Statistical Advances in the Biomedical Sciences

A collection of articles from the Advances in Biomedical and Biomimetic Materials symposium give insight into advances in biomedical and biomimetic materials. These selected articles cover such topics as scaffolds for tissue engineering, bioceramics, biomimetic materials, nanoparticles for medical diagnosis and treatment, and novel materials for drug delivery and biosensing.

A fascinating chronicle of the lives and achievements of the men and women who helped shapethe science of statistics This handsomely illustrated volume will make enthralling reading for scientists, mathematicians, and science history buffs alike. Spanning nearly four centuries, it chronicles the lives and achievements of more than 110 of the most prominent names in theoretical and applied statistics and probability. From Bernoulli to Markov, Poisson to Wiener, you will find intimate profiles of women and men whose work led to significant advances in the areas of statistical inference and theory, probability theory, government and economic statistics, medical and agricultural statistics, and science and engineering. To help readers arrive at a fuller appreciation of the contributions these pioneers made, the authors vividly re-create the times in which they lived while exploring the major intellectual currents that shaped their thinking and propelled their discoveries. Lavishly illustrated with more than 40 authentic photographs and woodcuts * Includes a comprehensive timetable of statistics from the seventeenth century to the present * Features edited chapters written by 75 experts from around the globe * Designed for easy reference, features a unique numbering scheme that matches the subject profiled with his or her particular field of interest

The new edition adds a chapter on multiple linear regression in biomedical research, with sections including the multiple linear regressions model and least squares; the ANOVA table, parameter estimates, and confidence intervals; partial f-tests; polynomial regression; and analysis of covariance. * Organized by problem rather than method, so it guides readers to the correct technique for solving the problem at hand.

New Edition of a Classic Guide to Statistical Applications in the Biomedical Sciences In the last decade, there have been significant changes in the way statistics is incorporated into biostatistical, medical, and public health research. Addressing the need for a modernized treatment of these statistical applications, Basic Statistics, Fourth Edition presents relevant, up-to-date coverage of research methodology using careful explanations of basic statistics and how they are used to address practical problems that arise in the medical and public health settings. Through concise and easy-to-follow presentations, readers will learn to interpret and examine data by applying common statistical tools, such as sampling, random assignment, and survival analysis. Continuing the tradition of its predecessor, this new edition outlines a thorough discussion of different kinds of studies and guides readers through the important, related decision-making processes such as determining what information is needed and planning the collections process. The book equips readers with the knowledge to carry out these practices by explaining the various types of studies that are commonly conducted in the fields of medical and public health, and how the level of evidence varies depending on the area of research. Data screening and data entry into statistical programs is explained and accompanied by illustrations of statistical analyses and graphs. Additional features of the Fourth Edition include: A new chapter on data collection that outlines the initial steps in planning biomedical and public health studies A new chapter on nonparametric statistics that includes a discussion and application of the Sign test, the Wilcoxon Signed Rank test, and the Wilcoxon Rank Sum test and its relationship to the Mann-Whitney U test An updated introduction to survival analysis that includes the Kaplan Meier method for graphing the survival function and a brief introduction to tests for comparing survival functions Incorporation of modern statistical software, such as SAS, Stata, SPSS, and Minitab into the presented discussion of data analysis Updated references at the end of each chapter Basic Statistics, Fourth Edition is an ideal book for courses on biostatistics, medicine, and public health at the upper-undergraduate and graduate levels. It is also appropriate as a reference for researchers and practitioners who would like to refresh their fundamental understanding of statistical techniques.

A comprehensive account of economic size distributions around the world and throughout the years In the course of the past 100 years, economists and applied statisticians have developed a remarkably diverse variety of income distribution models, yet no single resource convincingly accounts for all of these models, analyzing their strengths and weaknesses, similarities and differences. Statistical Size Distributions in Economics and Actuarial Sciences is the first collection to systematically investigate a wide variety of parametric models that deal with income, wealth, and related notions. Christian Kleiber and Samuel Kotz survey, compliment, compare, and unify all of the disparate models of income distribution, highlighting at times a lack of coordination between them that can result in unnecessary duplication. Considering models from eight languages and all continents, the authors discuss the social and economic implications of each as well as distributions of size of loss in actuarial applications. Specific models covered include: Pareto distributions Lognormal distributions Gamma-type size distributions Beta-type size distributions Miscellaneous size distributions Three appendices provide brief biographies of some of the leading players along with the basic properties of each of the distributions. Actuaries, economists, market researchers, social scientists, and physicists interested in econophysics will find Statistical Size Distributions in Economics and Actuarial Sciences to be a truly one-of-a-kind addition to the professional literature.

Biomedical Sciences is an indispensable, all encompassing core textbook for first/ second year biomedical science students that will support them throughout their undergraduate career. The book includes the key components of the IBMS accredited degree programmes, plus sections on actual practice in UK hospital laboratories (including the compilation of a reflective portfolio). The book is visually exciting, and written in an interesting and accessible manner while maintaining scientific rigour. Highlighted boxes within the text link the theory to actual clinical laboratory practice for example, the histopathology chapter includes a photographically illustrated flow chart of the progress of a specimen through the histopathology lab, so that students can actually see how the specimen reception/inking/cut-up/cassette/block/section/stain system works, with an emphasis on the safety procedures that ensure specimens are not confused).

An updated edition of a classic text on applying statistical analyses to the social sciences, with reviews, new chapters, an expanded set of post-hoc analyses, and information on computing in Excel and SPSS Now in its second edition,Statistical Applications for the Behavioral and Social Sciences has been revised and updated and continues to offer an essential guide to the conceptual foundations of statistical analyses (particularly inferential statistics), placing an emphasis on connecting statistical tools with appropriate research contexts. Designed to be accessible, the text contains an applications-oriented, step-by-step presentation of the statistical theories and formulas most often used by the social sciences. The revised text also includes an entire chapter on the basic concepts in research, presenting an overall context for all the book’s statistical theories and formulas. The authors cover descriptive statistics and z scores, the theoretical underpinnings of inferential statistics, z and t tests, power analysis, one/two-way and repeated-measures ANOVA, linear correlation and regression, as well as chi-square and other nonparametric tests. The second edition also includes a new chapter on basic probability theory. This important resource: • Contains information regarding the use of statistical software packages; both Excel and SPSS • Offers four strategically positioned and accumulating reviews, each containing a set of research-oriented diagnostic questions designed to help students determine which tests are applicable to which research scenarios • Incorporates additional statistical information on follow-up analyses such as post-hoc tests and effect sizes • Includes a series of sidebar discussions dispersed throughout the text that address, among other topics, the recent and growing controversy regarding the failed reproducibility of published findings in the social sciences • Puts renewed emphasis on presentation of data and findings using the APA format • Includes supplementary material consisting of a set of “kick-start” quizzes designed to get students quickly back up to speed at the start of an instructional period, and a complete set of ready-to-use PowerPoint slides for in-class use Written for students in areas such as psychology, sociology, criminology, political science, public health, and others, Statistical Applications for the Behavioral and Social Sciences, Second Edition continues to provide the information needed to understand the foundations of statistical analyses as relevant to the behavioral and social sciences.

This book provides an essential understanding of statistical concepts necessary for the analysis of genomic and proteomic data using computational techniques. The author presents both basic and advanced topics, focusing on those that are relevant to the computational analysis of large data sets in biology. Chapters begin with a description of a statistical concept and a current example from biomedical research, followed by more detailed presentation, discussion of limitations, and problems. The book starts with an introduction to probability and statistics for genome-wide data, and moves into topics such as clustering, classification, multi-dimensional visualization, experimental design, statistical resampling, and statistical network analysis. Clearly explains the use of bioinformatics tools in life sciences research without requiring an advanced background in math/statistics Enables biomedical and life sciences researchers to successfully evaluate the validity of their results and make inferences Enables statistical and quantitative researchers to rapidly learn novel statistical concepts and techniques appropriate for large biological data analysis Carefully revisits frequently used statistical approaches and highlights their limitations in large biological data analysis Offers programming examples and datasets Includes chapter problem sets, a glossary, a list of statistical notations, and appendices with references to background mathematical and technical material Features supplementary materials, including datasets, links, and a statistical package available online Statistical Bioinformatics is an ideal textbook for students in medicine, life sciences, and bioengineering, aimed at researchers who utilize computational tools for the analysis of genomic, proteomic, and many other emerging high-throughput molecular data. It may also serve as a rapid introduction to the bioinformatics science for statistical and computational students and audiences who have not experienced such analysis tasks before.

A one-of-a-kind compilation of modern statistical methods designed to support and advance research across the social sciences Statistics in the Social Sciences: Current Methodological Developments presents new and exciting statistical methodologies to help advance research and data analysis across the many disciplines in the social sciences. Quantitative methods in various subfields, from psychology to economics, are under demand for constant development and refinement. This volume features invited overview papers, as well as original research presented at the Sixth Annual Winemiller Conference: Methodological Developments of Statistics in the Social Sciences, an international meeting that focused on fostering collaboration among mathematical statisticians and social science researchers. The book provides an accessible and insightful look at modern approaches to identifying and describing current, effective methodologies that ultimately add value to various fields of social science research. With contributions from leading international experts on the topic, the book features in-depth coverage of modern quantitative social sciences topics, including: Correlation Structures Structural Equation Models and Recent Extensions Order-Constrained Proximity Matrix Representations Multi-objective and Multi-dimensional Scaling Differences in Bayesian and Non-Bayesian Inference Bootstrap Test of Shape Invariance across Distributions Statistical Software for the Social Sciences Statistics in the Social Sciences: Current Methodological Developments is an excellent supplement for graduate courses on social science statistics in both statistics departments and quantitative social sciences programs. It is also a valuable reference for researchers and practitioners in the fields of psychology, sociology, economics, and market research.

The development and application of multivariate statistical techniques in process monitoring has gained substantial interest over the past two decades in academia and industry alike. Initially developed for monitoring and fault diagnosis in complex systems, such techniques have been refined and applied in various engineering areas, for example mechanical and manufacturing, chemical, electrical and electronic, and power engineering. The recipe for the tremendous interest in multivariate statistical techniques lies in its simplicity and adaptability for developing monitoring applications. In contrast, competitive model, signal or knowledge based techniques showed their potential only whenever cost-benefit economics have justified the required effort in developing applications. Statistical Monitoring of Complex Multivariate Processes presents recent advances in statistics based process monitoring, explaining how these processes can now be used in areas such as mechanical and manufacturing engineering for example, in addition to the traditional chemical industry. This book: Contains a detailed theoretical background of the component technology. Brings together a large body of work to address the field’s drawbacks, and develops methods for their improvement. Details cross-disciplinary utilization, exemplified by examples in chemical, mechanical and manufacturing engineering. Presents real life industrial applications, outlining deficiencies in the methodology and how to address them. Includes numerous examples, tutorial questions and homework assignments in the form of individual and team-based projects, to enhance the learning experience. Features a supplementary website including Matlab algorithms and data sets. This book provides a timely reference text to the rapidly evolving area of multivariate statistical analysis for academics, advanced level students, and practitioners alike.