Interpretation of MS-MS Mass Spectra of Drugs and Pesticides

Although there are a number of books in this field, most of them lack an introduction of comprehensive analysis of MS and IR spectra, and others do not provide up-to-date information like tandem MS. This book fills the gap. The merit of this book is that the author will not only introduce knowledge for analyzing nuclear magnetic resonance spectra including 1H spectra (Chapter 1), 13C spectra (Chapter 2) and 2D NMR spectra (Chapter 3), he also arms readers systemically with knowledge of Mass spectra (including EI MS spectra and MS spectra by using soft ionizations) (Chapter 4) and IR spectra (Chapter 5). In each chapter the author presents very practical application skills by providing various challenging examples. The last chapter (Chapter 6) provides the strategy, skills and methods on how to identify an unknown compound through a combination of spectra. Based on nearly 40 years researching and teaching experience, the author also proposes some original and creative ideas, which are very practical for spectral interpretation.

Introduces the reader to the field of ion chromatography, species analysis and hyphenated methods IC-MS and IC-ICP-MS including the theory and theirs applications Covers the importance of species analysis and hyphenated methods in ion chromatography Includes practical applications of IC-MS and IC-ICP-MS in environmental analysis Details sample preparation methods for ion chromatography Discusses hyphenated methods IC-MS and IC-ICP-MS used in determining both the total element contents and its elements Details speciation analysis used in studying biochemical cycles of selected chemical compounds; determining toxicity and ecotoxicity of elements; food and pharmaceuticals quality control; and in technological process control and clinical analytics

Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.

This handbook provides a comprehensive examination of the past and present roles of drugs in society with a focus on theory, research, policy, and practice. Includes 28 original chapters with multi-disciplinary and international perspectives by top social and behavioral scientists Reviews current knowledge in the field, including key research findings, theoretical developments, and methodological debates Identifies ongoing controversies in the field, emergent topics, and areas in need of further inquiry Discusses individual drugs as well as topics like physiological theories of drug use and abuse, public health implications of drugs, patterns of drugs and crime, international drug trade and trafficking, and designer drugs

The only comprehensive reference on this popular and rapidly developing technique provides a detailed overview, ranging from fundamentals to applications, including a section on the evaluation of GC-MS analyses. As such, it covers all aspects, including the theory and principles, as well as a broad range of real-life examples taken from laboratories in environmental, food, pharmaceutical and clinical analysis. It also features a glossary of approximately 300 terms and a substance index that facilitates finding a specific application. For this new edition the work has been now extended to two volumes, reflecting the latest developments in the technique and related instrumentation, while also incorporating several new examples of applications in many fields. The first two editions were very well received, making this handbook a must-have in all analytical laboratories using GC-MS.

In 1969 the first edition of this book introduced the concepts of statistics and their medical application to readers with no formal training in this area. While retaining this basic aim, the authors have expanded the coverage in each subsequent edition to keep pace with the increasing use and sophistication of statistics in medical research. This fifth edition has undergone major restructuring, with some sections completely rewritten; it is now more logically organized and more user friendly (with the addition of 'summary boxes' throughout the text). It incorporates new statistical techniques and approaches that have made an appearance since the last edition. In addition, some chapters or chapter headings are specifically marked to signify material that is more difficult than the material in which it is embedded – such sections or chapters can be omitted at first reading. Several new chapters have been added . «Associations: Chance, Confounded and Causal?» explains without any formulae the concepts underlying confounding, confidence intervals and p values, and the interpretation of associations observed in research investigations. Another new chapter considers sample size calculations in some detail and provides, in addition to the relevant formulae, useful tables that should give the researcher an indication of the order of magnitude of the number of subjects he or she might require in different situations.

Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of the molecular basis of drug abuse and addiction. Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse. Subsequent sections look at specific families of drugs, including stimulants, depressants, and hallucinogens among others, and explore how their chemical make-up interacts with brain function. The final chapter provides a brief overview of clinical substance abuse treatment. Providing a concise, accessible introductory overview of the topic, Drugs of Abuse: Pharmacology and Molecular Mechanisms will be a valuable resource for students, researchers, and others interested in how drugs interact with the brain. Introduces readers to the basic principles of neuroscience and pharmacology as related to drug use and abuse. Explores how the chemical make-up of drugs interact with the brain and can lead to addiction Includes coverage of a wide array of commonly abused families of drugs, including stimulants, depressants, hallucinogens, and others. Provides an essential introduction to the chemical and molecular underpinnings of drug use and abuse

This book is concerned with modelling the fate of organic substances in the soil. Once a chemical enters the soil it is subject to various transformation processes. It partitions between the liquid, solid and gaseous phase, it is sorbed to different binding sites with a different strength of bonding, it may decay by a simple chemical process or it may be transformed by microorganisms. Solute transport through soil and subsurface is mediated by water flow and is strongly influenced by solute sorption. To complicate matters, soil structures are heterogeneous. All these processes are embedded in a spatio-temporal hierarchy. The book brings together many different aspects of environmental fate modelling of pesticides comprising such diverse subjects as, e.g., compartment theory, nonlinear biological degradation models, modelling toxicity, parameter identification, coupling of physical and biological processes, pedotransfer functions, translation of models across scales, coupling geographical information systems with models, and FUZZY-approaches.

This book describes the paleomagnetism of sediments and sedimentary rocks, how sediments and sedimentary rocks become magnetized, and how the physical and chemical processes involved can affect the accuracy of paleomagnetism. Topics covered include depositional and post-depositional remanence acquisition, the detection and correction of compaction-caused inclination shallowing, reduction diagenesis of magnetic minerals, chemical remagnetization, and rotation of remanence by grain-scale rock strain. The book also has a chapter on environmental paleomagnetism, including examples of the new technique of high-resolution rock magnetic cyclostratigraphy and its application to sedimentary sequences. By emphasising the accuracy of sedimentary paleomagnetism and the magnitude of post-depositional processes that can affect it, the book will be invaluable in the geologic interpretation of sedimentary paleomagnetic data. Paleomagnetism of Sedimentary Rocks will be welcomed by paleomagnetists, students of paleomagnetism and all Earth scientists who use sedimentary paleomagnetic data in their research. Additional resources for this book can be found at: www.wiley.com/go/kodama/paleomagnetism.

The one-stop resource for IFRS interpretation and application, updated for 2018 Wiley IFRS 2018 offers a complete resource for the interpretation and application of the latest International Financial Reporting Standards (IFRS) as outlined by the International Accounting Standards Board (IASB). With up-to-date coverage and a host of practical tools, this book provides invaluable guidance on the expanding framework for unified financial reporting. Organised for easy navigation, each chapter includes general statement information followed by topic-specific discussion to facilitate both quick-reference and in-depth study. The expert team at PKF International provides authoritative insight from a practitioner's perspective: IFRIC interpretations and practical real-world guidance ensure full understanding of the newest standards, and the Disclosure Checklist helps verify compliance. The IASB's efforts are paying off as more and more countries around the globe either adopt IFRS as their national standards, or adjust local standards in alignment. A working understanding of IFRS application is becoming essential, even as the rules continue to evolve. This book provides full coverage of the latest standards and thorough guidance for implementation. Review the latest IFRS rules and standards Apply guidelines and best practices appropriately Gain expert insight on IFRS interpretation and implementation Ensure compliance and verify completeness Uniform financial reporting reduces the costs of financial statement preparation for multinational companies, and streamlines the assessment of business results. As the standards themselves evolve, so must practitioners' understanding of how to apply them correctly in real-world cases. Wiley IFRS 2018 offers a complete, up-to-date reference to help you apply and comply with the latest international standards.