Pattern Recognition in Computational Molecular Biology

This book represents the most comprehensive and up-to-date collection of information on the topic of computational molecular biology. Bringing the most recent research into the forefront of discussion, Algorithms in Computational Molecular Biology studies the most important and useful algorithms currently being used in the field, and provides related problems. It also succeeds where other titles have failed, in offering a wide range of information from the introductory fundamentals right up to the latest, most advanced levels of study.

An invaluable tool in Bioinformatics, this unique volume provides both theoretical and experimental results, and describes basic principles of computational intelligence and pattern analysis while deepening the reader's understanding of the ways in which these principles can be used for analyzing biological data in an efficient manner. This book synthesizes current research in the integration of computational intelligence and pattern analysis techniques, either individually or in a hybridized manner. The purpose is to analyze biological data and enable extraction of more meaningful information and insight from it. Biological data for analysis include sequence data, secondary and tertiary structure data, and microarray data. These data types are complex and advanced methods are required, including the use of domain-specific knowledge for reducing search space, dealing with uncertainty, partial truth and imprecision, efficient linear and/or sub-linear scalability, incremental approaches to knowledge discovery, and increased level and intelligence of interactivity with human experts and decision makers Chapters authored by leading researchers in CI in biology informatics. Covers highly relevant topics: rational drug design; analysis of microRNAs and their involvement in human diseases. Supplementary material included: program code and relevant data sets correspond to chapters.

This book supplies an application-oriented introduction to molecular simulation techniques used to study a wide range of problems in molecular biology. Each chapter focuses in detail on one kind of application, including the scientific background, the appropriate methodology and the relationship to experimental results. The book contains many areas of interest to basic and industrial scientists, including: – flexibility of peptides – protein-peptide interactions – ion translocation across membranes – modelling protein and nucleic acid conformations – stability of mutant proteins – modelling conformational transitions Currently the only up-to-date compilation available, this book enables readers to get an overview of the methods and how they are used in various specialized applications without having to search for them in a large number of papers in different journals.

Two factors dominate current molecular biology: the amount of raw data is increasing very rapidly and successful applications in biomedical research require carefully curated and annotated databases. The quality of the experimental data – especially nucleic acid sequences – is satisfactory; however, annotations depend on features inferred from the data rather than measured directly, for instance the identification of genes in genome sequences. It is essential that these inferences are as accurate as possible and this requires human intervention. With the recognition of the importance of accurate database annotation and the requirement for individuals with particular constellations of skills to carry it out, annotators are emerging as specialists within the profession of bioinformatics. This book compiles information about annotation – its current status, what is required to improve it, what skills must be brought to bear on database curation and hence what is the proper training for annotators. The book should be essential reading for all people working on biological databases, both biologists and computer scientists. It will also be of interest to all users of such databases, including molecular biologists, geneticists, protein chemists, clinicians and drug developers.

A new approach to the issue of data quality in pattern recognition Detailing foundational concepts before introducing more complex methodologies and algorithms, this book is a self-contained manual for advanced data analysis and data mining. Top-down organization presents detailed applications only after methodological issues have been mastered, and step-by-step instructions help ensure successful implementation of new processes. By positioning data quality as a factor to be dealt with rather than overcome, the framework provided serves as a valuable, versatile tool in the analysis arsenal. For decades, practical need has inspired intense theoretical and applied research into pattern recognition for numerous and diverse applications. Throughout, the limiting factor and perpetual problem has been data—its sheer diversity, abundance, and variable quality presents the central challenge to pattern recognition innovation. Pattern Recognition: A Quality of Data Perspective repositions that challenge from a hurdle to a given, and presents a new framework for comprehensive data analysis that is designed specifically to accommodate problem data. Designed as both a practical manual and a discussion about the most useful elements of pattern recognition innovation, this book: Details fundamental pattern recognition concepts, including feature space construction, classifiers, rejection, and evaluation Provides a systematic examination of the concepts, design methodology, and algorithms involved in pattern recognition Includes numerous experiments, detailed schemes, and more advanced problems that reinforce complex concepts Acts as a self-contained primer toward advanced solutions, with detailed background and step-by-step processes Introduces the concept of granules and provides a framework for granular computing Pattern recognition plays a pivotal role in data analysis and data mining, fields which are themselves being applied in an expanding sphere of utility. By facing the data quality issue head-on, this book provides students, practitioners, and researchers with a clear way forward amidst the ever-expanding data supply.

State-of-the-art techniques for tapping the vast potential of polymers The use of specific non-covalent interactions to control polymer structure and properties is a rapidly emerging field with applications in diverse disciplines. Molecular Recognition and Polymers covers the fundamental aspects and applications of molecular recognition—in the creation of novel polymeric materials for use in drug delivery, sensors, tissue engineering, molecular imprinting, and other areas. This reference begins by explaining the fundamentals of supramolecular polymers; it progresses to cover polymer formation and self-assembly with a wide variety of examples, and then includes discussions of biomolecular recognition using polymers. With chapters contributed by the foremost experts in their fields, this resource: Provides an integrated resource for supramolecular chemistry, polymer science, and interfacial science Covers advanced, state-of-the-art techniques used in the design and characterization of non-covalent interactions in polymers Illustrates how to tailor the properties of polymeric materials for various applications Stand-alone chapters address specific applications independently for easy reference. This is a premier resource for graduate students and researchers in polymer chemistry, supramolecular chemistry, materials science, and physical organic chemistry.

Moments as projections of an image’s intensity onto a proper polynomial basis can be applied to many different aspects of image processing. These include invariant pattern recognition, image normalization, image registration, focus/ defocus measurement, and watermarking. This book presents a survey of both recent and traditional image analysis and pattern recognition methods, based on image moments, and offers new concepts of invariants to linear filtering and implicit invariants. In addition to the theory, attention is paid to efficient algorithms for moment computation in a discrete domain, and to computational aspects of orthogonal moments. The authors also illustrate the theory through practical examples, demonstrating moment invariants in real applications across computer vision, remote sensing and medical imaging. Key features: Presents a systematic review of the basic definitions and properties of moments covering geometric moments and complex moments. Considers invariants to traditional transforms – translation, rotation, scaling, and affine transform – from a new point of view, which offers new possibilities of designing optimal sets of invariants. Reviews and extends a recent field of invariants with respect to convolution/blurring. Introduces implicit moment invariants as a tool for recognizing elastically deformed objects. Compares various classes of orthogonal moments (Legendre, Zernike, Fourier-Mellin, Chebyshev, among others) and demonstrates their application to image reconstruction from moments. Offers comprehensive advice on the construction of various invariants illustrated with practical examples. Includes an accompanying website providing efficient numerical algorithms for moment computation and for constructing invariants of various kinds, with about 250 slides suitable for a graduate university course. Moments and Moment Invariants in Pattern Recognition is ideal for researchers and engineers involved in pattern recognition in medical imaging, remote sensing, robotics and computer vision. Post graduate students in image processing and pattern recognition will also find the book of interest.

Statistical pattern recognition is a very active area of study and research, which has seen many advances in recent years. New and emerging applications – such as data mining, web searching, multimedia data retrieval, face recognition, and cursive handwriting recognition – require robust and efficient pattern recognition techniques. Statistical decision making and estimation are regarded as fundamental to the study of pattern recognition. Statistical Pattern Recognition, Second Edition has been fully updated with new methods, applications and references. It provides a comprehensive introduction to this vibrant area – with material drawn from engineering, statistics, computer science and the social sciences – and covers many application areas, such as database design, artificial neural networks, and decision support systems. * Provides a self-contained introduction to statistical pattern recognition. * Each technique described is illustrated by real examples. * Covers Bayesian methods, neural networks, support vector machines, and unsupervised classification. * Each section concludes with a description of the applications that have been addressed and with further developments of the theory. * Includes background material on dissimilarity, parameter estimation, data, linear algebra and probability. * Features a variety of exercises, from 'open-book' questions to more lengthy projects. The book is aimed primarily at senior undergraduate and graduate students studying statistical pattern recognition, pattern processing, neural networks, and data mining, in both statistics and engineering departments. It is also an excellent source of reference for technical professionals working in advanced information development environments. For further information on the techniques and applications discussed in this book please visit www.statistical-pattern-recognition.net

Statistical pattern recognition relates to the use of statistical techniques for analysing data measurements in order to extract information and make justified decisions. It is a very active area of study and research, which has seen many advances in recent years. Applications such as data mining, web searching, multimedia data retrieval, face recognition, and cursive handwriting recognition, all require robust and efficient pattern recognition techniques. This third edition provides an introduction to statistical pattern theory and techniques, with material drawn from a wide range of fields, including the areas of engineering, statistics, computer science and the social sciences. The book has been updated to cover new methods and applications, and includes a wide range of techniques such as Bayesian methods, neural networks, support vector machines, feature selection and feature reduction techniques.Technical descriptions and motivations are provided, and the techniques are illustrated using real examples. Statistical Pattern Recognition, 3rd Edition: Provides a self-contained introduction to statistical pattern recognition. Includes new material presenting the analysis of complex networks. Introduces readers to methods for Bayesian density estimation. Presents descriptions of new applications in biometrics, security, finance and condition monitoring. Provides descriptions and guidance for implementing techniques, which will be invaluable to software engineers and developers seeking to develop real applications Describes mathematically the range of statistical pattern recognition techniques. Presents a variety of exercises including more extensive computer projects. The in-depth technical descriptions make the book suitable for senior undergraduate and graduate students in statistics, computer science and engineering. Statistical Pattern Recognition is also an excellent reference source for technical professionals. Chapters have been arranged to facilitate implementation of the techniques by software engineers and developers in non-statistical engineering fields. www.wiley.com/go/statistical_pattern_recognition

Groundbreaking, long-ranging research in this emergent field that enables solutions to complex biological problems Computational systems biology is an emerging discipline that is evolving quickly due to recent advances in biology such as genome sequencing, high-throughput technologies, and the recent development of sophisticated computational methodologies. Elements of Computational Systems Biology is a comprehensive reference covering the computational frameworks and techniques needed to help research scientists and professionals in computer science, biology, chemistry, pharmaceutical science, and physics solve complex biological problems. Written by leading experts in the field, this practical resource gives detailed descriptions of core subjects, including biological network modeling, analysis, and inference; presents a measured introduction to foundational topics like genomics; and describes state-of-the-art software tools for systems biology. Offers a coordinated integrated systems view of defining and applying computational and mathematical tools and methods to solving problems in systems biology Chapters provide a multidisciplinary approach and range from analysis, modeling, prediction, reasoning, inference, and exploration of biological systems to the implications of computational systems biology on drug design and medicine Helps reduce the gap between mathematics and biology by presenting chapters on mathematical models of biological systems Establishes solutions in computer science, biology, chemistry, and physics by presenting an in-depth description of computational methodologies for systems biology Elements of Computational Systems Biology is intended for academic/industry researchers and scientists in computer science, biology, mathematics, chemistry, physics, biotechnology, and pharmaceutical science. It is also accessible to undergraduate and graduate students in machine learning, data mining, bioinformatics, computational biology, and systems biology courses.