An Introduction to Molecular Biotechnology

Molecular anthropology uses molecular genetic methods to address questions and issues of anthropological interest. More specifically, molecular anthropology is concerned with genetic evidence concerning human origins, migrations, and population relationships, including related topics such as the role of recent natural selection in human population differentiation, or the impact of particular social systems on patterns of human genetic variation. Organized into three major sections, An Introduction to Molecular Anthropology first covers the basics of genetics – what genes are, what they do, and how they do it – as well as how genes behave in populations and how evolution influences them. The following section provides an overview of the different kinds of genetic variation in humans, and how this variation is analyzed and used to make evolutionary inferences. The third section concludes with a presentation of the current state of genetic evidence for human origins, the spread of humans around the world, the role of selection and adaptation in human evolution, and the impact of culture on human genetic variation. A final, concluding chapter discusses various aspects of molecular anthropology in the genomics era, including personal ancestry testing and personal genomics. An Introduction to Molecular Anthropology is an invaluable resource for students studying human evolution, biological anthropology, or molecular anthropology, as well as a reference for anthropologists and anyone else interested in the genetic history of humans.

An Introduction to Human Molecular Genetics Second Edition Jack J. Pasternak The Second Edition of this internationally acclaimed text expands its coverage of the molecular genetics of inherited human diseases with the latest research findings and discoveries. Using a unique, systems-based approach, the text offers readers a thorough explanation of the gene discovery process and how defective genes are linked to inherited disease states in major organ and tissue systems. All the latest developments in functional genomics, proteomics, and microarray technology have been thoroughly incorporated into the text. The first part of the text introduces readers to the fundamentals of cytogenetics and Mendelian genetics. Next, techniques and strategies for gene manipulation, mapping, and isolation are examined. Readers will particularly appreciate the text's exceptionally thorough and clear explanation of genetic mapping. The final part features unique coverage of the molecular genetics of distinct biological systems, covering muscle, neurological, eye, cancer, and mitochondrial disorders. Throughout the text, helpful figures and diagrams illustrate and clarify complex material. Readers familiar with the first edition will recognize the text's same lucid and engaging style, and will find a wealth of new and expanded material that brings them fully up to date with a current understanding of the field, including: * New chapters on complex genetic disorders, genomic imprinting, and human population genetics * Expanded and fully revised section on clinical genetics, covering diagnostic testing, molecular screening, and various treatments This text is targeted at upper-level undergraduate students, graduate students, and medical students. It is also an excellent reference for researchers and physicians who need a clinically relevant reference for the molecular genetics of inherited human diseases.

Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the applications of genetic medicine to clinical conditions; ethics and governmental regulations; and the burgeoning fields of genomics, biotechnology, and bioinformatics. By dividing the material into three sections – an introduction to basic science, a review of clinical applications, and a discussion of the evolving issues related to gene therapy and molecular medicine-this comprehensive manual describes the basic approaches to the broad range of actual and potential genetic-based therapies. In addition, An Introduction to Molecular Medicine and Gene Therapy: Covers new frontiers in gene therapy, animal models, vectors, gene targeting, and ethical/legal considerations Provides organ-based reviews of current studies in gene therapy for monogenetic, multifactoral or polygenic disorders, and infectious diseases Includes bold-faced terms, key concepts, summaries, and lists of helpful references by subject in each chapter Contains appendices on commercial implications and a review of the history of gene therapy This textbook offers a clear, concise writing style, drawing upon the expertise of the authors, all renowned researchers in their respective specialties of molecular medicine. Researchers in genetics and molecular medicine will all find An Introduction to Molecular Medicine and Gene Therapy to be an essential guide to the rapidly evolving field of gene therapy and its applications in molecular medicine.

This first introduction to the rapidly growing field of molecular magnetism is written with Masters and PhD students in mind, while postdocs and other newcomers will also find it an extremely useful guide. Adopting a clear didactic approach, the authors cover the fundamental concepts, providing many examples and give an overview of the most important techniques and key applications. Although the focus is one lanthanide ions, thus reflecting the current research in the field, the principles and the methods equally apply to other systems. The result is an excellent textbook from both a scientific and pedagogic point of view.

Comprehensive look at mechanical molecular devices that mimic the behavior of man-made devices Molecular devices and molecular machines are individual molecules and molecular systems capable of providing valuable device-like functions. Many of them have distinct conventional prototypes and therefore can be identified as technomimetic molecules. The last decade has seen an increasing rate of practical applications of molecular devices and machines, primarily in biomedical and material science fields. Molecular devices: An Introduction to Technomimetics and its Biological Applications focuses on mechanical molecular devices, including the early set of technomimetic molecules. Topics covered include the many simple molecular devices such as container compounds, gearing systems, belts and tubes, and tweezers. It touches upon each molecular machine and discusses in great detail the importance of their applications as well as the latest progress in the fields of chemistry, physics, and biotechnology. Interdisciplinary: Must-have content for physicists, chemists, and biologists Comprehensive: Details an extensive set of mechanical technomimetic molecular devices Thorough: Starts with the fundamental material characterization and finishes with real-world device application Molecular devices: An Introduction to Technomimetics and its Biological Applications is an important book for graduate students, researchers, scientists, and engineers in the fields of chemistry, materials science, molecular physics, engineering, biotechnology, and molecular medicine.

This new textbook is a lively and highly accessible introduction to philosophy. From the fundamental issues of philosophical thought to the latest theories in the philosophy of mind, An Introduction to Philosophy provides clear and incisive discussion of the key areas of philosophy for students new to the subject. Provides the tools new students need to tackle philosophical arguments themselves Clearly presents and explains contemporary issues and current debates Covers the key areas of philosophy, including perception, epistemology, metaphysics, the mind, philosophy of religion, ethics and political philosophy Contains numerous learning features such as introductions, summaries, questions and further reading An Introduction to Philosophy is an ideal text for AS level, A level and first-year undergraduate students or anyone studying the subject for the first time.

A modern, up-to-date introduction to optimization theory and methods This authoritative book serves as an introductory text to optimization at the senior undergraduate and beginning graduate levels. With consistently accessible and elementary treatment of all topics, An Introduction to Optimization, Second Edition helps students build a solid working knowledge of the field, including unconstrained optimization, linear programming, and constrained optimization. Supplemented with more than one hundred tables and illustrations, an extensive bibliography, and numerous worked examples to illustrate both theory and algorithms, this book also provides: * A review of the required mathematical background material * A mathematical discussion at a level accessible to MBA and business students * A treatment of both linear and nonlinear programming * An introduction to recent developments, including neural networks, genetic algorithms, and interior-point methods * A chapter on the use of descent algorithms for the training of feedforward neural networks * Exercise problems after every chapter, many new to this edition * MATLAB(r) exercises and examples * Accompanying Instructor's Solutions Manual available on request An Introduction to Optimization, Second Edition helps students prepare for the advanced topics and technological developments that lie ahead. It is also a useful book for researchers and professionals in mathematics, electrical engineering, economics, statistics, and business. An Instructor's Manual presenting detailed solutions to all the problems in the book is available from the Wiley editorial department.

An Introduction to Ministry is a comprehensive and ecumenical introduction to the craft of ministry for ministers, pastors, and priests that make up the mainline denominations in the United States. Ecumenically-focused, It offers a grounded account of ministry, covering areas such as vocation, congregational leadership, and cultivation of skills for an effective ministry. Covers the key components of the M.Div. curriculum, offering a map and guide to the central skills and issues in training Explores the areas of vocation, skills for ministry, and issues around congregational leadership Each topic ends with an annotated bibliography providing an indispensable gateway to further study Helps students understand both the distinctive approach of their denomination and the relationship of that approach to other mainline denominations Advocates and defends a generous understanding of the Christian tradition in its openness and commitment to broad conversation

Praise from the Second Edition «…an excellent introduction to optimization theory…» (Journal of Mathematical Psychology, 2002) «A textbook for a one-semester course on optimization theory and methods at the senior undergraduate or beginning graduate level.» (SciTech Book News, Vol. 26, No. 2, June 2002) Explore the latest applications of optimization theory and methods Optimization is central to any problem involving decision making in many disciplines, such as engineering, mathematics, statistics, economics, and computer science. Now, more than ever, it is increasingly vital to have a firm grasp of the topic due to the rapid progress in computer technology, including the development and availability of user-friendly software, high-speed and parallel processors, and networks. Fully updated to reflect modern developments in the field, An Introduction to Optimization, Third Edition fills the need for an accessible, yet rigorous, introduction to optimization theory and methods. The book begins with a review of basic definitions and notations and also provides the related fundamental background of linear algebra, geometry, and calculus. With this foundation, the authors explore the essential topics of unconstrained optimization problems, linear programming problems, and nonlinear constrained optimization. An optimization perspective on global search methods is featured and includes discussions on genetic algorithms, particle swarm optimization, and the simulated annealing algorithm. In addition, the book includes an elementary introduction to artificial neural networks, convex optimization, and multi-objective optimization, all of which are of tremendous interest to students, researchers, and practitioners. Additional features of the Third Edition include: New discussions of semidefinite programming and Lagrangian algorithms A new chapter on global search methods A new chapter on multipleobjective optimization New and modified examples and exercises in each chapter as well as an updated bibliography containing new references An updated Instructor's Manual with fully worked-out solutions to the exercises Numerous diagrams and figures found throughout the text complement the written presentation of key concepts, and each chapter is followed by MATLAB exercises and drill problems that reinforce the discussed theory and algorithms. With innovative coverage and a straightforward approach, An Introduction to Optimization, Third Edition is an excellent book for courses in optimization theory and methods at the upper-undergraduate and graduate levels. It also serves as a useful, self-contained reference for researchers and professionals in a wide array of fields.