Optimal Modified Continuous Galerkin CFD

This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities.

Discusses the CFD-DEM method of modeling which combines both the Discrete Element Method and Computational Fluid Dynamics to simulate fluid-particle interactions. Deals with both theoretical and practical concepts of CFD-DEM, its numerical implementation accompanied by a hands-on numerical code in FORTRAN Gives examples of industrial applications

CONTINUOUS EMISSION MONITORING The new edition of the only single-volume reference on both the regulatory and technical aspects of U.S. and international continuous emission monitoring (CEM) systems Continuous Emission Monitoring presents clear, accurate, and up-to-date information on the technical and regulatory issues that affect the design, application, and certification of CEM systems installed in power plants, cement plants, pulp and paper mills, smelters, and other stationary sources. Written by an international expert in the field, this classic reference guide covers U.S. and international CEM regulatory requirements, analytical techniques, operation and maintenance of CEM instrumentation, and more. The fully revised Third Edition remains the most comprehensive source of CEM information available, featuring three brand-new chapters on mercury monitoring, the reporting and ­certification of industrial greenhouse gas emissions, and the instrumentation and methods used to measure air toxic compounds including dioxins, furans, and hydrogen chloride. Thoroughly updated chapters discuss topics such as flow rate monitors, new EPA regulations, instrumentation and calibration techniques, CEM system control and data acquisition, and extractive system design. Providing environmental professionals with the knowledge of CEM systems necessary to address the present-day regulatory environment, Continuous Emission Monitoring: Discusses how CEM systems work, their advantages and limitations, and the regulatory requirements governing their operation Covers both the historical framework and technological basis of current CEM regulatory programs and standards in the United States, Canada, Europe, and Asia Offers practical guidance on sampling system selection, measurement techniques, advanced monitoring approaches, recordkeeping, and quality assurance Provides detailed technical descriptions of the technology necessary for regulatory compliance Includes new orthographic drawings to help instrument technicians and regulators with little technical background to easily understand key topics Continuous Emission Monitoring, Third Edition is an essential resource for professionals responsible for ensuring regulatory compliance, managers and technicians who purchase, operate, and maintain CEM instrumentation, regulatory personnel who write and enforce operating permits, and instructors and students in upper-level environmental engineering programs.

With contributions from an international group of expert authors, this book includes the latest trends in tailoring interfacial properties electrochemically. The chapters cover various organic and inorganic compounds, with applications ranging from electrochemistry to nanotechnology and biology. Of interest to physical, surface and electrochemists, materials scientists and physicists.

A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.

In recent years, the food industry has made substantial advances in replacing partially hydrogenated oils, high in trans-fatty acids, in foods. Trait-modified oils were then developed to produce trans-fat free, low saturated functional oils. Trait-modified Oils in Foods offers top line information on the sources, composition, performance, health, taste, and availability of modified next generation oils. Coverage extends to public policy development, discussions of real world transition to healthy oils by food service and food processing industries and the future of trait-modified oils. The book provides solutions to food companies with the potential of improving the health benefits of foods through eliminating trans-fats and reducing saturated fats from formulations. A landmark resource on modified next-generation, trait-modified oils, this book is essential reading for oil processors, manufacturers and producers, as well as any professional involved in food quality assurance and public health.

Automated Continuous Process Control pulls together–in one compact and practical volume–the essentials for understanding, designing, and operating process control systems. This comprehensive guide covers the major elements of process control in a well-defined and ordered framework. Concepts are clearly presented, with minimal reliance on mathematical equations and strong emphasis on practical, real-life examples. Beginning with the very basics of process control, Automated Continuous Process Control builds upon each chapter to help the reader understand and efficiently practice industrial process control. This complete presentation includes: A discussion of processes from a physical point of view Feedback controllers and the workhorse in the industry–the PID controller The concept and implementation of cascade control Ratio, override (or constraint), and selective control Block diagrams and stability Feedforward control Techniques to control processes with long dead times Multivariable process control Applicable for electrical, industrial, chemical, or mechanical engineers, Automated Continuous Process Control offers proven process control guidance that can actually be used in day-to-day operations. The reader will also benefit from the companion CD-ROM, which contains processes that have been successfully used for many years to practice tuning feedback and cascade controllers, as well as designing feedforward controllers.

This title considers the special of random processes known as semi-Markov processes. These possess the Markov property with respect to any intrinsic Markov time such as the first exit time from an open set or a finite iteration of these times. The class of semi-Markov processes includes strong Markov processes, L?vy and Smith stepped semi-Markov processes, and some other subclasses. Extensive coverage is devoted to non-Markovian semi-Markov processes with continuous trajectories and, in particular, to semi-Markov diffusion processes. Readers looking to enrich their knowledge on Markov processes will find this book a valuable resource.

Volume XVII in the «Advances in Electrochemical Science and Engineering» series, this monograph covers progress in this rapidly developing field with a particular emphasis on important applications, including spectroscopy, medicinal chemistry and analytical chemistry. As such it covers nanopatterned and nanoparticle-modified electrodes for analytical detection, surface spectroscopy, electrocatalysis and a fundamental understanding of the relation between the electrode structure and its function. Written by a group of international experts, this is a valuable resource for researchers working in such fields as electrochemistry, materials science, spectroscopy, analytical and medicinal chemistry.