Introduction to Statistical Analysis of Laboratory Data

The statistical analysis of cost-effectiveness data is becoming increasingly important within health and medical research. Statistical Analysis of Cost-Effectiveness Data provides a practical book that synthesises the huge amount of research that has taken place in the area over the last two decades. Comprising an up-to-date overview of the statistical analysis of cost-effectiveness data, the book is supported by numerous worked examples from the author’s own experience. It has been written in a style suitable for medical statisticians and health care professionals alike. Key features include: an overview of statistical methods used in the analysis of cost-effectiveness data. coverage of Bayesian methodology. illustrated throughout by worked examples using real data. suitability for health care professionals with limited statistical knowledge. discussion of software used for data analysis. An essential reference for biostatisticians and health economists engaged in cost-effectiveness analysis of health-care interventions, both in academia and industry. Also of interest to graduate students of biostatistics, public health and economics.

Provides well-organized coverage of statistical analysis and applications in biology, kinesiology, and physical anthropology with comprehensive insights into the techniques and interpretations of R, SPSS®, Excel®, and Numbers® output An Introduction to Statistical Analysis in Research: With Applications in the Biological and Life Sciences develops a conceptual foundation in statistical analysis while providing readers with opportunities to practice these skills via research-based data sets in biology, kinesiology, and physical anthropology. Readers are provided with a detailed introduction and orientation to statistical analysis as well as practical examples to ensure a thorough understanding of the concepts and methodology. In addition, the book addresses not just the statistical concepts researchers should be familiar with, but also demonstrates their relevance to real-world research questions and how to perform them using easily available software packages including R, SPSS®, Excel®, and Numbers®. Specific emphasis is on the practical application of statistics in the biological and life sciences, while enhancing reader skills in identifying the research questions and testable hypotheses, determining the appropriate experimental methodology and statistical analyses, processing data, and reporting the research outcomes. In addition, this book: • Aims to develop readers’ skills including how to report research outcomes, determine the appropriate experimental methodology and statistical analysis, and identify the needed research questions and testable hypotheses • Includes pedagogical elements throughout that enhance the overall learning experience including case studies and tutorials, all in an effort to gain full comprehension of designing an experiment, considering biases and uncontrolled variables, analyzing data, and applying the appropriate statistical application with valid justification • Fills the gap between theoretically driven, mathematically heavy texts and introductory, step-by-step type books while preparing readers with the programming skills needed to carry out basic statistical tests, build support figures, and interpret the results • Provides a companion website that features related R, SPSS, Excel, and Numbers data sets, sample PowerPoint® lecture slides, end of the chapter review questions, software video tutorials that highlight basic statistical concepts, and a student workbook and instructor manual An Introduction to Statistical Analysis in Research: With Applications in the Biological and Life Sciences is an ideal textbook for upper-undergraduate and graduate-level courses in research methods, biostatistics, statistics, biology, kinesiology, sports science and medicine, health and physical education, medicine, and nutrition. The book is also appropriate as a reference for researchers and professionals in the fields of anthropology, sports research, sports science, and physical education. KATHLEEN F. WEAVER, PhD, is Associate Dean of Learning, Innovation, and Teaching and Professor in the Department of Biology at the University of La Verne. The author of numerous journal articles, she received her PhD in Ecology and Evolutionary Biology from the University of Colorado. VANESSA C. MORALES, BS, is Assistant Director of the Academic Success Center at the University of La Verne. SARAH L. DUNN, PhD, is Associate Professor in the Department of Kinesiology at the University of La Verne and is Director of Research and Sponsored Programs. She has authored numerous journal articles and received her PhD in Health and Exercise Science from the University of New South Wales. KANYA GODDE, PhD, is Assistant Professor in the Department of Anthropology and is Director/Chair of Institutional Review Board at the University of La Verne. The author of numerous j

A complete set of statistical tools for beginning financial analysts from a leading authority Written by one of the leading experts on the topic, An Introduction to Analysis of Financial Data with R explores basic concepts of visualization of financial data. Through a fundamental balance between theory and applications, the book supplies readers with an accessible approach to financial econometric models and their applications to real-world empirical research. The author supplies a hands-on introduction to the analysis of financial data using the freely available R software package and case studies to illustrate actual implementations of the discussed methods. The book begins with the basics of financial data, discussing their summary statistics and related visualization methods. Subsequent chapters explore basic time series analysis and simple econometric models for business, finance, and economics as well as related topics including: Linear time series analysis, with coverage of exponential smoothing for forecasting and methods for model comparison Different approaches to calculating asset volatility and various volatility models High-frequency financial data and simple models for price changes, trading intensity, and realized volatility Quantitative methods for risk management, including value at risk and conditional value at risk Econometric and statistical methods for risk assessment based on extreme value theory and quantile regression Throughout the book, the visual nature of the topic is showcased through graphical representations in R, and two detailed case studies demonstrate the relevance of statistics in finance. A related website features additional data sets and R scripts so readers can create their own simulations and test their comprehension of the presented techniques. An Introduction to Analysis of Financial Data with R is an excellent book for introductory courses on time series and business statistics at the upper-undergraduate and graduate level. The book is also an excellent resource for researchers and practitioners in the fields of business, finance, and economics who would like to enhance their understanding of financial data and today's financial markets.

Few books on statistical data analysis in the natural sciences are written at a level that a non-statistician will easily understand. This is a book written in colloquial language, avoiding mathematical formulae as much as possible, trying to explain statistical methods using examples and graphics instead. To use the book efficiently, readers should have some computer experience. The book starts with the simplest of statistical concepts and carries readers forward to a deeper and more extensive understanding of the use of statistics in environmental sciences. The book concerns the application of statistical and other computer methods to the management, analysis and display of spatial data. These data are characterised by including locations (geographic coordinates), which leads to the necessity of using maps to display the data and the results of the statistical methods. Although the book uses examples from applied geochemistry, and a large geochemical survey in particular, the principles and ideas equally well apply to other natural sciences, e.g., environmental sciences, pedology, hydrology, geography, forestry, ecology, and health sciences/epidemiology. The book is unique because it supplies direct access to software solutions (based on R, the Open Source version of the S-language for statistics) for applied environmental statistics. For all graphics and tables presented in the book, the R-scripts are provided in the form of executable R-scripts. In addition, a graphical user interface for R, called DAS+R, was developed for convenient, fast and interactive data analysis. Statistical Data Analysis Explained: Applied Environmental Statistics with R provides, on an accompanying website, the software to undertake all the procedures discussed, and the data employed for their description in the book.

A thorough treatment of the statistical methods used to analyze doubly truncated data In The Statistical Analysis of Doubly Truncated Data, an expert team of statisticians delivers an up-to-date review of existing methods used to deal with randomly truncated data, with a focus on the challenging problem of random double truncation. The authors comprehensively introduce doubly truncated data before moving on to discussions of the latest developments in the field. The book offers readers examples with R code along with real data from astronomy, engineering, and the biomedical sciences to illustrate and highlight the methods described within. Linear regression models for doubly truncated responses are provided and the influence of the bandwidth in the performance of kernel-type estimators, as well as guidelines for the selection of the smoothing parameter, are explored. Fully nonparametric and semiparametric estimators are explored and illustrated with real data. R code for reproducing the data examples is also provided. The book also offers: A thorough introduction to the existing methods that deal with randomly truncated data Comprehensive explorations of linear regression models for doubly truncated responses Practical discussions of the influence of bandwidth in the performance of kernel-type estimators and guidelines for the selection of the smoothing parameter In-depth examinations of nonparametric and semiparametric estimators Perfect for statistical professionals with some background in mathematical statistics, biostatisticians, and mathematicians with an interest in survival analysis and epidemiology, The Statistical Analysis of Doubly Truncated Data is also an invaluable addition to the libraries of biomedical scientists and practitioners, as well as postgraduate students studying survival analysis.

Praise for the First Edition of Statistical Analysis with Missing Data «An important contribution to the applied statistics literature.... I give the book high marks for unifying and making accessible much of the past and current work in this important area.» —William E. Strawderman, Rutgers University «This book…provide[s] interesting real-life examples, stimulating end-of-chapter exercises, and up-to-date references. It should be on every applied statistician’s bookshelf.» —The Statistician «The book should be studied in the statistical methods department in every statistical agency.» —Journal of Official Statistics Statistical analysis of data sets with missing values is a pervasive problem for which standard methods are of limited value. The first edition of Statistical Analysis with Missing Data has been a standard reference on missing-data methods. Now, reflecting extensive developments in Bayesian methods for simulating posterior distributions, this Second Edition by two acknowledged experts on the subject offers a thoroughly up-to-date, reorganized survey of current methodology for handling missing-data problems. Blending theory and application, authors Roderick Little and Donald Rubin review historical approaches to the subject and describe rigorous yet simple methods for multivariate analysis with missing values. They then provide a coherent theory for analysis of problems based on likelihoods derived from statistical models for the data and the missing-data mechanism and apply the theory to a wide range of important missing-data problems. The new edition now enlarges its coverage to include: Expanded coverage of Bayesian methodology, both theoretical and computational, and of multiple imputation Analysis of data with missing values where inferences are based on likelihoods derived from formal statistical models for the data-generating and missing-data mechanisms Applications of the approach in a variety of contexts including regression, factor analysis, contingency table analysis, time series, and sample survey inference Extensive references, examples, and exercises Amstat News asked three review editors to rate their top five favorite books in the September 2003 issue. Statistical Analysis With Missing Data was among those chosen.

Praise for the Third Edition “. . . an easy-to read introduction to survival analysis which covers the major concepts and techniques of the subject.” —Statistics in Medical Research Updated and expanded to reflect the latest developments, Statistical Methods for Survival Data Analysis, Fourth Edition continues to deliver a comprehensive introduction to the most commonly-used methods for analyzing survival data. Authored by a uniquely well-qualified author team, the Fourth Edition is a critically acclaimed guide to statistical methods with applications in clinical trials, epidemiology, areas of business, and the social sciences. The book features many real-world examples to illustrate applications within these various fields, although special consideration is given to the study of survival data in biomedical sciences. Emphasizing the latest research and providing the most up-to-date information regarding software applications in the field, Statistical Methods for Survival Data Analysis, Fourth Edition also includes: Marginal and random effect models for analyzing correlated censored or uncensored data Multiple types of two-sample and K-sample comparison analysis Updated treatment of parametric methods for regression model fitting with a new focus on accelerated failure time models Expanded coverage of the Cox proportional hazards model Exercises at the end of each chapter to deepen knowledge of the presented material Statistical Methods for Survival Data Analysis is an ideal text for upper-undergraduate and graduate-level courses on survival data analysis. The book is also an excellent resource for biomedical investigators, statisticians, and epidemiologists, as well as researchers in every field in which the analysis of survival data plays a role.

Theoretical Foundations of Functional Data Analysis, with an Introduction to Linear Operators provides a uniquely broad compendium of the key mathematical concepts and results that are relevant for the theoretical development of functional data analysis (FDA). The self–contained treatment of selected topics of functional analysis and operator theory includes reproducing kernel Hilbert spaces, singular value decomposition of compact operators on Hilbert spaces and perturbation theory for both self–adjoint and non self–adjoint operators. The probabilistic foundation for FDA is described from the perspective of random elements in Hilbert spaces as well as from the viewpoint of continuous time stochastic processes. Nonparametric estimation approaches including kernel and regularized smoothing are also introduced. These tools are then used to investigate the properties of estimators for the mean element, covariance operators, principal components, regression function and canonical correlations. A general treatment of canonical correlations in Hilbert spaces naturally leads to FDA formulations of factor analysis, regression, MANOVA and discriminant analysis. This book will provide a valuable reference for statisticians and other researchers interested in developing or understanding the mathematical aspects of FDA. It is also suitable for a graduate level special topics course.

This book provides a clear and thorough introduction to meta-analysis, the process of synthesizing data from a series of separate studies. Meta-analysis has become a critically important tool in fields as diverse as medicine, pharmacology, epidemiology, education, psychology, business, and ecology. Introduction to Meta-Analysis: Outlines the role of meta-analysis in the research process Shows how to compute effects sizes and treatment effects Explains the fixed-effect and random-effects models for synthesizing data Demonstrates how to assess and interpret variation in effect size across studies Clarifies concepts using text and figures, followed by formulas and examples Explains how to avoid common mistakes in meta-analysis Discusses controversies in meta-analysis Features a web site with additional material and exercises A superb combination of lucid prose and informative graphics, written by four of the world’s leading experts on all aspects of meta-analysis. Borenstein, Hedges, Higgins, and Rothstein provide a refreshing departure from cookbook approaches with their clear explanations of the what and why of meta-analysis. The book is ideal as a course textbook or for self-study. My students, who used pre-publication versions of some of the chapters, raved about the clarity of the explanations and examples. David Rindskopf, Distinguished Professor of Educational Psychology, City University of New York, Graduate School and University Center, & Editor of the Journal of Educational and Behavioral Statistics. The approach taken by Introduction to Meta-analysis is intended to be primarily conceptual, and it is amazingly successful at achieving that goal. The reader can comfortably skip the formulas and still understand their application and underlying motivation. For the more statistically sophisticated reader, the relevant formulas and worked examples provide a superb practical guide to performing a meta-analysis. The book provides an eclectic mix of examples from education, social science, biomedical studies, and even ecology. For anyone considering leading a course in meta-analysis, or pursuing self-directed study, Introduction to Meta-analysis would be a clear first choice. Jesse A. Berlin, ScD Introduction to Meta-Analysis is an excellent resource for novices and experts alike. The book provides a clear and comprehensive presentation of all basic and most advanced approaches to meta-analysis. This book will be referenced for decades. Michael A. McDaniel, Professor of Human Resources and Organizational Behavior, Virginia Commonwealth University