Statistical Diagnostics for Cancer. Analyzing High-Dimensional Data

Amstat News asked three review editors to rate their top five favorite books in the September 2003 issue. Statistical Methods for Reliability Data was among those chosen. Bringing statistical methods for reliability testing in line with the computer age This volume presents state-of-the-art, computer-based statistical methods for reliability data analysis and test planning for industrial products. Statistical Methods for Reliability Data updates and improves established techniques as it demonstrates how to apply the new graphical, numerical, or simulation-based methods to a broad range of models encountered in reliability data analysis. It includes methods for planning reliability studies and analyzing degradation data, simulation methods used to complement large-sample asymptotic theory, general likelihood-based methods of handling arbitrarily censored data and truncated data, and more. In this book, engineers and statisticians in industry and academia will find: A wealth of information and procedures developed to give products a competitive edge Simple examples of data analysis computed with the S-PLUS system-for which a suite of functions and commands is available over the Internet End-of-chapter, real-data exercise sets Hundreds of computer graphics illustrating data, results of analyses, and technical concepts An essential resource for practitioners involved in product reliability and design decisions, Statistical Methods for Reliability Data is also an excellent textbook for on-the-job training courses, and for university courses on applied reliability data analysis at the graduate level. An Instructor's Manual presenting detailed solutions to all the problems in the book is available upon requestfrom the Wiley editorial department.

Environmental statistics is a rapidly growing field, supported by advances in digital computing power, automated data collection systems, and interactive, linkable Internet software. Concerns over public and ecological health and the continuing need to support environmental policy-making and regulation have driven a concurrent explosion in environmental data analysis. This textbook is designed to address the need for trained professionals in this area. The book is based on a course which the authors have taught for many years, and prepares students for careers in environmental analysis centered on statistics and allied quantitative methods of data evaluation. The text extends beyond the introductory level, allowing students and environmental science practitioners to develop the expertise to design and perform sophisticated environmental data analyses. In particular, it: Provides a coherent introduction to intermediate and advanced methods for modeling and analyzing environmental data. Takes a data-oriented approach to describing the various methods. Illustrates the methods with real-world examples Features extensive exercises, enabling use as a course text. Includes examples of SAS computer code for implementation of the statistical methods. Connects to a Web site featuring solutions to exercises, extra computer code, and additional material. Serves as an overview of methods for analyzing environmental data, enabling use as a reference text for environmental science professionals. Graduate students of statistics studying environmental data analysis will find this invaluable as will practicing data analysts and environmental scientists including specialists in atmospheric science, biology and biomedicine, chemistry, ecology, environmental health, geography, and geology.

Statistical data are not always precise numbers, or vectors, or categories. Real data are frequently what is called fuzzy. Examples where this fuzziness is obvious are quality of life data, environmental, biological, medical, sociological and economics data. Also the results of measurements can be best described by using fuzzy numbers and fuzzy vectors respectively. Statistical analysis methods have to be adapted for the analysis of fuzzy data. In this book, the foundations of the description of fuzzy data are explained, including methods on how to obtain the characterizing function of fuzzy measurement results. Furthermore, statistical methods are then generalized to the analysis of fuzzy data and fuzzy a-priori information. Key Features: Provides basic methods for the mathematical description of fuzzy data, as well as statistical methods that can be used to analyze fuzzy data. Describes methods of increasing importance with applications in areas such as environmental statistics and social science. Complements the theory with exercises and solutions and is illustrated throughout with diagrams and examples. Explores areas such quantitative description of data uncertainty and mathematical description of fuzzy data. This work is aimed at statisticians working with fuzzy logic, engineering statisticians, finance researchers, and environmental statisticians. It is written for readers who are familiar with elementary stochastic models and basic statistical methods.

Authored by an international authority in the field,Cancer Diagnostics with DNA Microarrays is a complete reference work on the rapidly growing use of DNA microarray data in the diagnosis of and treatment planning for a large number of human cancers. Uniquely deals with direct clinical application of microarray data to oncology diagnosis, leading to more effective diagnosis of and clearer treatment regimens for a wide range of human cancers Offers clinicians summary presentation of state-of-the-art science of DNA microarrays Each chapter includes bibliographic and further reading suggestions Easily accessible, assuming no special training in statistics or bioinformatics Replete with examples and mini-cases, Cancer Diagnostics with DNA Microarrays offers cancer researchers in private, pharmacologic, and governmental institutions, biomedical statisticians, and practicing oncologists concise, thoughtfully authored guidance on the use of microarray data and analysis as clinical tools. The text carefully addresses the needs of end users – researchers and physicians – using microarrays as a tool to be applied in common clinical situations, and is of interest for students in medicine and biology and professionals in health care as well.

Praise for the Third Edition “. . . an easy-to read introduction to survival analysis which covers the major concepts and techniques of the subject.” —Statistics in Medical Research Updated and expanded to reflect the latest developments, Statistical Methods for Survival Data Analysis, Fourth Edition continues to deliver a comprehensive introduction to the most commonly-used methods for analyzing survival data. Authored by a uniquely well-qualified author team, the Fourth Edition is a critically acclaimed guide to statistical methods with applications in clinical trials, epidemiology, areas of business, and the social sciences. The book features many real-world examples to illustrate applications within these various fields, although special consideration is given to the study of survival data in biomedical sciences. Emphasizing the latest research and providing the most up-to-date information regarding software applications in the field, Statistical Methods for Survival Data Analysis, Fourth Edition also includes: Marginal and random effect models for analyzing correlated censored or uncensored data Multiple types of two-sample and K-sample comparison analysis Updated treatment of parametric methods for regression model fitting with a new focus on accelerated failure time models Expanded coverage of the Cox proportional hazards model Exercises at the end of each chapter to deepen knowledge of the presented material Statistical Methods for Survival Data Analysis is an ideal text for upper-undergraduate and graduate-level courses on survival data analysis. The book is also an excellent resource for biomedical investigators, statisticians, and epidemiologists, as well as researchers in every field in which the analysis of survival data plays a role.

A user-friendly, hands-on guide to recognizing and conducting proper research techniques in data collection Offering a unique approach to numerical research methods, Analyzing Quantitative Data: An Introduction for Social Researchers presents readers with the necessary statistical applications for carrying out the key phases of conducting and evaluating a research project. The book guides readers through the steps of data analysis, from organizing raw data to utilizing descriptive statistics and tests of significance, drawing valid conclusions, and writing research reports. The author successfully provides a presentation that is accessible and hands-on rather than heavily theoretical, outlining the key quantitative processes and the use of software to successfully draw valid conclusions from gathered data. In its discussion of methods for organizing data, the book includes suggestions for coding and entry into spreadsheets or databases while also introducing commonly used descriptive statistics and clarifying their roles in data analysis. Next, inferential statistics is explored in-depth with explanations of and instructions for performing chi-square tests, t-tests, analyses of variance, correlation and regression analyses, and a number of advanced statistical procedures. Each chapter contains explanations of when to use the tests described, relevant formulas, and sample computations. The book concludes with guidance on extracting meaningful conclusions from statistical tests and writing research reports that describe procedures and analyses. Throughout the book, Statistical Resources for SPSS® sections provide fundamental instruction for using SPSS® to obtain the results presented. Where necessary, the author provides basic theoretical explanations for distributions and background information regarding formulas. Each chapter concludes with practice problems, and a related website features derivations of the book's formulas along with additional resources for performing the discussed processes. Analyzing Quantitative Data is an excellent book for social sciences courses on data analysis and research methods at the upper-undergraduate and graduate levels. It also serves as a valuable reference for applied statisticians and practitioners working in the fields of education, medicine, business and public service who analyze, interpret, and evaluate data in their daily work.

Praise for the First Edition «An indispensable addition to any serious collection on lifetime data analysis and . . . a valuable contribution to the statistical literature. Highly recommended . . .» -Choice «This is an important book, which will appeal to statisticians working on survival analysis problems.» -Biometrics «A thorough, unified treatment of statistical models and methods used in the analysis of lifetime data . . . this is a highly competent and agreeable statistical textbook.» -Statistics in Medicine The statistical analysis of lifetime or response time data is a key tool in engineering, medicine, and many other scientific and technological areas. This book provides a unified treatment of the models and statistical methods used to analyze lifetime data. Equally useful as a reference for individuals interested in the analysis of lifetime data and as a text for advanced students, Statistical Models and Methods for Lifetime Data, Second Edition provides broad coverage of the area without concentrating on any single field of application. Extensive illustrations and examples drawn from engineering and the biomedical sciences provide readers with a clear understanding of key concepts. New and expanded coverage in this edition includes: * Observation schemes for lifetime data * Multiple failure modes * Counting process-martingale tools * Both special lifetime data and general optimization software * Mixture models * Treatment of interval-censored and truncated data * Multivariate lifetimes and event history models * Resampling and simulation methodology

A comprehensive introduction to statistical methods for data mining and knowledge discovery. Applications of data mining and ‘big data’ increasingly take center stage in our modern, knowledge-driven society, supported by advances in computing power, automated data acquisition, social media development and interactive, linkable internet software. This book presents a coherent, technical introduction to modern statistical learning and analytics, starting from the core foundations of statistics and probability. It includes an overview of probability and statistical distributions, basics of data manipulation and visualization, and the central components of standard statistical inferences. The majority of the text extends beyond these introductory topics, however, to supervised learning in linear regression, generalized linear models, and classification analytics. Finally, unsupervised learning via dimension reduction, cluster analysis, and market basket analysis are introduced. Extensive examples using actual data (with sample R programming code) are provided, illustrating diverse informatic sources in genomics, biomedicine, ecological remote sensing, astronomy, socioeconomics, marketing, advertising and finance, among many others. Statistical Data Analytics: Focuses on methods critically used in data mining and statistical informatics. Coherently describes the methods at an introductory level, with extensions to selected intermediate and advanced techniques. Provides informative, technical details for the highlighted methods. Employs the open-source R language as the computational vehicle – along with its burgeoning collection of online packages – to illustrate many of the analyses contained in the book. Concludes each chapter with a range of interesting and challenging homework exercises using actual data from a variety of informatic application areas. This book will appeal as a classroom or training text to intermediate and advanced undergraduates, and to beginning graduate students, with sufficient background in calculus and matrix algebra. It will also serve as a source-book on the foundations of statistical informatics and data analytics to practitioners who regularly apply statistical learning to their modern data.

A multi-discipline, hands-on guide to microarray analysis of biological processes Analyzing Microarray Gene Expression Data provides a comprehensive review of available methodologies for the analysis of data derived from the latest DNA microarray technologies. Designed for biostatisticians entering the field of microarray analysis as well as biologists seeking to more effectively analyze their own experimental data, the text features a unique interdisciplinary approach and a combined academic and practical perspective that offers readers the most complete and applied coverage of the subject matter to date. Following a basic overview of the biological and technical principles behind microarray experimentation, the text provides a look at some of the most effective tools and procedures for achieving optimum reliability and reproducibility of research results, including: An in-depth account of the detection of genes that are differentially expressed across a number of classes of tissues Extensive coverage of both cluster analysis and discriminant analysis of microarray data and the growing applications of both methodologies A model-based approach to cluster analysis, with emphasis on the use of the EMMIX-GENE procedure for the clustering of tissue samples The latest data cleaning and normalization procedures The uses of microarray expression data for providing important prognostic information on the outcome of disease