapters on nutritional, pharmacotherapeutic, and exercise strategies, and two unique chapters cover owner compliance and wellness programs. Practical Weight Management in Dogs and Cats offers a collaborative approach to managing weight in pet dogs and cats.

Featuring updates and revisions, the second edition of Clinical Neuropsychology provides trainee and practicing clinicians with practical, real-world advice on neuropsychological assessment and rehabilitation. Offers illustrated coverage of neuroimaging techniques and updates on key neuro-pathological findings underpinning neurodegenerative disorders Features increased coverage of specialist areas of work, including severe brain injury, frontotemporal lobar degeneration, assessing mental capacity, and cognitive impairment and driving Features updated literature and increased coverage of topics that are of direct clinical relevance to trainee and practicing clinical psychologists Includes chapters written by professionals with many years' experience in the training of clinical psychologists

A valuable new edition of the trusted, practical guide to managing data in clinical trials Regardless of size, type, or complexity, accurate results for any clinical trial are ultimately determined by the quality of the collected data. Management of Data in Clinical Trials, Second Edition explores data management and trial organization as the keys to developing an accurate and reliable clinical trial. With a focus on the traditional aspects of data collection as well as recent advances in technology, this new edition provides a complete and accessible guide to the management structure of a clinical trial, from planning and development to design and analysis. Practical approaches that result in the collection of complete and timely data are also provided. While maintaining a comprehensive overview of the knowledge and tools that are essential for the organization of a modern clinical trial, the author has expanded the topical coverage in the Second Edition to reflect the possible uses of recent advances in technology in the data collection process. In addition, the Second Edition discusses the impact of international regulations governing the conduct of clinical trials and provides guidelines on ensuring compliance with national requirements. Newly featured topics include: The growing availability of «off-the-shelf» solutions for clinical trials Potential models for collaboration in the conduct of clinical trials between academia and the pharmaceutical industry The increasing use of the Internet in the collection of data and management of trials Regulatory requirements worldwide and compliance with the ICH Good Clinical Practice (GCP) Guidelines Development of Standard Operating Procedures for the conduct of clinical trials Complete with chapter summaries that reinforce key points as well as over one hundred examples, Management of Data in Clinical Trials, Second Edition is an ideal resource for practitioners in the clinical research community who are involved in the development of clinical trials, including data managers, research associates, data coordinators, physicians, and statisticians. This book also serves as an excellent supplemental text for courses in clinical trials at both the undergraduate and graduate levels.

This book will be an affordable, highly practical handbook on hepatology, aimed at residents/trainees in gastroenterology, GI nurses, and recently qualified consultants to use as a quick reference when managing patients presenting with possible or overt liver disease. It will be of particular use for those GI internists/residents who have an interest specifically in hepatology. It does not aim to be a specialist textbook, but a shorter, 250pp guide that provides key clinical information on each area of hepatology in an accessible form. Extracting relevant material from large reference textbooks can be very time consuming and for this reason, information in this handbook will be presented succinctly in a style suitable for quick reference and easy understanding. The chief emphasis will be on the clinical assessment and management of these patients, and all the major areas of liver disease will be covered, from liver cirrhosis to viral hepatitis, to autoimmune liver failure. Chapters will use a variety of structural features and colour coded boxes to increase the accessibility for residents. These include: key points/take-home points, case history, practice points and management algorithm/flow-charts. Each chapter will also contain sample multiple choice questions that the reader will be able to test themselves on.