Stage-Wise Adaptive Designs

ExpDesign Studio facilitates more efficient clinical trial design This book introduces pharmaceutical statisticians, scientists, researchers, and others to ExpDesign Studio software for classical and adaptive designs of clinical trials. It includes the Professional Version 5.0 of ExpDesign Studio software that frees pharmaceutical professionals to focus on drug development and related challenges while the software handles the essential calculations and computations. After a hands-on introduction to the software and an overview of clinical trial designs encompassing numerous variations, Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio: Covers both classical and adaptive clinical trial designs, monitoring, and analyses Explains various classical and adaptive designs including groupsequential, sample-size reestimation, dropping-loser, biomarker-adaptive, and response-adaptive randomization designs Includes instructions for over 100 design methods that have been implemented in ExpDesign Studio and step-by-step demos as well as real-world examples Emphasizes applications, yet covers key mathematical formulations Introduces readers to additional toolkits in ExpDesign Studio that help in designing, monitoring, and analyzing trials, such as the adaptive monitor, graphical calculator, the probability calculator, the confidence interval calculator, and more Presents comprehensive technique notes for sample-size calculation methods, grouped by the number of arms, the trial endpoint, and the analysis basis Written with practitioners in mind, this is an ideal self-study guide for not only statisticians, but also scientists, researchers, and professionals in the pharmaceutical industry, contract research organizations (CROs), and regulatory bodies. It's also a go-to reference for biostatisticians, pharmacokinetic specialists, and principal investigators involved in clinical trials. ERRATUM Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio By Mark Chang The license for the ExpDesign Studio software on the CD included with this book is good for one-year after installation of the software. Prior to the expiration of this period, the software will generate a reminder about renewal for the license. The user should contact CTriSoft International (the owners of ExpDesign Studio) at www.CTriSoft.net or by email at license@ctrisoft.net, about renewal for the license. This should have been made clear in the first printing of this book. We apologize for this error.

This innovative book sets forth two promising wireless approaches that support high-quality, high-speed data and multimedia service-multiple antenna technologies and cross layer transmitter adaptation designs-while highlighting the relationships and interactions between them. The latest advanced technologies of channel adaptation techniques for wireless communication systems with multiple antennas are thoroughly investigated. The book is divided into three parts, first giving readers a good foundation in underlying theory, then exploring applications as well as advanced topics: * Part 1 examines theoretical aspects of channel adaptation in wireless communications for point-to-point and multi-user systems with multiple antennas * Part 2 focuses on the applications of the channel-adaptive technologies in practical systems such as UMTS * Part 3 delves into topics such as multi-user scheduling for wideband systems, combined queuing theory and information theory, and ad hoc routing Using a hands-on, practical approach, Channel Adaptive Technologies and Cross Layer Designs for Wireless Systems with Multiple Antennas thoroughly covers detailed design considerations that help readers understand how to apply theory to real-world systems. Emphasis throughout the book is on joint optimization across different layers of a communications system based on an integrated approach. Examples of popular wireless systems, such as TDMA, wideband CDMA (UMTS), and HSDPA, are used throughout as practical illustrations. Each chapter ends with a summary that reviews key points and a set of problems that lets readers test their knowledge and continue to develop their skills as they progress to new topics. Figures and tables are also used extensively to help readers visualize complex theory and systems. Combining theory, design, and application into one integrated approach, this is a superior reference for advanced communications theory courses.

Adaptive structures have the ability to adapt, evolve or change their properties or behaviour in response to the environment around them. The analysis and design of adaptive structures requires a highly multi-disciplinary approach which includes elements of structures, materials, dynamics, control, design and inspiration taken from biological systems. Development of adaptive structures has been taking place in a wide range of industrial applications, but is particularly advanced in the aerospace and space technology sector with morphing wings, deployable space structures; piezoelectric devices and vibration control of tall buildings. Bringing together some of the foremost world experts in adaptive structures, this unique text: includes discussions of the application of adaptive structures in the aerospace, military, civil engineering structures, automotive and MEMS. presents the impact of biological inspiration in designing adaptive structures, particularly the use of hierarchy in nature, which typically induces multi-functional behavior. sets the agenda for future research in adaptive structures in one distinctive single volume. Adaptive Structures: Engineering Applications is essential reading for engineers and scientists working in the fields of intelligent materials, structural vibration, control and related smart technologies. It will also be of interest to senior undergraduate and postgraduate research students as well as design engineers working in the aerospace, mechanical, electrical and civil engineering sectors.

This second edition of Adaptive Filters: Theory and Applications has been updated throughout to reflect the latest developments in this field; notably an increased coverage given to the practical applications of the theory to illustrate the much broader range of adaptive filters applications developed in recent years. The book offers an easy to understand approach to the theory and application of adaptive filters by clearly illustrating how the theory explained in the early chapters of the book is modified for the various applications discussed in detail in later chapters. This integrated approach makes the book a valuable resource for graduate students; and the inclusion of more advanced applications including antenna arrays and wireless communications makes it a suitable technical reference for engineers, practitioners and researchers. Key features: • Offers a thorough treatment of the theory of adaptive signal processing; incorporating new material on transform domain, frequency domain, subband adaptive filters, acoustic echo cancellation and active noise control. • Provides an in-depth study of applications which now includes extensive coverage of OFDM, MIMO and smart antennas. • Contains exercises and computer simulation problems at the end of each chapter. • Includes a new companion website hosting MATLAB® simulation programs which complement the theoretical analyses, enabling the reader to gain an in-depth understanding of the behaviours and properties of the various adaptive algorithms.

Adaptive filtering is a topic of immense practical and theoretical value, having applications in areas ranging from digital and wireless communications to biomedical systems. This book enables readers to gain a gradual and solid introduction to the subject, its applications to a variety of topical problems, existing limitations, and extensions of current theories. The book consists of eleven parts?each part containing a series of focused lectures and ending with bibliographic comments, problems, and computer projects with MATLAB solutions.

This is the first book on adaptive aeroservoelasticity and it presents the nonlinear and recursive techniques for adaptively controlling the uncertain aeroelastic dynamics Covers both linear and nonlinear control methods in a comprehensive manner Mathematical presentation of adaptive control concepts is rigorous Several novel applications of adaptive control presented here are not to be found in other literature on the topic Many realistic design examples are covered, ranging from adaptive flutter suppression of wings to the adaptive control of transonic limit-cycle oscillations

Subband adaptive filtering is rapidly becoming one of the most effective techniques for reducing computational complexity and improving the convergence rate of algorithms in adaptive signal processing applications. This book provides an introductory, yet extensive guide on the theory of various subband adaptive filtering techniques. For beginners, the authors discuss the basic principles that underlie the design and implementation of subband adaptive filters. For advanced readers, a comprehensive coverage of recent developments, such as multiband tap–weight adaptation, delayless architectures, and filter–bank design methods for reducing band–edge effects are included. Several analysis techniques and complexity evaluation are also introduced in this book to provide better understanding of subband adaptive filtering. This book bridges the gaps between the mixed–domain natures of subband adaptive filtering techniques and provides enough depth to the material augmented by many MATLAB® functions and examples. Key Features: Acts as a timely introduction for researchers, graduate students and engineers who want to design and deploy subband adaptive filters in their research and applications. Bridges the gaps between two distinct domains: adaptive filter theory and multirate signal processing. Uses a practical approach through MATLAB®-based source programs on the accompanying CD. Includes more than 100 M-files, allowing readers to modify the code for different algorithms and applications and to gain more insight into the theory and concepts of subband adaptive filters. Subband Adaptive Filtering is aimed primarily at practicing engineers, as well as senior undergraduate and graduate students. It will also be of interest to researchers, technical managers, and computer scientists.

Online learning from a signal processing perspective There is increased interest in kernel learning algorithms in neural networks and a growing need for nonlinear adaptive algorithms in advanced signal processing, communications, and controls. Kernel Adaptive Filtering is the first book to present a comprehensive, unifying introduction to online learning algorithms in reproducing kernel Hilbert spaces. Based on research being conducted in the Computational Neuro-Engineering Laboratory at the University of Florida and in the Cognitive Systems Laboratory at McMaster University, Ontario, Canada, this unique resource elevates the adaptive filtering theory to a new level, presenting a new design methodology of nonlinear adaptive filters. Covers the kernel least mean squares algorithm, kernel affine projection algorithms, the kernel recursive least squares algorithm, the theory of Gaussian process regression, and the extended kernel recursive least squares algorithm Presents a powerful model-selection method called maximum marginal likelihood Addresses the principal bottleneck of kernel adaptive filters—their growing structure Features twelve computer-oriented experiments to reinforce the concepts, with MATLAB codes downloadable from the authors' Web site Concludes each chapter with a summary of the state of the art and potential future directions for original research Kernel Adaptive Filtering is ideal for engineers, computer scientists, and graduate students interested in nonlinear adaptive systems for online applications (applications where the data stream arrives one sample at a time and incremental optimal solutions are desirable). It is also a useful guide for those who look for nonlinear adaptive filtering methodologies to solve practical problems.

In the last fifty years, extensive studies have been carried out worldwide in the field of adaptive array systems. However, far from being a mature technology with little research left to tackle, there is seemingly unlimited scope to develop the fundamental characteristics and applications of adaptive antennas for future 3G and 4G mobile communications systems, ultra wideband wireless and satellite and navigation systems, and this informative text shows you how! Provides an accessible resource on adaptive array fundamentals as well as coverage of adaptive algorithms and advanced topics Analyses the performance of various wideband beamforming techniques in wideband array processing Comprehensively covers implementation issues related to such elements as circular arrays, channel modelling and transmit beam forming, highlighting the challenges facing a designer during the development phase Supports practical implementation considerations with detailed case studies on wideband arrays, radar, sonar and biomedical imaging, terrestrial wireless systems and satellite communication systems Includes examples and problems throughout to aid understanding Companion website features Solutions Manual, Matlab Programs and Electronic versions of some figures Adaptive Array Systems is essential reading for senior undergraduate and postgraduate students and researchers in the field of adaptive array systems. It will also have instant appeal to engineers and designers in industry engaged in developing and deploying the technology. This volume will also be invaluable to those working in radar, sonar and bio-medical applications.

The latest research and developments in robust adaptive beamforming Recent work has made great strides toward devising robust adaptive beamformers that vastly improve signal strength against background noise and directional interference. This dynamic technology has diverse applications, including radar, sonar, acoustics, astronomy, seismology, communications, and medical imaging. There are also exciting emerging applications such as smart antennas for wireless communications, handheld ultrasound imaging systems, and directional hearing aids. Robust Adaptive Beamforming compiles the theories and work of leading researchers investigating various approaches in one comprehensive volume. Unlike previous efforts, these pioneering studies are based on theories that use an uncertainty set of the array steering vector. The researchers define their theories, explain their methodologies, and present their conclusions. Methods presented include: * Coupling the standard Capon beamformers with a spherical or ellipsoidal uncertainty set of the array steering vector * Diagonal loading for finite sample size beamforming * Mean-squared error beamforming for signal estimation * Constant modulus beamforming * Robust wideband beamforming using a steered adaptive beamformer to adapt the weight vector within a generalized sidelobe canceller formulation Robust Adaptive Beamforming provides a truly up-to-date resource and reference for engineers, researchers, and graduate students in this promising, rapidly expanding field.