Proto-Oncogenes in Cell Development

Cell Migration matches nearly all research areas in cell and developmental biology, genetics, and biomedicine. The field shows radical progress powered by the combination of new genomic tools, cell labeling techniques and the incorporation of new model systems. This is the first book to comprehensively cover cell migration from the identification of molecular mechanisms to the understanding of certain pathological disorders and cancer development.

Catalysis in Electrochemistry: From Fundamental Aspects to Strategies for Fuel Cell Development is a modern, comprehensive reference work on catalysis in electrochemistry, including principles, methods, strategies, and applications. It points out differences between catalysis at gas/surfaces and electrochemical interfaces, along with the future possibilities and impact of electrochemical science on energy problems. This book contributes both to fundamental science; experience in the design, preparation, and characterization of electrocatalytic materials; and the industrial application of electrocatalytic materials for electrochemical reactions. This is an essential resource for scientists globally in academia, industry, and government institutions.

Intended for undergraduate and graduate courses in plant development, this book explains how the cells of a plant acquire and maintain their specific fates. Plant development is a continuous process occurring throughout the life cycle, with similar regulatory mechanisms acting at different stages and in different parts of the plant. Rather than focussing on the life cycle, the book is structured around these underlying mechanisms, using case studies to provide students with a framework to understand the many factors, both environmental and endogenous, that combine to regulate development and generate the enormous diversity of plant forms. New approach to the study of plant development and a refreshing look at this fast-moving area. Authors focus their discussion on the basic mechanisms which underpin plant development, tackling the fundamental question of how a single cell becomes a complex flowering plant from a cellular perspective. An up-to-date, modern text in plant development for advanced level undergraduates and postgraduates in plant science. Thought-provoking treatment of a difficult subject, the text will satisfy the needs of advanced level undergraduates and postgraduates in plant science. Experimental case studies throughout. The artwork from the book is available at www.blackwellpublishing.com/leyser

Examines the establishment of the germ layers and other cell lineages in the early embryo including details of cell movements during the beginning stages of primitive streak formation. Discusses patterns of gene expression during the development of such tissues as the limb bud, skeletal, muscle and the central nervous systems placing special emphasis on commitment to particular cell types. Although it concentrates on the mouse as an example of mammalian development–chick, amphibian and Drosophila embryogenesis are employed whenever these organisms are more applicable to the study of a particular problem.

Drug development is the process of finding and producing therapeutically useful pharmaceuticals, turning them into safe and effective medicine, and producing reliable information regarding the appropriate dosage and dosing intervals. With regulatory authorities demanding increasingly higher standards in such developments, statistics has become an intrinsic and critical element in the design and conduct of drug development programmes. Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug development. This highly readable second edition has been updated to include: Comprehensive coverage of the design and interpretation of clinical trials. Expanded sections on missing data, equivalence, meta-analysis and dose finding. An examination of both Bayesian and frequentist methods. A new chapter on pharmacogenomics and expanded coverage of pharmaco-epidemiology and pharmaco-economics. Coverage of the ICH guidelines, in particular ICH E9, Statistical Principles for Clinical Trials. It is hoped that the book will stimulate dialogue between statisticians and life scientists working within the pharmaceutical industry. The accessible and wide-ranging coverage make it essential reading for both statisticians and non-statisticians working in the pharmaceutical industry, regulatory bodies and medical research institutes. There is also much to benefit undergraduate and postgraduate students whose courses include a medical statistics component.

Sustainable development is an area that has world-wide appeal, from developed industrialized countries to the developing world. Development of innovative technologies to achieve sustainability is being addressed by many European countries, the USA and also China and India. The need for chemical processes to be safe, compact, flexible, energy efficient, and environmentally benign and conducive to the rapid commercialization of new products poses new challenges for chemical engineers. This book examines the newest technologies for sustainable development in chemical engineering, through careful analysis of the technical aspects, and discussion of the possible fields of industrial development. The book is broad in its coverage, and is divided into four sections: Energy Production, covering renewable energies, innovative solar technologies, cogeneration plants, and smart grids Process Intensification, describing why it is important in the chemical and petrochemical industry, the engineering approach, and nanoparticles as a smart technology for bioremediation Bio-based Platform Chemicals, including the production of bioethanol and biodiesel, bioplastics production and biodegradability, and biosurfactants Soil and Water Remediation, covering water management and re-use, and soil remediation technologies Throughout the book there are case studies and examples of industrial processes in practice.

Studies in bioequivalence are the commonly accepted method to demonstrate therapeutic equivalence between two medicinal products. Savings in time and cost are substantial when using bioequivalence as an established surrogate marker of therapeutic equivalence. For this reason the design, performance and evaluation of bioequivalence studies have received major attention from academia, the pharmaceutical industry and health authorities. Bioequivalence Studies in Drug Development focuses on the planning, conducting, analysing and reporting of bioequivalence studies, covering all aspects required by regulatory authorities. This text presents the required statistical methods, and with an outstanding practical emphasis, demonstrates their applications through numerous examples using real data from drug development. Includes all the necessary pharmacokinetic background information. Presents parametric and nonparametric statistical techniques. Describes adequate methods for power and sample size determination. Includes appropriate presentation of results from bioequivalence studies. Provides a practical overview of the design and analysis of bioequivalence studies. Presents the recent developments in methodology, including population and individual bioequivalence. Reviews the regulatory guidelines for such studies, and the existing global discrepancies. Discusses the designs and analyses of drug-drug and food-drug interaction studies. Bioequivalence Studies in Drug Development is written in an accessible style that makes it ideal for pharmaceutical scientists, clinical pharmacologists, and medical practitioners, as well as biometricians working in the pharmaceutical industry. It will also be of great value for professionals from regulatory bodies assessing bioequivalence studies.

At a time when people use more and more geographic information and tools, the management of geographical information in software systems still holds many challenges and motivates researchers from different backgrounds to propose innovative solutions. Representing geographical space beyond our mere perception is key to making relevant decisions, whether it is with respect to sustainable development or to the planning of everyday activities. Designing, sharing and exploiting such representations entails many challenges. This book presents recent software design projects, led in teams, which sometimes have different backgrounds, to address these challenges. It analyzes the specificities of these projects in terms of motivation, data models and analysis methods. Proposals are also put forward to improve resource sharing in this domain. Contents 1. Introduction, B?n?dicte Bucher and Florence Le Ber. Part 1. Software Presentation 2. ORBISGIS: Geographical Information System Designed by and for Research, Erwan Bocher and Gwendall Petit. 3. GEOXYGENE: an Interoperable Platform for Geographical Application Development, ?ric Grosso, Julien Perret and Micka?l Brasebin. 4. Spatiotemporal Knowledge Representation in AROM-ST, Bogdan Moisuc, Alina Miron, Marl?ne Villanova-Olivier and J?r?me Gensel. 5. GENGHIS: an Environment for the Generation of Spatiotemporal Visualization Interfaces, Paule-Annick Davoine, Bogdan Moisuc and J?r?me Gensel. 6. GEOLIS: a Logical Information System to Organize and Search Geo-Located Data, Olivier Bedel, S?bastien Ferr? and Olivier Ridoux. 7. GENEXP-LANDSITES: a 2D Agricultural Landscape Generating Piece of Software, Florence Le Ber and Jean-Fran?ois Mari. 8. MDWEB: Cataloging and Locating Environmental Resources, Jean-Christophe Desconnets and Th?r?se Libourel. 9. WEBGEN: Web Services to Share Cartographic Generalization Tools, Moritz Neun, Nicolas Regnauld and Robert Weibel. Part 2. Summary and Suggestions 10. Analysis of the Specificities of Software Development in Geomatics Research, Florence Le Ber and B?n?dicte Bucher. 11. Challenges and Proposals for Software Development Pooling in Geomatics, B?n?dicte Bucher, Julien Gaffuri, Florence Le Ber and Th?r?se Libourel.

This book analyses the development of Collective Intelligence by a better knowledge of the diversity of the temperaments and behavioural and relational processes. The purpose is to help the reader become a better Collective Intelligence Leader, who will be able to capitalize on the specificities and the differences of the individuals present in its collective, and transform these differences into complementarities, which are a source of wealth.

Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network. • A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field. • Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases • Reviews the complex processes of signal integration and regulation • Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.