Psychiatric Genetics

As more patients seek information about family risks of psychiatric illness – an interest likely to increase as gene-identification studies are publicized – most psychiatrists agree it is their role to discuss these issues but admit they are ill-prepared to do so. Psychiatric Genetics addresses that need as the first book to focus on clinical applications of genetics in psychiatry. It covers issues involved in genetic counseling, the interpretation of familial and genetic information for clinical use, information regarding risks associated with specific psychiatric disorders, risk/benefit considerations related to medication use during pregnancy, and the ethical and social implications of psychiatric genetic knowledge and research – including the prospects for genetic testing.While other books have been written for the genetics community, this volume is addressed to practitioners: a clinically relevant resource that can help them understand the often bewildering flood of information about genetics – information difficult to interpret, let alone integrate into practice – and enable them to respond to patients' requests to predict the risk of recurrence of psychiatric illness or provide information about reproductive and pregnancy-related issues. Experts from psychiatry, genetic epidemiology, molecular genetics, genetic counseling, cognitive psychology, and ethics focus on issues that have received little attention elsewhere yet are of increasing importance to clinicians. Written at a level that assumes no particular expertise in genetics, the book features these immediately applicable benefits: It offers a framework for understanding and critically evaluating the psychiatric genetic research literature, enabling clinicians to better understand the meaning and limitations of genetic discoveries when patients raise questions about media reports. It provides a resource for clinicians who would like more information about the role and content of genetic counseling, outlining a typical counseling session while demonstrating how risks are estimated and discussed. It summarizes genetic aspects of major psychiatric conditions – from childhood-onset disorders through psychotic, mood, and anxiety disorders to dementia – as well as neuropsychiatric manifestations of other genetic disorders. It alerts clinicians to risk/benefit considerations related to medication use during pregnancy. It covers the ethical, legal, and social implications of genetic research and counseling, illustrating the dilemmas that arise with new advances. Whether used as a clinical guide, reference, or ancillary text, this book sets the standard for the application of psychiatric genetic knowledge in everyday practice. Psychiatrists, mental health clinicians, and genetic counselors will find it an essential resource for all patient encounters in which genetic issues arise.

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Psychiatric diagnosis is one of the most important topics within the broad field of psychiatry. Clear, accurate definitions of the various disorders are essential for clinicians around the world to be confident that they are classifying patients in the same way, thereby enabling comparisons of treatment regimens and their outcomes. There are two major classification systems in use, one produced by the World Health Organization, the WHO International Classification of Diseases, Mental Disorders Chapter, and one by the American Psychiatric Association, the well known Diagnostic and Statistical Manual of Mental Disorders. Both of these are being revised so this book from the prestigious World Psychiatric Association is especially timely. In this book, leading experts in the field provide a broad and integrated coverage of the concepts, structure and context of psychiatric diagnosis. It begins by addressing mental health and illness around the world from historical, philosophical and cultural perspectives. Health is approached comprehensively, to include such aspects as resilience, resources and quality of life. The book then covers major specific psychopathology topics in Section II, including new categorizations and dimensional approaches. Section III concentrates on the complex problem of comorbidity, a primary challenge for modern diagnostic classifications in psychiatry. Finally, Section IV reviews emerging international diagnostic systems in psychiatry, considering innovative models and adaptations. This book will be essential reading for anyone involved in the diagnosis of psychiatric disorders.

The patient interview is at the heart of psychiatric practice. Listening and interviewing skills are the primary tools the psychiatrist uses to obtain the information needed to make an accurate diagnosis and then to plan appropriate treatment. The American Board of Psychiatry and Neurology and the Accrediting Council on Graduate Medical Education identify interviewing skills as a core competency for psychiatric residents. The Psychiatric Interview: Evaluation and Diagnosis is a new and modern approach to this topic that fulfils the need for training in biopsychosocial assessment and diagnosis. It makes use of both classical and new knowledge of psychiatric diagnosis, assessment, treatment planning, and doctor–patient collaboration. Written by world leaders in education, the book is based on the acclaimed Psychiatry, Third Edition, by Tasman and Kay et al., with new chapters to address assessment in special populations and formulation. The psychiatric interview is conceptualized as integrating the patient’s experience with psychological, biological, and environmental components of the illness. This is an excellent new text for psychiatry residents at all stages of their training. It is also useful for medical students interested in psychiatry and for practicing psychiatrists who may wish to refresh their interviewing skills.

Acute Psychiatric Emergencies is designed for all medical and healthcare professionals working with patients in mental health crisis. This manual is a key component of the Acute Psychiatric Emergencies (APEx) course, which uses a structured approach developed by leading psychiatry and emergency medicine specialists with years of practical experience. This valuable resource provides a practical approach for dealing with mental health emergencies, helping healthcare professionals from different specialties speak a common language and develop a shared understanding that expedites excellent care. The manual outlines the assessment and management of patients who have self-harmed, those that are apparently drunk, the patient behaving strangely, the patient with acute confusion, and those that are aggressive. Presents a structured, practical approach for the emergency care of patients presenting in acute psychiatric crisis Covers common presentations of psychiatric emergencies Emphasises close co-operation of emergency and mental health teams Offers content designed jointly by practicing psychiatrists and emergency physicians from the Advanced Life Support Group (ALSG) Acute Psychiatric Emergencies will be useful for practitioners of emergency medicine, psychiatry, emergency and mental health nursing as well as other mental health and crisis care professionals.

Pain Genetics: Basic to Translational Science is a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex concepts facing the field. The coverage is wide-ranging and will serves as an excellent entry point into understating the genetics of pain as well as providing a single resource for established researchers looking for a better understanding of the diverse strands of research going on in the area. With contributors painstakingly selected to provide a broad range of perspectives and research, Pain Genetics will be a valuable resource for geneticists, neuroscientists, and biomedical professionals alike.

Invasion Genetics: the Baker & Stebbins legacy provides a state-of-the-art treatment of the evolutionary biology of invasive species, whilst also revisiting the historical legacy of one of the most important books in evolutionary biology: The Genetics of Colonizing Species, published in 1965 and edited by Herbert Baker and G. Ledyard Stebbins. This volume covers a range of topics concerned with the evolutionary biology of invasion including: phylogeography and the reconstruction of invasion history; demographic genetics; the role of stochastic forces in the invasion process; the contemporary evolution of local adaptation; the significance of epigenetics and transgenerational plasticity for invasive species; the genomic consequences of colonization; the search for invasion genes; and the comparative biology of invasive species. A wide diversity of invasive organisms are discussed including plants, animals, fungi and microbes.

A revolutionary way to describe business, xBML (extended Business Modelling Language) is an intuitive graphical language that unlocks the DNA of a corporation using a system of diagrams based on five Ws (Who; What; Which; Where; When). xBML gives companies an complete and accurate map of their enterprise, that can then be re-used repeatedly to describe, plan and create improvement. It’s time to throw out the flow charts. xBML breaks down the silos of an enterprise and provides the means for clear, concise communication between all members of the organization. Tyler and Baker provide a complete guide to xBML, and to why unlocking an organization’s Business Genetics will lead to quantifiable business improvement.

Now updated for its second edition,  Population Genetics  is the classic, accessible introduction to the concepts of population genetics. Combining traditional conceptual approaches with classical hypotheses and debates, the book equips students to understand a wide array of empirical studies that are based on the first principles of population genetics.  Featuring a highly accessible introduction to coalescent theory, as well as covering the major conceptual advances in population genetics of the last two decades, the second edition now also includes end of chapter problem sets and revised coverage of recombination in the coalescent model, metapopulation extinction and recolonization, and the fixation index.

Ecological Genetics addresses the fundamental problems of which of the many molecular markers should be used and how the resulting data should be analysed in clear, accessible language, suitable for upper-level undergraduates through to research-level professionals. A very accessible straightforward text to deal with this difficult topic – applying modern molecular techniques to ecological processes. Written by active researchers and teachers within the field. There will be an accompanying web site managed by the authors, comprising of worked examples, test data sets and hyperlinks to relevant web pages.