Pumps, Channels and Transporters

A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance. This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

A practical guide to the majority of pumps and compressors used in engineering applications Pumps and compressors are ubiquitous in industry, used in manufacturing, processing and chemical plant, HVAC installations, aerospace propulsion systems, medical applications, and everywhere else where there is a need to pump liquids, or circulate or compress gasses. This well-illustrated handbook covers the basic function, performance, and applications for the most widely used pump and compressor types available on the market today. It explains how each device operates and includes the governing mathematics needed to calculate device performance such as flow rates and compression. Additionally, real-world issues such as cavitation, and priming are covered. Pumps & Compressors is divided into two sections, each of which offers a notation of variables and an introduction. The Pumps section covers piston pumps, radial turbopumps, axial turbopumps, rotating pumps, hydraulic pumps, and pumps with driving flow. The Compressors section covers piston compressors, rotating compressors, turbo compressors, ejectors, vacuum pumps, and compressors for cooling purposes. A virtual encyclopedia of all pumps and compressors that describes the mechanics of all devices and the theory, mathematics, and formulas governing their function Allows the reader to develop the skills needed to confidently select the appropriate pump or compressor type and specification for their applications Pumps & Compressors is an excellent text for courses on pumps and compressors, as well as a valuable reference for professional engineers and laymen seeking knowledge on the topic.

Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function. Written and edited by leading pioneers in the field, Cholesterol Regulation of Ion Channels and Receptors is divided into three parts: Part I, Cholesterol Regulation of Membrane Properties, introduces the heterogeneity of cholesterol distribution in biological membranes and the physical and biological implications of the formation of cholesterol-rich membrane domains. Part II, Cholesterol Regulation of Ion Channels, examines the mechanisms underlying cholesterol sensitivities of ion channels, including the regulation of ion channels by cholesterol as a boundary lipid. Part III, Cholesterol Regulation of Receptors, explores the latest discoveries concerning how cholesterol regulates distinct types of receptors, including G-protein coupled receptors, LDL and scavenger receptors, and innate immune system receptors. Increased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.

This book offers a practical guide on how to use and apply channel models for system evaluation In this book, the authors focus on modeling and simulation of multiple antennas channels, including multiple input multiple output (MIMO) communication channels, and the impact of such models on channel estimation and system performance. Both narrowband and wideband models are addressed. Furthermore, the book covers topics related to modeling of MIMO channel, their numerical simulation, estimation and prediction, as well as applications to receive diversity, capacity and space-time coding techniques. Key Features: Contains significant background material, as well as novel research coverage, which make the book suitable for both graduate students and researchers Addresses issues such as key-hole, correlated and non i.i.d. channels in the frame of the Generalized Gaussian approach Provides a unique treatment of generalized Gaussian channels and orthogonal channel representation Reviews different interpretations of scattering environment, including geometrical models Focuses on the analytical techniques which give a good insight into the design of systems on higher levels Describes a number of numerical simulators demonstrating the practical use of this material. Includes an accompanying website containing additional materials and practical examples for self-study This book will be of interest to researchers, engineers, lecturers, and graduate students.

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

Providing a comprehensive overview of the modelling, analysis and simulation of mobile radio channels, this book gives a detailed understanding of fundamental issues and examines state-of-the-art techniques in mobile radio channel modelling. It analyses several mobile fading channels, including terrestrial and satellite flat-fading channels, various types of wideband channels and advanced MIMO channels, providing a fundamental understanding of the issues currently being investigated in the field. Important classes of narrowband, wideband, and space-time wireless channels are explored in detail with descriptions of efficient simulation methods for mobile radio channels being central. Strong emphasis is placed on the detailed origin of the presented channel models and a high degree of mathematical unity is conveyed. Using the described channel models, the reader can evaluate the performance of wireless communication systems under propagation conditions which are typical for multipath channels in various environments. Introduces the fundamentals of stochastic and deterministic channel models Explores the modelling and simulation of both wideband and narrowband mobile radio channels as well as several classes of MIMO channels Describes general concepts including geometrical, reference and simulation models Discusses several methods for the modelling of given Doppler, delay, and angular profiles Elaborates on methods for the design, analysis, and realisation of efficient channel simulators Examines techniques for the development of fast channel simulators Provides links for downloading MATLAB®, programs enabling the simulation and analysis of the mobile fading channels models presented, on the companion website (www.wiley.com/go/paetzold)

Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug–drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.

This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

Wireless Communications over MIMO Channels: Applications to CDMA and Multiple Antenna Systems covers both, state-of-the-art channel coding concepts and CDMA and multiple antenna systems, rarely found in other books on the subject. Furthermore, an information theoretical analysis of CDMA and SDMA systems illuminate ultimate limits and demonstrates the high potential of these concepts. Besides spatial multiplexing, the use of multiple transmit antennas in order to increase the link reliability by diversity concepts (space-time coding) is described. Another focus is the application of error control coding in mobile radio communications Accompanying appendices include: basic derivations, tables of frequently used channel models, chain rules for entropy and information, data processing theorem, basics of linear algebra, Householder reflection and Givens rotation, and the LLL algorithm for lattice reduction.

IMP PUMPS (ИМП Пампс) GHN 32/60-180 - универсальный насос циркуляционного типа для работы в различных системах с горячей жидкостью. Конструкция оснащена мокрым ротором - рабочее колесо находится в перекачиваемой воде, что повышает производительность и уменьшает количество вырабатываемого шума. Особенности и преимущества: Катафорезное покрытие корпуса Рабочее колесо из норила Класс изоляции Н Диапазон рабочей температуры 0-40 градусов Уровень шума до 43 дБ GHN - серия циркуляционных насосов от европейского производителя IMP PUMPS подходит для использования с горячей водой в системах водоснабжения, отопления, кондиционирования и т.д. Весь ассортимент насосов работает с чистой водой. Доступен выбор из нескольких моделей, которые отличаются по мощности водяного потока (напора) и производительности.