High-Density Lipoproteins. Structure, Metabolism, Function and Therapeutics

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

This book contains extremely detailed and informative content on structure and function of ligands, receptors, and signalling intermediates plus interactions … the extent of detail and appropriate referencing is impressive. –Microbiology Today, July 2009 «A very well-written book suitable for use as a reference or textbook for an undergraduate subject in cell signalling. For researchers interested in the molecular basis of cell signalling and how aberrant regulation of cell signalling proteins causes diseases, this is an excellent resource of biochemical and structural information.» –Australian Biochemist, August 2009 «From basics to details, this is an elegantly written and carefully edited book. The chapters on cell cycle control and oncogenesis are particularly fascinating and valuable to biomedical research. This is the book to have if you are interested in molecular mechanisms of signal transduction. It is a great introduction to the literature that will be welcomed by students and experts alike.» –Doody's, January 2009 This text is a concise and accessible introduction to the dynamic but complex field of signal transduction. Rather than simply cataloguing all signalling molecules and delineating every known pathway, this book aims to break signalling down into common elements and activities – the ‘nuts and bolts’ of cellular information exchange. With an emphasis on clarity of presentation throughout, the book teaches the basic principles focusing on a mature core of knowledge, providing students with a foundation of learning in this complex and potentially confusing subject. It also addresses the issue of variation in the numbering of key amino acids as well as featuring interaction with RasMol software, and exercises to aid understanding. An accessible introduction to the complex field of cell signalling Interacts with RasMol software – freely downloadable for viewing structures in 3D Includes exercises and clear instructions in the use of RasMol Well illustrated in full colour throughout Structure and Function in Cell Signalling is an invaluable resource to students across a range of life science degree programmes including biochemistry, cell and molecular biology, physiology, biomedicine and oncology. This book provides a clear, accessible introduction to this rapidly expanding field.

Human Oral Mucosa: Development, Structure and Function is a new text that reflects the considerable increase in knowledge of oral mucosa that has occurred in recent years. Our understanding of the structure of oral mucosa is now established at a molecular rather than a tissue or cellular level. This in turn has revealed a level of function that was previously not suspected, including a sophisticated barrier to the penetration of exogenous materials, and the synthesis of specific antimicrobial compounds, representing components of the innate immune system. There is also a growing realization of commonality in structure and function between regions of oral mucosa and the mucosae of the esophagus and vagina. The aim of the present volume is to provide a more sophisticated text on human oral mucosa than presently exists in textbooks and to bring together information that is otherwise to be found in separate, specialist volumes into a comprehensive text. It relates structure at the molecular, cellular and tissue level to function and to clinical behavior. The volume is directed to advanced students and researchers in oral biology, as well as those in allied areas of investigation, such as dermatology, gynecology, internal medicine and pathology.

Presents an integrated view of the expression of bacterial genetic information, genome architecture and function, and bacterial physiology and pathogenesis This book blends information from the very latest research on bacterial chromosome and nucleoid architecture, whole-genome analysis, cell signaling, and gene expression control with well-known gene regulation paradigms from model organisms (including pathogens) to give readers a picture of how information flows from the environment to the gene, modulating its expression and influencing the competitive fitness of the microbe. Structure and Function of the Bacterial Genome explores the governance of the expression of the genes that make a bacterium what it is, and updates the basics of gene expression control with information about transcription promoter structure and function, the role of DNA as a regulatory factor (in addition to its role as a carrier of genetic information), small RNAs, RNAs that sense chemical signals, ribosomes and translation, posttranslational modification of proteins, and protein secretion. It looks at the forces driving the conservation and the evolution of the dynamic genome and offers chapters that cover DNA replication, DNA repair, plasmid biology, recombination, transposition, the roles of repetitive DNA sequences, horizontal gene transfer, the defense of the genome by CRISPR-Cas, restriction enzymes, Argonaute proteins and BREX systems. The book finishes with a chapter that gives an integrated overview of genome structure and function.  Blends knowledge of gene regulatory mechanisms with a consideration of nucleoid structure and dynamics Offers a 'DNA-centric' approach to considering transcription control Views horizontal gene transfer from a gene regulation perspective Assesses the opportunities and limitations of designing synthetic microbes or rewiring existing ones Structure and Function of the Bacterial Genome is an ideal book for graduate and undergraduate students studying microbial cell biology, bacterial pathogenesis, gene regulation, and molecular microbiology. It will also appeal to principal investigators conducting research on these and related topics and researchers in synthetic biology and other arms of biotechnology.

The Amazon Basin contains the largest and most diverse tropical rainforest in the world. Besides the Andes and the Atlantic Ocean, the rainforest is bounded to the north by the Guiana crystalline shield and to the south by the Brazilian crystalline shield, marked at their edges by cataracts in the rivers and often dominated by grasslands. This book is motivated not just by the Amazon's scientific interest but also by its role in many ecosystem functions critical to life on Earth. These ecosystems are characterized both by their complexity and their interactive, higher-order linkages among both abiotic and biotic components. Within Amazonia, the Western Amazon (west of 65° latitude) is the most pristine and, perhaps, the most complex within the Amazon Basin. This Western Amazon may be broadly divided into non-flooded forests (e.g. terra firme, white sand, palm) and forests flooded with white water (generally referred to as v?rzea) and with black water (generally referred to as igap?). Here, for the first time, is a book devoted entirely to Western Amazonia, containing chapters by scientists at the forefront of their own areas of expertise. It should be a valuable resource for all future researchers and scholars who venture into Western Amazonia, as it continues to be one of the most beautiful, mysterious, remote and important ecosystems on Earth.

Various plant metabolites are useful for human life, and the induction and reduction of these metabolites using modern biotechnical technique is of enormous potential important especially in the fields of agriculture and health. Plant Metabolism and Biotechnology describes the biosynthetic pathways of plant metabolites, their function in plants, and some applications for biotechnology. Topics covered include: biosynthesis and metabolism of starch and sugars lipid biosynthesis symbiotic nitrogen fixation sulfur metabolism nucleotide metabolism purine alkaloid metabolism nicotine biosynthesis terpenoid biosynthesis benzylisoquinoline alkaloid biosynthesis monoterpenoid indole alkaloid biosynthesis flavonoid biosynthesis pigment biosynthesis: anthocyanins, betacyanins and carotenoids metabolomics in biotechnology Plant Metabolism and Biotechnology is an essential guide to this important field for researchers and students of biochemistry, plant biology, metabolic engineering, biotechnology, food science, agriculture, and medicine.

Discover how to design, deliver, and implement high-density communications solutions High-Density Smart Campus Communications: Technologies, Integration, Implementation and Applications delivers a concise synthesis of the deployment technologies, strategies, and implementation issues that arise in the design and application of real-world high-density communications environments in airports, stadiums, convention centers, shopping malls, classrooms, hospitals, cruise ships, and more. You'll learn future-oriented strategies for the implementation of next-generation Wi-Fi and 5G communications networks in high density environments, like smart airposrts, advanced airport robotics, and wayfinding. You’ll also discover effective deployment strategies using a comprehensive case study based on a top-10 airport deployment by the Slice Wireless team. The book includes information about security requirements, large and boutique solution providers, applications, unbundled services, implementation planning and design, as well as operations and network management. An epilogue written by Josie Jo-Anne Dressendofer of Slice Wireless concludes the text. Readers will also benefit from the inclusion of: A thorough introduction to background and functional requirements for high density communications, including requirements for airports, stadiums, convention centers, classrooms, train and subway stations, and smart cities An exploration of traditional voice and cellular technology, including DAS designs and architectures and microcellularization Practical discussions of traditional data and Wi-Fi, including throughput/interference and security A treatment of evolved hotspot connectivity, including Wi-Fi and 5G Perfect for telecommunication researchers and engineers, networking professionals, technology professionals, campus administrators, and equipment vendors, High-Density Smart Campus Communications will also earn a place in the libraries of senior undergraduate and graduate students in applied communications technologies.

This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

How do our muscles produce energy for exercise and what are the underlying biochemical principles involved? These are questions that students need to be able to answer when studying for a number of sport related degrees. This can prove to be a difficult task for those with a relatively limited scientific background. Biochemistry for Sport and Exercise Metabolism addresses this problem by placing the primary emphasis on sport, and describing the relevant biochemistry within this context. The book opens with some basic information on the subject, including an overview of energy metabolism, some key aspects of skeletal muscle structure and function, and some simple biochemical concepts. It continues by looking at the three macromolecules which provide energy and structure to skeletal muscle – carbohydrates, lipids, and protein. The last section moves beyond biochemistry to examine key aspects of metabolism – the regulation of energy production and storage. Beginning with a chapter on basic principles of regulation of metabolism it continues by exploring how metabolism is influenced during high-intensity, prolonged, and intermittent exercise by intensity, duration, and nutrition. Key Features: A clearly written, well presented introduction to the biochemistry of muscle metabolism. Focuses on sport to describe the relevant biochemistry within this context. In full colour throughout, it includes numerous illustrations, together with learning objectives and key points to reinforce learning. Biochemistry for Sport and Exercise Metabolism will prove invaluable to students across a range of sport-related courses, who need to get to grips with how exercise mode, intensity, duration, training status and nutritional status can all affect the regulation of energy producing pathways and, more important, apply this understanding to develop training and nutrition programmes to maximise athletic performance.