Oral Bioavailability. Basic Principles, Advanced Concepts, and Applications

The definitive guide to PACS – now with more clinically applicable material In recent years, the field of picture archiving and communications systems—PACS—and image informatics has advanced due to both conceptual and technological advancements. This edition of PACS and Imaging Informatics: Basic Principles and Applications addresses the latest in this exciting field. In contrast to the previous edition, this updated text uses the framework of image informatics, not physics or engineering principles, to explain PACS. It is the only resource that thoroughly covers the critical issues of hardware/software design and implementation in a systematic and easily comprehensible manner. To strengthen and update the book, the author: Emphasizes clinical applications of PACS and integrates clinical examples throughout the text Reflects the many changes in the field, with new chapters on Web-based PACS, security, integrating the healthcare enterprise, clinical management systems, and the electronic patient record Uses the framework of imaging informatics to explain PACS, making the book accessible to those without advanced knowledge of physics, engineering, math, or information technology Explains how PACS can improve workflow, therapy, and treatment With the most systematic and thorough coverage of practical applications available, this text is the complete guide for all those involved in designing, implementing, and using PACS. Professionals in medical and allied health imaging informatics; radiologists and their technical staff; surgeons and oncologists and their teams; medical and electronic engineers; medical informaticians; and fellows, graduate students, and advanced undergraduates will all benefit from this valuable resource. «An excellent book for people involved in the design, implementation, or simply the operations of PACS and an appropriate textbook.» —From a review of the previous edition in IEEE Engineering in Medicine and Biology «The strength of the book lies in the vast experience of the author, who has implemented PACS at numerous institutions in the United States and abroad.» —From a review of the previous edition in Radiology

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

This book presents fundamental passive optical network (PON) concepts, providing you with the tools needed to understand, design, and build these new access networks. The logical sequence of topics begins with the underlying principles and components of optical fiber communication technologies used in access networks. Next, the book progresses from descriptions of PON and fiber-to-the-X (FTTX) alternatives to their application to fiber-to-the-premises (FTTP) networks and, lastly, to essential measurement and testing procedures for network installation and maintenance. An Instructor's Manual presenting detailed solutions to all the problems in the book is available from the Wiley editorial department.

Providing extensive coverage, including conducting, insulating and electroactive films, this handbook and ready reference deals with introductory topics and fundamentals as well as advanced insights. Clearly structured, in the first part of the book readers learn the fundamentals of electropolymerizatoin for all important types of polymers, mechanisms of film formation and functionalization, while the second part covers a wide range of applications in biochemistry, analytics, photovoltaics, energy and the environment as well as actuators.

A thorough, accessible, and general overview of chemosensors Providing a comprehensive overview of chemosensors—organic molecules designed to bind and sense small molecules or metal ions—and their applications, Chemosensors: Principles, Strategies, and Applications is an accessible one-stop resource for analysts, clinicians, and graduate students studying advanced chemistry and chemosensing. Chemosensors function on a molecular level, generating a signal upon binding. The book reviews their synthesis, design, and applications for detecting biological and organic molecules as well as metal ions. The text highlights applications in drug discovery and catalyses that have not been well covered elsewhere. Covering such topics as molecular recognition, detection methods, design strategies, and important biological issues, the book is broken into four sections that examine intermolecular interactions, strategies in sensor design, detection methods, and case studies in metal, saccharide, and amino acid sensing. An indispensable source of information for chemical and biomedical experts using sensors, Chemosensors includes case studies to make the material both accessible and understandable to chemists of all backgrounds.

This book began life as a series of lectures given to second and third year undergraduates at Oxford University. These lectures were designed to give students insights as to how marine ecosystems functioned, how they were being affected by natural and human interventions, and how we might be able to conserve them and manage them sustainably for the good of people, both recreationally and economically. This book presents 10 chapters, beginning with principles of oceanography important to ecology, through discussions of the magnitude of marine biodiversity and the factors influencing it, the functioning of marine ecosystems at within trophic levels such as primary production, competition and dispersal, to different trophic level interactions such as herbivory, predation and parasitism. The final three chapters look at the more applied aspects of marine ecology, discussion fisheries, human impacts, and management and conservation. Other textbooks covering similar topics tend to treat the topics from the point of view of separate ecosystems, with chapters on reefs, rocks and deep sea. This book however is topic driven as described above, and each chapter makes full use of examples from all appropriate marine ecosystems. The book is illustrated throughout with many full colour diagrams and high quality photographs. The book is aimed at undergraduate and graduate students at colleges and universities, and it is hoped that the many examples from all over the world will provide global relevance and interest. Both authors have long experience of research and teaching in marine ecology. Martin Speight’s first degree was in marine zoology at UCNW Bangor, and he has taught marine ecology and conservation at Oxford for 25 years. His research students study tropical marine ecology from the Caribbean through East Africa to the Far East. Peter Henderson is a Senior Research Associate at the University of Oxford, and is Director of Pisces Conservation in the UK. He has worked on marine and freshwater fisheries, as well as ecological and economic impacts and exploitation of the sea in North and South America as well as Europe.

Thoroughly revised to present the very latest in PACS-based multimedia in medical imaging informatics—from the electronic patient record to the full range of topics in digital medical imaging—this new edition by the founder of PACS and multimedia image informatics features even more clinically applicable material than ever before. It uses the framework of PACS-based image informatics, not physics or engineering principles, to explain PACS-based multimedia informatics and its application in clinical settings and labs. New topics include Data Grid and Cloud Computing, IHE XDS-I Workflow Profile (Integrating the Healthcare Enterprise Cross-enterprise Document Sharing for Imaging), extending XDS to share images, and diagnostic reports and related information across a group of enterprise health care sites. PACS-Based Multimedia Imaging Informatics is presented in 4 sections. Part 1 covers the beginning and history of Medical Imaging, PACS, and Imaging Informatics. The other three sections cover Medical Imaging, Industrial Guidelines, Standards, and Compliance; Informatics, Data Grid, Workstation, Radiation Therapy, Simulators, Molecular Imaging, Archive Server, and Cloud Computing; and multimedia Imaging Informatics, Computer-Aided Diagnosis (CAD), Image-Guide Decision Support, Proton Therapy, Minimally Invasive Multimedia Image-Assisted Surgery, BIG DATA. New chapter on Molecular Imaging Informatics Expanded coverage of PACS and eHR's (Electronic Health Record), with HIPPA compliance New coverage of PACS-based CAD (Computer-Aided Diagnosis) Reorganized and expanded clinical chapters discuss one distinct clinical application each Minimally invasive image assisted surgery in translational medicine Authored by the world's first and still leading authority on PACS and medical imaging PACS-Based Multimedia Imaging Informatics: Basic Principles and Applications, 3rd Edition is the single most comprehensive and authoritative resource that thoroughly covers the critical issues of PACS-based hardware and software design and implementation in a systematic and easily comprehensible manner. It is a must-have book for all those involved in designing, implementing, and using PACS-based Multimedia Imaging Informatics.

Focusing on the basic principles of semiconductor photocatalysis, this book also gives a brief introduction to photochemistry, photoelectrochemistry, and homogeneous photocatalysis. In addition, the author – one of the leading authorities in the field – presents important environmental and practical aspects. A valuable, one-stop source for all chemists, material scientists, and physicists working in this area, as well as novice researchers entering semiconductor photocatalysis.

A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.