Neuronal and Cognitive Effects of Oestrogens

Classical studies of steroid hormones are concerned with their regulation of protein synthesis via the modulation of genomic transcription. But many of the actions of these hormones occur too rapidly to be explained in this manner, particularly their effects on the central nervous system. This text deals with recent discoveries showing that steroids can modulate the activity of some neurotransmitters. It explores the role of GABA as an important regulator of neuronal activity in the central nervous system and its inhibitory action as mediated via the GABA receptor and potentiated by steroids. In addition, the binding of steroids to cell membranes, the components involved and the outcome of such interactions are described. Also discusses possible uses of steroids as anesthetics and anticonvulsants.

This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states It provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders. Novel and potentially controversial Will inspire future research directions

Comprehensive coverage of weapon damage effects on a variety of objects Damaging Effects of Weapons and Ammunition delivers a thorough exploration of a range of issues related to the effects of ammunition and weapons. The book includes coverage of the basic concepts of the theory of efficiency and the physical foundations of the functional and damaging effects of fragments, shaped charges, high-explosive and penetrating weapons. The author discusses the calculation formulas used to evaluation the parameters of damage fields and their interaction with various objects. Additionally, the book expands on the damage criteria of weapons, the characteristics of the vulnerability of objects with respect to a variety of damaging factors, dependencies for assessing safe distances, and the resistance of various structures to the effects of explosion and impact. Damaging Effects of Weapons and Ammunition also offers: Detailed calculation methods indicating areas of application and the necessary units of used quantities Extensive examples of classic designs of ammunition from around the world Discussions of the characterization of various types of ammunition, including high-explosive, fragment, penetrative, and shaped charges A chapter on the numerical simulation of high-speed processes Perfect for technical specialists working in the fields of explosion safety and explosives, Damaging Effects of Weapons and Ammunition also belongs in the libraries of researchers and students studying explosion phenomena, explosive technologies, explosion safety, and materials science.

Written by the world-renowned pioneer in the field of modern sociolinguistics, this volume examines the cognitive and cultural factors responsible for linguistic change, tracing the life history of these developments, from triggering events to driving forces and endpoints. Explores the major insights obtained by combining sociolinguistics with the results of dialect geography on a large scale Examines the cognitive and cultural influences responsible for linguistic change Demonstrates under what conditions dialects diverge from one another Establishes an essential distinction between transmission within the community and diffusion across communities Completes Labov’s seminal Principles of Linguistic Change trilogy

This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. • Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death • Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments • Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field • Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders

This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

This textbook focuses on the relationship between physical exercise and cognition, a very timely and important topic with major theoretical and practical implications for a number of areas including ageing, neurorehabilitation, depression and dementia. It brings together a wide range of analytical approaches and experimental results to provide a very useful overview and synthesis of this growing field of study. The book is divided into three parts: Part I covers the conceptual, theoretical and methodological underpinnings and issues. Part II focuses on advances in exercise and cognition research, with appropriate sub-sections on ‘acute’ and ‘chronic’ exercise and cognition. Part III presents an overview of the area and makes suggestions for the direction of future research. This text provides a cutting-edge examination of this increasingly important area written by leading experts from around the world. The book will prove invaluable to researchers and practitioners in a number of fields, including exercise science, cognitive science, neuroscience and clinical medicine. Key Features: Unique in-depth investigation of the relationship between physical exercise and brain function. Covers theoretical approaches and experimental results and includes chapters on the latest developments in research design. Examines the effects of both acute and chronic exercise on brain function. International list of contributors, who are leading researchers in their field.

A comprehensive treatment of cognitive radio networks and the specialized techniques used to improve wireless communications The human brain, as exemplified by cognitive radar, cognitive radio, and cognitive computing, inspires the field of Cognitive Dynamic Systems. In particular, cognitive radio is growing at an exponential rate. Fundamentals of Cognitive Radio details different aspects of the human brain and provides examples of how it can be mimicked by cognitive dynamic systems. The text offers a communication-theoretic background, including information on resource allocation in wireless networks and the concept of robustness. The authors provide a thorough mathematical background with data on game theory, variational inequalities, and projected dynamic systems. They then delve more deeply into resource allocation in cognitive radio networks. The text investigates the dynamics of cognitive radio networks from the perspectives of information theory, optimization, and control theory. It also provides a vision for the new world of wireless communications by integration of cellular and cognitive radio networks. This groundbreaking book: Shows how wireless communication systems increasingly use cognition to enhance their networks Explores how cognitive radio networks can be viewed as spectrum supply chain networks Derives analytic models for two complementary regimes for spectrum sharing (open-access and market-driven) to study both equilibrium and disequilibrium behaviors of networks Studies cognitive heterogeneous networks with emphasis on economic provisioning for resource sharing Introduces a framework that addresses the issue of spectrum sharing across licensed and unlicensed bands aimed for Pareto optimality Written for students of cognition, communication engineers, telecommunications professionals, and others, Fundamentals of Cognitive Radio offers a new generation of ideas and provides a fresh way of thinking about cognitive techniques in order to improve radio networks.

The essential reference for human development theory, updated and reconceptualized The Handbook of Child Psychology and Developmental Science, a four-volume reference, is the field-defining work to which all others are compared. First published in 1946, and now in its Seventh Edition, the Handbook has long been considered the definitive guide to the field of developmental science. Volume 2: Cognitive Processes describes cognitive development as a relational phenomenon that can be studied only as part of a larger whole of the person and context relational system that sustains it. In this volume, specific domains of cognitive development are contextualized with respect to biological processes and sociocultural contexts. Furthermore, key themes and issues (e.g., the importance of symbolic systems and social understanding) are threaded across multiple chapters, although every each chapter is focused on a different domain within cognitive development. Thus, both within and across chapters, the complexity and interconnectivity of cognitive development are well illuminated. Learn about the inextricable intertwining of perceptual development, motor development, emotional development, and brain development Understand the complexity of cognitive development without misleading simplification, reducing cognitive development to its biological substrates, or viewing it as a passive socialization process Discover how each portion of the developmental process contributes to subsequent cognitive development Examine the multiple processes – such as categorizing, reasoning, thinking, decision making and judgment – that comprise cognition The scholarship within this volume and, as well, across the four volumes of this edition, illustrate that developmental science is in the midst of a very exciting period. There is a paradigm shift that involves increasingly greater understanding of how to describe, explain, and optimize the course of human life for diverse individuals living within diverse contexts. This Handbook is the definitive reference for educators, policy-makers, researchers, students, and practitioners in human development, psychology, sociology, anthropology, and neuroscience.