Pediatric Drug Development

Despite the substantial interest in landscape genetics from the scientific community, learning about the concepts and methods underlying the field remains very challenging. The reason for this is the highly interdisciplinary nature of the field, which combines population genetics, landscape ecology, and spatial statistics. These fields have traditionally been treated separately in classes and textbooks, and very few scientists have received the interdisciplinary training necessary to efficiently teach or apply the diversity of techniques encompassed by landscape genetics. To address the current knowledge gap, this book provides the first in depth treatment of landscape genetics in a single volume. Specifically, this book delivers fundamental concepts and methods underlying the field, covering particularly important analytical methods in detail, and presenting empirical and theoretical applications of landscape genetics for a variety of environments and species. Consistent with the interdisciplinary nature of landscape genetics, the book combines an introductory, textbook like section with additional sections on advanced topics and applications that are more typical of edited volumes. The chapter topics and the expertise of the authors and the editorial team make the book a standard reference for anyone interested in landscape genetics. The book includes contributions from many of the leading researchers in landscape genetics. The group of scientists we have assembled has worked on several collaborative projects over the last years, including a large number of peer reviewed papers, several landscape genetics workshops at international conferences, and a distributed graduate seminar on landscape genetics. Based on the experiences gained during these collaborative teaching and research activities, the book includes chapters that synthesize fundamental concepts and methods underlying landscape genetics (Part 1), chapters on advanced topics that deserve a more in depth treatment (Part 2), and chapters illustrating the use of concepts and methods in empirical applications (Part 3). This structure ensures a high usefulness of the book for beginning landscape geneticists and experienced researchers alike, so that it has a broad target audience. At least one of the four co editors is involved in almost every chapter of the book, thereby ensuring a high consistency and coherency among chapters.

A practical approach to chemical reaction kinetics—from basic concepts to laboratory methods—featuring numerous real-world examples and case studies This book focuses on fundamental aspects of reaction kinetics with an emphasis on mathematical methods for analyzing experimental data and interpreting results. It describes basic concepts of reaction kinetics, parameters for measuring the progress of chemical reactions, variables that affect reaction rates, and ideal reactor performance. Mathematical methods for determining reaction kinetic parameters are described in detail with the help of real-world examples and fully-worked step-by-step solutions. Both analytical and numerical solutions are exemplified. The book begins with an introduction to the basic concepts of stoichiometry, thermodynamics, and chemical kinetics. This is followed by chapters featuring in-depth discussions of reaction kinetics; methods for studying irreversible reactions with one, two and three components; reversible reactions; and complex reactions. In the concluding chapters the author addresses reaction mechanisms, enzymatic reactions, data reconciliation, parameters, and examples of industrial reaction kinetics. Throughout the book industrial case studies are presented with step-by-step solutions, and further problems are provided at the end of each chapter. Takes a practical approach to chemical reaction kinetics basic concepts and methods Features numerous illustrative case studies based on the author’s extensive experience in the industry Provides essential information for chemical and process engineers, catalysis researchers, and professionals involved in developing kinetic models Functions as a student textbook on the basic principles of chemical kinetics for homogeneous catalysis Describes mathematical methods to determine reaction kinetic parameters with the help of industrial case studies, examples, and step-by-step solutions Chemical Reaction Kinetics is a valuable working resource for academic researchers, scientists, engineers, and catalyst manufacturers interested in kinetic modeling, parameter estimation, catalyst evaluation, process development, reactor modeling, and process simulation. It is also an ideal textbook for undergraduate and graduate-level courses in chemical kinetics, homogeneous catalysis, chemical reaction engineering, and petrochemical engineering, biotechnology.

Pipe Flow provides the information required to design and analyze the piping systems needed to support a broad range of industrial operations, distribution systems, and power plants. Throughout the book, the authors demonstrate how to accurately predict and manage pressure loss while working with a variety of piping systems and piping components. The book draws together and reviews the growing body of experimental and theoretical research, including important loss coefficient data for a wide selection of piping components. Experimental test data and published formulas are examined, integrated and organized into broadly applicable equations. The results are also presented in straightforward tables and diagrams. Sample problems and their solution are provided throughout the book, demonstrating how core concepts are applied in practice. In addition, references and further reading sections enable the readers to explore all the topics in greater depth. With its clear explanations, Pipe Flow is recommended as a textbook for engineering students and as a reference for professional engineers who need to design, operate, and troubleshoot piping systems. The book employs the English gravitational system as well as the International System (or SI).

'Ukraine is not a brothel!' This was the first cry of rage uttered by Femen during Euro 2012. Bare-breasted and crowned with flowers, perched on their high heels, Femen transform their bodies into instruments of political expression through slogans and drawings flaunted on their skin. Humour, drama, courage and shock tactics are their weapons. Since 2008, this 'gang of four' – Inna, Sasha, Oksana and Anna – has been developing a spectacular, radical, new feminism. First in Ukraine and then around the world, they are struggling to obtain better conditions for women, but they also fight poverty, discrimination, dictatorships and the dictates of religion. These women scale church steeples and climb into embassies, burst into television studios and invade polling stations. Some of them have served time in jail, been prosecuted for ‘hooliganism’ in their home country and are banned from living in other states. But thanks to extraordinary media coverage, the movement is gaining imitators and supporters in France, Germany, Brazil and elsewhere. Inna, Sasha, Oksana and Anna have an extraordinary story and here they tell it in their own words, and at the same time express their hopes and ambitions for women throughout the world.

Environmental Biotechnology: Theory and Applications, 2nd Edition is designed to draw together the microscopic, functional level and the macroscopic, practical applications of biotechnology and to explain how the two relate within an environmental context. It presents the practical biological approaches currently employed to address environmental problems and provides the reader with a working knowledge of the science that underpins them. Biotechnology has now become a realistic alternative to many established approaches for manufacturing, land remediation, pollution control and waste management and is therefore an essential aspect of environmental studies. Fully updated to reflect new developments in the field and with numerous new case studies throughout this edition will be essential reading for undergraduates and masters students taking modules in Biotechnology or Pollution Control as part of Environmental Science, Environmental Management or Environmental Biology programmes. Quote from the first edition: «There is no doubt that this book will be one of inspiration for all professionals in the field. It is a very good framework for understanding the complex nature of processes and technology and as such it will be useful for researchers, practitioners and other parties who need a working knowledge of this fascinating subject.» —Professor Bjorn Jensen, Chairman of the European Federation of Biotechnology, Environmental Biotechnology section and Research and Innovation Director, DHI Water and Environment