Applied Mixed Models in Medicine

Praise for the First Edition “This book will serve to greatly complement the growing number of texts dealing with mixed models, and I highly recommend including it in one’s personal library.” —Journal of the American Statistical Association Mixed modeling is a crucial area of statistics, enabling the analysis of clustered and longitudinal data. Mixed Models: Theory and Applications with R, Second Edition fills a gap in existing literature between mathematical and applied statistical books by presenting a powerful examination of mixed model theory and application with special attention given to the implementation in R. The new edition provides in-depth mathematical coverage of mixed models’ statistical properties and numerical algorithms, as well as nontraditional applications, such as regrowth curves, shapes, and images. The book features the latest topics in statistics including modeling of complex clustered or longitudinal data, modeling data with multiple sources of variation, modeling biological variety and heterogeneity, Healthy Akaike Information Criterion (HAIC), parameter multidimensionality, and statistics of image processing. Mixed Models: Theory and Applications with R, Second Edition features unique applications of mixed model methodology, as well as: Comprehensive theoretical discussions illustrated by examples and figures Over 300 exercises, end-of-section problems, updated data sets, and R subroutines Problems and extended projects requiring simulations in R intended to reinforce material Summaries of major results and general points of discussion at the end of each chapter Open problems in mixed modeling methodology, which can be used as the basis for research or PhD dissertations Ideal for graduate-level courses in mixed statistical modeling, the book is also an excellent reference for professionals in a range of fields, including cancer research, computer science, and engineering.

Using a problem-based approach, Tietz's Applied Laboratory Medicine, Second Edition presents interesting cases to illustrate the current use and interpretation of the most commonly available clinical laboratory tests. The cases present detailed descriptions of the symptoms, diagnosis, and treatment of disease. The book begins with an up-to-date general discussion of selection and use of laboratory diagnostic and prognostic tests. Cases are then grouped by category, including cardiovascular, pulmonary, renal, liver, gastrointestinal, endocrine, gynaecologic & obstetrical, haematological, CNS, lipid, congenital, toxicological, infectious, and autoimmune diseases. Tietz's Applied Laboratory Medicine, Second Edition: Presents over 100 cases organised by disease group Reflects latest treatment and risk factor guidelines, testing algorithms and recommendations Newly covers coagulopathies, infectious diseases, and autoimmune diseases Provides excellent coverage of relevant pathophysiology and biochemistry, and includes cases in molecular diagnostics Discusses legal implications This book is an invaluable resource for all clinical chemists, clinical lab technologists, pathologists, and allied health professionals. It is also of interest for general practitioners, residents, medical students, and educators.

Applications of mathematical heat transfer and fluid flow models in engineering and medicine Abram S. Dorfman, University of Michigan, USA Engineering and medical applications of cutting-edge heat and flow models This book presents innovative efficient methods in fluid flow and heat transfer developed and widely used over the last fifty years. The analysis is focused on mathematical models which are an essential part of any research effort as they demonstrate the validity of the results obtained. The universality of mathematics allows consideration of engineering and biological problems from one point of view using similar models. In this book, the current situation of applications of modern mathematical models is outlined in three parts. Part I offers in depth coverage of the applications of contemporary conjugate heat transfer models in various industrial and technological processes, from aerospace and nuclear reactors to drying and food processing. In Part II the theory and application of two recently developed models in fluid flow are considered: the similar conjugate model for simulation of biological systems, including flows in human organs, and applications of the latest developments in turbulence simulation by direct solution of Navier-Stokes equations, including flows around aircraft. Part III proposes fundamentals of laminar and turbulent flows and applied mathematics methods. The discussion is complimented by 365 examples selected from a list of 448 cited papers, 239 exercises and 136 commentaries. Key features: Peristaltic flows in normal and pathologic human organs. Modeling flows around aircraft at high Reynolds numbers. Special mathematical exercises allow the reader to complete expressions derivation following directions from the text. Procedure for preliminary choice between conjugate and common simple methods for particular problem solutions. Criterions of conjugation, definition of semi-conjugate solutions. This book is an ideal reference for graduate and post-graduate students and engineers.

Working from basic chemical principles, Metals in Medicine 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer’s, Wilson’s and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.

Highly Commended at the British Medical Association Book Awards 2016 Clinical Communication in Medicine brings together the theories, models and evidence that underpin effective healthcare communication in one accessible volume. Endorsed and developed by members of the UK Council of Clinical Communication in Undergraduate Medical Education, it traces the subject to its primary disciplinary origins, looking at how it is practised, taught and learned today, as well as considering future directions. Focusing on three key areas – the doctor-patient relationship, core components of clinical communication, and effective teaching and assessment – Clinical Communication in Medicine enhances the understanding of effective communication. It links theory to teaching, so principles and practice are clearly understood. Clinical Communication in Medicine is a new and definitive guide for professionals involved in the education of medical undergraduate students and postgraduate trainees, as well as experienced and junior clinicians, researchers, teachers, students, and policy makers.

This selection of in-depth, critical and comprehensive chapters on topical issues in applied health psychology features the work of key researchers and practitioners in the Australasian health system and deals with both theoretical and methodological aspects of the subject. The first health psychology text aimed specifically at regional postgraduate trainees Covers an array of topics and issues and focuses on applied aspects of clinical health and health promotion Includes both specialized topics and new frontiers of research Contextualizes health psychology teaching and learning for Australasian students

Recognize, understand, and manage sleep dysfunction in your patients Sleep disorders can cause neurological problems. Neurological problems can cause sleep disorders. Whatever the cause or effect, neurologists need to be well versed in sleep medicine. This enables effective discussion of sleep problems and improved patient outcomes and satisfaction. Sleep Medicine in Neurology introduces the practicing neurologist to sleep medicine, from examination of the patient to treatment of many sleep disorders. With a focused, practical approach throughout, the expert author team covers: History, examination and sleep testing of the patient Insomnia Excessive daytime sleepiness Narcolepsy Obstructive and central sleep apnea Movement disorders in sleep Parasomnias Sleep disorders in children Clinical in approach, practical in execution, Sleep Medicine in Neurology helps you diagnose and treat your sleep-disordered patients more effectively.

Applied C# in Financial Markets covers all the aspects of C# relevant to practitioners working in financial sector. It contains a practical workshop which builds on the material in the book, guiding you through all the stages of building a multiple model options calculator. An accompanying website features examples, illustrations and solutions to the workshops and a downloadable application to complement the book. Features examples and illustrations taken from a sample trading application, making the book relevant to those working in the financial markets. Provides a quick start to C# for financial professionals to hit the ground running in building financial applications. Workshops illustrate building an options calculator, exploring the various elements in C# as they progress.

A much-needed, precise and practical treatment of a key topic in the energy industry and beyond, Applied Concepts in Fractured Reservoirs is an invaluable reference for those in both industry and academia Authored by renowned experts in the field, this book covers the understanding, evaluation, and effects of fractures in reservoirs. It offers a comprehensive yet practical discussion and description of natural fractures, their origins, characteristics, and effects on hydrocarbon reservoirs. It starts by introducing the reader to basic definitions and classifications of fractures and fractured reservoirs. It then provides an outline for fractured-reservoir characterization and analysis, and goes on to introduce the way fractures impact operational activities. Well organized and clearly illustrated throughout, Applied Concepts in Fractured Reservoirs starts with a section on understanding natural fractures. It looks at the different types, their dimensions, and the mechanics of fracturing rock in extension and shear. The next section provides information on measuring and analyzing fractures in reservoirs. It covers: logging core for fractures; taking, measuring, and analyzing fracture data; new core vs. archived core; CT scans; comparing fracture data from outcrops, core, and logs; and more. The last part examines the effects of natural fractures on reservoirs, including: the permeability behavior of individual fractures and fracture systems; fracture volumetrics; effects of fractures on drilling and coring; and the interaction between natural and hydraulic fractures. Teaches readers to understand and evaluate fractures Compiles and synthesizes various concepts and descriptions scattered in literature and synthesizes them with unpublished oil-field observations and data, along with the authors’ own experience Bridges some of the gaps between reservoir engineers and geologists Provides an invaluable reference for geologists and engineers who need to understand naturally fractured reservoirs in order to efficiently extract hydrocarbons Illustrated in full color throughout Companion volume to the Atlas of Natural and Induced Fractures in Core

LEADERSHIP IN VETERINARY MEDICINE Leadership in Veterinary Medicine provides both theoretical and practical information for veterinary professionals who are contemplating leadership or currently facing day-to-day leadership challenges. This much-needed book introduces and explores key leadership concepts in the veterinary context whilst encouraging self-reflection through real-world scenarios. Each chapter outlines a particular leadership concept or issue and includes a topic summary, discussion questions, full references and further reading suggestions. This thought-provoking text: Explores the principal areas of leadership for both veterinary professionals and for those leading veterinary professionals Discusses various leadership styles, competencies, behaviours and perspectives Addresses topics such as leadership assessment, organisational dynamics, interpersonal communication, remote and virtual leadership, and collaboration skills Assists readers in developing strategy, leading change, creating effective teams and improving staff engagement Includes practical cases and examples highlighting challenges in veterinary leadership Leadership in Veterinary Medicine is a must-read for all veterinary professionals in leadership posts, for those aspiring to be leaders and for instructors in veterinary schools and veterinary nursing training organisations.