Proteomics in Practice

Intermediate Probability is the natural extension of the author's Fundamental Probability. It details several highly important topics, from standard ones such as order statistics, multivariate normal, and convergence concepts, to more advanced ones which are usually not addressed at this mathematical level, or have never previously appeared in textbook form. The author adopts a computational approach throughout, allowing the reader to directly implement the methods, thus greatly enhancing the learning experience and clearly illustrating the applicability, strengths, and weaknesses of the theory. The book: Places great emphasis on the numeric computation of convolutions of random variables, via numeric integration, inversion theorems, fast Fourier transforms, saddlepoint approximations, and simulation. Provides introductory material to required mathematical topics such as complex numbers, Laplace and Fourier transforms, matrix algebra, confluent hypergeometric functions, digamma functions, and Bessel functions. Presents full derivation and numerous computational methods of the stable Paretian and the singly and doubly non-central distributions. A whole chapter is dedicated to mean-variance mixtures, NIG, GIG, generalized hyperbolic and numerous related distributions. A whole chapter is dedicated to nesting, generalizing, and asymmetric extensions of popular distributions, as have become popular in empirical finance and other applications. Provides all essential programming code in Matlab and R. The user-friendly style of writing and attention to detail means that self-study is easily possible, making the book ideal for senior undergraduate and graduate students of mathematics, statistics, econometrics, finance, insurance, and computer science, as well as researchers and professional statisticians working in these fields.

Educating Citizens reports on how some American colleges and universities are preparing thoughtful, committed, and socially responsible graduates. Many institutions assert these ambitions, but too few act on them. The authors demonstrate the fundamental importance of moral and civic education, describe how the historical and contemporary landscapes of higher education have shaped it, and explain the educational and developmental goals and processes involved in educating citizens. They examine the challenges colleges and universities face when they dedicate themselves to this vital task and present concrete ways to overcome those challenges.

Understanding Minimalist Syntax introduces the logic of the Minimalist Program by analyzing well-known descriptive generalizations about long-distance dependencies. An introduction to the logic of the minimalist program – arguably the most important branch of syntax Proposes a new theory of how long-distance dependencies are formed, with implications for theories of locality, and the minimalist program as a whole Introduces the logic of the minimalist program by analyzing well-known descriptive generalizations about long-distance dependencies, and asks why they should be true of natural languages Rich in empirical coverage, which will be welcomed by experts in the field, yet accessible enough for students looking for an introduction to the minimalist program.

Explores mathematical statistics in its entirety—from the fundamentals to modern methods This book introduces readers to point estimation, confidence intervals, and statistical tests. Based on the general theory of linear models, it provides an in-depth overview of the following: analysis of variance (ANOVA) for models with fixed, random, and mixed effects; regression analysis is also first presented for linear models with fixed, random, and mixed effects before being expanded to nonlinear models; statistical multi-decision problems like statistical selection procedures (Bechhofer and Gupta) and sequential tests; and design of experiments from a mathematical-statistical point of view. Most analysis methods have been supplemented by formulae for minimal sample sizes. The chapters also contain exercises with hints for solutions. Translated from the successful German text, Mathematical Statistics requires knowledge of probability theory (combinatorics, probability distributions, functions and sequences of random variables), which is typically taught in the earlier semesters of scientific and mathematical study courses. It teaches readers all about statistical analysis and covers the design of experiments. The book also describes optimal allocation in the chapters on regression analysis. Additionally, it features a chapter devoted solely to experimental designs. Classroom-tested with exercises included Practice-oriented (taken from day-to-day statistical work of the authors) Includes further studies including design of experiments and sample sizing Presents and uses IBM SPSS Statistics 24 for practical calculations of data Mathematical Statistics is a recommended text for advanced students and practitioners of math, probability, and statistics.

The Tutorials in Biostatistics have become a very popular feature of the prestigious Wiley journal, Statistics in Medicine (SIM). The introductory style and practical focus make them accessible to a wide audience including medical practitioners with limited statistical knowledge. This book represents the second of two volumes presenting the best tutorials published in SIM, focusing on statistical modeling of complex data. Topics include clustered data, hierarchical models, mixed models, genetic modeling, and meta-analysis. Each tutorial is focused on a medical problem, has been fully peer-reviewed and edited, and is authored by leading researchers in biostatistics. Many articles include an appendix on the latest developments since publication in the journal and additional references. This will appeal to statisticians working in medical research, as well as statistically-minded clinicians, biologists, epidemiologists and geneticists. It will also appeal to graduate students of biostatistics.