The Innovative Company

Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery

This book helps you find innovative new technology ideas and guides you through the complete lifecycle of product innovation, including screening, funding, development, and commercialization. It gives you an edge by enabling you to start off with a solid foundation and strategy. Commercialization of Innovative Technologies focuses on three core areas that set the stage for successful commercialization: Developing and managing a strong, flexible «innovation team» of inventors, investors, technologists, and entrepreneurs; building a portfolio that spreads risk; leveraging input from technologists throughout the commercialization process.

Atrial fibrillation is underdiagnosed and preventative strategies are underutilized. The disease is estimated to rise to an epidemic level, increasing by over 50% by the end of the decade, occurring commonly in the setting of otherwise “healthy” aging. Innovative Management of Atrial Fibrillation provides a forum for a full discussion on this topical matter. Distinguished experts from both electrophysiology and cardiac surgery place their work in the context of future development, examining the short-comings of current pharmacological treatments. This results in a unique, comprehensive review for cardiologists, cardiac surgeons and anyone who wishes to gain a complete perspective on the fast-paced field of atrial fibrillation. Material ranges from atrial pathophysiology to advanced minimally invasive surgical ablation and cutting edge palliative and curative therapeutic options. The book also includes the examination of innovative management strategies and the next generation of therapies, giving an essential insight into the emerging potential of gene therapy.

Freight transport faces a dual challenge: it must satisfy the demands of globalized trade and meet environmental requirements. In this context, innovation is a crucial topic to enable the transition from the current transportation and logistics system to a sustainable system. This book provides an overview of the latest technological innovations in Europe and worldwide, based on ICT and new vehicle concepts, for all modes and all scales (urban, regional, national or international). The authors consider innovation supply, the process of innovation and innovative business models. Some perspectives and solutions are proposed on the deployment of innovation, specifically concerning the transformation of the organization of the system and the relationships between industry, governmental players, operators and users.

An in-depth look at new and emerging technologies for non-alcoholic beverage manufacturing The non-alcoholic beverage market is the fastest growing segment of the functional food industry worldwide. Consistent with beverage consumption trends generally, the demand among consumers of these products is for high-nutrient drinks made from natural, healthy ingredients, free of synthetic preservatives and artificial flavor and color enhancers. Such drinks require specialized knowledge of exotic ingredients, novel processing techniques, and various functional ingredients. The latest addition to the critically acclaimed IFST Advances in Food Science series this book brings together edited contributions from internationally recognized experts in their fields who offer insights and analysis of the latest developments in non-alcoholic beverage manufacture. Topics covered include juices made from pome fruits, citrus fruits, prunus fruits, vegetables, exotic fruits, berries, juice blends and non-alcoholic beverages, including grain-based beverages, soups and functional beverages. Waste and by-products generated in juice and non-alcoholic beverage sector are also addressed. Offers fresh insight and analysis of the latest developments in non-alcoholic beverage manufacture from leading international experts Covers all product segments of the non-alcoholic beverage market, including juices, vegetable blends, grain-based drinks, and alternative beverages Details novel thermal and non-thermal technologies that ensure high-quality nutrient retention while extending product shelf life Written with the full support of The Institute of Food Science and Technology (IFST), the leading qualifying body for food professionals in Europe Innovative Technologies in Beverage Processing is a valuable reference/working resource for food scientists and engineers working in the non-alcoholic beverage industry, as well as academic researchers in industrial food processing and nutrition.

At a time when people use more and more geographic information and tools, the management of geographical information in software systems still holds many challenges and motivates researchers from different backgrounds to propose innovative solutions. Representing geographical space beyond our mere perception is key to making relevant decisions, whether it is with respect to sustainable development or to the planning of everyday activities. Designing, sharing and exploiting such representations entails many challenges. This book presents recent software design projects, led in teams, which sometimes have different backgrounds, to address these challenges. It analyzes the specificities of these projects in terms of motivation, data models and analysis methods. Proposals are also put forward to improve resource sharing in this domain. Contents 1. Introduction, B?n?dicte Bucher and Florence Le Ber. Part 1. Software Presentation 2. ORBISGIS: Geographical Information System Designed by and for Research, Erwan Bocher and Gwendall Petit. 3. GEOXYGENE: an Interoperable Platform for Geographical Application Development, ?ric Grosso, Julien Perret and Micka?l Brasebin. 4. Spatiotemporal Knowledge Representation in AROM-ST, Bogdan Moisuc, Alina Miron, Marl?ne Villanova-Olivier and J?r?me Gensel. 5. GENGHIS: an Environment for the Generation of Spatiotemporal Visualization Interfaces, Paule-Annick Davoine, Bogdan Moisuc and J?r?me Gensel. 6. GEOLIS: a Logical Information System to Organize and Search Geo-Located Data, Olivier Bedel, S?bastien Ferr? and Olivier Ridoux. 7. GENEXP-LANDSITES: a 2D Agricultural Landscape Generating Piece of Software, Florence Le Ber and Jean-Fran?ois Mari. 8. MDWEB: Cataloging and Locating Environmental Resources, Jean-Christophe Desconnets and Th?r?se Libourel. 9. WEBGEN: Web Services to Share Cartographic Generalization Tools, Moritz Neun, Nicolas Regnauld and Robert Weibel. Part 2. Summary and Suggestions 10. Analysis of the Specificities of Software Development in Geomatics Research, Florence Le Ber and B?n?dicte Bucher. 11. Challenges and Proposals for Software Development Pooling in Geomatics, B?n?dicte Bucher, Julien Gaffuri, Florence Le Ber and Th?r?se Libourel.

THE DIFFERENT COMPANY Парфюмерная вода Pure eVe 50.0 Парфюмерия

The status of knowledge management (KM) as a mature science has long been recognized in the academic world. However, in the economic arena, its connection with companies and organizations has been more gradual. Jean-Louis Ermine established a theoretical and practical framework for KM in his book, Knowledge Management: The Creative Loop – issued by the same publishers as this book. In this latest tome, practical examples are illustrated with real case studies. Modeled on the four-step operational approach inspired by the creative loop, this book includes four sets of real case studies – each one following the basic presentation of the fundamental material per step. Knowledge Management in Innovative Companies 1 is especially useful for practitioners, as there are numerous illustrations based on best practices for each specific KM step and for global project implementation. Indeed, the last chapter is dedicated to the implementation of a global KM corporate project.

The status of knowledge management (KM) as a mature science has long been recognized in the academic world. However, in the economic arena, its connection with companies and organizations has been more gradual. Jean-Louis Ermine established a theoretical and practical framework for KM in Knowledge Management: The Creative Loop, which was also published by Wiley. In this second volume, practical examples are illustrated with real case studies. Modeled on the four-step operational approach inspired by the creative loop, this book includes four sets of real case studies – each one following the basic presentation of the fundamental material. Knowledge Management in Innovative Companies 2 is especially useful for practitioners, as there are numerous illustrations based on best practices for each specific KM step and for global project implementation. Indeed, the last chapter is dedicated to the implementation of a global KM corporate project.