Biological Knowledge Discovery Handbook

The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

The purpose of this edited book is to bring together the ideas and findings of data mining researchers and bioinformaticians by discussing cutting-edge research topics such as, gene expressions, protein/RNA structure prediction, phylogenetics, sequence and structural motifs, genomics and proteomics, gene findings, drug design, RNAi and microRNA analysis, text mining in bioinformatics, modelling of biochemical pathways, biomedical ontologies, system biology and pathways, and biological database management.

Recent trends within community policing suggest that the next generation of community policing will be more «knowledge-based», involving a shift toward a problem-oriented and strategic use of information as a basis for management and better use of police resources. The Handbook of Knowledge-Based Policing examines how knowledge-based policing can improve the effectiveness, equity and efficiency of community policing. With contributions from a mix of academics and practitioners, this volume: Critically evaluates the effectiveness of community policing in seven countries. Discusses intelligence-led policing and the emergence of knowledge-based policing. Examines the impact knowledge-based policing will have on policing initiatives. Discussions are set firmly within the context of current debates on risk and the risk society, the broadening or narrowing of the police role, the importance of networks and governance and regulation. This comprehensive collection identifies the factors that will shape the next generation of Community Policing. It is a must-have resource for researchers and students of policing, policy makers and police officers. It will also be of interest to the growing number of people actively involved in crime and disorder partnerships.

Honorable mention – Biomedicine and Neuroscience, 2011 Prose Awards An examination of how the cell should be described in order to effectively process biological data «The fruitful pursuit of biological knowledge requires one to take Einstein's admonition [on science without epistemology] as a practical demand for scientific research, to recognize Waddington's characterization of the subject matter of biology, and to embrace Wiener's conception of the form of biological knowledge in response to its subject matter. It is from this vantage point that we consider the epistemology of the cell.» —from the Preface In the era of high biological data throughput, biomedical engineers need a more systematic knowledge of the cell in order to perform more effective data handling. Epistemology of the Cell is the first authored book to break down this knowledge. This text examines the place of biological knowledge within the framework of science as a whole and addresses issues focused on the specific nature of biology, how biology is studied, and how biological knowledge is translated into applications, in particular with regard to medicine. The book opens with a general discussion of the historical development of human understanding of scientific knowledge, the scientific method, and the manner in which scientific knowledge is represented in mathematics. The narrative then gets specific for biology, focusing on knowledge of the cell, the basic unit of life. The salient point is the analogy between a systems-based analysis of factory regulation and the regulation of the cell. Each chapter represents a key topic of current interest, including: Causality and randomness Translational science Stochastic validation: classification Stochastic validation: networks Model-based experimentation in biology Epistemology of the Cell is written for biomedical researchers whose interests include bioinformatics, biological modeling, biostatistics, and biological signal processing.

An easy-to-follow introduction to support vector machines This book provides an in-depth, easy-to-follow introduction to support vector machines drawing only from minimal, carefully motivated technical and mathematical background material. It begins with a cohesive discussion of machine learning and goes on to cover: Knowledge discovery environments Describing data mathematically Linear decision surfaces and functions Perceptron learning Maximum margin classifiers Support vector machines Elements of statistical learning theory Multi-class classification Regression with support vector machines Novelty detection Complemented with hands-on exercises, algorithm descriptions, and data sets, Knowledge Discovery with Support Vector Machines is an invaluable textbook for advanced undergraduate and graduate courses. It is also an excellent tutorial on support vector machines for professionals who are pursuing research in machine learning and related areas.

A comprehensive synthesis of the best practices for management in the vital and rapidly growing field of sustainable water systems Handbook of Knowledge Management for Sustainable Water Systems offers an authoritative resource that goes beyond the current literature to provide an interdisciplinary approach to the topic. The text explores the concept of knowledge management as a key asset and a crucial component of organizational strategy as applied to the sustainability of water systems. Using the knowledge management framework, the authors discuss socio-hydrology sustainable water systems that reflect the present political, economic and technological reality. The book draws on contributors from a number of disciplines including: economic development, financial, systems-networks, IT/IS data/analytics, behavioral, social, water systems, governance systems and related ecosystems. This vital resource: Contains a multifaceted approach that draws on a number of disciplines and contains contributions from experts in their various fields Offers a coherent approach that discusses the dynamic concept of sustainability drawing on data from people, systems and processes of diverse water systems Includes a comprehensive review of the topic and offers a platform for dialog between theory and empirical analysis Explores opportunities for multi-constituent synthesis This book is written for regulators, water utility practitioners, researchers and students interested in the fledgling field of knowledge management and sustainable water systems and those who want to improve the effective and efficient management of a complex water system.

A complete, up-to-date resource of information on more than 200 dyes and stains Handbook of Biological Dyes and Stains is the most comprehensive volume available on the subject, covering all the available dyes and stains known to date in the literature for use in biology and medicine. Top dye expert Dr. Ram Sabnis organizes the compounds alphabetically by the most commonly used chemical name. He presents an easy-to-use reference complete with novel ideas for breakthrough research in medical, biological, chemical, and related fields. This is the first book to give the CAS registry number, chemical structure, Chemical Abstracts index name, all other chemical names, Merck Index number, chemical/dye class, molecular formula, molecular weight, physical form, solubility, melting point, boiling point, pH range, color change at pH, pKa, absorption, and emission maxima of dyes and stains, as well as to provide access to synthesis procedures (lab scale and industrial scale) of dyes and stains. This user-friendly handbook also features references on safety, toxicity, and adverse effects of dyes and stains on humans, animals, and the environment, including: acute/chronic toxicity aquatic toxicity carcinogenicity cytotoxicity ecotoxicity genotoxicity hepatotoxicity marine toxicity mutagenicity nephrotoxicity neurotoxicity oral toxicity phototoxicity phytotoxicity The use of biological dyes and stains has extremely high potential in today's business environment. This makes Handbook of Biological Dyes and Stains a convenient, must-have reference. Its staining, biological, and industrial applications make it a vital resource for industrial and academic researchers; the book also serves as a valuable desktop reference for medical professionals, biologists, chemists, chemical/optical engineers, physicists, materials scientists, intellectual property professionals, students, and professors.

Praise for The Handbook ofKnowledge-Based Coaching «Definitive, with extensive references and a commitment to connecting theory to practice in every chapter, this important contribution is a delicious and wide-ranging exploration of the lineages that have shaped the modern practice of coaching.» —Doug Silsbee, author, Presence-Based Coaching and The Mindful Coach «The translation of theories from multiple disciplines to the practice of coaching makes this book a must-read!» —Terrence E. Maltbia, senior lecturer, Adult Learning and Leadership; and faculty director, Columbia Coaching Certification Program, Teachers College, Columbia University «If you have an appetite for the scientific roots of what works best in coaching, and you are hungry for an easy-to-digest translation of the science to practice, this book is a feast and will be on your plate for many years to come.» —Margaret Moore (Coach Meg), founder and CEO, Wellcoaches Corporation; and codirector, Institute of Coaching, McLean Hospital, Harvard Medical School «Whether you're a beginner or an experienced coach, this rollicking ride through dozens of the most important theories and perspectives in coaching will be a vital companion. With quick and helpful summaries of key ideas and their use—and selective bibliographies should you wish to go deeper into a particular area—this book will help you support your clients in a targeted and sophisticated way.» —Jennifer Garvey Berger, author, Changing on the Job: Growing the Leaders Our Organizations Need; and coeditor, Executive Coaching: Practices and Perspectives «This is a book I have been missing. What a pleasure to read and what a stretching of my mind.» —Kim G?rtz, senior consultant, Copenhagen Coaching Center «Anyone who is serious about improving the quality of coaching will find The Handbook an invaluable resource that reflects the breadth and richness of the growing evidence-based approach to coaching practice.» —David Clutterbuck, visiting professor in the coaching and mentoring faculties, Oxford Brookes and Sheffield Hallam Universities

“This fantastic introduction to Biological Psychology brings the subject to life in a way that no traditional textbook can. I will certainly be recommending it.” Brian Wink, Southampton Solent University "My first reaction was that it was both imaginative and courageous. Having read it, I would add that it also makes a significant contribution to the available texts on biological psychology. This approach is just what students are looking for.” Graham Mitchell, University of Northampton Taking a refreshingly innovative approach to the subject, Biological Psychology: An Illustrated Survival Guide uses cartoons as an effective teaching medium. Each chapter is organised into a mini lecture, and offers an accessible introduction to key topics including: The brain and nervous system Vision and audition The mechanical and chemical senses Emotions and sexual behaviour Memory and learning Intended to complement traditional textbooks in the area, Biological Psychology: An Illustrated Survival Guide provides undergraduate and ‘A’ level students with an alternative introduction to biological psychology and an invaluable study aid.

Biological psychiatry has dominated psychiatric thinking for the past 40 years, but the knowledge base of the discipline has increased substantially more recently, particularly with advances in genetics and neuroimaging. The third edition of Biological Psychiatry has been thoroughly updated taking into account these developments. As in the earlier editions of the book, there are comprehensive reviews and explanations of the latest advances in neurochemistry, neuroanatomy, genetics and brain imaging— descriptions not only of methodologies but also of the application of these in clinical settings. It is within this context that there is a considerable emphasis in the book on brain–behaviour relationships both within and without the clinical setting. This edition has been enhanced by the inclusion of new chapters, one on anxiety and another on motivation and the addictions. The chapter that relates to treatments has been extended to include the latest information on brain stimulation techniques. The overall book is well illustrated in order to help with an understanding of the text. For the third edition, Professor Michael Trimble has been joined by Professor Mark George as co-author. These are two of the world's leading biological psychiatrists who both have considerable clinical as well as research experience which they have brought to the book. Unlike multiauthored texts, it has a continuity running through it which aids understanding and prevents repetition. This book is strongly recommended for all practising psychiatrists and trainees wishing for an up-to-date, authoritative, easy to digest and acessible review of the latest advances and conceptualizations in the field. It will also appeal to neurologists interested in neuropsychiatry and biological psychiatry or the psychiatric aspects of neurological disorders, as well as other practising clinicians (psychologists, social workers, nurses) in the mental health field.