Principles in Microbiome Engineering

This book is a short introduction to the engineering principles of harnessing the vast potential of microorganisms, and animal and plant cells in making biochemical products. It was written for scientists who have no background in engineering, and for engineers with minimal background in biology. The overall subject dealt with is process. But the coverage goes beyond the process of biomanufacturing in the bioreactor, and extends to the factory of cell’s biosynthetic machinery. Starting with an overview of biotechnology and organism, engineers are eased into biochemical reactions and life scientists are exposed to the technology of production using cells. Subsequent chapters allow engineers to be acquainted with biochemical pathways, while life scientist learn about stoichiometric and kinetic principles of reactions and cell growth. This leads to the coverage of reactors, oxygen transfer and scale up. Following three chapters on biomanufacturing of current and future importance, i.e. cell culture, stem cells and synthetic biology, the topic switches to product purification, first with a conceptual coverage of operations used in bioseparation, and then a more detailed analysis to provide a conceptual understanding of chromatography, the modern workhorse of bioseparation. Drawing on principles from engineering and life sciences, this book is for practitioners in biotechnology and bioengineering. The author has used the book for a course for advanced students in both engineering and life sciences. To this end, problems are provided at the end of each chapter.

Enables chemical engineering students to bridge theory and practice Integrating scientific principles with practical engineering experience, this text enables readers to master the fundamentals of chemical processing and apply their knowledge of such topics as material and energy balances, transport phenomena, reactor design, and separations across a broad range of chemical industries. The author skillfully guides readers step by step through the execution of both chemical process analysis and equipment design. Principles of Chemical Engineering Practice is divided into two sections: the Macroscopic View and the Microscopic View. The Macroscopic View examines equipment design and behavior from the vantage point of inlet and outlet conditions. The Microscopic View is focused on the equipment interior resulting from conditions prevailing at the equipment boundaries. As readers progress through the text, they'll learn to master such chemical engineering operations and equipment as: Separators to divide a mixture into parts with desirable concentrations Reactors to produce chemicals with needed properties Pressure changers to create favorable equilibrium and rate conditions Temperature changers and heat exchangers to regulate and change the temperature of process streams Throughout the book, the author sets forth examples that refer to a detailed simulation of a process for the manufacture of acrylic acid that provides a unifying thread for equipment sizing in context. The manufacture of hexyl glucoside provides a thread for process design and synthesis. Presenting basic thermodynamics, Principles of Chemical Engineering Practice enables students in chemical engineering and related disciplines to master and apply the fundamentals and to proceed to more advanced studies in chemical engineering.

Environmental Engineering: Principles and Practice is written for advanced undergraduate and first-semester graduate courses in the subject. The text provides a clear and concise understanding of the major topic areas facing environmental professionals. For each topic, the theoretical principles are introduced, followed by numerous examples illustrating the process design approach. Practical, methodical and functional, this exciting new text provides knowledge and background, as well as opportunities for application, through problems and examples that facilitate understanding. Students pursuing the civil and environmental engineering curriculum will fi nd this book accessible and will benefit from the emphasis on practical application. The text will also be of interest to students of chemical and mechanical engineering, where several environmental concepts are of interest, especially those on water and wastewater treatment, air pollution, and sustainability. Practicing engineers will find this book a valuable resource, since it covers the major environmental topics and provides numerous step-by-step examples to facilitate learning and problem-solving. Environmental Engineering: Principles and Practice offers all the major topics, with a focus upon: • a robust problem-solving scheme introducing statistical analysis; • example problems with both US and SI units; • water and wastewater design; • sustainability; • public health. There is also a companion website with illustrations, problems and solutions.

Environmental Engineering: Principles and Practice is written for advanced undergraduate and first-semester graduate courses in the subject. The text provides a clear and concise understanding of the major topic areas facing environmental professionals. For each topic, the theoretical principles are introduced, followed by numerous examples illustrating the process design approach. Practical, methodical and functional, this exciting new text provides knowledge and background, as well as opportunities for application, through problems and examples that facilitate understanding. Students pursuing the civil and environmental engineering curriculum will fi nd this book accessible and will benefit from the emphasis on practical application. The text will also be of interest to students of chemical and mechanical engineering, where several environmental concepts are of interest, especially those on water and wastewater treatment, air pollution, and sustainability. Practicing engineers will find this book a valuable resource, since it covers the major environmental topics and provides numerous step-by-step examples to facilitate learning and problem-solving. Environmental Engineering: Principles and Practice offers all the major topics, with a focus upon: • a robust problem-solving scheme introducing statistical analysis; • example problems with both US and SI units; • water and wastewater design; • sustainability; • public health. There is also a companion website with illustrations, problems and solutions.

A comprehensive and practical guide to methods for solving complex petroleum engineering problems Petroleum engineering is guided by overarching scientific and mathematical principles, but there is sometimes a gap between theoretical knowledge and practical application. Petroleum Engineering: Principles, Calculations, and Workflows presents methods for solving a wide range of real-world petroleum engineering problems. Each chapter deals with a specific issue, and includes formulae that help explain primary principles of the problem before providing an easy to follow, practical application. Volume highlights include: A robust, integrated approach to solving inverse problems In-depth exploration of workflows with model and parameter validation Simple approaches to solving complex mathematical problems Complex calculations that can be easily implemented with simple methods Overview of key approaches required for software and application development Formulae and model guidance for diagnosis, initial modeling of parameters, and simulation and regression Petroleum Engineering: Principles, Calculations, and Workflows is a valuable and practical resource to a wide community of geoscientists, earth scientists, exploration geologists, and engineers. This accessible guide is also well-suited for graduate and postgraduate students, consultants, software developers, and professionals as an authoritative reference for day-to-day petroleum engineering problem solving.

An introductory text on the investigation of industrial accidents Forensic engineering should be seen as a rigorous approach to the discovery of root causes that lead to an accident or near-miss. The approach should be suitable to identify both the immediate causes as well as the underlying factors that affected, amplified, or modified the events in terms of consequences, evolution, dynamics, etc., as well as the contribution of an eventual «human error». This book is a concise and introductory volume to the forensic engineering discipline which helps the reader to recognize the link among those important, very specialized aspects of the same problem in the global strategy of learning from accidents (or near-misses). The reader will benefit from a single point of access to this very large, technical literature that can be only correctly understood with the right terms, definitions, and links in mind. Keywords: Presents simple (real) cases, as well as giving an overview of more complex ones, each of them investigated within the same framework; Gives the readers the bibliography to access more in-depth specific aspects; Offers an overview of the most commonly used methodologies and techniques to investigate accidents, including the evidence that should be collected to define the cause, dynamics and responsibilities of an industrial accident, as well as the most appropriate methods to collect and preserve the evidence through an appropriate chain of security. Principles of Forensic Engineering Applied to Industrial Accidents is essential reading for researchers and practitioners in forensic engineering, as well as graduate students in forensic engineering departments and other professionals.

Explore the military and combat applications of modeling and simulation Engineering Principles of Combat Modeling and Distributed Simulation is the first book of its kind to address the three perspectives that simulation engineers must master for successful military and defense related modeling: the operational view (what needs to be modeled); the conceptual view (how to do combat modeling); and the technical view (how to conduct distributed simulation). Through methods from the fields of operations research, computer science, and engineering, readers are guided through the history, current training practices, and modern methodology related to combat modeling and distributed simulation systems. Comprised of contributions from leading international researchers and practitioners, this book provides a comprehensive overview of the engineering principles and state-of-the-art methods needed to address the many facets of combat modeling and distributed simulation and features the following four sections: Foundations introduces relevant topics and recommended practices, providing the needed basis for understanding the challenges associated with combat modeling and distributed simulation. Combat Modeling focuses on the challenges in human, social, cultural, and behavioral modeling such as the core processes of «move, shoot, look, and communicate» within a synthetic environment and also equips readers with the knowledge to fully understand the related concepts and limitations. Distributed Simulation introduces the main challenges of advanced distributed simulation, outlines the basics of validation and verification, and exhibits how these systems can support the operational environment of the warfighter. Advanced Topics highlights new and developing special topic areas, including mathematical applications fo combat modeling; combat modeling with high-level architecture and base object models; and virtual and interactive digital worlds. Featuring practical examples and applications relevant to industrial and government audiences, Engineering Principles of Combat Modeling and Distributed Simulation is an excellent resource for researchers and practitioners in the fields of operations research, military modeling, simulation, and computer science. Extensively classroom tested, the book is also ideal for courses on modeling and simulation; systems engineering; and combat modeling at the graduate level.

This book explores the structure-property-process relationship of biomaterials from engineering and biomedical perspectives, and the potential of bio-inspired materials and their applications. A large variety of natural materials with outstanding physical and mechanical properties have appeared in the course of evolution. From a bio-inspired viewpoint, materials design requires a novel and highly cross disciplinary approach. Considerable benefits can be gained by providing an integrated approach using bio-inspiration with materials science and engineering. The book is divided into three parts; Part One focuses on mechanical aspects, dealing with conventional material properties: strength, toughness, hardness, wear resistance, impact resistance, self-healing, adhesion, and adaptation and morphing. Part Two focuses on functional materials with unique capabilities, such as self-cleaning, stimuli-response, structural color, anti-reflective materials, catalytic materials for clean energy conversion and storage, and other related topics. Part Three describes how to mimic natural materials processes to synthesize materials with low cost, efficient and environmentally friendly approaches. For each chapter, the approach is to describe situations in nature first and then biomimetic materials, fulfilling the need for an interdisciplinary approach which overlaps both engineering and materials science.

The purpose of this book is to present the main metaheuristics and approximate and stochastic methods for optimization of complex systems in Engineering Sciences. It has been written within the framework of the European Union project ERRIC (Empowering Romanian Research on Intelligent Information Technologies), which is funded by the EU’s FP7 Research Potential program and has been developed in co-operation between French and Romanian teaching researchers. Through the principles of various proposed algorithms (with additional references) this book allows the reader to explore various methods of implementation such as metaheuristics, local search and populationbased methods. It examines multi-objective and stochastic optimization, as well as methods and tools for computer-aided decision-making and simulation for decision-making.