More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, 2 Volume Set

Here, all aspects of the topic are presented in a compact manner. The book is clearly structured, and divided into two sections – asymmetric synthesis of heterocycles containing only one nitrogen and that of those with more than one nitrogen as a heteroatom – such that the necessary information may be found at a glance. The international team of authors provides important experimental procedures, including industrial applications. Essential for synthetic chemists in pharmaceutical and agrochemical chemistry.

Developmental Approaches to Human Evolution encapsulates the current state of evolutionary developmental anthropology. This emerging scientific field applies tools and approaches from modern developmental biology to understand the role of genetic and developmental processes in driving morphological and cognitive evolution in humans, non-human primates and in the laboratory organisms used to model these changes. Featuring contributions from well-established pioneers and emerging leaders, this volume is designed to build research momentum and catalyze future innovation in this burgeoning field. The book’s broad research scope encompasses soft and hard tissues of the head and body, including the skeleton, special senses and the brain. Developmental Approaches to Human Evolution is an invaluable resource on the mechanisms of primate and vertebrate evolution for scholars across a wide array of intersecting disciplines, including primatology, paleoanthropology, vertebrate morphology, evolutionary developmental biology and health sciences.

The development of materials for clean and efficient energy generation and storage is one of the most rapidly developing, multi-disciplinary areas of contemporary science, driven primarily by concerns over global warming, diminishing fossil-fuel reserves, the need for energy security, and increasing consumer demand for portable electronics. Computational methods are now an integral and indispensable part of the materials characterisation and development process. Computational Approaches to Energy Materials presents a detailed survey of current computational techniques for the development and optimization of energy materials, outlining their strengths, limitations, and future applications. The review of techniques includes current methodologies based on electronic structure, interatomic potential and hybrid methods. The methodological components are integrated into a comprehensive survey of applications, addressing the major themes in energy research. Topics covered include: • Introduction to computational methods and approaches • Modelling materials for energy generation applications: solar energy and nuclear energy • Modelling materials for storage applications: batteries and hydrogen • Modelling materials for energy conversion applications: fuel cells, heterogeneous catalysis and solid-state lighting • Nanostructures for energy applications This full colour text is an accessible introduction for newcomers to the field, and a valuable reference source for experienced researchers working on computational techniques and their application to energy materials.

The field of forensic archaeology has developed over recent years from being a branch of conventional archaeology into a well-established discipline in its own right. Forensic Approaches to Buried Remains takes an innovative approach to the subject by placing the role of the forensic archaeologist within the wider forensic environment; it identifies new areas of interdisciplinary research and practice, and evaluates practical difficulties. The authors see this book as a reflection of the subject’s development, and as a knowledge base for the next generation of forensic archaeologists. Areas covered include: Search logistics, integration and specialist search scenarios Levels of confidence in site search and elimination Urban and rural landscape reconstruction in both short and long term cases The integration of cadaver dogs and earth-moving machinery The recovery of multiple evidence types Sampling strategies, spatial relevance and dating Multiple burial scenarios As part of the Essential Forensic Science book series this book will provide students and practitioners alike with an invaluable resource outlining both the major developments in the discipline, as well as original approaches to the search for, and recovery of buried remains.

DEEP LEARNING APPROACHES TO CLOUD SECURITY Covering one of the most important subjects to our society today, cloud security, this editorial team delves into solutions taken from evolving deep learning approaches, solutions allowing computers to learn from experience and understand the world in terms of a hierarchy of concepts, with each concept defined through its relation to simpler concepts. Deep learning is the fastest growing field in computer science. Deep learning algorithms and techniques are found to be useful in different areas like automatic machine translation, automatic handwriting generation, visual recognition, fraud detection, and detecting developmental delay in children. However, applying deep learning techniques or algorithms successfully in these areas needs a concerted effort, fostering integrative research between experts ranging from diverse disciplines from data science to visualization. This book provides state of the art approaches of deep learning in these areas, including areas of detection and prediction, as well as future framework development, building service systems and analytical aspects. In all these topics, deep learning approaches, such as artificial neural networks, fuzzy logic, genetic algorithms, and hybrid mechanisms are used. This book is intended for dealing with modeling and performance prediction of the efficient cloud security systems, thereby bringing a newer dimension to this rapidly evolving field. This groundbreaking new volume presents these topics and trends of deep learning, bridging the research gap, and presenting solutions to the challenges facing the engineer or scientist every day in this area. Whether for the veteran engineer or the student, this is a must-have for any library. Deep Learning Approaches to Cloud Security: Is the first volume of its kind to go in-depth on the newest trends and innovations in cloud security through the use of deep learning approaches Covers these important new innovations, such as AI, data mining, and other evolving computing technologies in relation to cloud security Is a useful reference for the veteran computer scientist or engineer working in this area or an engineer new to the area, or a student in this area Discusses not just the practical applications of these technologies, but also the broader concepts and theory behind how these deep learning tools are vital not just to cloud security, but society as a whole Audience: Computer scientists, scientists and engineers working with information technology, design, network security, and manufacturing, researchers in computers, electronics, and electrical and network security, integrated domain, and data analytics, and students in these areas

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of «personalized drugs» are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more

Many common human diseases have a multifactorial origin: they are influenced by a person's genetic predisposition as well as by factors in the environment. This volume deals with the application of recombinant DNA techniques to the identification of diseases that have more than one inherited component. Focus is on the polygenic factors responsible for coronary atherosclerosis. Several other disorders having a polygenic origin are also discussed, including hypertension, diabetes mellitus, psychiatric diseases, and autoimmune (HLA-related) disorders. Problems raised by the study of different families or different populations are covered, as well as the possibility of applying molecular techniques to disease prevention–for example, through gene therapy. Also, some of the ethical issues that relate to human gene mapping are briefly explored.

This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles. • Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification • Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance • Explains the role of natural products in chemistry and their formation • Discusses gene cluster identification and the use of biogenetic engineering in pharmaceutical application

A review of contemporary actinide research that focuses on new advances in experiment and theory, and the interplay between these two realms Experimental and Theoretical Approaches to Actinide Chemistry offers a comprehensive review of the key aspects of actinide research. Written by noted experts in the field, the text includes information on new advances in experiment and theory and reveals the interplay between these two realms. The authors offer a multidisciplinary and multimodal approach to the nature of actinide chemistry, and explore the interplay between multiple experiments and theory, as well as between basic and applied actinide chemistry. The text covers the basic science used in contemporary studies of the actinide systems, from basic synthesis to state-of-the-art spectroscopic and computational techniques. The authors provide contemporary overviews of each topic area presented and describe the current and anticipated experimental approaches for the field, as well as the current and future computational chemistry and materials techniques. In addition, the authors explore the combination of experiment and theory. This important resource: Provides an essential resource the reviews the key aspects of contemporary actinide research Includes information on new advances in experiment and theory, and the interplay between the two Covers the basic science used in contemporary studies of the actinide systems, from basic synthesis to state-of-the-art spectroscopic and computational techniques Focuses on the interplay between multiple experiments and theory, as well as between basic and applied actinide chemistry Written for academics, students, professionals and researchers, this vital text contains a thorough review of the key aspects of actinide research and explores the most recent advances in experiment and theory.