Single Molecule Dynamics in Life Science

Discover the experimental and theoretical developments in optical single-molecule spectroscopy that are changing the ways we think about molecules and atoms The Advances in Chemical Physics series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. This latest volume explores the advent of optical single-molecule spectroscopy, and how atomic force microscopy has empowered novel experiments on individual biomolecules, opening up new frontiers in molecular and cell biology and leading to new theoretical approaches and insights. Organized into two parts—one experimental, the other theoretical—this volume explores advances across the field of single-molecule biophysics, presenting new perspectives on the theoretical properties of atoms and molecules. Single-molecule experiments have provided fresh perspectives on questions such as how proteins fold to specific conformations from highly heterogeneous structures, how signal transductions take place on the molecular level, and how proteins behave in membranes and living cells.This volume is designed to further contribute to the rapid development of single-molecule biophysics research. Filled with cutting-edge research reported in a cohesive manner not found elsewhere in the literature, each volume of the Advances in Chemical Physics series serves as the perfect supplement to any advanced graduate class devoted to the study of chemical physics.

The authors describe basic theoretical concepts of vibrational spectroscopy, address instrumental aspects and experimental procedures, and discuss experimental and theoretical methods for interpreting vibrational spectra. It is shown how vibrational spectroscopy provides information on general aspects of proteins, such as structure, dynamics, and protein folding. In addition, the authors use selected examples to demonstrate the application of Raman and IR spectroscopy to specific biological systems, such as metalloproteins, and photoreceptors. Throughout, references to extensive mathematical and physical aspects, involved biochemical features, and aspects of molecular biology are set in boxes for easier reading. Ideal for undergraduate as well as graduate students of biology, biochemistry, chemistry, and physics looking for a compact introduction to this field.

A groundbreaking, unifying theory of computer science for low-cost, high-quality software The Cognitive Dynamics of Computer Science represents the culmination of more than thirty years of the author's hands-on experience in software development, which has resulted in a remarkable and sensible philosophy and practice of software development. It provides a groundbreaking ontology of computer science, while describing the processes, methodologies, and constructs needed to build high-quality, large-scale computer software systems on schedule and on budget. Based on his own experience in developing successful, low-cost software projects, the author makes a persuasive argument for developers to understand the philosophical underpinnings of software. He asserts that software in reality is an abstraction of the human thought system. The author draws from the seminal works of the great German philosophers–Kant, Hegel, and Schopenhauer–and recasts their theories of human mind and thought to create a unifying theory of computer science, cognitive dynamics, that opens the door to the next generation of computer science and forms the basic architecture for total autonomy. * Four detailed cases studies effectively demonstrate how philosophy and practice merge to meet the objective of high-quality, low-cost software. * The Autonomous Cognitive System chapter sets forth a model for a completely autonomous computer system, using the human thought system as the model for functional architecture and the human thought process as the model for the functional data process. * Although rooted in philosophy, this book is practical, addressing all the key areas that software professionals need to master in order to remain competitive and minimize costs, such as leadership, management, communication, and organization. This thought-provoking work will change the way students and professionals in computer science and software development conceptualize and perform their work. It provides them with both a philosophy and a set of practical tools to produce high-quality, low-cost software.

Structural Dynamics in Industry focuses on the behavior of structures subjected to a vibrational or shock environment. It takes a systematic approach to the basic concepts in order to enhance the reader's understanding and to allow industrial structures to be covered with the necessary degree of depth. The developments are explained with a minimum of mathematics and are frequently illustrated with simple examples, while numerous industry case studies are also provided.

Single Molecule Spectroscopy is one of the hottest topics in today's chemistry. It brings us close to the the most exciting vision generations of chemists have been dreaming of: To observe and examine single molecules! While most of chemistry deals with myriads of molecules, this books presents the latest developments for the detection and investigation of single entities. Written by internationally renowned authors, it is a thorough and comprehensive survey of current methods and their applications.

Spectral Element Method in Structural Dynamics is a concise and timely introduction to the spectral element method (SEM) as a means of solving problems in structural dynamics, wave propagations, and other related fields. The book consists of three key sections. In the first part, background knowledge is set up for the readers by reviewing previous work in the area and by providing the fundamentals for the spectral analysis of signals. In the second part, the theory of spectral element method is provided, focusing on how to formulate spectral element models and how to conduct spectral element analysis to obtain the dynamic responses in both frequency- and time-domains. In the last part, the applications of SEM to various structural dynamics problems are introduced, including beams, plates, pipelines, axially moving structures, rotor systems, multi-layered structures, smart structures, composite laminated structures, periodic lattice structures, blood flow, structural boundaries, joints, structural damage, and impact forces identifications, as well as the SEM-FEM hybrid method. Presents all aspects of SEM in one volume, both theory and applications Helps students and professionals master associated theories, modeling processes, and analysis methods Demonstrates where and how to apply SEM in practice Introduces real-world examples across a variety of structures Shows how models can be used to evaluate the accuracy of other solution methods Cross-checks against solutions obtained by conventional FEM and other solution methods Comes with downloadable code examples for independent practice Spectral Element Method in Structural Dynamics can be used by graduate students of aeronautical, civil, naval architectures, mechanical, structural and biomechanical engineering. Researchers in universities, technical institutes, and industries will also find the book to be a helpful reference highlighting SEM applications to various engineering problems in areas of structural dynamics, wave propagations, and other related subjects. The book can also be used by students, professors, and researchers who want to learn more efficient and more accurate computational methods useful for their research topics from all areas of engineering, science and mathematics, including the areas of computational mechanics and numerical methods.

This up-to-date review closes an important gap in the literature by providing a comprehensive description of the Mossbauer effect in lattice dynamics, along with a collection of applications in metals, alloys, amorphous solids, molecular crystals, thin films, and nanocrystals. It is the first to systematically compare Mossbauer spectroscopy using synchrotron radiation to conventional Mossbauer spectroscopy, discussing in detail its advantages and capabilities, backed by the latest theoretical developments and experimental examples. Intended as a self-contained volume that may be used as a complete reference or textbook, it adopts new pedagogical approaches with several non-traditional and refreshing theoretical expositions, while all quantitative relations are derived with the necessary details so as to be easily followed by the reader. Two entire chapters are devoted to the study of the dynamics of impurity atoms in solids, while a thorough description of the Mannheim model as a theoretical method is presented and its predictions compared to experimental results. Finally, an in-depth analysis of absorption of Mossbauer radiation is presented, based on recent research by one of the authors, resulting in an exact expression of fractional absorption, otherwise unavailable in the literature. The whole is supplemented by elaborate appendices containing constants and parameters.

This timely book brings readers up to date on the wide range of advances made in fisheries science since the publication in 1957 of On the Dynamics of Exploited Fish Populations (Beverton and Holt), regarded by many fisheries scientists as one of the most important books on fisheries yet published. Traditional fishery subjects covered include historic declines and changes in fishing fleets, fisheries management and stock assessments, data-poor situations, simulation and modelling of fished stocks, fisheries economics, assessing reproductive potential and dispersal of larvae, fisheries for sharks and rays, and use of marine technology. Additionally, related subjects of increasing importance now that ecological approaches to management are coming to the fore are presented. They include benthic ecology, ecosystem changes linked to fishing, life history theory, the effects of chemicals on fish reproduction, and use of sounds in the sea by marine life. Several chapters offer stimulating philosophical discussion of the many controversial areas still existing. This significant book, edited by Andy Payne, John Cotter and Ted Potter and containing contributions by world-renowned fisheries scientists, including many based at Cefas (where Beverton and Holt's original work was carried out) is an essential purchase for fisheries managers and scientists, fish biologists, marine scientists and ecologists. Libraries in all universities and research establishments where fisheries and biological sciences are studied and taught are likely to need copies of this landmark publication.

Forensic Science in Court: The Role of the Expert Witness is a practical handbook aimed at forensic science students, to help them prepare as an expert witness when presenting their evidence in court. Written in a clear, accessible manner, the book guides the student through the legal process and shows them how to handle evidence, write reports without ambiguity through to the more practical aspects of what to do when appearing in court. The book also offers advice on what to expect when working with lawyers in a courtroom situation. An essential text for all students taking forensic science courses who are required to take modules on how to present their evidence in court. The book is also an invaluable reference for any scientist requested to give an opinion in a legal context. · Integrates law and science in an easy to understand format · Inclusion of case studies throughout · Includes straightforward statistics essential for the forensic science student · An invaluable, practical textbook for anyone appearing as an expert witness in court · Unique in its approach aimed at forensic science students in a courtroom environment

Despite of many years of studies, predicting fluid flow, heat, and chemical transport in fractured-porous media remains a challenge for scientists and engineers worldwide. This monograph is the third in a series on the dynamics of fluids and transport in fractured rock published by the American Geophysical Union (Geophysical Monograph Series, Vol. 162, 2005; and Geophysical Monograph, No. 122, 2000). This monograph is dedicated to the late Dr. Paul Witherspoon for his seminal influence on the development of ideas and methodologies and the birth of contemporary fractured rock hydrogeology, including such fundamental and applied problems as environmental remediation; exploitation of oil, gas, and geothermal resources; disposal of spent nuclear fuel; and geotechnical engineering. This monograph addresses fundamental and applied scientific questions and is intended to assist scientists and practitioners bridge gaps in the current scientific knowledge in the areas of theoretical fluids dynamics, field measurements, and experiments for different practical applications. Readers of this book will include researchers, engineers, and professionals within academia, Federal agencies, and industry, as well as graduate/undergraduate students involved in theoretical, experimental, and numerical modeling studies of fluid dynamics and reactive chemical transport in the unsaturated and saturated zones, including studies pertaining to petroleum and geothermal reservoirs, environmental management and remediation, mining, gas storage, and radioactive waste isolation in underground repositories. Volume highlights include discussions of the following: Fundamentals of using a complex systems approach to describe flow and transport in fractured-porous media. Methods of Field Measurements and Experiments Collective behavior and emergent properties of complex fractured rock systems Connection to the surrounding environment Multi-disciplinary research for different applications