Preclinical Development Handbook

Lex Fullarton takes a closer look at the three pillars of the sustainable development framework known as the Triple Bottom Line (TBL). The concept of the TBL is that for a project to be sustainable it must not simply be profitable in economic terms, but it must also benefit society and enhance the natural environment. In the 21st century, the greatest threat to Earth’s natural environment and the population of the planet is the rise of greenhouse gas emissions caused from burning fossil fuel as an energy source. The rise of GHG emissions has resulted in a rise in the ambient air temperature of the Earth’s atmosphere and is resulting in a significant change in climatic conditions on Earth. Fullarton scrutinizes the problem of getting industry and governments to understand the significance of creating harmony within the TBL. One of the main problems is that partisan politics tends to fragment the factors of the TBL rather than bring them together. Fullarton takes a strong stand in suggesting that taxation systems, which have traditionally been viewed primarily as a means of raising government finance, can be effectively applied to influence industrial and consumer attitudes towards transiting away from polluting fossil-fuel energy sources towards non-polluting renewable energy use.

Anthony Barron explores the relationship between the philosophy of Schopenhauer and the forms and themes of Beckett’s critical and creative writings. He shows that Beckett’s aesthetic preoccupations are consonant with some of Schopenhauer’s seminal arguments regarding the arational basis of artistic composition and appreciation and the impotence of reason in human affairs. While Beckett’s critical writings are, in places, formidably opaque, this work examines the ways in which such texts can be elucidated when their intertextual affinities with Schopenhauer’s arguments are revealed. Using Schopenhauer’s thought as a presiding interpretative framework, Barron demonstrates how the widespread presence of philosophical and theological ideas in Beckett’s creative texts signifies less about his personal convictions than it does about his authorial aims. He thereby highlights the ways in which discursive ideas were appropriated and manipulated by Beckett for purely literary ends. A central contention of this book is that to judge the place of ideas within Beckett’s art, we should ignore questions of their theoretical persuasiveness and consider their role as purely aesthetic devices, the value of which is revealed in terms of the existential impact they have upon his characters. In each of the chapters that deal with Beckett’s fiction, Barron underscores the artistically energizing tensions that exist between the concepts that Beckett’s characters invoke in their attempts to comprehend the import of their experiences and their conative and affective tribulations which invariably prove resistant to such analysis. Here the means by which such conceptual aporias engender semantic potentialities underpin an exploration of Beckett’s creative assimilation of rational discourse. While the focus of this publication is upon Beckett’s early and middle fiction, which was composed at a time when the relationship between the chaos of quotidian ordeals and the value of rational thought became most acutely relevant for him, numerous cross-references to his dramatic and poetical works are provided in order to highlight the overall significance of these issues within his oeuvre.

Surrogate motherhood is expanding all over the world. Debates rage over how public policy should consider the signing away of the parental rights of birth mothers in favor of a 'commissioning' couple or an individual. In this book, Daniela Danna describes the situation in English-speaking countries and worldwide, from California to Greece, presenting the legal alternatives regulating (or not) these peculiar exchanges. Should surrogacy remain a private agreement? Should it be treated as an enforceable contract? Are surrogate mothers workers? What happens inside the countries that have chosen different ways of handling this new and controversial matter? And, the most important question of all: How can we live in this era of new techno-medical possibilities and try to stay human? Can we resist commodification in the field of human relations concerning procreation? Contract Children discusses the different ways available to obtain a child through surrogate motherhood. It is fundamental reading for anyone wanting to be involved in the surrogacy process. It gives prospective surrogate mothers and infertile couples the background information necessary for their own informed decision. It is also an essential instrument for policy makers and activists in the field of women's rights, social justice, and children's rights. The question of how to publicly deal with surrogate motherhood touches upon our social vision of motherhood, ultimately marking the position of women in contemporary society.

At the beginning of the new millennium, the social sciences discover an epochal “turn” making it necessary to revolutionize their theory-building: As a response to what they call the globalization of the social, they find the need to globalize their theorizing as well. It is odd to discover after two centuries of colonialism and imperialism, after two world wars and several economic world crises that there is a world beyond the national socials; it is even more strange that the social sciences globalize their theorizing by comparing theories about nationally confined socials and by creating all sorts of, preferably, “local theories”, just as if any national social was a secluded social biotope. Discussing how to globalize the social sciences, they argue that globalizing social science theorizing means finding a way of theorizing that must, above all, be liberated from “scientism” in order to allow a “provincialization” of thinking. Not surprisingly, the globalizing social sciences also rediscover mythological and moral thinking as a means for a “true scientific universalism”. Michael Kuhn’s new book presents many thought-provoking arguments on the oddities of the globalizing social sciences and on how these oddities are not accidents, but a consequence of the nature of how the social sciences theorize about the social.

This book ventures a critical gaze at the image of the European Union beyond the crisis. Keeping in mind that crises constitute organic parts of all systems, the volume attempts to apprehend the EU’s losses, gains, challenges, and opportunities deriving from the crisis and assesses what constitutes a viable and integrated exit from the current predicament. Moreover, through dealing with the EU as an everlasting process rather than a completed edifice, the collection aims at charting the conceptual weaknesses which resulted in a crisis so acute and long-lasting and at opening a discourse on the future and the required reconceptualization of the EU. The project is based on three large and interconnected thematic pillars that relate to the European Union after the crisis: – Facets of parliamentarism in the EU in the context of the crisis, – Political cohesion and institutional integration, – Perceptions, images, stereotypes, and their impact on the process of social and political integration of the EU.