Early Drug Development

A multidisciplinary approach that explores the diverse properties, functions, and applications of nanomaterials Drawing together the many scientific and engineering disciplines underlying the development of nanomaterials, Nanoscale Multifunctional Materials provides a multidisciplinary review of the diverse properties, functions, and applications of nanomaterials. The book examines both nanoparticles, which have larger-scale equivalents, and uniquely assembled nanomaterials, which do not have larger-scale equivalents. Readers will gain a tremendous appreciation of the versatility of nanomaterials as well as an understanding of how the same nanomaterial can have several distinct applications across a broad range of fields and industries. Nanoscale Multifunctional Materials is divided into three sections: ? Section I, Overview, describes the scientific phenomena underlying the special properties of nanomaterials, making them desirable as novel materials and different from conventional solids. Next, readers will learn about the effect of nanomaterials on contemporary society as well as future trends in nanomaterials production and use. ? Section II, Processing and Analysis, explores several experimental approaches in nanomaterial fabrication and characterization as well as in theoretical approaches in modeling and simulation. ? Section III, Applications, offers detailed examples of nanomaterial applications in alternative energy, thermal management, environmental cleanup, water treatment, and biomedicine. Each chapter has been written by one or more leading experts in the science, engineering, and application of nanomaterials. Within each chapter, readers will find a thorough review of the current literature, with references to facilitate further investigation of individual topics. Underscoring the multidisciplinary and multifunctional characteristics of nanomaterials, this book is recommended for students and professionals in science and engineering who need a broad perspective on both the nature and application of nanomaterials. The text also sets the stage for the development of new nanomaterials and new applications.

A provocative look at the tools and history of real analysis This new edition of Real Analysis: A Historical Approach continues to serve as an interesting read for students of analysis. Combining historical coverage with a superb introductory treatment, this book helps readers easily make the transition from concrete to abstract ideas. The book begins with an exciting sampling of classic and famous problems first posed by some of the greatest mathematicians of all time. Archimedes, Fermat, Newton, and Euler are each summoned in turn, illuminating the utility of infinite, power, and trigonometric series in both pure and applied mathematics. Next, Dr. Stahl develops the basic tools of advanced calculus, which introduce the various aspects of the completeness of the real number system as well as sequential continuity and differentiability and lead to the Intermediate and Mean Value Theorems. The Second Edition features: A chapter on the Riemann integral, including the subject of uniform continuity Explicit coverage of the epsilon-delta convergence A discussion of the modern preference for the viewpoint of sequences over that of series Throughout the book, numerous applications and examples reinforce concepts and demonstrate the validity of historical methods and results, while appended excerpts from original historical works shed light on the concerns of influential mathematicians in addition to the difficulties encountered in their work. Each chapter concludes with exercises ranging in level of complexity, and partial solutions are provided at the end of the book. Real Analysis: A Historical Approach, Second Edition is an ideal book for courses on real analysis and mathematical analysis at the undergraduate level. The book is also a valuable resource for secondary mathematics teachers and mathematicians.

Praise for the previous editions «An excellent text . . . will no doubt provide the benchmark for comparative works for many years.» —Journal of the American Chemical Society «An excellent state-of-the-art compilation of catalytic asymmetric chemistry . . . should be included in any chemistry reference collection.» —Choice «This is a tremendous resource and an excellent read. I recommend immediate purchase.» —Perkin Transactions Since this important work was first published in 1993, the field of catalytic asymmetric synthesis has grown explosively, spawning effective new methods for obtaining enantiomerically pure compounds on a large scale and stimulating new applications in diverse fields—from medicine to materials science. Catalytic Asymmetric Synthesis, Third Edition addresses these rapid changes through contributions from highly recognized world leaders in the field. This seminal text presents detailed accounts of the most important catalytic asymmetric reactions known today, and discusses recent advances and essential information on the initial development of certain processes. An excellent working resource for academic researchers and industrial chemists alike, the Third Edition features: Six entirely new chapters focusing on novel approaches to catalytic asymmetric synthesis including non-conventional media/conditions, organocatalysis, chiral Lewis and Bronsted acids, CH activation, carbon-heteroatom bond-forming reactions, and enzyme-catalyzed asymmetric synthesis A new section focusing on the important new reaction, asymmetric metathesis, in carbon-carbon bond-forming reactions Updated chapters on hydrogenation, carbon-carbon bond-forming reactions, hydrosilylations, carbonylations, oxidations, amplifications and autocatalysis, and polymerization reactions Retaining the best of its predecessors but now thoroughly up to date, Catalytic Asymmetric Synthesis, Third Edition serves as an excellent desktop reference and text for researchers and students from the upper-level undergraduates through experienced professionals in industry or academia.

Normativity is what gives reasons their force, makes words meaningful, and makes rules and laws binding. It is present whenever we use such terms as ‘correct,' ‘ought,' ‘must,' and the language of obligation, responsibility, and logical compulsion. Yet normativists, the philosophers committed to this idea, admit that the idea of a non-causal normative realm and a body of normative objects is spooky. Explaining the Normative is the first systematic, historically grounded critique of normativism. It identifies the standard normativist pattern of argument, and shows how this pattern depends on circularities, assumptions about the unique correctness of preferred descriptions, problematic transcendental arguments, and regress arguments that end in mysteries. The book considers in detail a paradigm case: legal normativity as constructed by Hans Kelsen. This case exemplifies the problems with normativist arguments. But it also shows how normativism was constructed as an alternative to ordinary social science explanation. The normativist argument is that social science explanations themselves are forced to rely on normative concepts?minimally, on normative rationality and on a normative view of ‘concepts' themselves. Empathic understanding of the reasoning and meanings of others, however, can solve the regress problems about meaning and rationality that are central to the appeal of normativism. This account has no need for a parallel normative world, and has a surprising and revealing lineage in the history of philosophy, as well as a basis in neuroscience.

Horticultural Reviews presents state-of-the-art reviews on topics in horticultural science and technology covering both basic and applied research. Topics covered include the horticulture of fruits, vegetables, nut crops, and ornamentals. These review articles, written by world authorities, bridge the gap between the specialized researcher and the broader community of horticultural scientists and teachers.