Construction Project Scheduling and Control

Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective therapeutic agents that modulate key processes in the brain, from their chemical synthesis to their mode of action in model systems as well as in the patient. Chemical Biology of Neurodegeneration: A Molecular Approach is presented in two parts. The first introduces the neurotransmitter systems and provides a general explanation of the synapse and a description of the main structures involved in neurotransmission that can be considered therapeutic targets for disorders of the central nervous system. The second part presents molecular and chemical aspects directly involved or affected in neurodegeneration, including the metabolism of neurotransmitters, enzymes processing neurotransmitters, protein misfolding, and therapeutic agents. -Uses an interdisciplinary approach to bridge the gap between the basic biochemical events in a nerve cell and their neurological effects on the brain -Places emphasis on the chemistry of small molecule modulators that are potential lead molecules for new drugs -Covers six key neurotransmitter systems and their enzymes and receptors?dopaminergic, noradrenergic, serotonergic, cholinergic, GABAergic, and glutamatergic Chemical Biology of Neurodegeneration: A Molecular Approach is a key resource for medicinal chemists, neurobiologists, neurochemists, biochemists, molecular biologists, and neurophysiologists.

What distinguishes fiction from ordinary experience is not a lack of reality but a surfeit of rationality – this was the thesis of Aristotle’s Poetics. The rationality of fiction is that appearances are inverted. Fiction overturns the ordinary course of events that occur one after the other, aiming to show how the unexpected arises, happiness transforms into unhappiness and ignorance into knowledge. In the modern age, argues Ranci?re, this fictional rationality was developed in new ways. The social sciences extended the model of causal linkage to all spheres of human action, seeking to show us how causes produce their effects by inverting appearances and expectations. Literature took the opposite path. Instead of democratizing fictional rationality to include all human activity in the world of rational knowledge, it destroyed its principles by abolishing the limits that circumscribed a reality peculiar to fiction. It aligned itself with the rhythms of everyday life and plumbed the power of the “random moment” into which an entire life is condensed. In the avowed fictions of literature as well as in the unavowed fictions of politics, social science or journalism, the central question is the same: how to construct the perceptible forms of a shared world. From Stendhal to Jo?o Guimar?es Rosa and from Marx to Sebald, via Balzac, Poe, Maupassant, Proust, Rilke, Conrad, Auerbach, Faulkner and some others, this book explores these constructions and sheds new light on the constitutive movement of modern fiction, the movement that shifted its centre of gravity from its traditional core toward those edges in which fiction gets confronted with its possible revocation.

The scientific expedition of H. M. S. Challenger in the 1870s marks the starting point of physical oceanography. This ship traveled the seas of the globe pursuing a dual objective: to conduct an in-depth study of animal life and to observe the physical properties of ocean waters. Volume 3 focuses on measurements and modeling of liquid compressibility. Based on the work initiated by the physicist Peter Tait, a detailed presentation of liquid equations-of-state is proposed. The physical interpretation of the parameters of these equations is discussed, leading to a description of the «structure» of liquid media. From Deep Sea to Laboratory is available in three volumes for curious readers drawn to travel, history and science. Students, researchers and teachers of physics, fluid mechanics and oceanography will find material to deepen their knowledge.

Provides fully updated coverage of new experiments in quantum optics This fully revised and expanded edition of a well-established textbook on experiments on quantum optics covers new concepts, results, procedures, and developments in state-of-the-art experiments. It starts with the basic building blocks and ideas of quantum optics, then moves on to detailed procedures and new techniques for each experiment. Focusing on metrology, communications, and quantum logic, this new edition also places more emphasis on single photon technology and hybrid detection. In addition, it offers end-of-chapter summaries and full problem sets throughout. Beginning with an introduction to the subject, A Guide to Experiments in Quantum Optics, 3rd Edition presents readers with chapters on classical models of light, photons, quantum models of light, as well as basic optical components. It goes on to give readers full coverage of lasers and amplifiers, and examines numerous photodetection techniques being used today. Other chapters examine quantum noise, squeezing experiments, the application of squeezed light, and fundamental tests of quantum mechanics. The book finishes with a section on quantum information before summarizing of the contents and offering an outlook on the future of the field. -Provides all new updates to the field of quantum optics, covering the building blocks, models and concepts, latest results, detailed procedures, and modern experiments -Places emphasis on three major goals: metrology, communications, and quantum logic -Presents fundamental tests of quantum mechanics (Schrodinger Kitten, multimode entanglement, photon systems as quantum emulators), and introduces the density function -Includes new trends and technologies in quantum optics and photodetection, new results in sensing and metrology, and more coverage of quantum gates and logic, cluster states, waveguides for multimodes, discord and other quantum measures, and quantum control -Offers end of chapter summaries and problem sets as new features A Guide to Experiments in Quantum Optics, 3rd Edition is an ideal book for professionals, and graduate and upper level students in physics and engineering science.

A concise introduction to the chemistry and design principles behind important metal-organic frameworks and related porous materials Reticular chemistry has been applied to synthesize new classes of porous materials that are successfully used for myraid applications in areas such as gas separation, catalysis, energy, and electronics. Introduction to Reticular Chemistry gives an unique overview of the principles of the chemistry behind metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and zeolitic imidazolate frameworks (ZIFs). Written by one of the pioneers in the field, this book covers all important aspects of reticular chemistry, including design and synthesis, properties and characterization, as well as current and future applications Designed to be an accessible resource, the book is written in an easy-to-understand style. It includes an extensive bibliography, and offers figures and videos of crystal structures that are available as an electronic supplement. Introduction to Reticular Chemistry: -Describes the underlying principles and design elements for the synthesis of important metal-organic frameworks (MOFs) and related materials -Discusses both real-life and future applications in various fields, such as clean energy and water adsorption -Offers all graphic material on a companion website -Provides first-hand knowledge by Omar Yaghi, one of the pioneers in the field, and his team. Aimed at graduate students in chemistry, structural chemists, inorganic chemists, organic chemists, catalytic chemists, and others, Introduction to Reticular Chemistry is a groundbreaking book that explores the chemistry principles and applications of MOFs, COFs, and ZIFs.