Toxicology and Risk Assessment. A Comprehensive Introduction

This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks at given exposures. With this basic understanding the reader also will be able to critically evaluate the available information on a chemical and to identify data gaps. In addition to the introductory chapters the book will offer the following systematic information, presented in six special sections: Principles in Toxicology Organ Toxicology Methods in Toxicology Risk Assessment Risk Management Toxicity of Chemicals Fulfilling a demand for such a book, this will be a welcomed introductory text for students and non-experts alike to focus on and understand the principles of hazard identification and risk assessment of toxicants. Relevant to all those studying toxicology, biochemistry, biology, medicine and chemistry, as well as toxicologists in hospitals, universities and in industry.

Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning … especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author’s training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.

Human and Ecological Risk Assessment: Theory and Practice assembles the expertise of more than fifty authorities from fifteen different fields, forming a comprehensive reference and textbook on risk assessment. Containing two dozen case studies of environmental or human health risk assessments, the text not only presents the theoretical underpinnings of the discipline, but also serves as a complete handbook and «how-to» guide for individuals conducting or interpreting risk assessments. In addition, more than 4,000 published papers and books in the field are cited. Editor Dennis Paustenbach has assembled chapters that present the most current methods for conducting hazard identification, dose-response and exposure assessment, and risk characterization components for risk assessments of any chemical hazard to humans or wildlife (fish, birds, and terrestrials). Topics addressed include hazards posed by: Air emissions Radiological hazards Contaminated soil and foods Agricultural hazards Occupational hazards Consumer products and water Hazardous waste sites Contaminated air and water The bringing together of so many of the world's authorities on these topics, plus the comprehensive nature of the text, promises to make Human and Ecological Risk Assessment the text against which others will be measured in the coming years.

Presents systems-based theory, methodology, and applications in risk modeling, assessment, and management This book examines risk analysis, focusing on quantifying risk and constructing probabilities for real-world decision-making, including engineering, design, technology, institutions, organizations, and policy. The author presents fundamental concepts (hierarchical holographic modeling; state space; decision analysis; multi-objective trade-off analysis) as well as advanced material (extreme events and the partitioned multi-objective risk method; multi-objective decision trees; multi-objective risk impact analysis method; guiding principles in risk analysis); avoids higher mathematics whenever possible; and reinforces the material with examples and case studies. The book will be used in systems engineering, enterprise risk management, engineering management, industrial engineering, civil engineering, and operations research. The fourth edition of Risk Modeling, Assessment, and Management features: Expanded chapters on systems-based guiding principles for risk modeling, planning, assessment, management, and communication; modeling interdependent and interconnected complex systems of systems with phantom system models; and hierarchical holographic modeling An expanded appendix including a Bayesian analysis for the prediction of chemical carcinogenicity, and the Farmer’s Dilemma formulated and solved using a deterministic linear model Updated case studies including a new case study on sequential Pareto-optimal decisions for emergent complex systems of systems A new companion website with over 200 solved exercises that feature risk analysis theories, methodologies, and application Risk Modeling, Assessment, and Management, Fourth Edition, is written for both undergraduate and graduate students in systems engineering and systems management courses. The text also serves as a resource for academic, industry, and government professionals in the fields of homeland and cyber security, healthcare, physical infrastructure systems, engineering, business, and more.

An introduction to risk assessment that utilizes key theory and state-of-the-art applications With its balanced coverage of theory and applications along with standards and regulations, Risk Assessment: Theory, Methods, and Applications serves as a comprehensive introduction to the topic. The book serves as a practical guide to current risk analysis and risk assessment, emphasizing the possibility of sudden, major accidents across various areas of practice from machinery and manufacturing processes to nuclear power plants and transportation systems. The author applies a uniform framework to the discussion of each method, setting forth clear objectives and descriptions, while also shedding light on applications, essential resources, and advantages and disadvantages. Following an introduction that provides an overview of risk assessment, the book is organized into two sections that outline key theory, methods, and applications. Introduction to Risk Assessment defines key concepts and details the steps of a thorough risk assessment along with the necessary quantitative risk measures. Chapters outline the overall risk assessment process, and a discussion of accident models and accident causation offers readers new insights into how and why accidents occur to help them make better assessments. Risk Assessment Methods and Applications carefully describes the most relevant methods for risk assessment, including preliminary hazard analysis, HAZOP, fault tree analysis, and event tree analysis. Here, each method is accompanied by a self-contained description as well as workflow diagrams and worksheets that illustrate the use of discussed techniques. Important problem areas in risk assessment, such as barriers and barrier analysis, human errors, and human reliability, are discussed along with uncertainty and sensitivity analysis. Each chapter concludes with a listing of resources for further study of the topic, and detailed appendices outline main results from probability and statistics, related formulas, and a listing of key terms used in risk assessment. A related website features problems that allow readers to test their comprehension of the presented material and supplemental slides to facilitate the learning process. Risk Assessment is an excellent book for courses on risk analysis and risk assessment at the upper-undergraduate and graduate levels. It also serves as a valuable reference for engineers, researchers, consultants, and practitioners who use risk assessment techniques in their everyday work.

Introduces risk assessment with key theories, proven methods, and state-of-the-art applications Risk Assessment: Theory, Methods, and Applications  remains one of the few textbooks to address current risk analysis and risk assessment with an emphasis on the possibility of sudden, major accidents across various areas of practice—from machinery and manufacturing processes to nuclear power plants and transportation systems. Updated to align with ISO 31000 and other amended standards, this all-new  2nd Edition  discusses the main ideas and techniques for assessing risk today. The book begins with an introduction of risk analysis, assessment, and management, and includes a new section on the history of risk analysis. It covers hazards and threats, how to measure and evaluate risk, and risk management. It also adds new sections on risk governance and risk-informed decision making; combining accident theories and criteria for evaluating data sources; and subjective probabilities. The risk assessment process is covered, as are how to establish context; planning and preparing; and identification, analysis, and evaluation of risk.  Risk Assessment  also offers new coverage of safe job analysis and semi-quantitative methods, and it discusses barrier management and HRA methods for offshore application. Finally, it looks at dynamic risk analysis, security and life-cycle use of risk.  Serves as a practical and modern guide to the current applications of risk analysis and assessment, supports key standards, and supplements legislation related to risk analysis Updated and revised to align with ISO 31000 Risk Management and other new standards and includes new chapters on security, dynamic risk analysis, as well as life-cycle use of risk analysis Provides in-depth coverage on hazard identification, methodologically outlining the steps for use of checklists, conducting preliminary hazard analysis, and job safety analysis Presents new coverage on the history of risk analysis, criteria for evaluating data sources, risk-informed decision making, subjective probabilities, semi-quantitative methods, and barrier management Contains more applications and examples, new and revised problems throughout, and detailed appendices that outline key terms and acronyms Supplemented with a book companion website containing Solutions to problems, presentation material and an Instructor Manual Risk Assessment: Theory, Methods, and Applications, Second Edition  is ideal for courses on risk analysis/risk assessment and systems engineering at the upper-undergraduate and graduate levels. It is also an excellent reference and resource for engineers, researchers, consultants, and practitioners who carry out risk assessment techniques in their everyday work.

Risk Assessment Explore the fundamentals of risk assessment with references to the latest standards, methodologies, and approaches The Second Edition of Risk Assessment: A Practical Guide to Assessing Operational Risks delivers a practical exploration of a wide array of risk assessment tools in the contexts of preliminary hazard analysis, job safety analysis, task analysis, job risk assessment, personnel protective equipment hazard assessment, failure mode and effect analysis, and more. The distinguished authors discuss the latest standards, theories, and methodologies covering the fundamentals of risk assessments, as well as their practical applications for safety, health, and environmental professionals with risk assessment responsibilities. “What If”/Checklist Analysis Methods are included for additional guidance. Now in full color, the book includes interactive exercises, links, videos, and online risk assessment tools that can be immediately applied by working practitioners. The authors have also included: Material that reflects the latest updates to ISO standards, the ASSP Technical Report, and the ANSI Z590.3 Prevention through Design standard New hazard phrases for chemical hazards in the Globally Harmonized System, as well as NIOSH’s new occupational exposure banding tool The new risk-based approach featured in the NAVY IH Field Manual New chapters covering business continuity, causal factors analysis, and layers of protection analysis and barrier analysis An indispensable resource for employed safety professionals in a variety of industries, business leaders and staff personnel with safety responsibilities, and environmental engineers Risk Assessment: A Practical Guide to Assessing Operational Risks is also useful for students in safety, health, and environmental science courses.

Exciting new developments in risk assessment and management Risk assessment and management is fundamentally founded on the knowledge available on the system or process under consideration. While this may be self-evident to the laymen, thought leaders within the risk community have come to recognize and emphasize the need to explicitly incorporate knowledge (K) in a systematic, rigorous, and transparent framework for describing and modeling risk. Featuring contributions by an international team of researchers and respected practitioners in the field, this book explores the latest developments in the ongoing effort to use risk assessment as a means for characterizing knowledge and/or lack of knowledge about a system or process of interest. By offering a fresh perspective on risk assessment and management, the book represents a significant contribution to the development of a sturdier foundation for the practice of risk assessment and for risk-informed decision making. How should K be described and evaluated in risk assessment? How can it be reflected and taken into account in formulating risk management strategies? With the help of numerous case studies and real-world examples, this book answers these and other critical questions at the heart of modern risk assessment, while identifying many practical challenges associated with this explicit framework. This book, written by international scholars and leaders in the field, and edited to make coverage both conceptually advanced and highly accessible: Offers a systematic, rigorous and transparent perspective and framework on risk assessment and management, explicitly strengthening the links between knowledge and risk Clearly and concisely introduces the key risk concepts at the foundation of risk assessment and management Features numerous cases and real-world examples, many of which focused on various engineering applications across an array of industries Knowledge of Risk Assessment and Management is a must-read for risk assessment and management professionals, as well as graduate students, researchers and educators in the field. It is also of interest to policy makers and business people who are eager to gain a better understanding of the foundations and boundaries of risk assessment, and how its outcomes should be used for decision-making.

An important guide to assessing and managing the environment from a landscape perspective Ecological relationships are nested within the landscape. Identifying the relevant spatial and temporal scales is critical for an effective understanding of ecological functions that human societies depend upon. Moreover, human encroachment into natural areas, or changes in climate, can alter spatial relationships, which in turn can negatively affect vital plant and wildlife patterns—and weaken economic structures needed to sustain human societies. This book is the first to combine multiple disciplines into one cohesive strategy to study these crucial connections, and looks toward building a social paradigm that embraces the dynamics of ecological systems. This book: Integrates landscape ecology, environmental risk assessment, valuation of ecological goods and services, and environmental management decision processes into one single source Includes chapters on quantitative measures, Bayesian modeling,?economic analysis, and sustainable landscapes Covers marine, forest, agricultural, and pharmaceutical risk assessment Has a chapter on predicting climate change risk to ecosystems Has a companion ftp site with color graphics, animations, and risk assessment tools With material that is accessible across all knowledge levels, Environmental Risk Assessment and Management from a Landscape Perspective moves beyond looking solely at chemical contaminants to diagnose environmental threats, and aims to accomplish practical risk assessment in a manner that supports long-term sustainable management.

This book integrates the physical processes of dam breaching and the mathematical aspects of risk assessment in a concise manner • The first book that introduces the causes, processes and consequences of dam failures • Integrates the physical processes of dam breaching and the mathematical aspects of risk assessment in a concise manner • Emphasizes integrating theory and practice to better demonstrate the application of risk assessment and decision methodologies to real cases • Intends to formulate dam-breaching emergency management steps in a scientific structure