Transcription Factors in the Nervous System

The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: Transcription factors and the megakaryocytic, myeloid, and erythroid lineages Leukemias due to chromosomal translocations involving gene encoding transcription factors Oncogenesis and hematopoiesis In vivo studies of transcription factors implicated in hematopoiesis And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.

Covers all aspects of the structure, function, neurochemistry, transmitter identification and development of the enteric nervous system This book brings together extensive knowledge of the structure and cell physiology of the enteric nervous system and provides an up-to-date synthesis of the roles of the enteric nervous system in the control of motility, secretion and blood supply in the gastrointestinal tract. It includes sections on the enteric nervous system in disease, genetic abnormalities that affect enteric nervous system function, and targets for therapy in the enteric nervous system. It also includes many newly created explanatory diagrams and illustrations of the organization of enteric nerve circuits. This new book is ideal for gastroenterologists (including trainees/fellows), clinical physiologists and educators. It is invaluable for the many scientists in academia, research institutes and industry who have been drawn to work on the gastrointestinal innervation because of its intrinsic interest, its economic importance and its involvement in unsolved health problems. It also provides a valuable resource for undergraduate and graduate teaching.

Over the last few years there have been huge advances made in our understanding of the interactions between the brain and the gut – the enteric nervous system. This book is particularly relevant in the understanding, diagnosis and management of irritable bowel syndrome – the most common functional disorder of the bowel. IBS has been diagnosed in 10-20% of adults in the US, and symptoms of IBS are responsible for more than 3 million visits to the physician in the US. This book is aimed at specialist gastroenterologists but also should be of interest for trainees and fellows in gastroenterology, as well as PCPs and GPs with an interest in this subject.

The first book-length reference to thoroughly describe diagnostic and therapeutic advances in the development of vascular radiology over the last decade The last ten years has seen vascular imaging of the central nervous system (CNS) evolve from fairly crude, invasive procedures to more advanced imaging methods that are safer, faster, and more precise—with computed tomographic (CT) and magnetic resonance (MR) imaging methods playing a special role in these advances. Vascular Imaging of the Central Nervous System is the first full-length reference text that shows radiologists—especially neuroradiologists—how to optimize the use of the many techniques available in order to increase the sensitivity and specificity of vascular imaging, thereby improving the diagnosis and treatment of individual patients. Each chapter is formatted carefully and divided into two essential parts: The first part describes the physical principles underlying each imaging technique, along potential associated artifacts and pitfalls; the second part addresses clinical applications and novel applications of each method. With a strong focus on the clinical application of each modality or technique in CNS radiology, this book provides in-depth chapter coverage of: • Ultrasound Vascular Imaging (UVI) • Computed Tomography Angiography (CTA) • Magnetic Resonance Vascular imaging (MRV) • Digital subtraction angiography (DSA) • Brain perfusion techniques: CT and MRI • Plaque imaging • Intravascular imaging • Pediatric vascular imaging Along with numerous illustrations and case studies, Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications, and Emerging Techniques is an important book for those faced with choosing from the wide range of choices available for clinical practice.

The term «unconventional virus» refers to virus-like agents that differ from conventional viruses in significant respects–resistance to agents that inactivate normal viruses, for example. Certain rare and fatal neurological disorders, such as the Creutzfeldt-Jacob syndrome and the Gerstmann-Straussler syndrome, are clearly produced by virus-like infectious agents, but the nature of these agents is not understood. This volume brings together the latest information on one such disease: Scrapie, a disease occurring in sheep. It discusses the nature of this infectious agent and insights gained through new techniques in molecular genetics. The work as a whole focuses on the implications of animal data for research on human disorders, such as the possible connection between unconventional viruses and Alzheimer's Disease. The discussions represent the work of specialists from a broad spectrum of fields including virology, neuropathology, and molecular biology.

All magnetized planets in our solar system (Mercury, Earth, Jupiter, Saturn, Uranus, and Neptune) interact strongly with the solar wind and possess well developed magnetotails. It is not only the strongly magnetized planets that have magnetotails. Mars and Venus have no global intrinsic magnetic field, yet they possess induced magnetotails. Comets have magnetotails that are formed by the draping of the interplanetary magnetic field. In the case of planetary satellites (moons), the magnetotail refers to the wake region behind the satellite in the flow of either the solar wind or the magnetosphere of its parent planet. The largest magnetotail of all in our solar system is the heliotail, the “magnetotail” of the heliosphere. The variety of solar wind conditions, planetary rotation rates, ionospheric conductivity, and physical dimensions provide an outstanding opportunity to extend our understanding of the influence of these factors on magnetotail processes and structures. Volume highlights include: Discussion on why a magnetotail is a fundamental problem of magnetospheric physics Unique collection of tutorials on a large range of magnetotails in our solar system In-depth reviews comparing magnetotail processes at Earth with other magnetotail structures found throughout the heliosphere Collectively, Magnetotails in the Solar System brings together for the first time in one book a collection of tutorials and current developments addressing different types of magnetotails. As a result, this book should appeal to a broad community of space scientists, and it should also be of interest to astronomers who are looking at tail-like structures beyond our solar system.

Complexity is an intrinsic property of natural systems. In the oceanic system, it is linked to many interactions with the atmosphere, geosphere and biosphere with which it exchanges energy and matter. Complexity of the ocean system has, at different spatial and temporal scales, hydrodynamic mechanisms of these exchanges and dynamics of elements and compounds, they are involved in biogeochemical cycles or used as tracers. By its pedagogical approach, it defines the terms, methods, techniques and analytical tools used. Then, it analyzes the consequences of climate change, future projections, human impact and the concept introduced with planktonic pelagic ecosystem component

Regulation of transcription represents a major, controlling step in plant gene expression, as it determines the tissue-specific and developmental stage-specific activity of many genes. Changes in gene expression have been shown to underlie the responses to environmental cues and stresses, the response against pathogens, the regulation of metabolic pathways, and the regulation of photosynthesis, for example. Regulation by transcription factors is an integral part of a highly complex network. In recent years, research on the regulation of transcription has made impressive progress. This volume provides a broad overview of the regulation of transcription in plants, introducing the key elements, the way in which it works in practice, and the potential within plant biotechnology. It is directed at researchers and professionals in plant molecular biology, biochemistry and biotechnology.

Human Factors Methods for Improving Performance in the Process Industries provides guidance for managers and plant engineering staff on specific, practical techniques and tools for addressing forty different human factors issues impacting process safety. Human factors incidents can result in injury and death, damage to the environment, fines, and business losses due to ruined batches, off-spec products, unplanned shutdowns, and other adverse effects. Prevention of these incidents increases productivity and profits. Complete with examples, case histories, techniques, and implementation methodologies, Human Factors Methods for Improving Performance in the Process Industries helps managers and engineering staff design and execute an efficient program. Organized for topical reference, the book includes: An overview on implementing a human factors program at the corporate level or the plant level, covering the business value, developing a program to meet specific needs, improving existing systems, roles and responsibilities, measures of performance, and more Summaries of forty different human factors relating to process safety, with a description of the tools, a practical example with graphics and visual aids, and additional resources Information on addressing the OSHA Process Safety Management (PSM) requirement for conducting human factors reviews in process hazard analyses (PHAs) A CD-ROM with a color version of the book Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

In this comprehensive, multidisciplinary volume, experts from a wide range fields explore violence in education’s different forms, contributing factors, and contextual nature. With contributions from noted experts in a wide-range of scholarly and professional fields, The Wiley Handbook on Violence in Education offers original research and essays that address the troubling issue of violence in education. The authors show the different forms that violence takes in educational contexts, explore the factors that contribute to violence, and provide innovative perspectives and approaches for prevention and response. This multidisciplinary volume presents a range of rigorous research that examines violence from both micro- and macro- approaches. In its twenty-nine chapters, this comprehensive volume’s fifty-nine contributors, representing thirty-three universities from the United States and six other countries, examines violence’s distinctive forms and contributing factors. This much-needed volume: Addresses the complexities of violence in education with essays from experts in the fields of sociology, psychology, criminology, education, disabilities studies, forensic psychology, philosophy, and critical theory Explores the many forms of school violence including physical, verbal, linguistic, social, legal, religious, political, structural, and symbolic violence Reveals violence in education’s stratified nature in order to achieve a deeper understanding of the problem Demonstrates how violence in education is deeply situated in schools, communities, and the broader society and culture Offers new perspectives and proposals for prevention and response The Wiley Handbook on Violence in Education is designed to help researchers, educators, policy makers, and community leaders understand violence in educational settings and offers innovative, effective approaches to this difficult challenge.