Large-Scale Inverse Problems and Quantification of Uncertainty

This book deals with the various aspects of stochastic dynamics, the resolution of large mechanical systems, and inverse problems. It integrates the most recent ideas from research and industry in the field of stochastic dynamics and optimization in structural mechanics over 11 chapters. These chapters provide an update on the various tools for dealing with uncertainties, stochastic dynamics, reliability and optimization of systems. The optimization–reliability coupling in structures dynamics is approached in order to take into account the uncertainties in the modeling and the resolution of the problems encountered. Accompanied by detailed examples of uncertainties, optimization, reliability, and model reduction, this book presents the newest design tools. It is intended for students and engineers and is a valuable support for practicing engineers and teacher-researchers.

Discrete Signals and Inverse Problems examines fundamental concepts necessary to engineers and scientists working with discrete signal processing and inverse problem solving, and places emphasis on the clear understanding of algorithms within the context of application needs. Based on the original ‘Introduction to Discrete Signals and Inverse Problems in Civil Engineering’, this expanded and enriched version: combines discrete signal processing and inverse problem solving in one book covers the most versatile tools that are needed to process engineering and scientific data presents step-by-step ‘implementation procedures’ for the most relevant algorithms provides instructive figures, solved examples and insightful exercises Discrete Signals and Inverse Problems is essential reading for experimental researchers and practicing engineers in civil, mechanical and electrical engineering, non-destructive testing and instrumentation. This book is also an excellent reference for advanced undergraduate students and graduate students in engineering and science.

This book is a new edition of a title originally published in1992. No other book has been published that treats inverse spectral and inverse scattering results by using the so called Poisson summation formula and the related study of singularities. This book presents these in a closed and comprehensive form, and the exposition is based on a combination of different tools and results from dynamical systems, microlocal analysis, spectral and scattering theory. The content of the first edition is still relevant, however the new edition will include several new results established after 1992; new text will comprise about a third of the content of the new edition. The main chapters in the first edition in combination with the new chapters will provide a better and more comprehensive presentation of importance for the applications inverse results. These results are obtained by modern mathematical techniques which will be presented together in order to give the readers the opportunity to completely understand them. Moreover, some basic generic properties established by the authors after the publication of the first edition establishing the wide range of applicability of the Poison relation will be presented for first time in the new edition of the book.

This book studies methods to concretely address inverse problems. An inverse problem arises when the causes that produced a given effect must be determined or when one seeks to indirectly estimate the parameters of a physical system. The author uses practical examples to illustrate inverse problems in physical sciences. He presents the techniques and specific methods chosen to solve inverse problems in a general domain of application, choosing to focus on a small number of methods that can be used in most applications. This book is aimed at readers with a mathematical and scientific computing background. Despite this, it is a book with a practical perspective. The methods described are applicable, have been applied, and are often illustrated by numerical examples.

This book provides researchers and engineers in the imaging field with the skills they need to effectively deal with nonlinear inverse problems associated with different imaging modalities, including impedance imaging, optical tomography, elastography, and electrical source imaging. Focusing on numerically implementable methods, the book bridges the gap between theory and applications, helping readers tackle problems in applied mathematics and engineering. Complete, self-contained coverage includes basic concepts, models, computational methods, numerical simulations, examples, and case studies. Provides a step-by-step progressive treatment of topics for ease of understanding. Discusses the underlying physical phenomena as well as implementation details of image reconstruction algorithms as prerequisites for finding solutions to non linear inverse problems with practical significance and value. Includes end of chapter problems, case studies and examples with solutions throughout the book. Companion website will provide further examples and solutions, experimental data sets, open problems, teaching material such as PowerPoint slides and software including MATLAB m files. Essential reading for Graduate students and researchers in imaging science working across the areas of applied mathematics, biomedical engineering, and electrical engineering and specifically those involved in nonlinear imaging techniques, impedance imaging, optical tomography, elastography, and electrical source imaging

Extremism and the Psychology of Uncertainty showcases cutting-edge scientific research on the extent to which uncertainty may lead to extremism. Contributions come from leading international scholars who focus on a wide variety of forms, facets and manifestations of extremist behavior. Systematically integrates and explores the growing diversity of social psychological perspectives on the uncertainty extremism relationship Showcases contemporary cutting edge scientific research from leading international scholars Offers a broad perspective on extremism and focuses on a wide variety of different forms, facets and manifestations Accessible to social and behavioral scientists, policy makers and those with a genuine interest in understanding the psychology of extremism

Written by leading experts in the field, Social Theories of Risk and Uncertainty is an introduction to mainstream theorizing on risk and uncertainty in sociology. Provides an overview of the historical developments and conceptual aspects of risk Identifies why theorizing on risk is necessary and highlights specific sociological contributions to this field of research Explores key topics including risk society and reflexive modernization, culture and risk, governmentality and risk, systems theory and risk, and edgework and voluntary risk taking Offers a comprehensive look at the promises, pitfalls, and perspectives of risk theorizing

Deal with information and uncertainty properly and efficiently using tools emerging from generalized information theory Uncertainty and Information: Foundations of Generalized Information Theory contains comprehensive and up-to-date coverage of results that have emerged from a research program begun by the author in the early 1990s under the name «generalized information theory» (GIT). This ongoing research program aims to develop a formal mathematical treatment of the interrelated concepts of uncertainty and information in all their varieties. In GIT, as in classical information theory, uncertainty (predictive, retrodictive, diagnostic, prescriptive, and the like) is viewed as a manifestation of information deficiency, while information is viewed as anything capable of reducing the uncertainty. A broad conceptual framework for GIT is obtained by expanding the formalized language of classical set theory to include more expressive formalized languages based on fuzzy sets of various types, and by expanding classical theory of additive measures to include more expressive non-additive measures of various types. This landmark book examines each of several theories for dealing with particular types of uncertainty at the following four levels: * Mathematical formalization of the conceived type of uncertainty * Calculus for manipulating this particular type of uncertainty * Justifiable ways of measuring the amount of uncertainty in any situation formalizable in the theory * Methodological aspects of the theory With extensive use of examples and illustrations to clarify complex material and demonstrate practical applications, generous historical and bibliographical notes, end-of-chapter exercises to test readers' newfound knowledge, glossaries, and an Instructor's Manual, this is an excellent graduate-level textbook, as well as an outstanding reference for researchers and practitioners who deal with the various problems involving uncertainty and information. An Instructor's Manual presenting detailed solutions to all the problems in the book is available from the Wiley editorial department.

The focus of this book is on «ill-posed inverse problems». These problems cannot be solved only on the basis of observed data. The building of solutions involves the recognition of other pieces of a priori information. These solutions are then specific to the pieces of information taken into account. Clarifying and taking these pieces of information into account is necessary for grasping the domain of validity and the field of application for the solutions built. For too long, the interest in these problems has remained very limited in the signal-image community. However, the community has since recognized that these matters are more interesting and they have become the subject of much greater enthusiasm. From the application field’s point of view, a significant part of the book is devoted to conventional subjects in the field of inversion: biological and medical imaging, astronomy, non-destructive evaluation, processing of video sequences, target tracking, sensor networks and digital communications. The variety of chapters is also clear, when we examine the acquisition modalities at stake: conventional modalities, such as tomography and NMR, visible or infrared optical imaging, or more recent modalities such as atomic force imaging and polarized light imaging.

The definitive book on the neutralization of recombinant biopharmaceuticals Recombinant biopharmaceuticals are an important tool for treating a range of illnesses; however, their efficacy can be severely impaired by their immunogenicity. When introduced into the body, these pharmaceuticals can cause the immune system to produce anti-drug antibodies (ADAs) that neutralize their effects. The first and only book to cover neutralization in connection with biopharmaceuticals and the measurement and application of neutralizing antibodies in modern medicine at any real length, Detection and Quantification of Antibodies to Biopharmaceuticals: Practical and Applied Considerations offers a comprehensive and in-depth look at all the principal aspects of the detection and quantification of antibodies that are essential to understanding and responding to the challenges they present. Bringing together a large-scale review of neutralization and biopharmaceuticals and the ability to measure, detect, and apply antibodies to modern science and medicine with international regulatory perspectives, the expectations of regulatory authorities, and the strengths and weaknesses of various assays, the book describes several novel ideas for detecting ADAs. Designed to serve as a resource for biopharmaceutical drug development, the book provides biotechnology companies and pharmaceutical drug development specialists, as well as non-experts, with key insights into the design, optimization, and qualification of assays, the establishment of sampling strategies, the choice of appropriate assay end-points, and data analysis for the detection and quantification of neutralizing antibodies.