Energy and Mass Transfers. Balance Sheet Approach and Basic Concepts

Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen. This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery. In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches—Caco-2 cell culture model, MDCK, and other related cell culture models—which are used to study the science of oral bioavailability.

While the topic of heat and mass transfer is an old subject, the way the book introduces the concepts, linking them strongly to the real world and to the present concerns, is particular. The scope of the different developments keeps in mind a practical energy engineering view.

Whether in a solar thermal power plant or at the heart of a nuclear reactor, convection is an important mode of energy transfer. This mode is unique; it obeys specific rules and correlations that constitute one of the bases of equipment-sizing equations. In addition to standard aspects of convention, this book examines transfers at very high temperatures where, in order to ensure the efficient transfer of energy for industrial applications, it is becoming necessary to use particular heat carriers, such as molten salts, liquid metals or nanofluids. With modern technologies, these situations are becoming more frequent, requiring appropriate consideration in design calculations. Energy Transfers by Convection also studies the sizing of electronic heat sinks used to ensure the dissipation of heat and thus the optimal operation of circuit boards used in telecommunications, audio equipment, avionics and computers.

Anyone who attempts to read genetics or epidemiology research literature needs to understand the essentials of biostatistics. This book, a revised new edition of the successful Essentials of Biostatistics has been written to provide such an understanding to those who have little or no statistical background and who need to keep abreast of new findings in this fast moving field. Unlike many other elementary books on biostatistics, the main focus of this book is to explain basic concepts needed to understand statistical procedures. This Book: Surveys basic statistical methods used in the genetics and epidemiology literature, including maximum likelihood and least squares. Introduces methods, such as permutation testing and bootstrapping, that are becoming more widely used in both genetic and epidemiological research. Is illustrated throughout with simple examples to clarify the statistical methodology. Explains Bayes’ theorem pictorially. Features exercises, with answers to alternate questions, enabling use as a course text. Written at an elementary mathematical level so that readers with high school mathematics will find the content accessible. Graduate students studying genetic epidemiology, researchers and practitioners from genetics, epidemiology, biology, medical research and statistics will find this an invaluable introduction to statistics.

This book presents fundamental passive optical network (PON) concepts, providing you with the tools needed to understand, design, and build these new access networks. The logical sequence of topics begins with the underlying principles and components of optical fiber communication technologies used in access networks. Next, the book progresses from descriptions of PON and fiber-to-the-X (FTTX) alternatives to their application to fiber-to-the-premises (FTTP) networks and, lastly, to essential measurement and testing procedures for network installation and maintenance. An Instructor's Manual presenting detailed solutions to all the problems in the book is available from the Wiley editorial department.

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.

Explores and identifies the main issues, concepts, principles and evolution of software testing, including software quality engineering and testing concepts, test data generation, test deployment analysis, and software test management This book examines the principles, concepts, and processes that are fundamental to the software testing function. This book is divided into five broad parts. Part I introduces software testing in the broader context of software engineering and explores the qualities that testing aims to achieve or ascertain, as well as the lifecycle of software testing. Part II covers mathematical foundations of software testing, which include software specification, program correctness and verification, concepts of software dependability, and a software testing taxonomy. Part III discusses test data generation, specifically, functional criteria and structural criteria. Test oracle design, test driver design, and test outcome analysis is covered in Part IV. Finally, Part V surveys managerial aspects of software testing, including software metrics, software testing tools, and software product line testing. Presents software testing, not as an isolated technique, but as part of an integrated discipline of software verification and validation Proposes program testing and program correctness verification within the same mathematical model, making it possible to deploy the two techniques in concert, by virtue of the law of diminishing returns Defines the concept of a software fault, and the related concept of relative correctness, and shows how relative correctness can be used to characterize monotonic fault removal Presents the activity of software testing as a goal oriented activity, and explores how the conduct of the test depends on the selected goal Covers all phases of the software testing lifecycle, including test data generation, test oracle design, test driver design, and test outcome analysis Software Testing: Concepts and Operations is a great resource for software quality and software engineering students because it presents them with fundamentals that help them to prepare for their ever evolving discipline.

MRI Susceptibility Weighted Imaging discusses the promising new MRI technique called Susceptibility Weighted Imaging (SWI), a powerful tool for the diagnosis and treatment of acute stroke, allowing earlier detection of acute stroke hemorrhage and easier detection of microbleeds in acute ischemia. The book is edited by the originators of SWI and features contributions from the top leaders in the science. Presenting an even balance between technical/scientific aspects of the modality and clinical application, this book includes over 100 super high-quality radiographic images and 100 additional graphics and tables.

Energy Budgets at Risk (EBar)® provides everyone from facility energy managers and financial managers to government policy-makers and electric utilities program planners with the background information required to understand energy cost, price, efficiency, and related issues important in developing a balanced approach to facility energy risk management. Throughout the book, respected energy economist Dr. Jerry Jackson clearly shows how to reduce energy costs and increase cash flows by using risk management concepts developed in the financial industry.