Micro and Nano Scale NMR

An introduction to micro and nano replication processes and applications Micro/Nano Replication: Processes and Applications provides an overview of the fundamentals, processes, and applications involved in micro and nano replication in the manufacturing of product parts. A major field of nanotechnology, the study of micro/nano replication is sure to become one of increasing importance as the construction of completely new devices based on innovative concepts and crafted at the molecular level increases. Designed to help the reader understand and learn to work with the growing number of tools for molding plastic components, the book covers the key topics related to replication, including patterning technology, the modification of mold surface properties, and much more. In addition, it addresses the strengths and weaknesses of different molding processes. With a strong focus not only on how micro/nano replication works, but also the broader implications for the industry, the book is packed with examples of real world applications. These are drawn from a variety of fields, including information storage devices, optoelectronic elements, optical communication, and biosensors, in order to provide a complete view of the importance of micro and nano processes. A valuable introduction to a new but fast-growing field, Micro/Nano Replication is an essential resource for anyone looking to get a head start on understanding this emerging discipline.

Providing a detailed overview of the fundamentals and latest developments in the field of energy autonomous microsystems, this book delivers an in-depth study of the applications in the fields of health and usage monitoring in aeronautics, medical implants, and home automation, drawing out the main specifications on such systems. Introductory information on photovoltaic, thermal and mechanical energy harvesting, and conversion, is given, along with the latest results in these fields. This book also provides a state of the art of ultra-low power sensor interfaces, digital signal processing and wireless communications. In addition, energy optimizations at the sensor node and sensors network levels are discussed, thus completing this overview. This book details the challenges and latest techniques available to readers who are interested in this field. A major strength of this book is that the first three chapters are application orientated and thus, by setting the landscape, introduce the technical chapters. There is also a good balance between the technical application, covering all the system-related aspects and, within each chapter, details on the physics, materials and technologies associated with electronics. Contents Introduction. Introduction to Energy Autonomous Micro
and Nano Systems and Presentation of Contributions, Marc Belleville and Cyril Condemine. 1. Sensors at the Core of Building Control, Gilles Chabanis, Laurent Chiesi, Hynek Raisigel,
Isabelle Ressejac and V?ronique Boutin. 2. Toward Energy Autonomous MedicalImplants, Raymond Campagnolo and Daniel Kroiss. 3. Energy Autonomous Systems in Aeronautic Applications, Thomas Becker, Jirka Klaue and Martin Kluge. 4. Energy Harvesting by Photovoltaic Effect, Emmanuelle Rouvi?re, Simon Perraud, Cyril Condemine and
Guy Waltisperger. 5. Mechanical Energy Harvesting, Ghislain Despesse, Jean Jacques Chaillout,
S?bastien Boisseau and Claire Jean-Mistral. 6. Thermal Energy Harvesting, Tristan Caroff, Emmanuelle Rouvi?re and J?r?me Willemin. 7. Lithium Micro-Batteries, Rapha?l Salot. 8. Ultra-Low-Power Sensors, Pascal Nouet, Norbert Dumas, Laurent Latorre and
Fr?d?rick Mailly. 9. Ultra-Low-Power Signal Processing in Autonomous Systems, Christian Piguet. 10. Ultra-Low-Power Radio Frequency Communications and Protocols, Eric Mercier. 11. Energy Management in an Autonomous Microsystem, Jean-Fr?d?ric Christmann, Edith Beigne, Cyril Condemine, J?r?me Willemin and Christian Piguet. 12. Optimizing Energy Efficiency of Sensor Networks, Olivier Sentieys and Olivier Berder.

This book examines the current state of the art, new challenges, opportunities, and applications of IPNs. With contributions from experts across the globe, this survey is an outstanding resource reference for anyone involved in the field of polymer materials design for advanced technologies. • Comprehensively summarizes many of the recent technical research accomplishments in the area of micro and nanostructured Interpenetrating Polymer Networks • Discusses various aspects of synthesis, characterization, structure, morphology, modelling, properties, and applications of IPNs • Describes how nano-structured IPNs correlate their multiscale structure to their properties and morphologies • Serves as a one-stop reference resource for important research accomplishments in the area of IPNs and nano-structured polymer systems • Includes chapters from leading researchers in the IPN field from industry, academy, government and private research institutions

Today’s scientific and engineering community has a good grasp on how to model fluid flows at macro and molecular scales, with well-developed theory and supporting technologies. Between these two extremes lies the nano/meso scale (i.e. in the range of 50nm-500nm) where fluid flow models continue to be problematic. Continuum models used at macro scales assume a negligible influence from molecular interactions, while molecular models do not predict flow well at nano/meso dimensions. The solution, and the subject of this book, is to use elements from both to capture correctly the proper physics (from the molecular scale) and provide a description in terms of useful fluid properties (as characterized on the continuum scale). Fluid Properties at Nano/Meso Scale is based on the authors’ past five years’ research that has yielded new innovations in fluid simulation strategies at the nano/meso scale. The authors approach this subject in a straightforward and easy to understand format, providing a first step into the subject for researchers at all levels. They present new tools that allow the numerical computation of fluid properties from first principles, enabling the reader to begin to model successfully fluids at nano/meso scale. It is hoped that these first steps will engender the further development and advancement of simulation techniques at this scale, and keep engineering simulation at the cutting edge of technology. Presents internationally leading developments in the field of fluid properties at nano/meso scale Provides the reader with the first steps to fluid modelling at nano/meso-scales as well as state-of-the-art applications Includes innovative and new simulation techniques along with a detailed examination of existing numerical methods

Presents basic concepts, experimental methodology and data acquisition, and processing standards of in vivo NMR spectroscopy This book covers, in detail, the technical and biophysical aspects of in vivo NMR techniques and includes novel developments in the field such as hyperpolarized NMR, dynamic 13C NMR, automated shimming, and parallel acquisitions. Most of the techniques are described from an educational point of view, yet it still retains the practical aspects appreciated by experimental NMR spectroscopists. In addition, each chapter concludes with a number of exercises designed to review, and often extend, the presented NMR principles and techniques. The third edition of In Vivo NMR Spectroscopy: Principles and Techniques has been updated to include experimental detail on the developing area of hyperpolarization; a description of the semi-LASER sequence, which is now a method of choice; updated chemical shift data, including the addition of 31P data; a troubleshooting section on common problems related to shimming, water suppression, and quantification; recent developments in data acquisition and processing standards; and MatLab scripts on the accompanying website for helping readers calculate radiofrequency pulses. Provide an educational explanation and overview of in vivo NMR, while maintaining the practical aspects appreciated by experimental NMR spectroscopists Features more experimental methodology than the previous edition End-of-chapter exercises that help drive home the principles and techniques and offer a more in-depth exploration of quantitative MR equations Designed to be used in conjunction with a teaching course on the subject In Vivo NMR Spectroscopy: Principles and Techniques, 3rd Edition is aimed at all those involved in fundamental and/or diagnostic in vivo NMR, ranging from people working in dedicated in vivo NMR institutes, to radiologists in hospitals, researchers in high-resolution NMR and MRI, and in areas such as neurology, physiology, chemistry, and medical biology.

Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (> 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis. This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition of polymer excipients, the characterization of isomeric drug mixtures, the complexity of drugs with small-size components or ions, and the behavior of drugs in acid and basic solution. In addition, NMR spectroscopy and especially the hyphenated technique with HPLC is shown to be a powerful tool to measure a drug and its metabolites in various body fluids. The solid state NMR technique can give information on the structure, especially the conformation of drugs and excipients in drug formulations. Recently, SAR by NMR, introduced by Fesik, impressively demonstrated the potential of NMR spectroscopy in drug development and in the characterization of the interaction between large molecules and ligands. The complexation between proteins, lipids and cyclodextrins with drugs is described. Finally, NMR imaging (MRI and MRS) can be used to characterize the liberation of drugs from a drug formulation. Furthermore, the distribution of substances in plants, in animals, in tissues and in humans can be visualized by imaging. In short, this book covers all aspects of drug analysis.

Nuclear Magnetic Resonance (NMR) spectroscopy, a physical phenomenon based upon the magnetic properties of certain atomic nuclei, has found a wide range of applications in life sciences over recent decades. The dramatic advances in NMR techniques have led to corresponding advances in the ability of NMR to study structure, dynamics and interactions of biological macromolecules in solution under close to physiological conditions. This volume focuses on the use of NMR to study proteins. NMR can be used to determine detailed three-dimensional structures of proteins in solution. Furthermore, it provides information about conformational or chemical exchange, internal mobility and dynamics at timescales varying from pcoseconds to seconds. It is the primary technique used to obtain information on intrinsically disordered (unfolded) proteins, since these proteins will not crystallize easily. NMR is also a very powerful method for the study of interactions of protein with other molecules, whether small molecules (including drugs), nuclear acids or other proteins. This up-to-date volume covers NMR techiniques and their application to proteins, with a focus on practical details. This book will provide a newcomer to NMR with the practical guidance in order to carry out successful experiments with proteins and to analyze the resulting spectra. Those who are familiar with the chemical applications of NMR will also find is useful in understanding the special requirements of protien NMR.

This book is the first contemporary book to compare and integrate the various ways geographers think about and use scale across the spectrum of the discipline and includes state-of-the-art contributions by authoritative human geographers, physical geographers and GIS specialists. Provides a state of the art survey of how geographers think about scale. Brings together recent interest in scale in human and physical geography, as well as geographic information science Places competing concepts of scale side by side in order to compare them. The introduction and conclusion, by the editors, explores the common ground.

Two exciting worlds of science and technology – the nano and micro dimensions. The former is a booming new field of research, the latter the established size range for electronics, and for mutual technological benefit and future commercialization, suitable junctions need to be found. Functional nanostructures such as DNA computers, sensors, neural interfaces, nanooptics or molecular electronics need to be wired to their 'bigger' surroundings. Coming from the opposite direction, microelectronics have experienced an unprecedented miniaturization drive in the last decade, pushing ever further down through the micro size scale towards submicron circuitry. Bringing these two worlds together is a new interdisciplinary challenge for scientists and engineers alike – recognized and substantially funded by the European Commission and other major project initiators worldwide. This book offers a wide range of information from technologies to materials and devices as well as from research to administrative know-how collected by the editors from renowned key members of the nano/micro community.

From complex structure elucidation to biomolecular interactions – this applicationoriented textbook covers both theory and practice of modern NMR applications. Part one sets the stage with a general description of NMR introducing important parameters such as the chemical shift and scalar or dipolar couplings. Part two describes the theory behind NMR, providing a profound understanding of the involved spin physics, deliberately kept shorter than in other NMR textbooks, and without a rigorous mathematical treatment of all the physico-chemical computations. Part three discusses technical and practical aspects of how to use NMR. Important phenomena such as relaxation, exchange, or the nuclear Overhauser effects and the methods of modern NMR spectroscopy including multidimensional experiments, solid state NMR, and the measurement of molecular interactions are the subject of part four. The final part explains the use of NMR for the structure determination of selected classes of complex biomolecules, from steroids to peptides or proteins, nucleic acids, and carbohydrates. For chemists as well as users of NMR technology in the biological sciences.