Biomedical Optics

The book discusses in a detailed manner various nanomaterials used for biomedical applications, including clinical applications, diagnosis and tissue engineering. After the presentation of an overview of biomedical nanomaterials, including their classification and applications, the first part of the book is devoted to biomedical nanomaterials for therapy applications. For example, polymer micelles, dendrimers, polymer-drug conjugates as well as antibody-drug conjugates are discussed with respect to their cancer drug delivery properties. The next parts discuss biomedical nanomaterials that are used for imaging, diagnosis and sensors, as well as for tissue engineering. In the final section, the safety of biomedical nanomaterials is elaborated.

Learn to Use Nanoscale Materials to Design Novel Biomedical Devices and Applications Discover how to take full advantage of nanoscale materials in the design and fabrication of leading-edge biomedical devices. The authors introduce you to a variety of possible clinical applications such as drug delivery, diagnostics, and cancer therapy. In addition, the authors explore the interface between micron and nanoscale materials for the development of applications such as tissue engineering. Finally, they examine the mechanisms of cell interactions with material surfaces through the use of nanotechnology-based material processing and characterization methods. The text's three sections highlight its interdisciplinary approach: * Part One: Nanostructure Fabrication * Part Two: Bio-Nano Interfaces * Part Three: Clinical Applications of Nanostructures Among the key topics covered are nanotechnology in tissue regeneration; biomolecular engineering; receptor-ligand interactions; cell-biomaterial interactions; nanomaterials in diagnostics, drug delivery, and cancer therapy; and nano- and micron-level engineering and fabrication. Throughout the text, clear examples guide you through the chemistry and the processing involved in designing and developing nanoscale materials for biomedical devices. Each chapter begins with an introduction and ends with a conclusion highlighting the key points. In addition, references at the end of the chapter help you expand your research on any individual topic. In summary, this book helps biomedical researchers and engineers understand the physical phenomena that occur at the nanoscale in order to design novel cell-based constructs for a wide range of applications.

It is said if you take care of the pennies, the pounds will take care of themselves. Richard Burton's excellent book takes this approach to calculations applied to the biomedical sciences…This is certainly interesting and engaging but it avoids being complicated. –Journal of Biological Education, April 2009 Biomedical Calculations: Principles and Practice is an accessible, student-friendly introduction to calculating, applying formulae and solving quantitative problems within these subjects. This book targets a problem area for many students and aims to give them the confidence which they are so often lacking when undertaking scientific calculations. It takes a unique approach to the subject and uses unit analysis as a central theme throughout the book to enhance student understanding. Clearly structured throughout, little basic knowledge of mathematics is assumed, but even the most numerate readers will be interested in the sometimes-novel biological detail. Numerous worked examples, supplementary questions and practice problems are provided and although the book is written to be read in sequence, it will also be a useful reference. The central theme of the book focuses on the value of unit analysis in solving quantitative problems, with explanations on how to avoid errors in calculations and in checking, understanding and deriving formulae and equations. As a background to this, there is extensive treatment of physical units, both individually (e.g. kg, m, mmol) and in combination (e.g. m s??, mmol L??), and also of other aspects of quantitative thinking. A variety of topics (mostly from physiology, pharmacology and biochemistry) are used to demonstrate these calculations in practice. Key features: An accessible, student-friendly introduction for all those hesitant in calculating, applying formulae and solving quantitative problems An innovative approach to scientific calculations and how to work with unfamiliar formulae for the biomedical and life sciences Includes modern, up to date definition of pH eliminating the need for logarithms and a discussion of the importance of pH Clear introduction on how to use the book, guidance on units and unit conversion, and an appendix on basic mathematics and notation Use of unit analysis as a central theme Includes numerous worked examples and supplementary questions throughout the text to enhance student understanding

Biomedical Devices: Design, Prototyping, and Manufacturing features fundamental discussions of all facets of materials processing and manufacturing processes across a wide range of medical devices and artificial tissues. Represents the first compilation of information on the design, prototyping, and manufacture of medical devices into one volume Offers in-depth coverage of medical devices, beginning with an introductory overview through to the design, manufacture, and applications Features examples of a variety of medical applications of devices, including biopsy micro forceps, micro-needle arrays, wrist implants, spinal spacers, and fixtures Provides students, doctors, scientists, and technicians interested in the development and applications of medical devices the ideal reference source

An important resource that puts the focus on the chemical engineering aspects of biomedical engineering In the past 50 years remarkable achievements have been advanced in the fields of biomedical and chemical engineering. With contributions from leading chemical engineers, Biomedical Engineering Challenges reviews the recent research and discovery that sits at the interface of engineering and biology. The authors explore the principles and practices that are applied to the ever-expanding array of such new areas as gene-therapy delivery, biosensor design, and the development of improved therapeutic compounds, imaging agents, and drug delivery vehicles. Filled with illustrative case studies, this important resource examines such important work as methods of growing human cells and tissues outside the body in order to repair or replace damaged tissues. In addition, the text covers a range of topics including the challenges faced with developing artificial lungs, kidneys, and livers; advances in 3D cell culture systems; and chemical reaction methodologies for biomedical imagining analysis. This vital resource: Covers interdisciplinary research at the interface between chemical engineering, biology, and chemistry Provides a series of valuable case studies describing current themes in biomedical engineering Explores chemical engineering principles such as mass transfer, bioreactor technologies as applied to problems such as cell culture, tissue engineering, and biomedical imaging Written from the point of view of chemical engineers, this authoritative guide offers a broad-ranging but concise overview of research at the interface of chemical engineering and biology.

The book will help assist a reader in the development of techniques for analysis of biomedical signals and computer aided diagnoses with a pedagogical examination of basic and advanced topics accompanied by over 350 figures and illustrations. Wide range of filtering techniques presented to address various applications 800 mathematical expressions and equations Practical questions, problems and laboratory exercises Includes fractals and chaos theory with biomedical applications

A must-have compendium on biomedical telemetry for all biomedical professional engineers, researchers, and graduate students in the field Handbook of Biomedical Telemetry describes the main components of a typical biomedical telemetry system, as well as its technical challenges. Written by a diverse group of experts in the field, it is filled with overviews, highly-detailed scientific analyses, and example applications of biomedical telemetry. The book also addresses technologies for biomedical sensing and design of biomedical telemetry devices with special emphasis on powering/integration issues and materials for biomedical telemetry applications. Handbook of Biomedical Telemetry: Describes the main components of a typical biomedical telemetry system, along with the technical challenges Discusses issues of spectrum regulations, standards, and interoperability—while major technical challenges related to advanced materials, miniaturization, and biocompatibility issues are also included Covers body area electromagnetics, inductive coupling, antennas for biomedical telemetry, intra-body communications, non-RF communication links for biomedical telemetry (optical biotelemetry), as well as safety issues, human phantoms, and exposure assessment to high-frequency biotelemetry fields Presents biosensor network topologies and standards; context-aware sensing and multi-sensor fusion; security and privacy issues in biomedical telemetry; and the connection between biomedical telemetry and telemedicine Introduces clinical applications of Body Sensor Networks (BSNs) in addition to selected examples of wearable, implantable, ingestible devices, stimulator and integrated mobile healthcare system paradigms for monitoring and therapeutic intervention Covering biomedical telemetry devices, biosensor network topologies and standards, clinical applications, wearable and implantable devices, and the effects on the mobile healthcare system, this compendium is a must-have for professional engineers, researchers, and graduate students.

An overview of nanotechnology and its potential The field of nanotechnology is undergoing rapid developments on many fronts. This reference provides a comprehensive review of various nanotechnologies with a view to their biomedical applications. With chapters contributed by distinguished scientists from diverse disciplines, Biomedical Applications of Nanotechnology : Reviews recent advances in the designing of various nanotechnologies based on nucleic acids, polymers, biomaterials, and metals Discusses biomedical nanotechnology in areas such as drug and gene delivery Covers advanced aspects of imaging and diagnostics Includes a chapter on the issue of nanotoxicology Complete with figures and tables, this is a practical, hands-on reference book for researchers in pharmaceutical and biotech industries, biomedical engineers, pharmaceutical scientists, pharmacologists, and materials scientists as well as for the policymakers who need to understand the potential of nanotechnology. It is also an excellent resource book for graduate-level students in pharmaceutical sciences, biomedical engineering, and other fields in which nanotechnology is playing an increasingly important role.

MATERIALS FOR BIOMEDICAL ENGINEERING A comprehensive yet accessible introductory textbook designed for one-semester courses in biomaterials Biomaterials are used throughout the biomedical industry in a range of applications, from cardiovascular devices and medical and dental implants to regenerative medicine, tissue engineering, drug delivery, and cancer treatment. Materials for Biomedical Engineering: Fundamentals and Applications provides an up-to-date introduction to biomaterials, their interaction with cells and tissues, and their use in both conventional and emerging areas of biomedicine. Requiring no previous background in the subject, this student-friendly textbook covers the basic concepts and principles of materials science, the classes of materials used as biomaterials, the degradation of biomaterials in the biological environment, biocompatibility phenomena, and the major applications of biomaterials in medicine and dentistry. Throughout the text, easy-to-digest chapters address key topics such as the atomic structure, bonding, and properties of biomaterials, natural and synthetic polymers, immune responses to biomaterials, implant-associated infections, biomaterials in hard and soft tissue repair, tissue engineering and drug delivery, and more. Offers accessible chapters with clear explanatory text, tables and figures, and high-quality illustrations Describes how the fundamentals of biomaterials are applied in a variety of biomedical applications Features a thorough overview of the history, properties, and applications of biomaterials Includes numerous homework, review, and examination problems, full references, and further reading suggestions Materials for Biomedical Engineering: Fundamentals and Applications is an excellent textbook for advanced undergraduate and graduate students in biomedical materials science courses, and a valuable resource for medical and dental students as well as students with science and engineering backgrounds with interest in biomaterials.

Brings together, analyzes, and contextualizes the latest findings and practical applications Polyphosphazenes, an emerging class of polymers, include macromolecules, which have been proven to be biocompatible, biodegradable, and bioactive. Their unprecedented structural diversity and unique properties make them suitable as vaccine adjuvants, microencapsulating agents, biodegradable materials, scaffolds for tissue engineering, biocompatible coatings, and carriers for gene delivery. Polyphosphazenes for Biomedical Applications offers a thorough review of polyphosphazene research findings in the life sciences, chemistry, and chemical engineering. It emphasizes biomedical applications as well as recent advances in polyphosphazene development such as high-throughput discovery and the latest controlled methods of synthesis. The book brings together, analyzes, and contextualizes a wealth of knowledge that previously could only be found scattered throughout the scientific literature. Following two introductory chapters, the book reviews: Vaccine delivery and immunomodulation Biomaterials Drug delivery systems Biodetection Well-defined polyphosphazenes: synthetic aspects and novel molecular architectures All the chapters have been written by leading researchers in the field. Editor Alexander Andrianov, who has led the effort to commercialize polyphosphazenes for biomedical applications, has carefully reviewed and edited all chapters to ensure readability, accuracy, and thoroughness. Polyphosphazenes for Biomedical Applications is not only intended for researchers working in polyphosphazene chemistry, but also for all researchers seeking solutions to problems arising in the areas of biomaterials, drug delivery systems, and controlled release formulations.