Introduction to Proteomics. Principles and Applications

The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

Combines clear and concise discussions of key NMR concepts with succinct and illustrative examples Designed to cover a full course in Nuclear Magnetic Resonance (NMR) Spectroscopy, this text offers complete coverage of classic (one-dimensional) NMR as well as up-to-date coverage of two-dimensional NMR and other modern methods. It contains practical advice, theory, illustrated applications, and classroom-tested problems; looks at such important ideas as relaxation, NOEs, phase cycling, and processing parameters; and provides brief, yet fully comprehensible, examples. It also uniquely lists all of the general parameters for many experiments including mixing times, number of scans, relaxation times, and more. Nuclear Magnetic Resonance Spectroscopy: An Introduction to Principles, Applications, and Experimental Methods, 2nd Edition begins by introducing readers to NMR spectroscopy – an analytical technique used in modern chemistry, biochemistry, and biology that allows identification and characterization of organic, and some inorganic, compounds. It offers chapters covering: Experimental Methods; The Chemical Shift; The Coupling Constant; Further Topics in One-Dimensional NMR Spectroscopy; Two-Dimensional NMR Spectroscopy; Advanced Experimental Methods; and Structural Elucidation. Features classical analysis of chemical shifts and coupling constants for both protons and other nuclei, as well as modern multi‐pulse and multi-dimensional methods Contains experimental procedures and practical advice relative to the execution of NMR experiments Includes a chapter-long, worked-out problem that illustrates the application of nearly all current methods Offers appendices containing the theoretical basis of NMR, including the most modern approach that uses product operators and coherence-level diagrams By offering a balance between volumes aimed at NMR specialists and the structure-determination-only books that focus on synthetic organic chemists, Nuclear Magnetic Resonance Spectroscopy: An Introduction to Principles, Applications, and Experimental Methods, 2nd Edition is an excellent text for students and post-graduate students working in analytical and bio-sciences, as well as scientists who use NMR spectroscopy as a primary tool in their work.

The one-stop reference to the essentials of color science and technology—now fully updated and revised The fully updated Third Edition of Color: An Introduction to Practice and Principles continues to provide a truly comprehensive, non-mathematical introduction to color science, complete with historical, philosophical, and art-related topics. Geared to non-specialists and experts alike, Color clearly explains key technical concepts concerning light, human vision, and color perception phenomena. It covers color order systems in depth, examines color reproduction technologies, and reviews the history of color science as well as its relationship to art and color harmony. Revised throughout to reflect the latest developments in the field, the Third Edition: Features many new color illustrations, now fully incorporated into the text Offers new perspectives on what color is all about, diverging from conventional thinking Includes new information on perception phenomena, color order, and technological advances Updates material on such topics as the CIE colorimetric system and optimal object colors Extends coverage of color reproduction to display systems, photography, and color management Contains a unique timetable of color in science and art, plus a glossary of important terms Praise for the previous editions: «A nice bridge to areas usually not covered in academic visual science programs . . . outstanding.» —Joel Pokorny, visual scientist at The University of Chicago «A good addition to any library, this should be useful for the color interests of artists, designers, craftsmen, philosophers, psychologists, color technologies, and students in related fields.» —CHOICE

Covering both fundamental and advanced aspects in an accessible way, this textbook begins with an overview of nuclear reactor systems, helping readers to familiarize themselves with the varied designs. Then the readers are introduced to different possibilities for materials applications in the various sections of nuclear energy systems. Materials selection and life prediction methodologies for nuclear reactors are also presented in relation to creep, corrosion and other degradation mechanisms. An appendix compiles useful property data relevant for nuclear reactor applications. Throughout the book, there is a thorough coverage of various materials science principles, such as physical and mechanical metallurgy, defects and diffusion and radiation effects on materials, with serious efforts made to establish structure-property correlations wherever possible. With its emphasis on the latest developments and outstanding problems in the field, this is both a valuable introduction and a ready reference for beginners and experienced practitioners alike.

Written by a university lecturer with more than forty years experience in plasma technology, this book adopts a didactic approach in its coverage of the theory, engineering and applications of technological plasmas. The theory is developed in a unified way to enable brevity and clarity, providing readers with the necessary background to assess the factors that affect the behavior of plasmas under different operating conditions. The major part of the book is devoted to the applications of plasma technology and their accompanying engineering aspects, classified by the various pressure and density regimes at which plasmas can be produced. Two chapters on plasma power supplies round off the book. With its broad range of topics, from low to high pressure plasmas, from characterization to modeling, and from materials to components, this is suitable for advanced undergraduates, postgraduates and professionals in the field.

This is an authoritative, comprehensive book on the fate of drug molecules in the body, including implications for pharmacological and clinical effects. The text provides a unique, balanced approach, examining the specific physical and biological factors affecting the absorption, distribution, metabolism and excretion of drugs, together with mathematical assessment of the concentrations in plasma and body fluids. Understanding the equations requires little more than a basic knowledge of algebra, laws of indices and logarithms, and very simple calculus. A companion web site contains additional illustrations, further equations and numerous worked examples. Whilst this book has its roots in the highly acclaimed book of the same name, written by Stephen Curry nearly thirty years ago, it is essentially a new book having been restructured and largely rewritten. This readable and informative book is an invaluable resource for professionals and students needing to develop a rational approach to the investigation and application of drugs.

An in-depth look at the theory and applications of frequency stability An understanding of the acquisition of stable frequency is essential for anyone who needs to solve noise problems in wireless communications. This book offers a thorough introduction to the principles and applications of frequency stability, arming practicing engineers with the tools they need to minimize noise in systems and devices that affect everyday communications for millions of people. With an emphasis on both practical and scientific points of view, Frequency Stability: Introduction and Applications examines frequency and time fluctuations in resonators, as well as the stability of both standard and practical microwave oscillators. It explains noise properties of building circuit blocks, introducing time domain properties and how they relate to noise spectral densities. Including a special chapter devoted to the design and properties of phase locked loops—a crucial topic for frequency synthesizers—the book also: Examines in detail L/F noise, showing how power losses in the propagation material extend over a long period of time Covers sapphire, optoelectronics, MW, and ring oscillators with the discussion of noise in delay-line oscillators with lasers Offers an extended treatment of phase noise in semiconductors and amplifiers based on Van der Ziel investigations Emphasizes the modified Allan variance in the time domain, including exact computations Outlines the relationship between resonator frequency and output phase noises via the feedback theory Featuring numerous tables with actual data, Frequency Stability: Introduction and Applications is an invaluable guide for engineers wishing to rein in acoustic and electromagnetic interference in modern communications.

A thorough, accessible, and general overview of chemosensors Providing a comprehensive overview of chemosensors—organic molecules designed to bind and sense small molecules or metal ions—and their applications, Chemosensors: Principles, Strategies, and Applications is an accessible one-stop resource for analysts, clinicians, and graduate students studying advanced chemistry and chemosensing. Chemosensors function on a molecular level, generating a signal upon binding. The book reviews their synthesis, design, and applications for detecting biological and organic molecules as well as metal ions. The text highlights applications in drug discovery and catalyses that have not been well covered elsewhere. Covering such topics as molecular recognition, detection methods, design strategies, and important biological issues, the book is broken into four sections that examine intermolecular interactions, strategies in sensor design, detection methods, and case studies in metal, saccharide, and amino acid sensing. An indispensable source of information for chemical and biomedical experts using sensors, Chemosensors includes case studies to make the material both accessible and understandable to chemists of all backgrounds.

This book presents and describes imaging technologies that can be used to study chemical processes and structural interactions in dynamic systems, principally in biomedical systems. The imaging technologies, largely biomedical imaging technologies such as MRT, Fluorescence mapping, raman mapping, nanoESCA, and CARS microscopy, have been selected according to their application range and to the chemical information content of their data. These technologies allow for the analysis and evaluation of delicate biological samples, which must not be disturbed during the profess. Ultimately, this may mean fewer animal lab tests and clinical trials.

Basin Analysis is an up-to-date overview of the essential processes of the formation and evolution of sedimentary basins, and their implications for the development of hydrocarbon resources. The new edition features: A consideration of the fundamental physical state of the lithosphere. A discussion on the major types of lithospheric deformation relevant to basin development – stretching and flexure. A new chapter on the effects of mantle dynamics. Radically revised chapters on the basin-fill. A new chapter on the erosional engine for sediment delivery to basins, reflecting the massive and exciting advances in this area in the last decade. Expansion of the techniques used in approaching problems in basin analysis. Updated chapters on subsidence analysis and measurements of thermal maturity of organic and non-organic components of the basin-fill. New material on thermochronological and exposure dating tools. Inclusion of the important petroleum system concept in the updated section on the application to the petroleum play. Visit: www.blackwellpublishing.com/allen for practical exercises related to problems in Basin Analysis 2e. To run the programs you will need a copy of Matlab 6 or 7. An Instructor manual CD-ROM for this title is available. Please contact our Higher Education team at HigherEducation@wiley.com for more information.