Postimplantation Development in the Mouse

After WWII, the United States of America proposed their way of life, based on an unlimited consumption of land, goods, and energy, as a model for the entire world. Nowadays, this expansionist model has reached its limits. This book provides a comprehensive study of the geographical basis of the American settlements, assuming that part of the U.S. overshooting is related to geography because of harsh climates and the continental size of the Nation, but another part is the result of a cultural habits of expansion and segregation. Urban Sprawl, for instance, is the real Achille's heel of America, because it challenges the cultural revolution required by sustainability. From the continental physiography to the New Orleans – Katrina case, this book explores these issues with maps and charts created with the help of a nationwide multiscalar GIS.

New edition of the classic The Role of the Father in Child Development The Role of the Father in Child Development, Fourth Edition brings together contributions from an international group of experts on the role of fathers in child development. Under the auspices of editor Michael Lamb, this guide offers a single-source reference for the most recent findings and beliefs related to fathers and fatherhood. This new and thoroughly updated edition provides the latest material on such topics as: The development of father-child relationships Gay fathers The effects of divorce on fathers and children Fathers in violent and neglectful families Cross-cultural issues of fatherhood Fathers in nonindustrialized cultures The Role of the Father in Child Development, Fourth Edition helps mental health professionals bridge scientific theories to application and practice that teach fathers how to positively influence their children's development.

The Definitive reference on the important role fathers play in child development today Edited by Dr. Michael Lamb—the recognized authority on the role of fathers in child development, The Role of the Father in Child Development, Fifth Edition brings together contributions from international experts on each subject to provide a thorough and current summary of the state of fatherhood across cultures, classes, economic systems, and family formations. This classic guide offers a single-source reference for the most recent findings and beliefs related to fathers and fatherhood. This thoroughly updated new edition provides the latest material on topics such as: The effects of divorce Fathers from low-income backgrounds Stepfathers’ lives: exploring social context and interpersonal complexity Social policy Gay fathers Fatherhood and masculinity The definitive book on when, why, and how fathers matter to their children and families, The Role of the Father in Child Development, Fifth Edition is an essential reference for all mental health professionals who endeavor to understand and support fathers in becoming positive influences in their children’s development.

The Definitive reference on the important role fathers play in child development today Edited by Dr. Michael Lamb—the recognized authority on the role of fathers in child development, The Role of the Father in Child Development, Fifth Edition brings together contributions from international experts on each subject to provide a thorough and current summary of the state of fatherhood across cultures, classes, economic systems, and family formations. This classic guide offers a single-source reference for the most recent findings and beliefs related to fathers and fatherhood. This thoroughly updated new edition provides the latest material on topics such as: The effects of divorce Fathers from low-income backgrounds Stepfathers’ lives: exploring social context and interpersonal complexity Social policy Gay fathers Fatherhood and masculinity The definitive book on when, why, and how fathers matter to their children and families, The Role of the Father in Child Development, Fifth Edition is an essential reference for all mental health professionals who endeavor to understand and support fathers in becoming positive influences in their children’s development.

The first edition was extremely well received, providing an introduction and insight to this important topic in a comprehensive yet easy to read form. It was chosen to be issued to the representatives of the organizations from the G8 and G20 countries attending the University Summit held in Turin in 2009 which addressed the issue of how education and research can assist sustainable development. The second edition, completely updated to reflect the significant advances and new insights that have been made since publication of the first edition, focuses on two main issues: Facilitating a dialogue between all stakeholders so that the complexity of the problem can be exposed, structured and communicated Understanding how to assess progress in sustainable development It continues to provide coherent guidance on the techniques that can be used to assess sustainable development in a rigorous manner. The approach is introduced using illustrations and case studies, together with follow-up references. It remains the ideal starting point for those trying to get a handle on the subject and for those who wish to examine a structured and systematic approach to the evaluation of sustainable development in the built environment.

A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field. Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include: A general discussion of challenges and proven approaches in the development of ligand-binding assays More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules A practical approach to «fit-for-purpose» validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.

Urban design enables better places to be created for people and is thus seen in Urban Design in the Real Estate Development Process as a place-making activity, rather than the application of architectural aesthetics. Urban design policy can change the 'decision environment' of developers, financiers, designers and other actors in the real estate development process to make them take place-making more seriously. This book reports diverse international experience from Europe and North America on the role and significance of urban design in the real estate development process and explores how higher quality development and better places can be achieved through public policy. The book is focused on four types of policy tool or instrument that have been deployed to promote better urban design: those that seek to shape, regulate or provide stimulus to real estate markets along with those aim to build capacity to achieve these. Urban design is therefore seen as a form of public policy that seeks to steer real estate development towards policy-shaped rather than market-led outcomes. The editors set the examples, case studies and evidence from international contributors within a substantive discussion of the impact of urban design policy tools and actions in specific development contexts. Contributions from leading urban design theorists and practitioners explore how: Masterplanning and infrastructure provision encourage high quality design Design codes reconcile developers' needs for certainty and flexibility Clear policy combined with firm regulation can transform developer behaviour Intelligent parcelisation can craft the character of successful new urban districts Powerful real estates interests can capture regulatory initiatives Stimulus instruments can encourage good design Development competitions need careful management Design review can foster developer commitment to design excellence Speculative housebuilders respond in varied ways to the brownfield design challenge Physical-financial models could help in assessing the benefits of design investment Urban design can add value to the benefit of developers and cities as a whole.

Here is a practical guide that not only presents insights into the organization and management of the disciplines involved in chemical process development but also provides basic knowledge of these disciplines, enabling process development practitioners to recognize and assimilate them in their work. This book illustrates practical considerations through many examples of the successful direction and integration of the activities of chemists, analysts, chemical engineers, and biologists, as well as safety, regulatory, and environmental professionals in productive teams. Moreover, this reference provides guidance on: Directing and carrying out specific tasks and courses of action Making and communicating clear and achievable decisions Solving problems on the spot Managing the administrative aspects of chemical process development The author, Dr. Derek Walker, has directed chemical process development work for four decades, combining firsthand chemical synthesis experience with many other disciplines needed to create chemical processes. You will benefit from his advice and unique insights into: Understanding the workings of matrix organizations Defining missions and creating action plans Developing interdisciplinary approaches to problem solving Holding review meetings, revising goals, and motivating staff Prioritizing programs and responses to emergencies In addition, you'll learn how successful chemists, in collaboration with other disciplines, define the best (green) chemistry for process scale-up, including accommodating FDA requirements in the last process steps and addressing safety and environmental matters early in their work. Case studies provide incisive perspective on these issues. A chapter on recognizing and patenting intellectual property emphasizes the importance of comprehensive literature surveys and understanding invention. A chapter on the future challenges you to think beyond narrow constraints and explore new horizons.

Intended for undergraduate and graduate courses in plant development, this book explains how the cells of a plant acquire and maintain their specific fates. Plant development is a continuous process occurring throughout the life cycle, with similar regulatory mechanisms acting at different stages and in different parts of the plant. Rather than focussing on the life cycle, the book is structured around these underlying mechanisms, using case studies to provide students with a framework to understand the many factors, both environmental and endogenous, that combine to regulate development and generate the enormous diversity of plant forms. New approach to the study of plant development and a refreshing look at this fast-moving area. Authors focus their discussion on the basic mechanisms which underpin plant development, tackling the fundamental question of how a single cell becomes a complex flowering plant from a cellular perspective. An up-to-date, modern text in plant development for advanced level undergraduates and postgraduates in plant science. Thought-provoking treatment of a difficult subject, the text will satisfy the needs of advanced level undergraduates and postgraduates in plant science. Experimental case studies throughout. The artwork from the book is available at www.blackwellpublishing.com/leyser

The complete, hands-on guide to sustainable development Today's process industries must develop natural resources within an eco-friendly framework that balances current demand with future need. Realizing this goal necessitates global vigilance of three key areas—people, planet, and prosperity—known as the Triple Bottom Line or, simply, the Triple P. Sustainable Development in the Process Industries details how worldwide implementation of sustainable processes in present-day industries can positively influence the Triple P going forward by lowering poverty, reducing pollution, and conserving resources. This in-depth guide includes: Real-world case studies and examples Individual chapters written by industry experts Application in industries such as petroleum and fuel, food, recycling, mineral processing, and water processing Focus on the micro (molecules, unit operations, processes) to the macro (industrial sites, value chains, regions, the world) Providing lessons with practical application rather than pure theory, Sustainable Development in the Process Industries offers sound solutions to social, ecological, and economic challenges imperative to assuring our planet's well-being for generations.