Handbook of GC/MS

The only comprehensive reference on this popular and rapidly developing technique provides a detailed overview, ranging from fundamentals to applications, including a section on the evaluation of GC-MS analyses. As such, it covers all aspects, including the theory and principles, as well as a broad range of real-life examples taken from laboratories in environmental, food, pharmaceutical and clinical analysis. It also features a glossary of approximately 300 terms and a substance index that facilitates finding a specific application. For this new edition the work has been now extended to two volumes, reflecting the latest developments in the technique and related instrumentation, while also incorporating several new examples of applications in many fields. The first two editions were very well received, making this handbook a must-have in all analytical laboratories using GC-MS.

This is the first comprehensive reference work for GC/MS now in its second edition. It offers broad coverage, from sample preparation to the evaluation of MS-Data, including library searches. Fundamentals, techniques, and applications are described. A large part of the book is devoted to numerous examples for GC/MS-applications in environmental, food, pharmaceutical and clinical analysis. These proven examples come from the daily practice of various laboratories. The book also features a glossary of terms and a substance index that helps the reader to find information for his particular analytical problem. The author presents in a consistent and clear style his experience from numerous user workshops which he has organized. This is a thoroughly revised and updated English edition based on an edition which was highly successful in Germany.

Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.

THE COMPLETE COLLECTION NECESSARY FOR A CONCRETE UNDERSTANDING OF PROBABILITY Written in a clear, accessible, and comprehensive manner, the Handbook of Probability presents the fundamentals of probability with an emphasis on the balance of theory, application, and methodology. Utilizing basic examples throughout, the handbook expertly transitions between concepts and practice to allow readers an inclusive introduction to the field of probability. The book provides a useful format with self-contained chapters, allowing the reader easy and quick reference. Each chapter includes an introduction, historical background, theory and applications, algorithms, and exercises. The Handbook of Probability offers coverage of: Probability Space Probability Measure Random Variables Random Vectors in Rn Characteristic Function Moment Generating Function Gaussian Random Vectors Convergence Types Limit Theorems The Handbook of Probability is an ideal resource for researchers and practitioners in numerous fields, such as mathematics, statistics, operations research, engineering, medicine, and finance, as well as a useful text for graduate students.

A multidisciplinary resource that combines the latest research with the best practices for working with older adults The Handbook of Gerontology: Evidence-Based Approaches to Theory, Practice, and Policy provides an essential source of important theoretical and applied information on gerontology for all mental health professionals interested in optimizing the health and well-being of older adults. Interdisciplinary and incorporating the most current evidence-based practices in its focus, this timely book considers the many factors that affect the way this growing population experiences the world-and provides a positive and proactive guide to administering care. Integrating the latest research findings with important practice implications for working with an older client population, the Handbook of Gerontology draws on a multidisciplinary team of expert contributors who provide coverage and insight into a diverse range of topics, including: A global perspective on aging Elder abuse Family caregiving Parenting grandchildren Depression Substance abuse Alzheimer's disease Successful aging and personality Biological and cognitive aspects and theories of aging An exceptional resource for practitioners, researchers, policymakers, and students, the Handbook of Gerontology is essential reading for anyone who works with older adults.

This two-volume handbook is unique in spanning the entire field of evolution, from the origins of life up to the formation of social structures and science and technology. The author team of world-renowned experts considers the subject from a variety of disciplines, with continuous cross-referencing so as to retain a logical internal structure. The uniformly structured contributions discuss not merely the general knowledge behind the evolution of life, but also the corresponding development of language, society, economies, morality and politics. The result is an overview of the history and methods used in the study of evolution, including controversial theories and discussions. A must for researchers in the natural sciences, sociology and philosophy, as well as for those interested in an interdisciplinary view of the status of evolution today.

Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies. The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives. Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: «I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology.»

ATP-dependent active ion transport enables cells to regulate their pH value and to control their ion composition. The reverse process, transforming an ion imbalance into chemical energy, drives mitochondrial and chloroplast ATP synthesis. The mediators of these fundamental processes are ion-motive ATPases, highly conserved enzymes that play key roles in cell physiology from bacteria to man. As the first comprehensive overview of this important class of enzymes, this handbook summarizes recent knowledge about the molecular mechanism of ATPases, relating this information to the physiology and pathopyhsiology of ion transport, mitochondrial function, vesicle transport and lysosomal acidification. All important P-type, F-type and V-type ATPases are treated systematically, complemented by a special section on the cell biology and physiology of acidic compartments, and backed by an extensive bibliography and index. This premier reference source for physiologists, molecular biologists, biophysicists and clinical researchers contains contributions by the world's foremost ATPase research groups.

Handbook of Industrial Mixing will explain the difference and uses of a variety of mixers including gear mixers, top entry mixers, side entry mixers, bottom entry mixers, on-line mixers, and submerged mixers The Handbook discusses the trade-offs among various mixers, concentrating on which might be considered for a particular process. Handbook of Industrial Mixing explains industrial mixers in a clear concise manner, and also: * Contains a CD-ROM with video clips showing different type of mixers in action and a overview of their uses. * Gives practical insights by the top professional in the field. * Details applications in key industries. * Provides the professional with information he did receive in school

Presupposing no prior knowledge of linguistics,The Handbook of Linguistics is the ideal resource for people who want to learn about the subject and its subdisciplines.