Principles of Computational Cell Biology. From Protein Complexes to Cellular Networks

Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.

An accessible and straightforward intro to cell biology In the newly revised Fourth Edition of Cell Biology: A Short Course , a distinguished team of researchers delivers a concise and accessible introduction to modern cell biology, integrating knowledge from genetics, molecular biology, biochemistry, physiology, and microscopy. The book places a strong emphasis on drawing connections between basic science and medicine. Telling the story of cells as the units of life in a colorful and student-friendly manner, Cell Biology: A Short Course takes an “essentials only” approach. It conveys critical points without overburdening the reader with extraneous or secondary information. Clear diagrams and examples from current research accompany special boxed sections that focus on the importance of cell biology in medicine and industry. A new feature, “BrainBoxes” describes some of the key people who created the current understanding of Cell Biology. The book has been thoroughly revised and updated since the last edition and includes: Thorough introduction to cells and tissues, membranes, organelles, and the structure of DNA and genetic code Explorations of DNA as a data storage medium, transcription and the control of gene expression, and recombinant DNA and genetic engineering Discussion of the manufacture of proteins, protein structure, and intracellular protein trafficking Description of ions and voltages, intracellular and extracellular signaling Introduction to the cytoskeleton and cell movement Discussion of cell division and apoptosisPerfect for undergraduate students seeking an accessible, one-stop reference on cell biology, Cell Biology: A Short Course is also an ideal reference for pre-med students.

Controlled expansion of cell populations is a fundamental feature of living organisms, being a finely-tuned balance between cell proliferation and cell death. This book aims to explain the molecular mechanisms that lie behind the multiplication and survival of eukaryotic cells. This encompasses both the normal regulation of cell populations in development or physiological adaptation and pathological mechanisms of cell cycle control in cancer. Principles of Cell Proliferation progressively introduces the function of growth factors, receptors, signal transduction pathways, gene expression and the conserved mechanisms of the cell cycle engine. This provides a context for understanding the mechanistic consequences of the genetic alterations in oncogenes and tumour suppresser genes which underlie tumour formation. The book should satisfy advanced level courses in Cell Proliferation, Cell Cycle Control and Cancer Biology for biologists, biochemists and medical students. The book comes at a time when the underlying molecular mechanisms of cancer are beginning to be unravelled. Ideal for advanced level courses in Cell Proliferation, Cell Cycle or Cancer Biology. An accessible account of a subject many students find complex.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Addressing the fundamental technologies and theories associated with designing complex communications systems and networks, Principles of Communications Networks and Systems provides models and analytical methods for evaluating their performance. Including both the physical layer (digital transmission and modulation) and networking topics, the quality of service concepts belonging to the different layers of the protocol stack are interrelated to form a comprehensive picture. The book is designed to present the material in an accessible but rigorous manner. It jointly addresses networking and transmission aspects following a unified approach and using a bottom up style of presentation, starting from requirements on transmission links all the way up to the corresponding quality of service at network and application layers. The focus is on presenting the material in an integrated and systematic fashion so that students will have a clear view of all the principal aspects and of how they interconnect with each other. A comprehensive introduction to communications systems and networks, addressing both network and transmission topics Structured for effective learning, with basic principles and technologies being introduced before more advanced ones are explained Features examples of existing systems and recent standards as well as advanced digital modulation techniques such as CDMA and OFDM Contains tools to help the reader in the design and performance analysis of modern communications systems Provides problems at the end of each chapter, with answers on an accompanying website

This text tells the story of cells as the unit of life in a colorful and student-friendly manner, taking an «essentials only» approach. By using the successful model of previously published Short Courses, this text succeeds in conveying the key points without overburdening readers with secondary information. The authors (all active researchers and educators) skillfully present concepts by illustrating them with clear diagrams and examples from current research. Special boxed sections focus on the importance of cell biology in medicine and industry today. This text is a completely revised, reorganized, and enhanced revision of From Genes to Cells.

A timely publication providing coverage of radio resource management, mobility management and standardization in heterogeneous cellular networks The topic of heterogeneous cellular networks has gained momentum in industry and the research community, attracting the attention of standardization bodies such as 3GPP LTE and IEEE 802.16j, whose objectives are looking into increasing the capacity and coverage of the cellular networks. This book focuses on recent progresses, covering the related topics including scenarios of heterogeneous network deployment, interference management in the heterogeneous network deployment, carrier aggregation in a heterogeneous network, cognitive radio, cell selection/reselection and load balancing, mobility and handover management, capacity and coverage optimization for heterogeneous networks, traffic management and congestion control. This book enables readers to better understand the technical details and performance gains that are made possible by this state-of-the-art technology. It contains the information necessary for researchers and engineers wishing to build and deploy highly efficient wireless networks themselves. To enhance this practical understanding, the book is structured to systematically lead the reader through a series of case-studies of real world scenarios. Key features: Presents this new paradigm in cellular network domain: a heterogeneous network containing network nodes with different characteristics such as transmission power and RF coverage area Provides a clear approach by containing tables, illustrations, industry case studies, tutorials and examples to cover the related topics Includes new research results and state-of-the-art technological developments and implementation issues

Computational Approaches to Studying the Co-evolution of Networks and Behaviour in Social Dilemmas shows students, researchers, and professionals how to use computation methods, rather than mathematical analysis, to answer research questions for an easier, more productive method of testing their models. Illustrations of general methodology are provided and explore how computer simulation is used to bridge the gap between formal theoretical models and empirical applications.

This timely book provides an overview of technologies for Public Safety Networks (PSNs). Including real-life examples of network application and services, it introduces readers to the many public safety network technologies and covers the historical developments as well as emerging trends in PSNs such as today’s 4G and tomorrow’s 5G cellular network related solutions. Public Safety Networks from LTE to 5G explores the gradual changes and transformation in the PSNs from the traditional approaches in communications, and examines the new technologies that have permeated this realm, as well as their advantages. It gives readers a look at the challenges public safety networks face by developing solutions for data rates such as introducing broadband data services into safer communication. Topics covered include: TETRA and TETRAPOL; Digital Mobile Radio (DMR), Next-Generation Digital Narrowband (NXDN), Digital Private Mobile Radio (dPMR); and Professional Digital Trunking (PDT). The book also presents information on FirstNet, ESN, and Safenet; Satellite Communications in EMS (Emergency Management) and Public Protection and Disaster Relief (PPDR); Wi-Fi in Ambulances; Technology in Patrol Communications; and more.