Muscle Aging, Inclusion-Body Myositis and Myopathies

Reviews our current understanding of the role of protein oxidation in aging and age-related diseases Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging. Protein Oxidation and Aging begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers: Major aspects of the protein oxidation process Cellular mechanisms for managing oxidized proteins Role of protein oxidation in aging Influence of genetic and environmental factors on protein oxidation Measuring protein oxidation in the aging process Protein oxidation in age-related diseases References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.

The third edition of this essential text has been updated and expanded with new material that reflects the most recent developments in the field, and explores our current understanding of a broad range of topics related to aging and older adulthood. Fresh edition includes updated content such as revised case histories and reworked material on key concepts and research applications Retains the winning format of the second edition, with chapter contents framed by individual histories Dual models add cohesiveness to the presentation of theory Thematic structure facilitates reader comprehension Instructor resources provided online upon publication at www.wiley.com/go/erber

A state-of-the-art, multidisciplinary approach to cancer and aging With the majority of cancers occurring in individuals over the age of 65 against a backdrop of an expanding aging population, there is an urgent need to integrate the areas of clinical oncology and geriatric care. This timely work tackles these issues head-on, presenting a truly multidisciplinary and international perspective on cancer and aging from world-renowned experts in geriatrics, oncology, behavioral science, psychology, gerontology, and public health. Unlike other books on geriatric oncology that focus mainly on treatment, Cancer and Aging Handbook: Research and Practice examines all phases of the cancer care continuum, from prevention through evidence-based diagnosis and treatment to end-of-life care. Detailed clinical and research information helps guide readers on effective patient care as well as caregiver training, research, and intervention. Coverage includes: Epidemiology of cancer in older adults, plus the unique physical, mental, and social issues involved Strategies and guidelines for prevention, screening, and treatment of older individuals with cancer The most common cancers in the elderly, including breast, colorectal, lung, prostate, and ovarian cancer Cancer survivorship in older adults as well as the all-critical issues of palliative care and pain management Emerging topics such as caregiver and family issues, different models of care, and cost considerations An essential resource for clinicians and caregivers as well as researchers interested in this evolving field, Cancer and Aging Handbook is also useful for public health professionals and policymakers who need to formulate services and allocate resources for the growing population of older cancer patients.

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Cellular Physiology of Nerve and Muscle, Fourth Edition offers a state of the art introduction to the basic physical, electrical and chemical principles central to the function of nerve and muscle cells. The text begins with an overview of the origin of electrical membrane potential, then clearly illustrates the cellular physiology of nerve cells and muscle cells. Throughout, this new edition simplifies difficult concepts with accessible models and straightforward descriptions of experimental results. An all-new introduction to electrical signaling in the nervous system. Expanded coverage of synaptic transmission and synaptic plasticity. A quantitative overview of the electrical properties of cells. New detailed illustrations.

Examines the concept of aging process facilities and infrastructure in high hazard industries and highlights options for dealing with the problem while addressing safety issues This book explores the many ways in which process facilities, equipment, and infrastructure might deteriorate upon continuous exposure to operating and climatic conditions. It covers the functional and physical failure modes for various categories of equipment and discusses the many warning signs of deterioration. Dealing with Aging Process Facilities and Infrastructure also explains how to deal with equipment that may not be safe to operate. The book describes a risk-based strategy in which plant leaders and supervisors can make more informed decisions on aging situations and then communicate them to upper management effectively. Additionally, it discusses the dismantling and safe removal of facilities that are approaching their intended lifecycle or have passed it altogether. Filled with numerous case studies featuring photographs to illustrate the positive and negative experiences of others who have dealt with aging facilities, Dealing with Aging Process Facilities and Infrastructure covers the causes of equipment failures due to aging and their consequences; plant management commitment and responsibility; inspection and maintenance practices for managing life cycle; specific aging asset integrity management practices; and more. Describes symptoms and causal mechanisms of aging in various categories of process equipment Presents key considerations for making informed risk-based decisions regarding the repair or replacement of aging process facilities and infrastructure Discusses practices for managing process facility and infrastructure life cycle Includes examples and case histories of failures related to aging Dealing with Aging Process Facilities and Infrastructure is an important book for industrial practitioners who are often faced with the challenge of managing process facilities and infrastructure as they approach the end of their useful lifecycle.

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Independent living with smart technologies Smart Technology for Aging, Disability, and Independence: The State of the Science brings together current research and technological developments from engineering, computer science, and the rehabilitation sciences, detailing how its applications can promote continuing independence for older persons and those with disabilities. Leading experts from multiple disciplines worldwide have contributed to this volume, making it the definitive resource. The text begins with a thorough introduction that presents important concepts, defines key terms, and identifies demographic trends at work. Using detailed product descriptions, photographs and illustrations, and case studies, subsequent chapters discuss cutting-edge technologies, including: * Wearable systems * Human-computer interactions * Assisted vision and hearing * Smart wheelchairs * Handheld devices and smart phones * Visual sensors * Home automation * Assistive robotics * In-room monitoring systems * Telehealth After considering specific high-technology solutions, the text examines recent trends in other critical areas, such as basic assistive technologies, driving, transportation and community mobility, home modifications and design, and changing standards of elder care. Students and professionals in the rehabilitation sciences, health care providers, researchers in computer science and engineering, and non-expert readers will all appreciate this text's thorough coverage and clear presentation of the state of the science.

This book is the third in a series with the International Association for the Scientific Study of Intellectual Disabilities (Series Editor: Matthew P. Janicki). These publications are designed to address the issues of health, adult development and aging among persons with intellectual disabilities. For many years it has been recognized that some adults with intellectual disabilities are at elevated risk for mental and behavioral health problems. Often the aging process can complicate the identification, diagnosis, treatment and prevention of this type of dual diagnosis and present complex challenges to clinicians and carers. This book is designed as a practical resource for those involved with the support, care and treatment of persons with intellectual disabilities, and should prove particularly useful as this community achieves increased longevity. The book is divided into three parts: Prevalence and Characteristics; Diagnosis and Treatment; and Service System Issues.